NAGAI Tatsuo 永井立夫

Researcher Number	60365947
Affiliation (based on the past Project Information) *help	2015 – 2017: 北里大学, 医学部, 講師 2010 – 2013: 北里大学, 医学部, 講師 2009: 北里大学, 医学部, 助教 2004 – 2005: 帝京大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 Except Principal Investigator 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology
Keywords	Principal Investigator Fcγ受容体 / IL-6 / TNFα / リボソームP抗原 / ヒト末梢血単球 / Th1 / IL-12 / IFN-γ / 全身性エリテマトーデス / 抗リボソームP抗体 … More Except Principal Investigator … More 自己抗体 / IL-6 / グルタミン酸レセプター / エピトープ / 抗神経細胞抗体 / ループス精神病 / 中枢神経ループス / 脳MRI / ループス腎炎 / 補体第５成分 / 単球 / 抗Sm抗体 / 脳血液関門 / C5a / anti-Sm / MRI / acute confusional state / NPSLE / lupus psychosis / epitope / anti-glutamate receptor antibody / ribosomal P proteins / anti-neuronal antibody / cerebrospinal fluid / central nervous system / systemic lupus erythematosus / リボソームP蛋白 / リボソームP0蛋白 / リボソームPO蛋白 / 髄液 / CNSループス / TNF-α / Staphylococcus aureus / CTLA-4 / 抗CD3抗体 / アバタセプト / 抗体産生 / マクロファージ / CD80 / CTLA4 / クラススイッチ / 抗CD３抗体 / Tリンパ球 / Bリンパ球 / 神経細胞 / Th1反応 / 抗リボソームP抗体 / 脳脊髄液 / 中枢神経病変 / 全身性エリテマトーデス / 核酸結合タンパク質 / ミトコンドリア酵素タンパク質 / プロテオミクス / 神経芽細胞腫細胞 Less

Analysis of the mechanism of blood-brain barrier damages in NPSLE
- Principal Investigator
  
  Hirohata Shunsei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kitasato University
Analysis of the mechanism of production of pathologic autoantibodies
- Principal Investigator
  
  HIROHATA Shunsei
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kitasato University
Analysis of anti-neuronal antibodies in neuropsychiatric systemic lupus erythematosu
- Principal Investigator
  
  HIROHATA Shunsei
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kitasato University
全身性エリテマトーデスの病態形成における抗リボソームP抗体の役割の解析Principal Investigator
- Principal Investigator
  
  永井立夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Teikyo University
Role of anti-neuronal antibodies in the pathogenesis of central nervous system lupus erythematosus
- Principal Investigator
  
  HIROHATA Shunsei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Teikyo University School of Medicine

All 2017 2016 2015 2013 2012 2011 2010 2009 2005

All Journal Article Presentation Book

[Book] 今日の治療と看護　改訂第3版2013
- Author(s)
  廣畑俊成, 永井良三（編集）他
- Total Pages
  1493
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591447
[Journal Article] Differential activation mechanisms of serum C5a in lupus nephritis and neuropsychiatric systemic lupus erythematosus.2017
- Author(s)
  Sakuma Y, Nagai T, Yoshio T, Hirohata S.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 27 Issue: 2 Pages: 292-297
- DOI
  10.1080/14397595.2016.1193965
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09556
[Journal Article] Association of antibodies to the NR1 subunit of N-methyl-D-aspartate receptors with neuropsychiatric systemic lupus erythematosus.2015
- Author(s)
  Ogawa E, Nagai T, Sakuma Y, Arinuma Y, Hirohata S
- Journal Title
  
  Mod Rheumatol
  
  Volume: 26 Issue: 3 Pages: 377-383
- DOI
  10.3109/14397595.2015.1083163
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09556
[Journal Article] Effects of anti-IL-6 receptor antibody on human monocytes.2015
- Author(s)
  Tono T, Aihara S, Hoshiyama T, Arinuma Y, Nagai T, Hirohata S.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 25 Issue: 1 Pages: 79-84
- DOI
  10.3109/14397595.2014.914016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09556
[Journal Article] Differential in vitro effects of biological agents on cytokine production of peripheral blood mononuclear cells.2013
- Author(s)
  Tejima S, Tono T, Nagai T, Hirohata S
- Journal Title
  
  Kitasato Med J
  
  Volume: 43 Pages: 126-132
- NAID
  40019788614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591447
[Journal Article] Role of FK506 binding protein 5 (FKBP5) in osteoclast differentiation.2013
- Author(s)
  Kimura, M., Nagai, T., Matsushita. R., Hashimoto. A., Miyashita. T., and Hirohata. S.
- Journal Title
  
  Mod. Rheumatol.
  
  Volume: 23 Pages: 1133-1139
- DOI
  10.1007/s10165-012-0809-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501269, KAKENHI-PROJECT-23591447
[Journal Article] Incidence and the risk factor of malignancy in Japanese patients with systemic sclerosis.2012
- Author(s)
  Hashimoto A, Arinuma Y, Nagai T, Tanaka S, Matsui T, Tohma S, Endo H, Hirohata S
- Journal Title
  
  Intern Med
  
  Volume: 51 Pages: 1683-1688
- NAID
  130002062218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591447
[Journal Article] Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis2011
- Author(s)
  Hirohata S, Nagai T, Asako K, Tomita T, Yoshikawa H
- Journal Title
  
  Clin Immunol
  
  Volume: 140(3) Issue: 3 Pages: 276-83
- DOI
  10.1016/j.clim.2011.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591447
[Journal Article] Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis.2011
- Author(s)
  Hirohata S, Nagai T, Asako K, Tomita T, Yoshikawa H:
- Journal Title
  
  Clin Immunol
  
  Volume: 140 Pages: 276-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591447
[Journal Article] Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement.2010
- Author(s)
  Iizuka N, Okamoto K, Matsushita R, Kimura M, Nagai K, Arito M, Kurokawa MS, Masuko K, Suematsu N, Hirohata S, Kato T
- Journal Title
  
  Lupus 19
  
  Pages: 717-726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591175
[Journal Article] Anti-ribosomal P protein antibody induces Th1 responses by enhancing the production of IL-12 in activated monocytes.2010
- Author(s)
  Nagai T, Yanagida T, Hirohata S.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21 Pages: 57-62
- NAID
  10029361301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591175
[Journal Article] Anti-ribosomal P protein antibody induces Th1 responses by enhancing the production of IL-12 in activated monocytes.2010
- Author(s)
  Nagai T, Yanagida T, Hirohata S
- Journal Title
  
  Mod Rheumatol 21
  
  Pages: 57-62
- NAID
  10029361301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591175
[Journal Article] Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement.2010
- Author(s)
  Iizuka N, Okamoto K, Matsushita R, Kimura M, Nagai K, Arito M, Kurokawa MS, Masuko K, Suematsu N, Hirohata S, Kato T.
- Journal Title
  
  Lupus
  
  Volume: 19 Pages: 717-726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591175
[Journal Article] 抗リボソームP抗体はヒト単球系白血病細胞株THP-1からのVEGF産生を亢進する.2009
- Author(s)
  永井立夫、廣畑俊成
- Journal Title
  
  臨床リウマチ 21
  
  Pages: 151-156
- NAID
  130005141225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591175
[Journal Article] Antiribosomal P protein antibody in human systemic lupus erythematosus upregulates the expression of inflammatory cytokines by human peripheral blood monocytes2005
- Author(s)
  Nagai T, Arinuma Y, Yanagida T, Yamamoto K, Hirohata S
- Journal Title
  
  Arthritis & Rheumatism 52
  
  Pages: 847-855
- Data Source
  KAKENHI-PROJECT-16590996
[Journal Article] Antiribosomal P protein antibody in human systemic lupus erythematosus upregulates the expression of inflammatory cytokines by human peripheral blood monocytes2005
- Author(s)
  Nagai T, Arinuma Y, Yanagida T, Yamamoto K, Hirohata S
- Journal Title
  
  Arthritis & Rheumatism 52
  
  Pages: 847-855
- Data Source
  KAKENHI-PROJECT-16790560
[Journal Article] Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytes.2005
- Author(s)
  Nagai T, et al.
- Journal Title
  
  Arthritis Rheum 52
  
  Pages: 847-855
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590996
[Presentation] Serum C5a is increased in lupus nephritis as well as in neuropsychiatric systemic lupus erythematosus through different mechanisms.2016
- Author(s)
  Sakuma Y, Nagai T, Yoshio T, Hirohata S
- Organizer
  EULAR 2016
- Place of Presentation
  London (U.K.)
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09556
[Presentation] 神経精神ループスに対するミコフェノール酸モフェチルの有効性に関する検討.2016
- Author(s)
  児玉華子、小川英佑、田中住明、谷名、田中知樹、安部学朗、工藤雄大、和田達彦、永井立夫、廣畑俊成
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜　（神奈川県横浜市）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K09556
[Presentation] Association of Antibodies to the NR1 Subunit of N-Methyl-D-Aspartate Receptors with Neuropsychiatric Systemic Lupus Erythematosus.2015
- Author(s)
  Ogawa E, Nagai T, Sakuma Y, Arinuma Y, Hirohata S.
- Organizer
  79th Annual Scientific Meeting, American College of Rheumatology
- Place of Presentation
  San Francisco (U.S.A.)
- Year and Date
  2015-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09556
[Presentation] Analysis of cerebrospinal fluid anti-NR1 glutamate receptor antibodies in neuropsychiatric systemic lupus erythematosus.2015
- Author(s)
  Ogawa E, Nagai T, Sakuma Y, Arinuma Y, Hirohata S
- Organizer
  LUPUS2015
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09556
[Presentation] Brain MRI findings in patients with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus2013
- Author(s)
  Arinuma Y, Kikuchi H, Ogawa E, Wada T, Nagai T, Tanaka S, Hirohata S
- Organizer
  EULAR 2013
- Place of Presentation
  Madrid(FRI0327)
- Year and Date
  2013-06-14
- Data Source
  KAKENHI-PROJECT-23591447
[Presentation] Enhanced expression of mRNA for triggering receptor expressed on myeloid cells 1 in CD34+ cells of the bone marrow in rheumatoid arthritis2013
- Author(s)
  Nagai T, Tomita T, Yoshikawa H, Hirohata S
- Organizer
  77^<th> Annual Scientific Meeting, American College of Rheumatology
- Place of Presentation
  San Diego
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-23591447
[Presentation] Differential effects of TNF inhibitors, anti-IL-6 receptor antibody and CTLA4-Ig on human monocytes2013
- Author(s)
  Tono T, Arinuma Y, Nagai T, Tanaka S, Hirohata S
- Organizer
  77^<th> Annual Scientific Meeting, American College of Rheumatology
- Place of Presentation
  San Diego
- Year and Date
  2013-10-28
- Data Source
  KAKENHI-PROJECT-23591447
[Presentation] Retrospective analysis of the efficacy and tacrolimus in rheumatoid arthritis : suggestive synergistic effects with methotrexate2011
- Author(s)
  Hoshi K, Tanaka S, Wada T, Tanaka J, Nagai T, Hirohata S
- Organizer
  75^<th> Annual Scientific Meeting, American College of Rheumatology
- Place of Presentation
  Chicago
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-23591447
[Presentation] Antiribosomal P protein antibody induces in vitro IL-17 production by PBMC.2011
- Author(s)
  Nagai T, Tejima S, Tono T, Hirohata S
- Organizer
  EAGOR 2011
- Place of Presentation
  京王プラザホテル（Tokyo）
- Data Source
  KAKENHI-PROJECT-23591447
[Presentation] Determination of the accurate incidence of pulmonary arterial hypertension in patients with systemic sclerosis, mixed connective tissue disease and systemic lupus erythematosus by prospective study for 3 years.2010
- Author(s)
  Tanaka S, Hoshi K, Tanaka J, Wada T, Matsui T, Nagai T, Okada J, Hirohata S
- Organizer
  74th Annual Scientific Meeting
- Place of Presentation
  American College of Rheumatology, Atlanta, USA
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-20591175
[Presentation] Jaccould関節症を呈し、肺高血圧症を合併した抗CCP抗体陽性のSLEの一例.2009
- Author(s)
  安部学朗、星山隆行、東野紀子、東野俊洋、田中淳一、松井俊通、永井立夫、田中住明、石川章、廣畑俊成、岡田純
- Organizer
  第20回日本リウマチ学会関東支部学術集会
- Place of Presentation
  パシフィコ横浜横浜
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-20591175
[Presentation] ステロイド抵抗性間質性肺炎を伴ったamyopathic dermatomyositis(DM)の一症例.2009
- Author(s)
  松井俊通、田中淳一、永井立夫、田中住明、石川章、廣畑俊成
- Organizer
  第24回日本臨床リウマチ学会
- Place of Presentation
  いわて県民情報交流センター盛岡
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20591175
[Presentation] Antiribosomal P protein antibody induces Th1 responses by enhancing the production of IL-12 in activated monocytes.2009
- Author(s)
  Nagai T, Yanagida T Hirohata S.
- Organizer
  73rd Annual Scientific Meeting, American College of Rheumatology
- Place of Presentation
  Phladelphia USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-20591175
[Presentation] Proteomic analysis of autoantigens in SLE patients with CNS involvement.2009
- Author(s)
  Iizuka N, Okamoto, K Matsushita R, Arito M, Nagai K, Kurokawa MS, Suematsu N, Masuko K, Hirohata S, Kato T
- Organizer
  73rd Annual Scientific Meeting
- Place of Presentation
  American College of Rheumatology, Phladelphia, USA
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-20591175

1. HIROHATA Shunsei (90189895)

# of Collaborated Projects: 4 results

# of Collaborated Products: 28 results
2. WADA Tatsuhiko (60383585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. ENDO Hirahito (20213598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUI Toshimichi (20348519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. HASHIMOTO Atsushi (50327376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATO Tomohiro (80233807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIKUCHI Hirotoshi (80338681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小川英佑 (30525423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 加藤智啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 宮下俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGAI Tatsuo 永井 立夫

Research Projects

Research Products

Co-Researchers

Analysis of the mechanism of blood-brain barrier damages in NPSLE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism of production of pathologic autoantibodies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of anti-neuronal antibodies in neuropsychiatric systemic lupus erythematosu

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

全身性エリテマトーデスの病態形成における抗リボソームP抗体の役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of anti-neuronal antibodies in the pathogenesis of central nervous system lupus erythematosus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 今日の治療と看護 改訂第3版2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Differential activation mechanisms of serum C5a in lupus nephritis and neuropsychiatric systemic lupus erythematosus.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of antibodies to the NR1 subunit of N-methyl-D-aspartate receptors with neuropsychiatric systemic lupus erythematosus.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of anti-IL-6 receptor antibody on human monocytes.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential in vitro effects of biological agents on cytokine production of peripheral blood mononuclear cells.2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Role of FK506 binding protein 5 (FKBP5) in osteoclast differentiation.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Incidence and the risk factor of malignancy in Japanese patients with systemic sclerosis.2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis.2011

Author(s)

Journal Title

Data Source

[Journal Article] Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement.2010

Author(s)

NAGAI Tatsuo 永井立夫

[Book] 今日の治療と看護　改訂第3版2013