Okamoto Ryuji 岡本隆二

… Alternative Names

OKAMOTO Ryuji 岡本隆二

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Researcher Number	60378346
Other IDs	https://orcid.org/0000-0002-8067-398X
Affiliation (Current)	2025: 三重大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 三重大学, 医学部附属病院, 教授 2018 – 2019: 三重大学, 医学部附属病院, 准教授 2014: 三重大学, 医学部附属病院, 講師 2013: 三重大学, 医学部附属病院, 助教 2012: 三重大学, 医学(系)研究科(研究院), 助教 … More 2009 – 2010: 三重大学, 大学院・医学系研究科, 助教 2006: 三重大, 医学部附属病院, 助手 2006: Mie University, Graduate School of Medicine, Department of Cardiology, Assistant Professor, 大学院医学系研究科, 助手 2005: 三重大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Circulatory organs internal medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Circulatory organs internal medicine
Keywords	Principal Investigator 心肥大 / 心筋症 / ミオシン軽鎖 / ねじれ運動 / 心不全 / 高血圧 / アルドステロン / ミネラルコルチコイド受容体 / ミオシン / Rhoキナーゼ … More / TGFβ / 内皮間葉移行現象 / 高血圧症 / 線維化 / レポーターマウス / 内皮間葉以降 / 心筋梗塞 / 心臓線維化 … More Except Principal Investigator 心不全 / SGLT2阻害薬 / 循環器 / PAI-1 / Rho-kinase / Rho / CRP / 食塩感受性 / 副腎 / バソプレシンV2受容体拮抗薬 / 慢性心不全 / 自己免疫性心筋炎 / CYP11B2 / アルドステロン / トルバプタン / NF-_KB / glucose / endothelial cell / 血管内皮細胞 / C反応性蛋白質 / グルコース / 内皮細胞 / ミオシンホスファターゼ / ミオシン軽鎖キナーゼ / リン酸化 / 心筋ミオシン Less

MR関連高血圧症による心不全発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  岡本隆二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Mie University
Interaction between renal tissue SGLT2 and the AT1R-NHE3 pathway as a mechanism for the progression of heart failure.
- Principal Investigator
  
  Dohi Kaoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Mie University
MLC phosphatase plays an important role in cardiac function and fibrosisPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Mie University
Effects of Tolvaptan via vasopressin V2 receptor-independent pathway on adrenal aldosterone synthesis.
- Principal Investigator
  
  Ito Masaaki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Mie University
The effect of sodium-glucose co-transporter 2 inhibition on heart failure prevention in Dahl salt-sensitive rats.
- Principal Investigator
  
  DOHI KAORU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Mie University
Investigation to clarify the role of endothelial mesenchymal transition in cardiac fibrosisPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University
Novel molecular mechanisms for cardiotonic action, their involvement in diseases and application for treatment
- Principal Investigator
  
  ITO Masaaki (MASAAKI Ito)
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University
遺伝子改変マウスを用いた心筋ミオシンホスファターゼの生理学的・病理学的機能解析Principal Investigator
- Principal Investigator
  
  岡本隆二
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University
CRP as a biomediator of atherosclerosis and its intracellular signaling
- Principal Investigator
  
  ITO Masaaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Mie University

All 2023 2022 2021 2020 2019 2018 2015 2014 2013 2012 2011 2010 2008 2007 2005

All Journal Article Presentation

[Journal Article] A hyperaldosteronism subtypes predictive model using ensemble learning2023
- Author(s)
  Karashima S, Kawakami M, Nambo H, Kometani M, Kurihara I, Ichijo T, Katabami T, Tsuiki M, Wada N, Oki K, Ogawa Y, Okamoto R, Tamura K, Inagaki N, Yoshimoto T, Kobayashi H, Kakutani M, Fujita M, Izawa S, Suwa T, Kamemura K, Yamada M, Tanabe A, Naruse M, Yoneda T; JPAS/JRAS Study Group.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3043-3043
- DOI
  10.1038/s41598-023-29653-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-21K08557, KAKENHI-PROJECT-22K08098
[Journal Article] Letter by Okamoto et al Regarding Article, “Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin”2023
- Author(s)
  Okamoto Ryuji、Ye Zhe、Dohi Kaoru
- Journal Title
  
  Circulation
  
  Volume: 148 Issue: 25 Pages: 2073-2073
- DOI
  10.1161/circulationaha.123.066090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08098
[Journal Article] Endovascular Treatment for Lower-extremity Arterial Thrombosis in a Patient with Congenital Afibrinogenemia and a History of Bleeding Complications2022
- Author(s)
  Hiramatsu Daisuke、Ogihara Yoshito、Matsumoto Takeshi、Sato Kei、Takasaki Akihiro、Kurita Tairo、Okamoto Ryuji、Wada Hideo、Dohi Kaoru
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 3 Pages: 361-364
- DOI
  10.2169/internalmedicine.7542-21
- NAID
  130008150387
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-02-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life2022
- Author(s)
  Oshita H, Sawada H, Mitani Y, Tsuboya N, Kabwe JC, Maruyama J, Yusuf A, Ito H, Okamoto R, Otsuki S, Yodoya N, Ohashi H, Oya K, Kobayashi Y, Kobayashi I, Dohi K, Nishimura Y, Saitoh S, Maruyama K, Hirayama M
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 2022 Aug 1;323(2):L178-L192.
  
  Volume: 323 Issue: 2 Pages: 178-192
- DOI
  10.1152/ajplung.00422.2021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09043, KAKENHI-PROJECT-22K07843, KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-20K08565, KAKENHI-PROJECT-21K07817
[Journal Article] Elderly Man With “Overalls” Edema2022
- Author(s)
  Nakaya Hitoshi、Okamoto Ryuji、Nagashima Kazunori、Sugino Yuichi、Ogihara Yoshito、Sakuma Hajime、Dohi Kaoru
- Journal Title
  
  Circ J
  
  Volume: 86 Issue: 2 Pages: 333
- DOI
  10.1253/circj.CJ-21-0700
- NAID
  130008144240
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2022-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism2022
- Author(s)
  Sakaguchi S, Okamoto R, Inoue C, Akao M, Kamemura K, Kurihara I, Takeda Y, Ohno Y, Inagaki N, Rakugi H, Katabami T, Tsuiki M, Tanabe A, Tamura K, Fujita S, Yano Y, Dohi K; JRAS investigators; Naruse M.
- Journal Title
  
  Journal of Human Hypertension
  
  Volume: - Issue: 9 Pages: 757-766
- DOI
  10.1038/s41371-022-00753-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-22K08098
[Journal Article] Regulation of myosin light-chain phosphorylation and its roles in cardiovascular physiology and pathophysiology2022
- Author(s)
  Ito Masaaki、Okamoto Ryuji、Ito Hiromasa、Zhe Ye、Dohi Kaoru
- Journal Title
  
  Hypertension Research
  
  Volume: 45 Issue: 1 Pages: 40-52
- DOI
  10.1038/s41440-021-00733-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] A Perihilar Variant of Focal Segmental Glomerulosclerosis Due to <i>De novo</i> Branchio-oto-renal Syndrome2022
- Author(s)
  Saiki R, Katayama K, Kitano M, Tsujimoto K, Tanaka F, Suzuki Y, Murata T, Kurita T, Okamoto R, Takeuchi K, Dohi K.
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 13 Pages: 2033-2038
- DOI
  10.2169/internalmedicine.8508-21
- NAID
  130008124756
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-07-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08255, KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension2022
- Author(s)
  Kabwe JC, Sawada H, Mitani Y, Oshita H, Tsuboya N, Zhang E, Maruyama J, Miyasaka Y, Ko H, Oya K, Ito H, Yodoya N, Otsuki S, Ohashi H, Okamoto R, Dohi K, Nishimura Y, Mashimo T, Hirayama M, Maruyama K.
- Journal Title
  
  Respir Res.
  
  Volume: ;23 Issue: 1 Pages: 1-22
- DOI
  10.1186/s12931-022-02005-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08192, KAKENHI-PROJECT-22K07843, KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-20K08565, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-21K07817
[Journal Article] Cardiac Fibrosis: Chronic Inflammatory Disease and Promising Therapeutic Target2022
- Author(s)
  Okamoto Ryuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 15 Pages: 8074-8074
- DOI
  10.3390/ijms23158074
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Thrombotic Microangiopathy Due to Severe Hypertension in a Patient With Primary Aldosteronism2022
- Author(s)
  Hirabayashi Yosuke、Okamoto Ryuji、Miura Shoko、Inoue Chisa、Uemura Mei、Sugino Yuichi、Murata Tomohiro、Katayama Kan、Yano Yutaka、Sakuma Hajime、Dohi Kaoru
- Journal Title
  
  Circ J
  
  Volume: 86 Issue: 2 Pages: 334
- DOI
  10.1253/circj.CJ-21-0653
- NAID
  130008144233
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2022-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Arrhythmogenic right ventricular cardiomyopathy complicating hypertrophic cardiomyopathy2022
- Author(s)
  Kagawa Yoshihiko、Okamoto Ryuji、Asano Yoshihiro、Sakata Yasushi、Dohi Kaoru
- Journal Title
  
  European Heart Journal - Cardiovascular Imaging
  
  Volume: 23 Issue: 9 Pages: e326-e326
- DOI
  10.1093/ehjci/jeac103
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Moyamoya Disease Complicating Ebstein's Anomaly2022
- Author(s)
  Goto Itaru、Okamoto Ryuji、Sato Yu、Tsuji Akihiro、Tanigawa Takashi、Dohi Kaoru
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 24 Pages: 3683-3686
- DOI
  10.2169/internalmedicine.9516-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-12-15
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Cardiorenal protective effects of sodium-glucose cotransporter 2 inhibition in combination with angiotensin II type 1 receptor blockade in salt-sensitive Dahl rats.2022
- Author(s)
  Ito H, Okamoto R, Ali Y, Zhe Y, Katayama K, Ito M, Dohi K.
- Journal Title
  
  J Hypertens.
  
  Volume: 40 Issue: 5 Pages: 956-968
- DOI
  10.1097/hjh.0000000000003099
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08255, KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Prevalence and Clinical Characteristics of Proximal Deep Venous Thrombosis After a High-Density Coronavirus Disease 2019 Cluster in a Japanese Psychiatric Hospital2022
- Author(s)
  Sato Toru、Ogihara Yoshito、Fujimoto Naoki、Usami Akihiro、Hamaguchi Tatsuya、Tanabe Masaki、Okamoto Ryuji、Nakase Shinji、Dohi Kaoru
- Journal Title
  
  Circ J
  
  Volume: 86 Issue: 3 Pages: 458-463
- DOI
  10.1253/circj.CJ-21-0987
- NAID
  130008163882
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2022-02-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Serum-Induced Expression of Brain Natriuretic Peptide Contributes to Its Increase in Patients with HFpEF2022
- Author(s)
  Okamoto Ryuji、Hashizume Ryotaro、Suzuki Noboru、Ito Rie、Tokuhara Tomoko、Fujiwara Hiroshi、Zhe Ye、Ito Hiromasa、Abe Takaya、Dohi Kaoru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 6 Pages: 2991-2991
- DOI
  10.3390/ijms23062991
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098, KAKENHI-PROJECT-19K08578
[Journal Article] Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C2021
- Author(s)
  Yonebayashi Saori、Tajiri Kazuko、Hara Mari、Saito Hiromitsu、Suzuki Noboru、Sakai Satoshi、Kimura Taizo、Sato Akira、Sekimoto Akiyo、Fujita Satoshi、Okamoto Ryuji、Schwartz Robert J.、Yoshida Toshimichi、Imanaka-Yoshida Kyoko
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 620541-620541
- DOI
  10.3389/fimmu.2021.620541
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07662, KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-19H03442
[Journal Article] Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish2020
- Author(s)
  Okamoto Ryuji、Goto Itaru、Nishimura Yuhei、Kobayashi Issei、Hashizume Ryotaro、Yoshida Yoshinori、Ito Rie、Kobayashi Yuhko、Nishikawa Misato、Ali Yusuf、Saito Shunsuke、Tanaka Toshio、Sawa Yoshiki、Ito Masaaki、Dohi Kaoru
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 10 Pages: 0240129-0240129
- DOI
  10.1371/journal.pone.0240129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07318, KAKENHI-PROJECT-19K08578, KAKENHI-PROJECT-18K05644, KAKENHI-PROJECT-17H04176
[Journal Article] BNP as a Major Player in the Heart-Kidney Connection.2019
- Author(s)
  Okamoto R, Ali Y, Hashizume R, Suzuki N, Ito M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 14 Pages: 3581-3581
- DOI
  10.3390/ijms20143581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08578
[Journal Article] Novel molecular mechanisms in the inhibition of adrenal aldosterone synthesis: Action of tolvaptan via vasopressin V(2) receptor-independent pathway.2019
- Author(s)
  Ali Y, Dohi K, Okamoto R, Katayama K, Ito M
- Journal Title
  
  Br J Pharmacol.
  
  Volume: 176(9) Issue: 9 Pages: 1315-1327
- DOI
  10.1111/bph.14630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08066
[Journal Article] Fulminant myocarditis in a patient with severe coronary artery disease2014
- Author(s)
  Fujita S, Okamoto R, Takamura T, Nakajima H, Tanabe M, Nakamori S, Dohi K, Tanigawa T, Nakamura M, Ito M.
- Journal Title
  
  Journal of Cardiology Cases
  
  Volume: 9 Issue: 1 Pages: 15-17
- DOI
  10.1016/j.jccase.2013.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591113
[Journal Article] Effects of cardiac resynchronization therapy on left ventricular mechanical dyssynchrony induced by right ventricular pacing in a patient with heart failure and preserved ejection fraction.2014
- Author(s)
  Takeuchi T, Dohi K, Kumagai N, Nakamori S, Fujimoto N, Okamoto R, Fujii E, Kitamura T, Yamada N, Nakamura M, Hamada M, Ito M.
- Journal Title
  
  Int J Cardiol.
  
  Volume: 177 Issue: 3 Pages: 1069-1072
- DOI
  10.1016/j.ijcard.2014.10.083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591113
[Journal Article] Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility.2014
- Author(s)
  Tameda M, Sugimoto K, Shiraki K, Yamamoto N, Okamoto R, Usui M, Ito M, Takei Y, Nobori T, Kojima T, Suzuki H, Uchida M, Uchida K.
- Journal Title
  
  Int J Oncol.
  
  Volume: 45 Issue: 2 Pages: 541-548
- DOI
  10.3892/ijo.2014.2445
- NAID
  120007136651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591113
[Journal Article] Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.2014
- Author(s)
  Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, Imanaka-Yoshida K, Tsuda K, Kakeda M, Okamoto R, Fujita S, Iwakura Y, Suzuki N, Ito M, Maruyama K, Gabazza EC, Yoshida T, Shimaoka M, Mizutani H.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 8 Pages: 104479-104479
- DOI
  10.1371/journal.pone.0104479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591113, KAKENHI-PROJECT-24591128, KAKENHI-PROJECT-24591647, KAKENHI-PROJECT-26461690, KAKENHI-PROJECT-26670528
[Journal Article] Resveratrol sensitizes HepG2 cells to TRAIL-induced apoptosis.2014
- Author(s)
  Tameda M, Sugimoto K, Shiraki K, Inagaki Y, Ogura S, Kasai C, Yoneda M, Okamoto R, Yamamoto N, Takei Y, Ito M, Nobori T.
- Journal Title
  
  Anticancer Drugs.
  
  Volume: 25 Issue: 9 Pages: 1028-1034
- DOI
  10.1097/cad.0000000000000128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591113
[Journal Article] Marked improvement of renal failure and severe hypertension after renal artery stenting in the solitary functioning kidney2013
- Author(s)
  Sawai T, Miyahara M, Okamoto R, Dohi K, Tanigawa T, Yamada N, Nakamura M, Ito M.
- Journal Title
  
  Journal of Cardiology Cases
  
  Volume: 7 Issue: 3 Pages: e82-e85
- DOI
  10.1016/j.jccase.2012.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591113
[Journal Article] FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.2013
- Author(s)
  Noma K, Okamoto R, Li Y, Hiroi Y, Liu PY, Taniguchi M, Ito M, Liao JK.
- Journal Title
  
  FASEB J.
  
  Volume: 27 Issue: 4 Pages: 1439-1449
- DOI
  10.1096/fj.12-217018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591043, KAKENHI-PROJECT-23790883, KAKENHI-PROJECT-24591113
[Journal Article] A case of aortic thrombosis and embolism preceding the progression of early esophageal cancer2013
- Author(s)
  Goto I, Okamoto R, Sawai T, Takasaki A, Takeuchi T, Matsuo H, Miyahara M, Nakamura M, Ito M.
- Journal Title
  
  Journal of Cardiology Cases
  
  Volume: 7 Issue: 5 Pages: e123-e125
- DOI
  10.1016/j.jccase.2012.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591113
[Journal Article] Identification of bovine hibernation-specific protein complex and evidence of its regulation in fasting and aging2013
- Author(s)
  Fujita, S., Okamoto, R., Taniguchi, M., Ban-Tokuda, T., Konishi, K., Goto, I., Yamamoto, Y., Sugimoto, K., Takamatsu, N., Nakamura, M., Shiraki, K., Buechler, C., Ito, M.
- Journal Title
  
  J. Biochem
  
  Volume: 153巻 Issue: 5 Pages: 453-461
- DOI
  10.1093/jb/mvt008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580107, KAKENHI-PROJECT-24591113
[Journal Article] Overexpression of myosin phosphatase reduced Ca2+ sensitivity of contraction and impairs cardiac function.2010
- Author(s)
  Mizutani H, Okamoto R, Moriki N, Konishi K, Taniguchi M, Fujita S, Dohi K, Onishi K, Suzuki M, Satoh S, Makino N, Itoh T, Hartshorne DJ, Ito M.
- Journal Title
  
  Circ.J. 74
  
  Pages: 120-128
- NAID
  10025941436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390211
[Journal Article] Overexpression of myosin phosphatase reduced Ca^<2+> sensitivity of contraction and impairs cardiac function2010
- Author(s)
  Mizutani H., Okamoto R., Moriki N., Konishi K., Taniguchi M., Fujita S., Dohi K., Onishi K., Suzuki N., Satoh S., Makino N., Itoh T., Hartshorne D. J., Ito M.
- Journal Title
  
  Circ J. 74
  
  Pages: 120-128
- NAID
  10025941436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390211
[Journal Article] High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase- mediated NF-kB activation in bovine aortic endothelial cells.2008
- Author(s)
  Iwasaki H, Okamoto R, Kato S, Konishi K, Mizutani H, Yamada N, Isaka N, Nakano T, Ito M.
- Journal Title
  
  Atherosclerosis. 196
  
  Pages: 22-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390211
[Journal Article] High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-kB activation in bovine aortic endothelial cells.2007
- Author(s)
  Iwasaki H, Okamoto R, Kato S, Konishi K, Mizutani H, Yamada N, Isaka N, Nakano T, Ito M.
- Journal Title
  
  Atherosclerosis (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590725
[Journal Article] Rho/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cells.2005
- Author(s)
  Nakakuki T, Ito M, Iwasaki H, Kureishi Y, Okamoto R, Moriki N, Kongo M, Kato S, Yamada N, Isaka N, Nakano T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 25(10)
  
  Pages: 2088-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590725
[Presentation] Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism2023
- Author(s)
  Shintaro Sakaguchi, Ryuji Okamoto, Masaharu Akao, Kohei Kamemura, Hiromi Rakugi5, Satoshi Fujita, Kaoru Dohi; JRAS investigators; Mitsuhide Naruse
- Organizer
  日本循環器学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] The Regulation of Myosin Light Chain Phosphorylation Plays an Important Role in the Development of Cardiac Fibrosis in MRRelated Hypertension2023
- Author(s)
  Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Rie Ito, Mizuki Ida, Masaaki Ito, Kaoru Dohi
- Organizer
  日本循環器学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] Cardiac-specific knockout of myosin phosphatase targeting subunit 2 prevents cardiac fibrosis in a connective tissue growth factor‐dependent manner in mineralocorticoid receptor-related hypertension mice2023
- Author(s)
  Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Moriwaki Keishi, Rie Ito, Mizuki Ida, Masaaki Ito, Kaoru Dohi
- Organizer
  アメリカ心臓協会学会(AHA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism2023
- Author(s)
  Shintaro Sakaguchi, Ryuji Okamoto, Masaharu Akao, Kohei Kamemura, Hiromi Rakugi5, Satoshi Fujita, Kaoru Dohi; JRAS investigators; Mitsuhide Naruse
- Organizer
  日本循環器学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] The Regulation of Myosin Light Chain Phosphorylation Plays an Important Role in the Development of Cardiac Fibrosis in MR-Related Hypertension2023
- Author(s)
  Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Rie Ito, Mizuki Ida, Masaaki Ito, Kaoru Dohi
- Organizer
  日本循環器学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism2023
- Author(s)
  Shintaro Sakaguchi, Ryuji Okamoto, Masaharu Akao, Kohei Kamemura, Hiromi Rakugi, Satoshi Fujita, Kaoru Dohi; JRAS investigators; Mitsuhide Naruse
- Organizer
  日本循環器学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08578
[Presentation] Cardiac-specific deletion of myosin phosphatase targeting subunit 2 alleviates cardiac fibrosis in mineralocorticoid receptor-related hypertension2023
- Author(s)
  Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Moriwaki Keishi, Rie Ito, Mizuki Ida, Masaaki Ito, Kaoru Dohi
- Organizer
  ヨーロッパ心臓病学会(ESC)
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] Predictors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism2022
- Author(s)
  Shintaro Sakaguchi, Ryuji Okamoto, Chisa Inoue, Kohei Kamemura, Isao Kurihara, Yoshiyu Takeda, Youichi Ohno, Hiromi Rakugi, Takuyuki Katabami, Akiyo Tanabe, Kouichi Tamura, Fujita Satoshi, Yutaka Yano, Kaoru Dohi and Mitsuhide Naruse ,JPAS/JRAS Study Group
- Organizer
  国際高血圧学会(ISH)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08098
[Presentation] Tolvaptan Inhibits Aldosterone Production and Blood Pressure Elevation Induced by Angiotensin II in Hypertensive Rat Model2018
- Author(s)
  Yusuf Ali, Kaoru Dohi, Ryuji Okamoto, Kan Katayama, Masaaki Ito
- Organizer
  American Heart Association 2018 Scientifc Sessions (AHA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08066
[Presentation] Endothelial mesenchymal transitions do not contribute to the development of pulmonary arterial hypertension caused by a VEGF receptor inhibitor in mice2015
- Author(s)
  Ryuji Okamoto, Itaru Goto, Yoshito Ogihara, Norikazu Yamada, Hirokazu Okada and Masaaki Ito
- Organizer
  European Society of Cardiology (ESC) congress
- Place of Presentation
  英国ロンドン市
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-24591113
[Presentation] The Identification of Mutation in ELP2 using Whole Exome Sequence in a Severe Form of Familial Hypertrophic Cardiomyopathy.2015
- Author(s)
  Ryuji Okamoto, Itaru Goto, Ryotaro Hashizume, Naoshi Shimojo, Kaoru Dohi, Mashio Nakamura and Masaaki Ito.
- Organizer
  日本循環器学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-24591113
[Presentation] A mutation in Elongator Protein 2 can cause a severe form of familial hypertrophic cardiomyopathy2014
- Author(s)
  Ryuji Okamoto, Itaru Goto, Issei Kobayashi, Naoshi Shimojo, Kaoru Dohi, Mashio Nakamura and Masaaki Ito.
- Organizer
  European Society of Cardiology (ESC) congress
- Place of Presentation
  スペインバルセロナ市
- Year and Date
  2014-08-31
- Invited
- Data Source
  KAKENHI-PROJECT-24591113
[Presentation] A Familial Hypertrophic Cardiomyopathy is Caused by a Mutation in Elp2, Encoding One of Subunits of Elongator Acetyltransferase Complex2014
- Author(s)
  Ryuji Okamoto, Itaru Goto, Issei Kobayashi, Ryotaro Hashizume, Naoshi Shimojo, Kaoru Dohi, Mashio Nakamura and Masaaki Ito.
- Organizer
  American Heart Association (AHA) meeting
- Place of Presentation
  米国シカゴ市
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24591113
[Presentation] Identification of Bovine Hibernation-Specific Protein Complex and Evidence of its Regulation in Fasting and Aging2012
- Author(s)
  岡本隆二
- Organizer
  第72回米国糖尿病学会(ADA)
- Place of Presentation
  フィラデルフィア国際会議場
- Data Source
  KAKENHI-PROJECT-24591113
[Presentation] 心血管疾患発症進展における遺伝・環境的要因（パネルディスカッション）2012
- Author(s)
  岡本隆二
- Organizer
  第60回日本心臓病学会学術集会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-24591113
[Presentation] 心筋ミオシン軽鎖キナーゼの生化学的性状解析2011
- Author(s)
  谷口正弥, 岡本隆二, 後藤至, 藤田聡,小西克尚, 中村真潮, 伊藤正明
- Organizer
  第40回日本心脈管作動物質学会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-19390211
[Presentation] Olmesartan, hydralazine and carvedilol decrease myosin light chain phosphorylation in vascular smooth muscle and Partly Exert Their Antihypertensive Effects.2010
- Author(s)
  Konishi K, Okamoto R, Fujita S, Taniguchi M, Mizutani H, Miyahara M, Nakamura M, Ito M
- Organizer
  第42回日本動脈硬化学会総会・学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390211
[Presentation] ラット高血圧自然発症モデルに対する種々の降圧薬の効果とミオシン軽鎖リン酸レベルの変化とその機序に関する検討2010
- Author(s)
  小西克尚, 岡本隆二, 藤田聡, 谷口正弥, 伊藤正明
- Organizer
  第39回日本心脈管作動物質学会
- Place of Presentation
  名古屋
- Year and Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-19390211
[Presentation] ラット高血圧自然発症モデルにおける各種降圧薬のミオシン軽鎖リン酸化レベルに対する効果2010
- Author(s)
  小西克尚, 岡本隆二, 後藤至, 藤田聡, 谷口正弥, 水谷英夫, 宮原眞敏, 中村真潮, 伊藤正明
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390211
[Presentation] 心筋ミオシンホスファターゼの分子性状とその機能2008
- Author(s)
  水谷英夫, 森木宣行, 岡本隆二, 井阪直樹,中野赳, 伊藤正明, 大西勝也, 鈴木昇, 佐藤真司, 牧野直樹, David Hartshorne.
- Organizer
  第37回日本心脈管作動物質学会
- Place of Presentation
  仙台
- Year and Date
  2008-02-02
- Data Source
  KAKENHI-PROJECT-19390211

1. ITO Masaaki (00223181)

# of Collaborated Projects: 6 results

# of Collaborated Products: 25 results
2. DOHI KAORU (50422837)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
3. 片山鑑 (90742247)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. ONISHI Katsuya (40343222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 伊藤弘将 (50898195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAMATSU Nobuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 丸山一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 三谷義英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 澤田博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 丸山淳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 野間玄督

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 吉田利通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 西村有平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okamoto Ryuji 岡本 隆二

OKAMOTO Ryuji 岡本 隆二

Research Projects

Research Products

Co-Researchers

MR関連高血圧症による心不全発症メカニズムの解明Principal Investigator

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Interaction between renal tissue SGLT2 and the AT1R-NHE3 pathway as a mechanism for the progression of heart failure.

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MLC phosphatase plays an important role in cardiac function and fibrosisPrincipal Investigator

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Effects of Tolvaptan via vasopressin V2 receptor-independent pathway on adrenal aldosterone synthesis.

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Review Section

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The effect of sodium-glucose co-transporter 2 inhibition on heart failure prevention in Dahl salt-sensitive rats.

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Review Section

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Investigation to clarify the role of endothelial mesenchymal transition in cardiac fibrosisPrincipal Investigator

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Novel molecular mechanisms for cardiotonic action, their involvement in diseases and application for treatment

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遺伝子改変マウスを用いた心筋ミオシンホスファターゼの生理学的・病理学的機能解析Principal Investigator

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CRP as a biomediator of atherosclerosis and its intracellular signaling

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[Journal Article] A hyperaldosteronism subtypes predictive model using ensemble learning2023

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Journal Title

DOI

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[Journal Article] Letter by Okamoto et al Regarding Article, “Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin”2023

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[Journal Article] Endovascular Treatment for Lower-extremity Arterial Thrombosis in a Patient with Congenital Afibrinogenemia and a History of Bleeding Complications2022

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[Journal Article] Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life2022

Author(s)

Okamoto Ryuji 岡本隆二

OKAMOTO Ryuji 岡本隆二

[Journal Article] Moyamoya Disease Complicating Ebstein's Anomaly2022