Ishida Hisashi 石田恒

… Alternative Names

石田恒イシダヒサシ

ISHIDA Hisashi 石田恒

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Researcher Number	60360418
Other IDs
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, 上席研究員(定常) 2018: 国立研究開発法人量子科学技術研究開発機構, 関西光科学研究所量子生命科学研究部, 上席研究員(定常) 2012: 独立行政法人日本原子力研究開発機構, その他部局等, 研究員 2010 – 2012: 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 … More 2008: Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究員 2007: Japan Atomic Energy Agency, 独立行政法人・日本原子力研究開発機構量子ビーム応用研究部門, 研究職 2006: JAEA, QuBS, Researcher, 量子ビーム応用研究部門, 研究職 2005: 独立行政法人, 日本原子力研究開発機構・量子ビーム応用研究部門・中性子生命科学ユニット, 研究職 2005: 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門・中性子生命科学ユニット, 研究職 2004: 特殊法人日本原子力研究所, 中性子利用研究センター, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Biological Sciences / Biophysics / Biological Sciences Except Principal Investigator Biophysics
Keywords	Principal Investigator 分子動力学シミュレーション / 自由エネルギー / DNA / ヌクレオソーム / 自由エネルギー計算 / 電子顕微鏡像 / 分子動力学法 / リボソーム / RuvB / RuvA … More / 酸性アミノ酸 / 自由エネルギー面 / 分岐点移動 / ホリデイ構造 / ドキソルビシン / YOYO1 / SYBR-Gold / インターカレーション / ヒストン / DNA解離 / ねじれ / 遺伝子発現 / 構造変化 / 立体構造構築 / 当てはめ / ラチェット様運動 / チェット様運動 / tRNA転位 / 伸長因子EFG / tRNA 転位 / 伸長因子EF-G / 分子動力学 / 電子顕微鏡 / 自由エネルギー成分解析 / Muts / ATP加水分解 / 損傷DNA修復誘導反応 / ミスマッチDNA認識 / 天然変性タンパク質 / MutS / RuvAB / DNA組換え / モーター蛋白質 / 主成分解析 / X線結晶解析 / 基準振動解析 / 立体構造 / DNA修復 … More Except Principal Investigator RuvA / MutT / molecular dynamics / molecular evolution / DNA photolyase / database / genome / DNA repair protein / アノテーション / 分子動力学 / 分子進化 / DNAホトリアーゼ / データベース / ゲノム / DNA修復タンパク質 Less

インターカレーターが引き起こすDNA・ヌクレオソーム構造変化メカニズム解析Principal Investigator
- Principal Investigator
  
  石田恒
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  National Institutes for Quantum Science and Technology
Analysis of conformational change of nucleosome by molecular dynamics simulationPrincipal Investigator
- Principal Investigator
  
  Ishida Hisashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
天然変性タンパク質としてのMutSの損傷DNA修復誘導メカニズム解析Principal Investigator
- Principal Investigator
  
  石田恒
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Japan Atomic Energy Agency
Analysis of conformational changes in ribosome during protein synthesis reaction cyclePrincipal Investigator
- Principal Investigator
  
  ISHIDA Hisashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Japan Atomic Energy Agency
分子シミュレーションによる、DNA組換えをおこすモーター蛋白質の分子機構解明Principal Investigator
- Principal Investigator
  
  石田恒
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japan Atomic Energy Agency
電子顕微鏡像に基づくリボソームの精密な立体構造解析Principal Investigator
- Principal Investigator
  
  石田恒
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japan Atomic Energy Agency
分子動力学シミュレーションによるDNA修復メカニズムの解明Principal Investigator
- Principal Investigator
  
  石田恒
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Japan Atomic Energy Agency
Function annotation of DNA repair related proteins using molecular evolution information and computer simulation of protein dynamics
- Principal Investigator
  
  YURA Kei
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Japan Atomic Energy Agency

All 2024 2023 2021 2020 2019 2013 2012 2011 2010 2008

All Journal Article Presentation

[Journal Article] Torsional stress can regulate the unwrapping of two outer half superhelical turns of nucleosomal DNA2021
- Author(s)
  Ishida Hisashi、Kono Hidetoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 7
- DOI
  10.1073/pnas.2020452118
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-18K06173
[Journal Article] Nucleosome unwrapping and unstacking2020
- Author(s)
  Kono Hidetoshi、Ishida Hisashi
- Journal Title
  
  Current Opinion in Structural Biology
  
  Volume: 64 Pages: 119-125
- DOI
  10.1016/j.sbi.2020.06.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-18K06173
[Journal Article] Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome2019
- Author(s)
  Kono Hidetoshi、Sakuraba Shun、Ishida Hisashi
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 16 Issue: 0 Pages: 337-343
- DOI
  10.2142/biophysico.16.0_337
- NAID
  130007752747
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06173, KAKENHI-PLANNED-18H05534
[Journal Article] Molecular Dynamics Simulation System for structural analysis of biomolecules by high performance computing2011
- Author(s)
  Ishida, H
- Journal Title
  
  Progress in Nuclear Science and Technology
  
  Volume: 2 Pages: 470-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] 抗がん剤doxorubicinとヌクレオソームの分子動力学シミュレーション2024
- Author(s)
  石田恒、河野秀俊
- Organizer
  第41回染色体ワークショップ・第22回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-23K05726
[Presentation] 分子シミュレーションによるDNAインターカレーター構造の網羅的探索2023
- Author(s)
  石田恒、河野秀俊
- Organizer
  第10回「富岳」を中核とするHPCIシステム利用研究課題成果報告会
- Data Source
  KAKENHI-PROJECT-23K05726
[Presentation] Analysis of conformations of intercalated DNA using molecular dynamics simulations2023
- Author(s)
  Ishida Hisashi and Kono Hidetoshi
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K05726
[Presentation] 全原子分子動力学シミュレーションを用いた、ヌクレオソーム安定性に対するねじれストレス影響の解析2020
- Author(s)
  石田恒
- Organizer
  量子生命科学会第２回大会
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] 分子シミュレーションによるヌクレオソーム構造変化の網羅的探索2020
- Author(s)
  石田恒
- Organizer
  第７回「京」を中核とするHPCIシステム利用研究課題成果報告会
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] Positive torsional stress on DNA enhances unwrapping of nucleosomal DNA2020
- Author(s)
  Hisashi Ishida, Hidetoshi Kono
- Organizer
  Biophysical Society Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] ヌクレオソームの崩壊と転写2019
- Author(s)
  河野　秀俊, ルオ　ディ, 石田　恒
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] 分子シミュレーションによるヌクレオソーム構造変化の網羅的探索ヌクレオソームのH2A/H2B脱離メカニズム解析2019
- Author(s)
  石田　恒
- Organizer
  第６回「京」を中核とする HPCI システム利用研究課題　成果報告会
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] Free energy profile of eviction of H2A/H2B dimer from nucleosome2019
- Author(s)
  Hisashi Ishida, Hidetoshi Kono
- Organizer
  3rd QST International Symposium
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] Integrated approach of experimental data and computer modeling and simulation for understanding chromatin structure and dynamics2019
- Author(s)
  Hidetoshi Kono, Atsushi Matsumoto, Shun Sakuraba, Hisashi Ishida
- Organizer
  第57回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] Sequence dependence of nucleosomal DNA unwrapping2019
- Author(s)
  角南　智子, ルオ　ディ, 石田　恒, 河野　秀俊
- Organizer
  第３回DSB研究成果報告会
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] FREE ENERGY PROFILES FOR UNWRAPPING THE OUTER SUPERHELICAL2019
- Author(s)
  石田恒、河野秀俊
- Organizer
  Multiscale Modeling of Chromatin:Bridging Experiment with Theory
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06173
[Presentation] Free-energy landscape of tRNA translocation through ribosome revealed by electron microscopy density map and molecular dynamics simulations2013
- Author(s)
  Ishida, H and Matsumoto, A
- Organizer
  Biophysical society 57th annual meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2013-02-04
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Energy landscape of translocation of tRNA molecules through ribosome revealed by electron microscopy density map and molecular dynamics simulations2013
- Author(s)
  Hisashi Ishida
- Organizer
  Biophysical society 57th annual meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Dynamics of tRNA translocation revealed by electron microscopy density map and molecular dynamics simulations2012
- Author(s)
  Ishida, H and Matsumoto, A
- Organizer
  Mini-Symposium on Modeling, Simulation and Function of Biomolecular Assemblies
- Place of Presentation
  Tokyo
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] 分子動力学シミュレーションプログラムSCUBAの開発とタンパク質-核酸複合体の大規模シミュレーション2012
- Author(s)
  石田恒
- Organizer
  第4回HPCI戦略プログラム合同研究交流会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Free-energy landscape of translocation through ribosome analysed using MD simulations and cryo-EM density maps2012
- Author(s)
  石田恒
- Organizer
  第５０回日本生物物理学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Free-energy landscape of translocation through ribosome analysed using MD simulations and cryo-EM density maps2012
- Author(s)
  Ishida, H. and Matsumoto, A
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-24
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] 分子動力学シミュレーションを用いたMutSタンパク質2量体の損傷DNA認識・修復誘導メカニズム解析2012
- Author(s)
  石田恒、松本淳
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  千里ライフサイエンスセンター・ライフホール(大阪市)
- Year and Date
  2012-01-24
- Data Source
  KAKENHI-PUBLICLY-22113522
[Presentation] Energy landscape of translocation of tRNA molecules through ribosome revealed by electron microscopy density map and molecular dynamics simulations2011
- Author(s)
  Ishida, H. and Matsumoto, A
- Organizer
  CECAM workshop on "Dynamics of protein-nucleic acid interactions : Integrating simulations with experiment"
- Place of Presentation
  Switzerland, Zurich
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] MutSのDNA修復誘導変性ループと損傷DNA認識の関連性解析2011
- Author(s)
  石田恒、松本淳
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回領域会議
- Place of Presentation
  宮崎県宮崎市
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PUBLICLY-22113522
[Presentation] Ribosome dynamics and tRNA movement using electron microscopy density map and molecular dynamics simulations2011
- Author(s)
  石田恒
- Organizer
  7^<th> Asian Biophysics Association Symposium & Annual Meeting of the Indian Biophysical Society
- Place of Presentation
  New Delhi, India
- Year and Date
  2011-01-30
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Energy landscape of translocation of tRNA molecules through ribosome revealed by electron microscopy density map and molecular dynamics simulations2011
- Author(s)
  Hisashi Ishida, Atsushi Matsumoto
- Organizer
  CECAM workshop on "Dynamics of protein-nucleic acid interactions : Integrating simulations with experiment"
- Place of Presentation
  ETHZ(Switzerland, Zurich)(招待講演)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Recognition mechanism of damaged DNA by MutS analysed by molecular dynamics simulations2011
- Author(s)
  Hisashi Ishida, Atsushi Matsumoto
- Organizer
  17^<th> International Biophysics Congress (IUPAB) & 12^<th> National Biophysics Congress
- Place of Presentation
  Beijing, China
- Year and Date
  2011-11-02
- Data Source
  KAKENHI-PUBLICLY-22113522
[Presentation] Analysis of translocation of tRNA molecules through ribosome using electron microscopy density map and molecular dynamics simulations2010
- Author(s)
  石田恒
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  仙台
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Molecular Dynamics Simulation System for structural analysis of biomolecules by high performance computing2010
- Author(s)
  石田恒
- Organizer
  Joint International Conference on Supercomputing in Nuclear Applications and Monte Carlo 2010 (SNA+MC2010)
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2010-10-20
- Data Source
  KAKENHI-PROJECT-22570165
[Presentation] Analysis of-mechanism of branch migration by RuvB using molecular dynamics simulation2008
- Author(s)
  石田恒
- Organizer
  第46回日本生物物理年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19042021

1. YURA Kei (50252226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HIGUCHI Mariko (90370460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松本淳 (10399420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 角南智子 (50554648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 河野秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ishida Hisashi 石田 恒

石田 恒 イシダ ヒサシ

ISHIDA Hisashi 石田 恒

Research Projects

Research Products

Co-Researchers

インターカレーターが引き起こすDNA・ヌクレオソーム構造変化メカニズム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of conformational change of nucleosome by molecular dynamics simulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

天然変性タンパク質としてのMutSの損傷DNA修復誘導メカニズム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of conformational changes in ribosome during protein synthesis reaction cyclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

分子シミュレーションによる、DNA組換えをおこすモーター蛋白質の分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

電子顕微鏡像に基づくリボソームの精密な立体構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

分子動力学シミュレーションによるDNA修復メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function annotation of DNA repair related proteins using molecular evolution information and computer simulation of protein dynamics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Torsional stress can regulate the unwrapping of two outer half superhelical turns of nucleosomal DNA2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleosome unwrapping and unstacking2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Molecular Dynamics Simulation System for structural analysis of biomolecules by high performance computing2011

Author(s)

Journal Title

Data Source

[Presentation] 抗がん剤doxorubicinとヌクレオソームの分子動力学シミュレーション2024

Author(s)

Organizer

Data Source

Ishida Hisashi 石田恒

石田恒イシダヒサシ

ISHIDA Hisashi 石田恒

[Presentation] 分子シミュレーションによるヌクレオソーム構造変化の網羅的探索ヌクレオソームのH2A/H2B脱離メカニズム解析2019