higuchi kazuhiro 樋口和宏

… Alternative Names

樋口和宏ヒグチカズヒロ

Higuchi Kazuhiro 樋口和宏

HIGUCHI Kazuhiro 樋口和宏

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Researcher Number	60360195
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 明治薬科大学, 薬学部, 准教授 2016 – 2018: 明治薬科大学, 薬学部, 准教授 2008 – 2010: Meiji Pharmaceutical University, 薬学部, 講師 2007: Meiji Pharmaceutical University, 薬学部, 助教 2003 – 2004: 明治薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry
Keywords	Principal Investigator インドリン-3-オン / 極性転換反応 / オキシアリルカチオン / アルキルスルホニウム塩 / トリアリールスルホニウム / スルホニウム塩 / 薬学 / 有機化学 / カップリング / ビアリール … More / チオニウム / ラピジレクチンB / ハークリンA / フェノールカップリング / チオニウム種 / 連続的環化反応 / ビアリールカップリング / スルホキシド / 活性チオニウム種 / トリフルオロ酢酸無水物 / α-ケトイミン / ジ置換インドリン-3-オン / 不斉反応 / イミニウム / イサチシンA / マンニッヒ型反応 / 血小板凝集抑制作用 / パーヒドロフェナントレン / 血小板凝集抑制 / RGD / パーヒドロフェナントレン骨格 / G4120 / 細胞膜外粘着タンパク質 / インテングリン / インテグリン / 血小板凝集 / ペプチドミミック / ストリキニーネ / ツビホリジン / アスピドスペルミジン / ピロロ[2,3-d]カルバゾール Less

４価硫黄原子利用法の開拓：新規アルキルスルホニウム塩の合成と反応についてPrincipal Investigator
- Principal Investigator
  
  樋口和宏
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Meiji Pharmaceutical University
Development of aryl coupling reactions using thionium species and application to the synthesis of condensed heterocyclic skeletonPrincipal Investigator
- Principal Investigator
  
  Higuchi Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meiji Pharmaceutical University
Synthesis and Utilities of 2, 2-Disubstituted Indolin-3-one Using of Mannich-type ReactionPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Kazuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meiji Pharmaceutical University
Synthetic Study of Low Molecular Peptide Mimetics toward Platelet Aggregation InhibitorsPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Kazuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Meiji Pharmaceutical University
ピロロカルバゾール構造を鍵シントンとするインドールアルカロイドの合成研究Principal Investigator
- Principal Investigator
  
  樋口和宏
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meiji Pharmaceutical University

All 2023 2022 2019 2018 2017 2016 2010 2009 2007 2006

All Journal Article Presentation

[Journal Article] Preparation of Alkyl Di(p-tolyl)sulfonium Salts and Their Application in Metal-Free C(sp3)-C(sp3) and C(sp3)-C(sp2) Bond Formations2023
- Author(s)
  Higuchi Kazuhiro、Yamamoto Kai、Nakamura Shunsuke、Naruse Haruka、Ito Motoki、Sugiyama Shigeo
- Journal Title
  
  Organic Letters
  
  Volume: 25 Issue: 20 Pages: 3766-3771
- DOI
  10.1021/acs.orglett.3c01233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06512
[Journal Article] A metal-free biaryl coupling reaction activated by a sulfonium salt2018
- Author(s)
  Higuchi Kazuhiro、Tago Takuhiro、Kokubo Yusuke、Ito Motoki、Tayu Masanori、Sugiyama Shigeo、Kawasaki Tomomi
- Journal Title
  
  Organic Chemistry Frontiers
  
  Volume: 5 Issue: 22 Pages: 3219-3225
- DOI
  10.1039/c8qo00798e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15427, KAKENHI-PROJECT-17K15428, KAKENHI-PROJECT-16K08181
[Journal Article] 分子間interrupted Pummerer反応を利用したインドール類の官能基化反応2018
- Author(s)
  田湯正法, 樋口和宏, 川﨑知己
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 76 Pages: 678-689
- NAID
  130007403450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08181
[Journal Article] Total Synthesis of (+)-Gliocladin C Based on One-Pot Construction of a 3a-(3-Indolyl)pyrroloindoline Skeleton by Sulfonium-Mediated Cross-Coupling of Tryptophan and Indole2017
- Author(s)
  Tayu, M.; Hui, Y.; Takeda, S.; Higuchi, K.; Saito, N.; Kawasaki, T
- Journal Title
  
  Org. Lett.
  
  Volume: 19 Issue: 24 Pages: 6582-6585
- DOI
  10.1021/acs.orglett.7b03293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08181, KAKENHI-PROJECT-17K08226, KAKENHI-PROJECT-17K15427
[Journal Article] Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt2017
- Author(s)
  Masanori Tayu, Kazuya Nomura, Koki Kawachi, Kazuhiro Higuchi, Nozomi Saito, Tomomi Kawasaki
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 23 Issue: 45 Pages: 10925-10930
- DOI
  10.1002/chem.201702338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08181, KAKENHI-PROJECT-17K08226, KAKENHI-PROJECT-17K15427
[Journal Article] Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction2010
- Author(s)
  樋口和宏, 佐藤幸洋, 小島滋, 羽鳥雅俊, 土持芽衣, 杉浦健太, 川嶋知己
- Journal Title
  
  Tetrahedron 66
  
  Pages: 1236-1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790027
[Journal Article] Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction2010
- Author(s)
  樋口和宏, 佐藤幸洋, 小島滋, 羽鳥雅俊, 土持芽衣, 杉浦健太, 川崎知己
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 1236-1243
- Data Source
  KAKENHI-PROJECT-21790027
[Journal Article] Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction2010
- Author(s)
  樋口和宏・佐藤幸洋・小島滋・土持芽衣・杉浦健太・羽鳥雅俊・川崎知己*
- Journal Title
  
  Tetrahedron 66巻
  
  Pages: 1236-1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790027
[Presentation] アルキルスルホニウム塩の合成とその炭素－炭素結合形成反応への応用2023
- Author(s)
  中村俊介、山本加偉、高木愛理、阿部遥真、成瀬晴香、伊藤元気、樋口和宏、杉山重夫
- Organizer
  日本薬学会第143年会北海道
- Data Source
  KAKENHI-PROJECT-22K06512
[Presentation] スルホニウム塩が拓く機能性分子創製へのアプローチ2023
- Author(s)
  樋口和宏
- Organizer
  第67回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06512
[Presentation] アルキルスルホニウム塩を用いた炭素－炭素結合形成反応2022
- Author(s)
  樋口和宏、山本加偉、中村俊介、阿部遥真、高木愛里、伊藤元気、杉山重夫
- Organizer
  第48回反応と合成の進歩シンポジウム千葉
- Data Source
  KAKENHI-PROJECT-22K06512
[Presentation] Activated thionium induced bond formation2019
- Author(s)
  Kazuhiro HIGUCHI
- Organizer
  35th International annual meeting in pharmaceutical sciences (IAMPS35) and CU-MPU international collaborative research conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08181
[Presentation] スルホニウム種によるピロロインドリンワンポット合成法を利用した(+)-gliocladin C の不斉全合成2017
- Author(s)
  回芸・田湯正法・武田詩織・樋口和宏・齋藤望・川﨑知己
- Organizer
  第47 回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-16K08181
[Presentation] スルホニウム種を用いたインドールの芳香族求核置換反応2017
- Author(s)
  田湯正法, 野村和也, 河内晃樹, 樋口和宏, 齋藤望, 川﨑知己
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台、宮城
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08181
[Presentation] ジアステレオ選択的ピロロインドリン骨格ワンポット構築反応の開発と(+)-gliocladin C 合成研究への応用2017
- Author(s)
  回芸、田湯正法、武田詩織、樋口和宏、齋藤望、川﨑知己
- Organizer
  第73回有機合成化学協会関東支部シンポジウム（目白シンポジウム）
- Data Source
  KAKENHI-PROJECT-16K08181
[Presentation] Nucleophilic Aromatic Substitution on Electron-Rich Indoles Mediated by DMSO-Tf2O2016
- Author(s)
  Masanori Tayu, Koki Kawachi, Kazuya Nomura, Kazuhiro Higuchi, Tomomi Kawasaki, Nozomi Saito
- Organizer
  French- Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  多摩、東京
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08181
[Presentation] Sulfonium Species Mediated Coupling Reaction of Phenol Derivatives2016
- Author(s)
  Kazuhiro Higuchi, Takuhiro Tago, Yusuke Kokubo, Masanori Tayu, Tomomi Kawasaki and Shigeo Sugiyama
- Organizer
  French- Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  多摩、東京
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08181
[Presentation] Isatisine Aの合成を目指した2,2-ジ置換インドリノン骨格構築2009
- Author(s)
  小島滋・後藤洋孝・佐藤幸洋・樋口和宏・川崎知己
- Organizer
  第39回複素環化学討論会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-21790027
[Presentation] Isatisine Aの合成を目指した2,2-ジ置換インドリノン骨格構築2009
- Author(s)
  小島滋, 後藤洋孝, 佐藤幸洋, 樋口和宏, 川崎知己
- Organizer
  第39回複素環化学討論会
- Place of Presentation
  柏
- Data Source
  KAKENHI-PROJECT-21790027
[Presentation] Mannich型反応を利用した(±)-Hinckdentine Aの全合成2009
- Author(s)
  樋口和宏, 佐藤幸洋, 羽鳥雅俊, 川暗知己
- Organizer
  第7回次世代を担う有機化学シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21790027
[Presentation] 血小板凝集阻害剤を指向した非ペプチド性RGDミメティクスの合成2007
- Author(s)
  樋口和宏、疋田英樹、小島滋、油利大地、小早川奈津、川崎知己
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-19790099
[Presentation] 血小板凝集阻害活性を指向したRGDミミックの合成研究2006
- Author(s)
  樋口和宏、疋田英樹、小早川奈津、油利大地、川崎知己
- Organizer
  第50回日本薬学会関東支部大会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-19790099

1. Tago Takuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Matsumura Kazunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Hui Yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Tayu Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. Saito Nozomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. Sugiyama Shigeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Ito Motoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

higuchi kazuhiro 樋口 和宏

樋口 和宏 ヒグチ カズヒロ

Higuchi Kazuhiro 樋口 和宏

HIGUCHI Kazuhiro 樋口 和宏

Research Projects

Research Products

Co-Researchers

４価硫黄原子利用法の開拓：新規アルキルスルホニウム塩の合成と反応についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of aryl coupling reactions using thionium species and application to the synthesis of condensed heterocyclic skeletonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis and Utilities of 2, 2-Disubstituted Indolin-3-one Using of Mannich-type ReactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthetic Study of Low Molecular Peptide Mimetics toward Platelet Aggregation InhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ピロロカルバゾール構造を鍵シントンとするインドールアルカロイドの合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Preparation of Alkyl Di(p-tolyl)sulfonium Salts and Their Application in Metal-Free C(sp3)-C(sp3) and C(sp3)-C(sp2) Bond Formations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A metal-free biaryl coupling reaction activated by a sulfonium salt2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 分子間interrupted Pummerer反応を利用したインドール類の官能基化反応2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Total Synthesis of (+)-Gliocladin C Based on One-Pot Construction of a 3a-(3-Indolyl)pyrroloindoline Skeleton by Sulfonium-Mediated Cross-Coupling of Tryptophan and Indole2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction2010

Author(s)

Journal Title

Data Source

[Journal Article] Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction2010

Author(s)

Journal Title

Data Source

[Journal Article] Preparation of 2,2-disubstituted 1,2-dihydro-3H-indol-3-ones via oxidation of 2-substituted indoles and Mannich-type reaction2010

Author(s)

Journal Title

Data Source

[Presentation] アルキルスルホニウム塩の合成とその炭素－炭素結合形成反応への応用2023

Author(s)

Organizer

Data Source

[Presentation] スルホニウム塩が拓く機能性分子創製へのアプローチ2023

Author(s)

higuchi kazuhiro 樋口和宏

樋口和宏ヒグチカズヒロ

Higuchi Kazuhiro 樋口和宏

HIGUCHI Kazuhiro 樋口和宏