KOMUKAI Kimiaki 小武海公明

… Alternative Names

小武海公明コムカイキミアキ

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Researcher Number	60360145
Other IDs
External Links
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2004 – 2012: 東京慈恵会医科大学, 医学部, 講師 2003 – 2004: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Neurophysiology and muscle physiology / Neurophysiology and muscle physiology
Keywords	Principal Investigator パッチクランプ法 / KN-93 / α受容体 / カルシウム電流 / アンギオテンシン / 生理活性 / ETB受容体 / カルシウム / ラット / プロテインキナーゼ … More / ETA受容体 / プロテインキナーゼC / CaMKII / シグナル伝達 / 心筋 / エンドセリン / アルファ受容体 / 交感神経 / 心筋収縮 / カルシウムチャネル / ウェスタンブロッティング / カルシウムイオン / 穿孔パッチクランプ法 / カルモデュリン … More Except Principal Investigator 細胞内Ca / 拡張型心筋症 / Ca感受性 / 細胞内Ca^<2+> / トロポニン / Ca^<2+>感受性 / SERCA / Acidosis / Diastolic dysfunction / Intracellular calcium concentration / Mouse heart / 心不全 / アンジオテンシンII / 細胞内カルシウム濃度 / 筋小胞体Caポンプ / アシドーシス / 拡張障害 / 細胞内Ca濃度 / マウス心筋 / RAA系 / 線維化 / アンギオテンシン / 遺伝子改変 / リン酸化調節 / 筋小胞体機能 / 細胞内Ca動態 / 心臓病態学 / CaMKII / 細胞内Ca2^<2+> / Ca 感受性 / 心エコー / レニン・アンギオテンシン系 / Ca transient / マウス / DCM / アンギオテンシンII / Caトランジェント / 筋小胞体 / Ca^<2+> / アンギオテンシンII受容体 / トロポニンT / 心筋 Less

Molecular mechanisms of an improvement in prognosis in the mouse model of dilated cardiomyopathy treated by inhibition of the RAA system
- Principal Investigator
  
  KURIHARA Satoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Jikei University School of Medicine
Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T
- Principal Investigator
  
  KURIHARA Satoshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Jikei University School of Medicine
Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.
- Principal Investigator
  
  HONGO Kenichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jikei University School of Medicine
Coupling of protein kinase C and Ca/calmodulin dependent protein kinase II in cardiac musclePrincipal Investigator
- Principal Investigator
  
  KOMUKAI Kimiaki
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jikei University School of Medicine
カルモデュリン依存性キナーゼによる心筋の興奮・収縮の調節Principal Investigator
- Principal Investigator
  
  小武海公明
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jikei University School of Medicine
Mechanism of diastolic dysfunction in pressure-overloaded mouse heart
- Principal Investigator
  
  HONGO Kenichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The Jikei University School of Medicine

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Alpha_1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta_1-adrenoceptor2013
- Author(s)
  O-Uchi J, Komukai K, Kusakari Y, Morimoto S, Kawai M, Jhun BS, Hurst S, Hongo K, Sheu SS, Kurihara S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 433(2) Issue: 2 Pages: 188-93
- DOI
  10.1016/j.bbrc.2013.02.072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300130, KAKENHI-PUBLICLY-23136515
[Journal Article] 冠動脈疾患2010
- Author(s)
  小武海公明, 他
- Journal Title
  
  日本臨床 68(増刊2)
  
  Pages: 388-92
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Role of Ca^/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca^current during endothelin-1 stimulation2010
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 298(6) Issue: 6 Pages: H1902-H1907
- DOI
  10.1152/ajpheart.01141.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300130
[Journal Article] Role of Ca^<2+>/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca^<2+> current during endothelin-1 stimulation.2010
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300130
[Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current during endothelin-1 stimulation.2010
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Journal Title
  
  Am J Physiol Heart Circ Physiol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Role of Ca^<2+>/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca^<2+> current during endothelin-1 stimulation.2010
- Author(s)
  Komukai K
- Journal Title
  
  Am J Physiol Heart Circ Physiol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] ACE阻害薬の臨床上の効能と副作用2010
- Author(s)
  小武海公明, 他
- Journal Title
  
  Modern Physician 30
  
  Pages: 387-90
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Infiltration of macrophages through the atrial endocardium in inflammation-induced rats: the contribution of fractalkine.2009
- Author(s)
  Date T, Yamashita T, Iwasaki Y, Aizawa T, Aramaki Y, Komukai K, Taniguchi I, Yoshimura M.
- Journal Title
  
  Circ J 73
  
  Pages: 932-937
- NAID
  10025930542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Hoshina T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S
- Journal Title
  
  BBRC 390
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500357
[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart.2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Hoshina T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S
- Journal Title
  
  Biochem Biophys Res Commun 390(1)
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] 選択的抗アルドステロン薬2009
- Author(s)
  小武海公明, 他
- Journal Title
  
  日本臨床 67(増刊7)
  
  Pages: 359-62
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009
- Author(s)
  Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M.
- Journal Title
  
  in renovascular hypertensive rats. Hypertens Res 32
  
  Pages: 604-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] 薬物療法・ACE阻害薬2009
- Author(s)
  小武海公明, 他
- Journal Title
  
  Medicina 46
  
  Pages: 1284-6
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats2009
- Author(s)
  Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I Mochizuki S. Yoshimura M.
- Journal Title
  
  Hypertension Res 32
  
  Pages: 604-10
- NAID
  10025164290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increase Ca(2+) leak in mouse heart.2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Hosh T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S.
- Journal Title
  
  Biochem Biophys Res Commun 390
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Infiltration of macrophages through the atrial endocardium in inflammation-induced rats : the contribution of fractalkine2009
- Author(s)
  Date T, Yamashita T, Iwasaki Y, Aizawa T, Aramaki Y, Komukai K, Taniguchi I, Yoshimura M.
- Journal Title
  
  Circ J 75
  
  Pages: 923-7
- NAID
  10025930542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca^<2+> leak in mouse heart.2009
- Author(s)
  Morimoto S, O-Uchi J, kawai M, Hoshina T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S
- Journal Title
  
  BBRC 390
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500357
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009
- Author(s)
  Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M
- Journal Title
  
  in renovascular hypertensive rats. Hypertens Res 32(7)
  
  Pages: 604-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] ACE阻害薬・ARB・抗アルドステロン薬の共通点と相違点2009
- Author(s)
  小武海公明, 他
- Journal Title
  
  診断と治療 97
  
  Pages: 694-700
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] ACE阻害薬2009
- Author(s)
  小武海公明, 他
- Journal Title
  
  循環器科 66
  
  Pages: 24-31
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca^<2+> channel2008
- Author(s)
  O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S.
- Journal Title
  
  Circ Res 102
  
  Pages: 1378-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction.2008
- Author(s)
  Komukai K, Yagi H, Ogawa T, Date T, Morimoto S, Kawai M, Hongo K, Taniguchi I, Yoshimura M
- Journal Title
  
  Circ J 72(12)
  
  Pages: 2004-2008
- NAID
  110006987355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction.2008
- Author(s)
  Komukai K
- Journal Title
  
  Circulation Jounal 72
  
  Pages: 2004-2008
- NAID
  110006987355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure.2008
- Author(s)
  Komukai K, Ogawa T, Yagi H, Date T, Sakamoto H, Kanzaki Y, Shibayama K, Hashimoto K, Inada K, Minai K, Ogawa K, Kosuga T, Kawai M, Hongo K, Taniguchi I, Yoshimura M
- Journal Title
  
  Circ J 72(7)
  
  Pages: 1152-1157
- NAID
  110006792071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure.2008
- Author(s)
  Komukai K
- Journal Title
  
  Circulation Jounal 72
  
  Pages: 1152-1157
- NAID
  110006792071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Inhibition of the renin-angiotensin system prevents r-hospitalization in heart failure patients with peserved ejection fraction2008
- Author(s)
  Komukai, et al
- Journal Title
  
  Circulation Journal 72
  
  Pages: 2004-2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization in heart failure patients with preserved ejection fraction2008
- Author(s)
  Komukai K, Yagi H, Ogawa T, Date T, Morimoto S, Kawai M, Hongo K, Taniguchi I, Yoshimura M.
- Journal Title
  
  Circ J 72
  
  Pages: 2004-8
- NAID
  110006987355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2 channel2008
- Author(s)
  O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S
- Journal Title
  
  Circ Res 102(11)
  
  Pages: 1378-1388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500357
[Journal Article] Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.2008
- Author(s)
  O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S
- Journal Title
  
  Circ Res 102(11)
  
  Pages: 1378-1388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Interaction of alphal-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca^<2+>channel.2008
- Author(s)
  O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S
- Journal Title
  
  Circ Res. 102(11)
  
  Pages: 1378-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500357
[Journal Article] Interaction of {alpha}1-Adrenoceptor Subtypes With Different G Proteins Induces Opposite Effects on Cardiac L-type Ca(2+) Channel.2008
- Author(s)
  O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S.
- Journal Title
  
  Circ Res 102
  
  Pages: 1378-1388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure2008
- Author(s)
  Komukai, et al
- Journal Title
  
  Circulation Journal 72
  
  Pages: 1152-1157
- NAID
  110006792071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] 心不全とアルドステロン2008
- Author(s)
  小武海ら
- Journal Title
  
  最新医学 63
  
  Pages: 854-857
- NAID
  40015976195
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Renal insufficiency is related to painless myocardial infarction.2007
- Author(s)
  Komukai K, Ogawa T, Yagi H, Date T, Suzuki K, Sakamoto H, Miyazaki H, Takatsuka H, Shibayama K, Ogawa K, Kanzaki Y, Kosuga T, Kawai M, Hongo K, Yoshida S, Taniguchi I, Mochizuki S
- Journal Title
  
  Circ J 71(9)
  
  Pages: 1366-1369
- NAID
  110006399679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Renal insufficiency is related to painless myocardial infarction2007
- Author(s)
  Komukai, et. al.
- Journal Title
  
  Circulation Journal 71
  
  Pages: 1366-1369
- NAID
  110006399679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] 大動脈解離と酸素化障害(総説)2006
- Author(s)
  小武海公明ら
- Journal Title
  
  呼吸と循環 54・7
  
  Pages: 739-43
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] a1-adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmoduoin-dependent PKII (CaMKII) activation in rat ventricular myocytes2005
- Author(s)
  O-Uchi J, Komukai K et al.
- Journal Title
  
  Proc Natl Acad Sci USA 102(26)
  
  Pages: 9400-9405
- Data Source
  KAKENHI-PROJECT-15790397
[Journal Article] C-reactive protein is related to impaired oxygenation in patients with acute aortic dissection2005
- Author(s)
  Komukai K, et al.
- Journal Title
  
  Int Heart J 46(5)
  
  Pages: 795-799
- NAID
  130000068565
- Data Source
  KAKENHI-PROJECT-15790397
[Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current durinendothelin-1 stimulation.
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, KaM, Hongo K, Yoshimura M, Kurihara S.
- Journal Title
  
  Am Physiol Heart Circ Physiol 2010 press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Compensatory increase in the Ca^ transient is important for contractile recovery of dilated cardiomyopathy in mice2012
- Author(s)
  Hongo K, Morimoto S, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Kurihara S
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22300130
[Presentation] Selective modulation of SERCA did not affect Ca^ leak from sarcoplasmic reticulum in transgenic mouse models2012
- Author(s)
  Morimoto S, Hongo K, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Kurihara S
- Organizer
  Scientific session of American Heart Association
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-22300130
[Presentation] Direct renin inhibition improved cardiac remodeling and survival in mouse model of dilated cardiomyopathy2011
- Author(s)
  Hongo K, Morimoto S, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Kurihara S
- Organizer
  Scientific Session of American Heart Association
- Place of Presentation
  Orlando FL USA
- Data Source
  KAKENHI-PROJECT-22300130
[Presentation] マウス拡張型心筋症における心筋線維化に対する直接レニン阻害の効果2011
- Author(s)
  本郷賢一、森本智、草刈洋一郎、小武海公明、川井真、吉村道博、栗原敏
- Organizer
  日本生理学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22300130
[Presentation] Beta-adrenergic stimulation enhances Ca^ leak from sarcoplasmic reticulum through protein kinase A-dependent phosphorylation of ryanodine receptor under physiological condition2010
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Kusakari Y,Komukai K,Sasaki H, Yoshimura M, Hongo K,Kurihara S
- Organizer
  Scientific Session of American Heart Association
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-22300130
[Presentation] Factors modulating the effect of endothelin-1 on L-type Ca current.2010
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-03-07
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Factors modulating the effect of endothelin-1 on L-type Ca current2010
- Author(s)
  Komukai K, et al
- Organizer
  第74回日本循環器学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-03-07
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] β-Adrenoceptor stimulation increased Ca2+ leak from sarcoplasmic reticulum without dissociation of FKBP12. 6 under physiological condition2009
- Author(s)
  Morimoto S, O-uchi J, Kawai M, Komukai K, Sasaki H, Yoshimura M, Hongo K, Kurihara S
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Endothelin-1 Increases L-type Ca Current of Rat Ventricular Myocytes via an Activation of Protein Kinase C and Ca/calmodulin Dependent Protein Kinase II.2009
- Author(s)
  Komukai K, O-Uchi J, Hongo K, Kawai K, Morimoto S, Yoshimura M, Kurihara S
- Organizer
  AHA Scientific Sessions
- Place of Presentation
  Orlando USA
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mouse.2009
- Author(s)
  Hongo K, Morimoto S, O-Uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
- Organizer
  XXXVIth International Congress of Physiological Sciences
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 potentiates L-type Ca2+ current by activating CaMKII in rat ventricular myocytes2009
- Author(s)
  Komukai K, O-uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Endothelin-1 increases L-type Ca2+ current of rat ventricular myocytes via an activation of protein kinase C and Ca2+/calmodulin dependent protein kinaseII2009
- Author(s)
  Komukai K, O-Uchi J, Hongo K, Kawai M, Morimoto S, Yoshimura M, Kurihara S
- Organizer
  American Heart Association
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mouse2009
- Author(s)
  Hongo K, Morimoto S, O-Uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] β-adrenoceptor stimulation increased Ca leak from sarcoplasmic reticulum without dissociation of FKBP12. 6 under physiological condition.2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Komukai K, Sasaki H, Yoshimura M, Hongo K, Kurihara S
- Organizer
  XXXVIth International Congress of Physiological Sciences
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 increases L-type Ca current of rat ventricular myocytesvia an activation of protein kinase C and Ca/calmodulin dependent protein kinase II2009
- Author(s)
  Komukai K, et al
- Organizer
  American Heart Association Scientific Session 2009
- Place of Presentation
  Orlando, Florica
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 increases L-type Ca current of rat ventricular myocytes via an activation of protein kinase C and Ca/calmodulin dependt protein kinase II.2009
- Author(s)
  Komukai K, O-Uchi J, Hongo K, Kawai M, Morimoto S, Yoshimura M, Kurihara S.
- Organizer
  American Heart Association Scientific Session 2009
- Place of Presentation
  Orlando, Florida
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in ratventricular myocytes2009
- Author(s)
  Komukai K
- Organizer
  36^<th> International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Rennin-angiotensin system plays an important role in the pathogenesis of DCM in mouse.2009
- Author(s)
  Hongo K, Morimoto S, O-uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in rat ventricular myocytes.2009
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Organizer
  The 36th Congress of the International Union of Physiological Sciences.
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in rat Ventricular myocytes2009
- Author(s)
  Komukai K, et al
- Organizer
  The 36th Congress of the International Union of Physiological Sciences
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] β-Adrenoceptor stimulation increased Ca leak from sarcoplasmic reticulum without dissociation of FKBP12.6 under physiological condition.2009
- Author(s)
  Morimoto S, O-uchi J, Kawai M, Komukai K, Sasaki H, Yoshimura M, Hongo K, Kurihara S
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in ratventricular myocytes.2009
- Author(s)
  Komukai K, O-uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Organizer
  The XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Cardiacα1A-adrenoceptor stimulation inhibits L-type Ca2+ current in the presence ofβ-adrenoceptor stimulation through tyrosine kinase.2009
- Author(s)
  O-Uchi J, Komukai K, Morimoto S, Hongo K, Kurihara S
- Organizer
  Biophysical Society 53rd Annual Meeting
- Place of Presentation
  Boston USA
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] β-adrenoceptor stimulation accelerates Ca2+ turnover through PKA-dependent phosphorylation in saponin-treated mouse myocardium.2008
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Komukai K, Hongo K, Sasaki H, Kurihara S
- Organizer
  第84回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin dependent protein kinase II in rat ventricular myocytes2008
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Organizer
  日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin-dependent protein kinase II in rat ventricular myocytes.2008
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin- dependent protein kinase II in rat ventricular myocytes2008
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Molecular basis for the Frank-Starli-ng mechanism of the heart2008
- Author(s)
  Kurihara S, Fukuda N, Ohtsuki I, Terui T, Hongo K, Komukai K, Ishikawa T
- Organizer
  心臓循環器系調節機構の病態生理学に関する国際シンポジウム
- Place of Presentation
  山形
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin protein kinase II in rat ventricular myocytes2008
- Author(s)
  Komukai, et. al.
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Molecular basis for the Frank-Starling mechanism of the heart.2008
- Author(s)
  Kurihara S, Fukuda N, Ohtsuki I, Terui T, Hongo K, Komukai K, Ishikawa T
- Organizer
  心臓循環器系調節機構の病態生理学に関する国際シンポジウム
- Place of Presentation
  山形
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Decreased Ca^<2+>affinity of thin filament is an important factor for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy.2008
- Author(s)
  0-Uchi J, Hongo K, Morimoto s. Komukai K, Kawai M, Ohtsuki I, Morimoto S*, Kurihara S(*Laboratory of clinical pharmacology, Kyushu University graduate school of medicine)
- Organizer
  Thick and thin filament regulation in striated muscle
- Place of Presentation
  Madison, USA
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Decreased Ca2+ sensitivity of the myofilament is critical for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy.2008
- Author(s)
  Hongo K, Morimoto S, Komukai K, Kawai M, O-Uchi J, Yoshimura M, Kurihara S
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Decreased Ca2+ affinity of thin filament is an important factor for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy2008
- Author(s)
  O-Uchi J, Hongo K, Morimoto S, Komukai K, Kawai M, Ohtsuki I, Morimoto S, Kurihara S
- Organizer
  Thick and thin filament regulation in striated muscle
- Place of Presentation
  Madison, USA
- Data Source
  KAKENHI-PROJECT-19500357
[Presentation] Effect of endothelin-I on L-type Ca current in rat ventricular myocytes2007
- Author(s)
  Komukai, et. al.
- Organizer
  第11回日本心不全学会学術集会
- Place of Presentation
  浦安
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Effect of endothelin-1 on L-type Ca current in rat ventricular myocytes.2007
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Kurihara S.
- Organizer
  第11回日本心不全学会学術集会
- Place of Presentation
  浦安
- Data Source
  KAKENHI-PROJECT-18590789

1. HONGO Kenichi (00256447)

# of Collaborated Projects: 5 results

# of Collaborated Products: 50 results
2. KAWAI Makoto (40277025)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. MORIMOTO Sachio (50202362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
4. KURIHARA Satoshi (90057026)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
5. SASAKI Hiroyuki (60170693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. KUSAKARI Yoichiro (80338889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. FUKUDA Norio (30301534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. OTSU Kinya (20294051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

KOMUKAI Kimiaki 小武海 公明

小武海 公明 コムカイ キミアキ

Research Projects

Research Products

Co-Researchers

Molecular mechanisms of an improvement in prognosis in the mouse model of dilated cardiomyopathy treated by inhibition of the RAA system

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Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T

Principal Investigator

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Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.

Principal Investigator

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Coupling of protein kinase C and Ca/calmodulin dependent protein kinase II in cardiac musclePrincipal Investigator

Principal Investigator

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Research Institution

カルモデュリン依存性キナーゼによる心筋の興奮・収縮の調節Principal Investigator

Principal Investigator

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Research Institution

Mechanism of diastolic dysfunction in pressure-overloaded mouse heart

Principal Investigator

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Research Institution

[Journal Article] Alpha_1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta_1-adrenoceptor2013

Author(s)

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DOI

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[Journal Article] 冠動脈疾患2010

Author(s)

Journal Title

Data Source

[Journal Article] Role of Ca^/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca^current during endothelin-1 stimulation2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Ca^<2+>/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca^<2+> current during endothelin-1 stimulation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current during endothelin-1 stimulation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Role of Ca^<2+>/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca^<2+> current during endothelin-1 stimulation.2010

Author(s)

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[Journal Article] ACE阻害薬の臨床上の効能と副作用2010

Author(s)

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[Journal Article] Infiltration of macrophages through the atrial endocardium in inflammation-induced rats: the contribution of fractalkine.2009

Author(s)

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NAID

Data Source

[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart2009

Author(s)

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KOMUKAI Kimiaki 小武海公明

小武海公明コムカイキミアキ