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KOKURYOU TOSHIO  國料 俊男

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KOKURYO Toshio  國料 俊男

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Researcher Number 60378023
Affiliation (Current) 2022: 名古屋大学, 医学部附属病院, 病院准教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 名古屋大学, 医学部附属病院, 病院准教授
2018 – 2021: 名古屋大学, 医学部附属病院, 講師
2017 – 2018: 名古屋大学, 医学部附属病院, 病院講師
2016: 名古屋大学, 医学部附属病院, 病院助教
2011 – 2016: 名古屋大学, 医学(系)研究科(研究院), 特任講師 … More
2011 – 2016: 名古屋大学, 医学系研究科, 特任講師
2012 – 2013: 名古屋大学, 医学(系)研究科(研究院), 講師
2012: 名古屋大学, 医学(系)・研究科(研究院), 講師
2012: 名古屋大学, 大学院・医学系研究科, 特任講師
2008 – 2011: 名古屋大学, 大学院・医学系研究科, 特任助教
2010: 名古屋, 医学系研究科, 特任助教
2010: Nagoya University, 医学系研究科, 特任助教
2010: 名古屋大学, 大学院・医学研究科, 講師
2008 – 2009: Nagoya University, 大学院・医学研究科, 特任助教
2008: 名古屋大学, 医学部附属病院, 助教
2007: 名古屋大学, 大学院・医学系研究科, COE研究員
2007: 名古屋大学, 大学院・医学系研究科, 助教
2007: Nagoya University Graduate School of Medicine, Division of Surgical Oncology, Assistant Professor Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related
Except Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related / General surgery
Keywords
Principal Investigator
Nek2 / TLK1 / FAK / 膵癌 / 治療抵抗性遺伝子 / TPX2 / IGFBP-3 / ビサボロール / 誘導体 / 胆管癌 / ノンコーディングRNA / 胆道癌 / 全ゲノム解析 … More
Except Principal Investigator
… More 分子標的治療 / Nek2 / 胆管癌 / 膵癌 / TFF / TLR7 / 食道癌 / 大腸癌 / 肝障害 / Danger signal / 肝虚血再灌流障害 / siRNA / 融合遺伝子 / ノンコーディングRNA / TFF1 / 術後肝障害 / 胆管癌幹細胞 / 肝門部胆管癌 / NeK2 / トランスレーショナルリサーチ / 肝再生 / カルシトニン / CGRP / PPAR_Y / 15D-PGJ_2 / PPARγ / 15d-PGJ2 / GW9662 / グルタチオン / Gamma-glutamyltransferase / 微小転移 / 微小転移関連遺伝子 / FAK / 微小転移開連遺伝子 / microscopic abscess / 免疫誘導阻止関連遺伝子 / Hedgehog / 相互マシンラーニング法 / Senescence / HJURP / セリンスレオニンキナーゼ / 化学療法関連肝障害 / Blue liver症候群 / 肝虚血・再灌流 / 一酸化窒素 / 肝虚血・再潅流 / Chromothripsis / Denger Signal / 分枝鎖アミノ酸 / 肝虚血再潅流障害 / 分子進化 / molecular targeted therapy / RAGE / 術後感染症 / 癌幹細胞 / システイン / 肝星細胞 / エンドセリン / 敗血症性ショックモデル / 必須アミノ酸 / Pre-metastatic niche / TPX2 / 血管新生関連分子 / 核酸医薬 / 深紫外線LED / 細胞障害作用 / 癌治療 / 前癌病変 / 癌 / 脂肪幹細胞 / 周術期対策 / 血中循環腫瘍細胞 / 生着関連遺伝子 / 非対称分裂 / 自己組織化 / invisible膵癌 / エクソソーム / バイオマーカー / Barrett上皮 / Barrett食道 / barrett食道 / 食道 / 肝細胞癌 / 原発性肝癌 / TLR4 / 予防治療法 / 胆道癌 / 全ゲノム解析 / 化学療法抵抗性 / 早期転移 / dormancy / 腹腔鏡下肝切除 / Navigation Surgery / ナビゲーション手術 / リアルタイムナビゲーションシステム / 高度侵襲消化器外科手術 / 腸内細菌叢プロファイル / 便中有機酸濃度 / バクテリアルトランスロケーション / 術後感染性合併症 / プロバイオティクス / 短鎖脂肪酸 Less
  • Research Projects

    (39 results)
  • Research Products

    (60 results)
  • Co-Researchers

    (28 People)
  •  胆道癌における融合型ノンコーディングRNAの機能解明と臨床応用Principal Investigator

    • Principal Investigator
      國料 俊男
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Whole genome sequencing concerning the chemoresistance of bile duct cancer

    • Principal Investigator
      水野 隆史
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  消化器外科手術後感染性合併症を予防するプロバイオティクス製剤の開発

    • Principal Investigator
      横山 幸浩
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The mechanisms of early dissemination and tumor dormancy of pancreatic cancer

    • Principal Investigator
      山口 淳平
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel treatment using adipose stem cell for postoperative liver damage

    • Principal Investigator
      ONOE Shunsuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel therapy based on engraftment, asymmetric division and Self-organization of circulating tumor cells

    • Principal Investigator
      相場 利貞
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel diagnostic methods for invisible pancreas cancer

    • Principal Investigator
      WATANABE Nobuyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The role of Trefoil Factors in hepato-carcinogenesis

    • Principal Investigator
      Ebata Tomoki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel nucleic acid medicine for the fusion genes in cholangiocarcinoma

    • Principal Investigator
      Nagino Masato
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Aichi Cancer Center Research Institute
      Nagoya University
  •  Novel therapy for cancer using deep ultraviolet

    • Principal Investigator
      Miyata Kazushi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The mechanisms of cancer development from Barrett esophagus regarding Trefoil Factors.

    • Principal Investigator
      Fukaya Masahide
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Development of real-time navigation system for hepatectomy

    • Principal Investigator
      IGAMI TSUYOSHI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The role of TFF1 to inhibit the development of pancreatic cancer

    • Principal Investigator
      Yamaguchi Junpei
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  術後肝障害に対するTLR4を標的にした予防治療法の開発

    • Principal Investigator
      菅原 元
    • Project Period (FY)
      2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategies for cancer stem cells

    • Principal Investigator
      TSUNODA NOBUYUKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya University
  •  Mechanism of a new cancer treatment targeting TLR7

    • Principal Investigator
      UEHARA KEISUKE
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Analysis of the inhibitory effect of cysteine on liver damage

    • Principal Investigator
      YOKOYAMA YUKIHIRO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategies to target the premetastatic niche for cancer metastasis

    • Principal Investigator
      MIZUNO TAKASHI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Mechanism of action of a bisabolol derivative and its clinical applicationPrincipal Investigator

    • Principal Investigator
      KOKURYO TOSHIO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategies targeting RAGE for postoperative infectious complications

    • Principal Investigator
      FUKAYA MASAHIDE
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel treatment for chromothripsis in breast cancer

    • Principal Investigator
      Tsunoda Nobuyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya University
  •  Novel strategies for endogenous danger signals by a TLR7 aptamer

    • Principal Investigator
      Uehara Keisuke
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Analysis of a new molecular system of branched-chain amino acids in liver damage following ischemia and re-perfusion

    • Principal Investigator
      Sugawara Gen
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Functional analysis of novel genes based on molecular evolution

    • Principal Investigator
      Yokoyama Yukihiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel inhibitor of serine threonine kinase for the treatment of cholangiocarcinoma and pancreas cancer

    • Principal Investigator
      Nagino Masato
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  化学療法関連肝障害の外科手術への影響とその病態生理の解明

    • Principal Investigator
      YOSHIOKA YUICHIRO
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategy for the gene concerning chemoresistance in pancreas cancerPrincipal Investigator

    • Principal Investigator
      KOKURYO TOSHIO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Development of the monitoring system for the liver function in hepatectomy

    • Principal Investigator
      NAGINO Masato
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Analysis of novel Hedgehog inhibitors for esophageal cancer

    • Principal Investigator
      FUKAYA MASAHIDE
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Analysis of Oncogene-induced-Senescence related genes in cancer for clinical application

    • Principal Investigator
      IGAMI TSUYOSHI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel cancer therapy based ongene profiling in micrometastasis

    • Principal Investigator
      TSUNODA Nobuyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya University
  •  Analysis of immunity induction in rectal cancer in association with microscopic abscess formation

    • Principal Investigator
      UEHARA Keisuke
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  GGTトランスジェニックマウスを用いた肝虚血/再潅流障害メカニズムの解明

    • Principal Investigator
      菅原 元
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Comprehensive cancer therapy targeted Nek2 and translational research

    • Principal Investigator
      NIMURA Yuji
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Aichi Cancer Center Research Institute
  •  The role of calcitonin in the early phase of liver regeneration and its molecular mechanism.

    • Principal Investigator
      YOKOYAMA Yukihiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  The role of PPARγ in bile duct ligation-induced hepatic injury in rats.

    • Principal Investigator
      EBATA Tomoki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  The development of the novel treatment that targeted plural cancer specific genesPrincipal Investigator

    • Principal Investigator
      KOKURYO Toshio
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Molecule targeted therapy for Cholangiocarcinoma based on the gene profiling of cancer stem cell

    • Principal Investigator
      NAGINO Masato
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  The Profiling of Cholangiocarcinoma and the Development of Molecular targeted therapy

    • Principal Investigator
      NIMURA Yuji
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Aichi Cancer Center Research Institute
      Nagoya University

All 2021 2020 2019 2018 2017 2015 2013 2012 2011 2010 2009 2007 2005 Other

All Journal Article Presentation

  • [Journal Article] Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice2021

    • Author(s)
      Keiji Hasebe, Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Yosuke Ochiai, Masato Nagino and Tomoki Ebata
    • Journal Title

      Carcinogenesis

      Volume: 42 (12) Pages: 1496-1505

    • DOI

      10.1093/carcin/bgab093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09141
  • [Journal Article] Premalignant pancreatic cells seed stealth metastasis in distant organs in mice2021

    • Author(s)
      Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Tomoki Ebata, Yosuke Ochiai, Masato Nagino
    • Journal Title

      Oncogene

      Volume: 40 Pages: 2273-2284

    • DOI

      10.1038/s41388-021-01706-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03751
  • [Journal Article] Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation2020

    • Author(s)
      Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M
    • Journal Title

      Hepatology

      Volume: - Pages: 503-517

    • DOI

      10.1002/hep.31039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09141
  • [Journal Article] Trefoil Factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm.2018

    • Author(s)
      Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Enomoto A, Nagino M.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128(8) Pages: 3619-3629

    • DOI

      10.1172/jci97755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Journal Article] Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer2017

    • Author(s)
      Masaki Sunagawa, Junpei Yamaguchi, Toshio Kokuryo, Tomoki Ebata, Yukihiro Yokoyama, Gen Sugawara, Masato Nagino
    • Journal Title

      Pancreatology

      Volume: 17 (5) Pages: 782-787

    • DOI

      10.1016/j.pan.2017.07.188

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Journal Article] Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy.2010

    • Author(s)
      Kawai K, Kokuryo T, Nagino M., (他5名)
    • Journal Title

      Ann Surg. 251(4)

      Pages: 692-700

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.2010

    • Author(s)
      Takayama Y, Kokuryo T, Nagino M., 他6名
    • Journal Title

      Cancer Lett.296(1):27-34.2010

      Volume: 296(1) Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy.2010

    • Author(s)
      Kawai K, Kokuryo T, Nagino M.
    • Journal Title

      Ann Surg. 251(4), 249(2)

    • Data Source
      KAKENHI-PROJECT-20591624
  • [Journal Article] Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin.2010

    • Author(s)
      Suzuki K, Kokuryo T, Hamaguchi M., 他5名
    • Journal Title

      Cancer Sci. 101(5)

      Pages: 1163-1169

    • NAID

      10026592095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Journal Article] Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.2010

    • Author(s)
      Takayama Y, Kokuryo T, Senga T.
    • Journal Title

      Cancer Lett. 296(1)

      Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Journal Article] Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin.2010

    • Author(s)
      Suzuki K, Kokuryo T, Nagino M
    • Journal Title

      Cancer Sci.

      Volume: 101(5) Pages: 1163-1169

    • NAID

      10026592095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin2010

    • Author(s)
      Suzuki K, Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M.
    • Journal Title

      Cancer Sci.

      Volume: 101(5) Pages: 1163-1169

    • NAID

      10026592095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Journal Article] A Novel Combination Treatment for Colorectal Cancer using Nek2 siRNA and Cisplatin2010

    • Author(s)
      Kazushi Suzuki, Toshio Kokuryo, Takeshi Senga, Yukihiro Yokoyama, Masato Nagino, Michinari Hamaguchi
    • Journal Title

      Cancer Science (In press)

    • NAID

      10026592095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Journal Article] Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.2010

    • Author(s)
      Takayama Y, Kokuryo T, Senga T., 他6名
    • Journal Title

      Cancer Lett. 296(1)

      Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Journal Article] Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.2010

    • Author(s)
      Takayama Y, Kokuryo T, Yokoyama Y, Ito S, Nagino M, Hamaguchi M, Senga T.
    • Journal Title

      Cancer Lett.

      Volume: 296(1) Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Journal Article] Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.2010

    • Author(s)
      Takayama Y, Kokuryo T, Senga T., (他6名)
    • Journal Title

      Cancer Lett. 296(1)

      Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] Silencing of Tousled-like kinase 1 sensitizes cholangiocazcinoma cells to cisplatin-induced apoptosis.2010

    • Author(s)
      Takayama Y, Kokuryo T, Nagino M., 他6名
    • Journal Title

      Cancer Lett.

      Volume: 296(1) Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Journal Article] Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin.2010

    • Author(s)
      Suzuki K, Kokuryo T, Hamaguchi M., (他5名)
    • Journal Title

      Cancer Sci. 101(5)

      Pages: 1163-1169

    • NAID

      10026592095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] 15-deoxy-delta12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis.2010

    • Author(s)
      Watanabe K, Yokovama Y, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 298(3)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591608
  • [Journal Article] Nek2 as a novel molecular target for the treatment of breast carcinoma.2009

    • Author(s)
      Tsunoda N, Kokuryo T, Nagino M.
    • Journal Title

      Cancer Sci. 100(1)

      Pages: 111-116

    • NAID

      10025141544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Journal Article] Nek2 as a novel molecular target for the treatment of breast carcinoma.2009

    • Author(s)
      Tsunoda N, Kokuryo T, Nagino M., (他4名)
    • Journal Title

      Cancer Sci. 100(1)

      Pages: 111-116

    • NAID

      10025141544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.2007

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.
    • Journal Title

      Cancer Res 67

      Pages: 9637-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Journal Article] Nek2 as an affective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.2007

    • Author(s)
      Kokuryo T, Yokoyama Y, Nagino M, (他3名)
    • Journal Title

      Cancer Research 67(20)

      Pages: 9637-9642

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Journal Article] Nek2 as effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.2007

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.
    • Journal Title

      Cancer Research 67

      Pages: 9637-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Journal Article] Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.2007

    • Author(s)
      Kokuryo T.
    • Journal Title

      Cancer Res 67

      Pages: 9637-42

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] Trefoil Factor Family 1 (TFF1) Inhibits Epithelial-mesenchymal Transition and Enhances the Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC)2019

    • Author(s)
      J Yamaguchi, T Kokuryo, Y Yokoyama, T Ebata, and M Nagino
    • Organizer
      APA annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation.2019

    • Author(s)
      Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M
    • Organizer
      The Liver Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09141
  • [Presentation] Trefoil Factor 1 inhibits epithelial-mesenchymal transition (EMT) of pancreatic intraepithelial neoplasm.2018

    • Author(s)
      Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino
    • Organizer
      AACR Pancreatic cancer: advances in science and clinical care
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] 2-Hydroxypropyl-beta-cyclodextrin encapsulated α-bisabolol (CD-BSB) improves the antitumor effect of α-bisabolol for pancreatic cancer2018

    • Author(s)
      Taisuke Baba, Toshio Kokuryo , Yukihiro Yokoyama, Junpei Yamaguchi, Masato Nagino
    • Organizer
      the AACR’s fifth Pancreatic Cancer Special Conference: Advances in Science and Clinical Care
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10591
  • [Presentation] Preserved expression of TFF1 in invasive front is a poor prognostic factor in PDAC2017

    • Author(s)
      Junpei Yamaguchi, Masaki Sunagawa, Yukihiro yokoyama, Toshio Kokuryo, Tomoki Ebata, Masato Nagino
    • Organizer
      Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association & The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] 遺伝子改変マウスを用いたTFF1欠損による膵浸潤癌発生に関する検討2017

    • Author(s)
      山口淳平、江畑智希、横山幸浩、國料俊男、梛野正人
    • Organizer
      第48回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] Targeting protein for Xklp2(TPX2)を標的にした膵癌治療法の開発2015

    • Author(s)
      三輪 知弘, 國料 俊男, 横山 幸浩, 山口 淳平, 梛野 正人
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      愛知県名古屋市. 名古屋国際会議場
    • Year and Date
      2015-04-16
    • Data Source
      KAKENHI-PROJECT-24592023
  • [Presentation] The expression pattern of MyD88 in rectal cancer in association with microscopic abscess formation2013

    • Author(s)
      Masanori Uno, Toshio Kokuryo, Yukihiro Yokoyama, Keisuke Uehara, Yuichiro Yoshioka, Masato Nagino
    • Organizer
      Ninth AACR Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui, USA
    • Data Source
      KAKENHI-PROJECT-22591483
  • [Presentation] The expression pattern of MyD88 in rectal cancer in association with microscopic abscess formation.2013

    • Author(s)
      Masanori Uno, Toshio Kokuryo, Yukihiro Yokoyama, Keisuke Uehara, Yuichiro Yoshioka, Masato Nagino
    • Organizer
      Ninth AACR Japanese Cancer Association Joint Conference
    • Place of Presentation
      Maui, USA
    • Data Source
      KAKENHI-PROJECT-22591483
  • [Presentation] The combination treatments using siRNA and CDDP are effective therapeutic options for cancers.2012

    • Author(s)
      T Kokuryo, Y Yokoyama, K Suzuki, T Ebata, N Tsunoda, T Igami, G Sugawara, M Fukaya, Y Takahashi, K Uehara, Y Yoshioka, M Nagino.
    • Organizer
      AACR 102nd annual meeting
    • Place of Presentation
      Orange County Convention Center (Orlando, USA)
    • Year and Date
      2012-04-04
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] Nek2 siRNAの非臨床試験と臨床応用2012

    • Author(s)
      國料俊男, 横山幸浩, 江畑智希, 菅原 元, 高橋 祐, 伊神 剛, 深谷昌秀, 上原圭介, 板津慶太, 吉岡裕一郎, 梛野正人
    • Organizer
      第67回 日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2012-07-19
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] The efficiency of Nek2 siRNAfor liver metastasis of pancreatic cancer2012

    • Author(s)
      Kokuryo T, Yokoyama Y, Nagino M.
    • Organizer
      AACR 103rd annual meeting
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2012-04-01
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] The combination treatments using siRNA and CDDP are effective therapeutic options for cancers2011

    • Author(s)
      Toshio Kokuryo
    • Organizer
      AACR 102nd annual meeting
    • Place of Presentation
      Orange County Convention Center Orlando, USA
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] siRNAを用いた癌分子標的治療のトランス2010

    • Author(s)
      國料俊男、横山幸浩、梛野正人
    • Organizer
      レーショナルリサーチJDDW2010
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Presentation] Nek2 as an effective molecular target for cancer treatment2010

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M.
    • Organizer
      AACR 101^<st> annual meeting
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Presentation] siRNAを用いた癌分子標的治療のトランスレーショナルリサーチ2010

    • Author(s)
      國料俊男、横山幸浩、梛野正人
    • Organizer
      JDDW 2010
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] siRNAを用いた癌分子標的治療のトランスレーショナルリサーチ2010

    • Author(s)
      國料俊男、横山幸浩、梛野正人
    • Organizer
      JDDW 2010
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390348
  • [Presentation] siRNAを用いた癌分子標的治療のトランスレーショナルリサーチ2010

    • Author(s)
      國料俊男、横山幸浩、梛野正人
    • Organizer
      JDDW 2010
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] Nek2 as an effective molecular target for cancer treatment2010

    • Author(s)
      Kokuryo T
    • Organizer
      AACR annual meeting
    • Place of Presentation
      Walter E.Washington Convention Center(USA)
    • Year and Date
      2010-04-19
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] Nek2 as an effective molecular target for cancer treatment.2010

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M.
    • Organizer
      AACR 101st annual meeting.
    • Place of Presentation
      Walter E. Washington Convention Center (Washington DC, USA)
    • Year and Date
      2010-04-19
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] Nek2 as an effective molecular target for cancer treatment2010

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M.
    • Organizer
      AACR 101^<st>annual meeting
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Presentation] siRNAを用いた癌分子標的治療のトランスレーショナルリサーチ2010

    • Author(s)
      國料俊男
    • Organizer
      JDDW 2010
    • Place of Presentation
      パシフィコ横浜,(神奈川県)
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] Nek2 as an effective molecular target for cancer treatment2010

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M.
    • Organizer
      AACR 101^<st> annual meeting
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] siRNAを用いた癌分子標的治療のトランスレーショナルリサーチ2010

    • Author(s)
      國料俊男、横山幸浩、梛野正人
    • Organizer
      JDDW 2010
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Presentation] Nek2 as an effective molecular target for cancer treatment2010

    • Author(s)
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M
    • Organizer
      AACR 101^<st> annual meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-19
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Presentation] 肝内結石症の網羅的遺伝子解析より始まった癌分子標的治療の開発2009

    • Author(s)
      國料俊男、横山幸浩、菅原元、江畑智希、西尾秀樹、梛野正人
    • Organizer
      日本肝胆膵外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-10
    • Data Source
      KAKENHI-PROJECT-20591624
  • [Presentation] 肝内結石症の網羅的遺伝子解析より始まつた癌分子標的治療の開発2009

    • Author(s)
      國料俊男
    • Organizer
      日本肝胆膵外科学会
    • Place of Presentation
      ウエスティンナゴヤキャッスル(名古屋)
    • Year and Date
      2009-06-10
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] 胆管癌に対するNek2 siRNAによる新規治療法の開発2007

    • Author(s)
      國料俊男
    • Organizer
      第62回日本消化器外科学会定期学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] The efficency of Nek2 siRNA for peritoneal dissemination2007

    • Author(s)
      Kokuryo T, Igami T, Ebata T, Nishio H, Nagino M, Nimura Y.
    • Organizer
      The 107th Annual Meeting of Japan Surgical Society
    • Place of Presentation
      Osaka
    • Year and Date
      2007-04-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] The development of novel therapy for Cholangiocarcinoma By usage of Nek2 siRNA2007

    • Author(s)
      Kokuryo T, Hibino S, Takayama Y, Kawai T, Oda K, Yokoyama Y, Nagino M, Nimura Y.
    • Organizer
      The 62th Annual Meeting of Japanese Society of Gastroenterological Surgery
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] 腹膜播種に対するNek2 siRNA腹腔内投与の有効性および臨床応用2007

    • Author(s)
      國料俊男
    • Organizer
      第107回日本外科学会定期学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] 胆管癌における網羅的遺伝子発現解析および分子標的治療の開発2005

    • Author(s)
      國料俊男
    • Organizer
      第17回日本肝胆膵外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2005-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] The profiling of Cholangiocarcinoma and the development of molecular Targeted therapy by usage of Nek2 siRNA2005

    • Author(s)
      Kokuryo T, Oda K, Ebata T, Nishio H, Arai T, Yuasa N, Nagino M, Nimura Y.
    • Organizer
      The 17th Annual Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery
    • Place of Presentation
      Yokohama
    • Year and Date
      2005-06-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209039
  • [Presentation] Nek2 siRNAの非臨床試験と臨床応用

    • Author(s)
      國料俊男,横山幸浩,江畑智希,菅原 元,高橋 祐,伊神 剛,,深谷昌秀,上原圭介,板津慶太,吉岡裕一郎,梛野正人
    • Organizer
      第67回 日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山)
    • Data Source
      KAKENHI-PROJECT-20249062
  • [Presentation] The efficiency of Nek2 siRNA for liver metastasis of pancreatic cancer

    • Author(s)
      Kokuryo T, Yokoyama Y, Nagino M.
    • Organizer
      AACR annual meeting
    • Place of Presentation
      McCormick Place (Chicago)
    • Data Source
      KAKENHI-PROJECT-20249062
  • 1.  NAGINO Masato (20237564)
    # of Collaborated Projects: 35 results
    # of Collaborated Products: 46 results
  • 2.  YOKOYAMA Yukihiro (80378091)
    # of Collaborated Projects: 35 results
    # of Collaborated Products: 37 results
  • 3.  Yamaguchi Junpei (00566987)
    # of Collaborated Projects: 20 results
    # of Collaborated Products: 11 results
  • 4.  EBATA Tomoki (60362258)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 6 results
  • 5.  UEHARA Keisuke (50467320)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 2 results
  • 6.  SUGAWARA Gen (00402587)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 7.  IGAMI TSUYOSHI (50420378)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  FUKAYA MASAHIDE (10420382)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  ABE Tetsuya (90378092)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 10.  SENGA Takeshi (80419431)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 11.  TSUNODA Nobuyuki (40542684)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  NIMURA Yuji (80126888)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 13.  YOSHIOKA YUICHIRO (50597854)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  ITATSU Keita (90534842)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  MIZUNO TAKASHI (90444413)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  WATANABE Nobuyuki (20746903)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  西尾 秀樹 (30345897)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  SANO Tsuyoshi (60303632)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  ISHIGURO Seiji (50571345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SHIMIZU Yasuhiro (40470166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  HAMAGUCHI Michinari (90135351)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  ODA Koji (30311715)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 23.  Miyata Kazushi (90752759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ONOE Shunsuke (20807515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  新井 利幸 (80335041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 26.  相場 利貞 (60789569)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  砂川 真輝 (50892709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KITAGAWA TOMOMI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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