KIMURA Hironobu 木村博信

Researcher Number	60378891
Other IDs	https://orcid.org/0009-0000-9190-3659
Affiliation (based on the past Project Information) *help	2015: 大阪大学, 蛋白質研究所, 助教 2012 – 2015: 大阪大学, たんぱく質研究所, 助教 2013: 大阪大学, 蛋白質研究所, 助教
Review Section/Research Field	Principal Investigator Molecular biology Except Principal Investigator Functional biochemistry / Genome biology
Keywords	Principal Investigator 転写伸長因子 / DNAのメチル化機構 / 転写伸長 / DNAメチル化 Except Principal Investigator DNAメチル化酵素 / DNAメチル化 / DNAメチル基転移酵素 / DNAヒドロキシメチル化修飾 / 生物工学

Development of a method to determine hydroxymethylcytosine in DNA at single base resolution utilizing recombinant DNMT1
- Principal Investigator
  
  TAJIMA Shoji
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
DNA methylation coupled with transcription elongation machineryPrincipal Investigator
- Principal Investigator
  
  Kimura Hironobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
DNA amplification conserving DNA methylation patterns
- Principal Investigator
  
  TAJIMA Shoji
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genome biology
- Research Institution
  Osaka University

All 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] Establishment and maintenance of DNA methylation. In DNA replication, recombination, and repair2016
- Author(s)
  Shoji Tajima, Hironobu Kimura, Isao Suetake
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K14478
[Book] エピジェネティクスキーワード事典-分子機構から疾患・解析技術まで-(牛島俊和、眞貝洋一編集)2013
- Author(s)
  木村博信, 他(牛島俊和、眞貝洋一編集)
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24651214
[Book] エピジェネティクスキーワード事典-分子機構から疾患・解析技術まで-（牛島俊和、眞貝洋一編集）2013
- Author(s)
  木村博信、田嶋正二
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24651214
[Journal Article] Dual functions of the RFTS domain of Dnmt1 in replication-coupled DNA methylation and in protection of the genome from aberrant methylation2015
- Author(s)
  Ronald Garingalao Garvilles, Takashi Hasegawa, Hironobu Kimura, Jafar Sharif, Masahiro Muto, Haruhiko Koseki, Saori Takahashi, Isao Suetake, and Shoji Tajima
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 9 Pages: e0137509-e0137509
- DOI
  10.1371/journal.pone.0137509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18456, KAKENHI-PROJECT-25650007, KAKENHI-PROJECT-25291025
[Journal Article] The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase2014
- Author(s)
  Mori S, Nada S, Kimura H, Tajima S, Takahashi Y, Kitamura A, Oneyama C, Okada M.
- Journal Title
  
  PLos ONE
  
  Volume: 9(2) Issue: 2 Pages: e88891-e88891
- DOI
  10.1371/journal.pone.0088891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22240088, KAKENHI-PROJECT-23370087, KAKENHI-PUBLICLY-24116515, KAKENHI-PROJECT-24659150, KAKENHI-PUBLICLY-25117716, KAKENHI-PROJECT-25650007, KAKENHI-PROJECT-26640078
[Journal Article] Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.2013
- Author(s)
  Otani J, Kimura H, Sharif J, Endo TA, Mishima Y, Kawakami T, Koseki H, Shirakawa M, Suetake I, Tajima S
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12 Pages: e82961-e82961
- DOI
  10.1371/journal.pone.0082961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06488, KAKENHI-PUBLICLY-24116515, KAKENHI-PROJECT-24570153, KAKENHI-PROJECT-24651214, KAKENHI-PROJECT-25291025, KAKENHI-PROJECT-25650007
[Journal Article] Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system2013
- Author(s)
  Horii T, Morita S, Kimura M, Kobayashi R, Tamura D, Takahashi RU, Kimura H, Suetake I, Ohata H, Okamoto K, Tajima S, Ochiya T, Abe Y, Hatada I
- Journal Title
  
  PeerJ
  
  Volume: 1 Pages: e230-e230
- DOI
  10.7717/peerj.230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591816, KAKENHI-PUBLICLY-24116515, KAKENHI-PROJECT-24570153, KAKENHI-PROJECT-24613002, KAKENHI-PROJECT-25650007
[Journal Article] Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4.2013
- Author(s)
  Otani, J., Arita, K., Kato, T., Kinoshita, M., Kimura, H., Suetake, I., Tajima, S., Ariyoshi, M., Shirakawa, M.
- Journal Title
  
  J Biol. Chem.
  
  Volume: 288 Issue: 9 Pages: 6351-6362
- DOI
  10.1074/jbc.m112.431098
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21121006, KAKENHI-PROJECT-22370053, KAKENHI-PROJECT-24570153, KAKENHI-PROJECT-25650007, KAKENHI-PLANNED-23114005, KAKENHI-PUBLICLY-24113711, KAKENHI-PUBLICLY-24116515
[Presentation] 細胞周期阻害剤による5hmC産生機構の解明2015
- Author(s)
  木村博信、堀居拓郎、大谷順二、末武　勲、畑田出穂、田嶋正二
- Organizer
  第9回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] 細胞の形質を司るエピジェネティクス～DNAメチル化から考える～2014
- Author(s)
  木村博信
- Organizer
  第１８回関西大学先端科学技術シンポジウム
- Place of Presentation
  大阪府関西大学
- Invited
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] プロモーター領域でのヒドロキシメチルシトシンのメチルシトシンに対する相対位置は遺伝子発現と相関する2014
- Author(s)
  木村博信, 他
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京大学伊藤国際会館
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] Relative positions of 5-hydroxymethylcytosine and 5-methylcytosine at promoter correlate with the level of gene expression.2013
- Author(s)
  Kimura, H., Suetake, I., Tooi, N., Kawakami, T., Thomoto, T., Aiba, K., Nakatsuji, N and Shoji Tajima
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  兵庫県淡路夢舞台
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] Relative positions of 5-hydroxymethylcytosine and 5-methylcytosine at promoter correlates with the level of gene expression2013
- Author(s)
  Hironobu Kimura, et al.
- Organizer
  International Symposium on Transcription and metabolism
- Place of Presentation
  Awaji Yumebutai International Conference Center, Hyogo, Japan
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] Dnmt1のRFTSと触媒領域間の水素結合のDNAメチル化に果たす役割2013
- Author(s)
  ロナルド G. ガルビレス、長谷川貴志、木村博信、ジャファルシャリフ、古関明彦、末武勲、田嶋正二
- Organizer
  第７回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] マウスES細胞におけるヒドロキシメチルシトシンの産生と消去2013
- Author(s)
  木村博信、大谷淳二、川上　徹、白川昌宏、末武勲、田嶋正二
- Organizer
  第７回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] マウスES細胞におけるヒドロキシメチルシトシンの産生と消去2013
- Author(s)
  木村博信, 他
- Organizer
  第7回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] マウスES細胞におけるヒドロキシメチルシトシンの産生と消去2013
- Author(s)
  木村博信、大谷淳二、川上徹、ジャファル・シャリフ、古関明彦、白川昌宏、末武勲、田嶋正二
- Organizer
  第7回日本エピジェネティクス研究会年会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] Relative positions of 5-hydroxymethylcytosine and 5-methylcytosine at promoter correlates with the level of gene expression2013
- Author(s)
  Hironobu Kimura, Norie Tooi, Toru Kawakami, Tatsuhiro Thomoto, Kazuhiro Aiba, Isao Suetake, Norio Nakatsuji, Shoji Tajima
- Organizer
  International Symposium on Transcription and Metabolism
- Place of Presentation
  Awaji Yumebutai International Conference Center, Hyogo, Japan
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] Dnmt1によるDNA維持メチル化のin vivoにおける責任領域2012
- Author(s)
  長谷川貴志、木村博信、末武勲、武藤正弘、Jafar　Sharif、古関明彦、田嶋正二
- Organizer
  第6回日本エピジェネティクス研究会年会
- Place of Presentation
  学術総合センター（東京千代田区一ツ橋）
- Data Source
  KAKENHI-PROJECT-24651214
[Presentation] マウスES細胞における5mCと5hmCの連続変換によるメチル化制御
- Author(s)
  首浦武作志、岡野正樹、木村博信、田嶋正二、多田政子
- Organizer
  第８回日本エピジェネティクス研究会年会
- Place of Presentation
  伊藤国際学術研究センター（東京）
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] マウスES細胞での5hmC化を介した脱メチル化後のDnmt1の役割
- Author(s)
  首浦武作志、木村博信、田嶋正二、多田政子
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] CRISPR/Cas法による樹立したTetトリプルノックアウトES細胞の特性
- Author(s)
  35.堀居拓郎、森田純代、木村美香、小林遼平、田村大樹、木村博信、末武勲、安部由美子、畑田出穂
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] 遺伝性知覚神経疾患の原因となるDnmt1のRFTS内の変異がDNA維持メチル化に及ぼす影響
- Author(s)
  ロナルド・G・ガルビレス、木村博信、アーメット・キャン・ベルキュレック、末武勲、田嶋正二
- Organizer
  第８回日本エピジェネティクス研究会年会
- Place of Presentation
  伊藤国際学術研究センター（東京）
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] マウス半数体ES細胞とCRISPR/Cas9法を用いたTet1ファミリーのゲノム編集
- Author(s)
  堀居拓郎、森田純代、木村美香、小林遼平、田村大樹、高橋陵宇、木村博信、末武勲、大畑広和、岡本康司、田嶋正二、落谷孝広、安部由美子、畑田出穂
- Organizer
  第８回日本エピジェネティクス研究会年会
- Place of Presentation
  伊藤国際学術研究センター（東京）
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25650007
[Presentation] プロモーター領域でのヒドロキシメチルシトシンのメチルシトシンに対する相対位置は遺伝子発現と相関する
- Author(s)
  木村博信、末武　勲、遠井紀江、川上　徹、饗庭一博、中辻憲夫、田嶋正二
- Organizer
  第８回日本エピジェネティクス研究会年会
- Place of Presentation
  伊藤国際学術研究センター（東京）
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25650007

1. TAJIMA Shoji (50132931)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. SUETAKE Isao (80304054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. ITO Takashi (90201326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ARIYOSI Mariko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 安部由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 岡田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 白川昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋沙央里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Hironobu 木村 博信

Research Projects

Research Products

Co-Researchers

Development of a method to determine hydroxymethylcytosine in DNA at single base resolution utilizing recombinant DNMT1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA methylation coupled with transcription elongation machineryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA amplification conserving DNA methylation patterns

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Establishment and maintenance of DNA methylation. In DNA replication, recombination, and repair2016

Author(s)

Publisher

Data Source

[Book] エピジェネティクスキーワード事典-分子機構から疾患・解析技術まで-(牛島俊和、眞貝洋一編集)2013

Author(s)

Publisher

Data Source

[Book] エピジェネティクスキーワード事典-分子機構から疾患・解析技術まで-（牛島俊和、眞貝洋一編集）2013

Author(s)

Publisher

Data Source

[Journal Article] Dual functions of the RFTS domain of Dnmt1 in replication-coupled DNA methylation and in protection of the genome from aberrant methylation2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 細胞周期阻害剤による5hmC産生機構の解明2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 細胞の形質を司るエピジェネティクス～DNAメチル化から考える～2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] プロモーター領域でのヒドロキシメチルシトシンのメチルシトシンに対する相対位置は遺伝子発現と相関する2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Relative positions of 5-hydroxymethylcytosine and 5-methylcytosine at promoter correlate with the level of gene expression.2013

Author(s)

Organizer

Place of Presentation

Data Source

KIMURA Hironobu 木村博信