Onishi Hidenori 大西秀典

… Alternative Names

Ohnishi Hidenori 大西秀典

OHNISHI Hidenori 大西秀典

Less

Researcher Number	60381620
Other IDs
Affiliation (Current)	2025: 岐阜大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2025: 岐阜大学, 大学院医学系研究科, 教授 2020 – 2023: 岐阜大学, 大学院医学系研究科, 教授 2018 – 2020: 岐阜大学, 医学部附属病院, 准教授 2014 – 2016: 岐阜大学, 医学部附属病院, 講師 2011 – 2013: 岐阜大学, 医学(系)研究科(研究院), 助教 … More 2009 – 2010: Gifu University, 医学部附属病院, 助教 2008: Gifu University, 大学院・医学系研究科, 助教 2007: Gifu University, 医学部附属病院, 医員 2006: 岐阜大学, 医学附属病院, 医員 2005: 岐阜大学, 大学院・医学系研究科, 非常勤講師 Less
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 09050:Tertiary education-related
Keywords	Principal Investigator 自己炎症性疾患 / 自然免疫 / 遺伝子変異 / タンパク立体構造 / Toll-like receptor / IL-18 / MyD88 / I型インターフェロン異常症 / 病的意義不明バリアント / 遺伝子解析 … More / 原発性免疫不全症 / サイトカイン / 乾癬 / 蛋白立体構造解析 / Toll-like recetor / 創薬 / Toll like receptor / NMR / アレルギー / 慢性炎症性疾患 … More Except Principal Investigator 修学支援 / 高等教育 / 大学新入学生 / 注意欠如多動性障害 / 自閉スペクトラム症 / 高等教育機関 / 発達障害 / 大学生 / メンタルヘルス / CCAPS / 注意欠如多動症 / 自閉症スペクトラム障害 Less

The research of the pathophysiology of type I interferonopathy with disease-specific iPS cellsPrincipal Investigator
- Principal Investigator
  
  大西秀典
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Gifu University
発達障害を有する大学生の頻度・特徴・介入の有効性を明らかにし支援モデルを構築する
- Principal Investigator
  
  足立美穂
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09050:Tertiary education-related
- Research Institution
  Gifu University
The development of in vitro functional assay system for the genetic variants in inherited autoinflammatory diseases.Principal Investigator
- Principal Investigator
  
  Ohnishi Hidenori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Gifu University
The protein structure determination of IL-36 related molecules and their clinical application.Principal Investigator
- Principal Investigator
  
  Ohnishi Hidenori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Gifu University
The structural analysis of the onset mechanism of cryopyrin-associated periodic syndromePrincipal Investigator
- Principal Investigator
  
  Ohnishi Hidenori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Gifu University
The development of immune-modulate molecule using the binding specificity of Toll-Interleukin-1 receptor domainPrincipal Investigator
- Principal Investigator
  
  OHNISHI Hidenori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Gifu University
The structure based drug design for controlling the innate immune response and interleukin-18 signaling.Principal Investigator
- Principal Investigator
  
  OHNISHI Hidenori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Gifu University
自然免疫・獲得免疫スイッチング機構の構造生物学的解析に基づく抗アレルギー薬開発Principal Investigator
- Principal Investigator
  
  大西秀典
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Gifu University

[Book] メバロン酸キナーゼ欠損症別冊日本臨床先天代謝異常症候群(第2版)上2012
- Author(s)
  深尾敏幸、大西秀典
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 自己炎症性疾患・自然免疫不全症の病因・病態と診断フローチャート自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 免疫異常疾患に対する免疫療法と抗体療法-その3-自己炎症性疾患に対する生物学的製剤アレルギー疾患の免疫療法と分子標的治療2012
- Author(s)
  大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 原発性免疫不全症の概念と分類,および自己炎症性疾患・自然免疫不全症・近縁疾患の位置づけ自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  近藤直実、大西秀典、渡邉倫子
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] Castleman病自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  寺本貴英、大西秀典、近藤直実
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 慢性皮膚粘膜カンジダ症(STAT1異常症)自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  堀友博、大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 自然免疫不全症総論自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 易肺炎球菌感染症自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] カンジダ感染と外胚葉異形成を伴う自己免疫性多腺性内分泌不全症自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  堀友博、大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 自己炎症性疾患総論自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  加藤善一郎、大西秀典、近藤直実
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] ヒトパピローマウイルス易感染症自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  加藤善一郎、大西秀典、近藤直実
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] (家族性)単純ヘルペス脳炎自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  久保田一生、山本崇裕、大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] MEFV遺伝子と炎症性疾患自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  久保田一生、大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] 慢性皮膚粘膜カンジダ症を伴う免疫不全症自己炎症性疾患・自然免疫不全症とその近縁疾患2012
- Author(s)
  堀友博、大西秀典
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791161
[Book] Allergy Frontiers (volumel Allergy Frontiers : Epigenetics, Allergens and Risk Factors)2009
- Author(s)
  Kondo N, Matsui E, Kaneko H, Fukao T, Teramoto T, Kato Z, Ohnishi H, Nishimura A : Genetics of Pediatric Asthma. In : Pawankar R, Holgate ST, Rosenwasser LJ eds
- Total Pages
  442
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20790723
[Book] Genetics of Pediatric Asthma.(Allergy Frontiers (volumel Allergy Frontiers : Epigenetics, Allergens and Risk Factors))(Pawankar R, Holgate ST, Rosenwasser LJ eds.)2009
- Author(s)
  Kondo N, Matsui E, Kaneko H, Fukao T, Teramoto T, Kato Z, Ohnishi H, Nishimura A
- Total Pages
  442
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Pharmacokinetics, safety, and efficacy of 20% subcutaneous immunoglobulin (Ig20Gly) administered weekly or every 2 weeks in Japanese patients with primary immunodeficiency diseases: a phase 3, open-label study2024
- Author(s)
  Kanegane Hirokazu、Endo Akifumi、Okada Satoshi、Ohnishi Hidenori、Ishimura Masataka、Nishikomori Ryuta、Imai Kohsuke、Nonoyama Shigeaki、Muramatsu Hideki、Wada Taizo、Kuga Atsushi、Sakamoto Ko、Russo-Schwarzbaum Sharon、Chu Liang-Hui、McCoy Barbara、Li Zhaoyang、Yel Leman
- Journal Title
  
  Immunotherapy Advances
  
  Volume: 4 Issue: 1
- DOI
  10.1093/immadv/ltae001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07770
[Journal Article] A case of A20 haploinsufficiency complicated by autoimmune hepatitis2024
- Author(s)
  Iwasa Taisei、Miwa Takao、Unome Shinji、Hanai Tatsunori、Imai Kenji、Takai Koji、Miwa Yuki、Hori Tomohiro、Ohnishi Hidenori、Matsumoto Munekazu、Niwa Ayumi、Miyazaki Tatsuhiko、Shimizu Masahito
- Journal Title
  
  Hepatology Research
  
  Volume: － Issue: 6 Pages: 606-611
- DOI
  10.1111/hepr.14003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07770
[Journal Article] A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis2023
- Author(s)
  Sakura F, Noma K, Asano T, Tanita K, Toyofuku E, Kato K, Tsumura M, Nihira H, Izawa K, Mitsui-Sekinaka K, Konno R, Kawashima Y, Mizoguchi Y, Karakawa S, Hayakawa S, Kawaguchi H, Imai K, Nonoyama S, Yasumi T, Ohnishi H, Kanegane H, Ohara O, Okada S
- Journal Title
  
  PNAS Nexus
  
  Volume: 2 Issue: 4 Pages: 1-12
- DOI
  10.1093/pnasnexus/pgad104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22K20772, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-22K15939, KAKENHI-PROJECT-23K24302
[Journal Article] Development of a system adapted for the diagnosis and evaluation of peroxisomal disorders by measuring bile acid intermediates2023
- Author(s)
  Kawai Hiroki、Takashima Shigeo、Ohba Akiko、Toyoshi Kayoko、Kubota Kazuo、Ohnishi Hidenori、Shimozawa Nobuyuki
- Journal Title
  
  Brain and Development
  
  Volume: 45 Issue: 1 Pages: 58-69
- DOI
  10.1016/j.braindev.2022.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K19638
[Journal Article] Comprehensive targeted next-generation sequencing in patients with slow-flow vascular malformations2022
- Author(s)
  Nozawa Akifumi、Fujino Akihiro、Yuzuriha Shunsuke、Suenobu Souichi、Kato Aiko、Shimizu Fumiaki、Aramaki-Hattori Noriko、Kuniyeda Kanako、Sakaguchi Kazuya、Ohnishi Hidenori、Aoki Yoko、Ozeki Michio
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 67 Issue: 12 Pages: 721-728
- DOI
  10.1038/s10038-022-01081-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K07838, KAKENHI-PROJECT-21K19436
[Journal Article] Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience.2022
- Author(s)
  Miyamoto T, Honda Y, Izawa K, Kanazawa N, Saito MK, Takita J, Nishikomori R, Yasumi T, et al.
- Journal Title
  
  Front Immunol
  
  Volume: 13 Pages: 905960-905960
- DOI
  10.3389/fimmu.2022.905960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K06999, KAKENHI-PROJECT-22K07829, KAKENHI-PROJECT-22K07867, KAKENHI-PROJECT-19K08754, KAKENHI-PROJECT-23K24302
[Journal Article] Monogenic causes of pigmentary mosaicism2022
- Author(s)
  Saida Ken、Chong Pin Fee、Yamaguchi Asuka、...Mitsuhiro Kato, et al.
- Journal Title
  
  Human Genetics
  
  Volume: 141 Issue: 11 Pages: 1771-1784
- DOI
  10.1007/s00439-022-02437-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-20K17936, KAKENHI-PROJECT-23K24308
[Journal Article] Clinical and Genetic Characterization of Patients with Artemis Deficiency in Japan2022
- Author(s)
  Inoue Kento、Miyamoto Satoshi、Tomomasa Dan、Adachi Eriko、Azumi Shohei、Horikoshi Yasuo、Ishihara Takashi、Osone Shinya、Kawahara Yuta、Kudo Ko、Kato Zenichiro、Ohnishi Hidenori、Kashimada Kenichi、Imai Kohsuke、Ohara Osamu、van Zelm Menno C.、Cowan Morton J.、Morio Tomohiro、Kanegane Hirokazu
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 43 Issue: 3 Pages: 585-594
- DOI
  10.1007/s10875-022-01405-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07841, KAKENHI-PROJECT-22K07887
[Journal Article] Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A202022
- Author(s)
  Toyofuku Etsushi、Takeshita Kozue、Ohnishi Hidenori、Kiridoshi Yuko、Masuoka Hiroaki、Kadowaki Tomonori、Nishikomori Ryuta、Nishimura Kenichi、Kobayashi Chie、Ebato Takasuke、Shigemura Tomonari、Inoue Yuzaburo、Suda Wataru、Hattori Masahira、Morio Tomohiro、Honda Kenya、Kanegane Hirokazu
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 11 Pages: 787667-787667
- DOI
  10.3389/fcimb.2021.787667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887
[Journal Article] Novel STAT1 Variants in Japanese Patients with Isolated Mendelian Susceptibility to Mycobacterial Diseases2022
- Author(s)
  Ono R, Tsumura M, Shima S, Matsuda Y, Gotoh K, Miyata Y, Yoto Y, Tomomasa D, Utsumi T, Ohnishi H, Kato Z, Ishiwada N, Ishikawa A, Wada T, Uhara H, Nishikomori R, Hasegawa D, Okada S, Kanegane H.
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 43 Issue: 2 Pages: 466-478
- DOI
  10.1007/s10875-022-01396-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07829, KAKENHI-PROJECT-22K07841, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-22KK0113, KAKENHI-PROJECT-20K16937, KAKENHI-PROJECT-23K24302
[Journal Article] Serum Fibrinogen Level and Cytokine Production as Prognostic Biomarkers for Idiopathic Sudden Sensorineural Hearing Loss2022
- Author(s)
  Okuda Hiroshi、Aoki Mitsuhiro、Ohashi Toshimitsu、Ogawa Bakushi、Shibata Hirofumi、Ueda Natsuko、Hayashi Hisamitsu、Nishihori Takezumi、Kuze Bunya、Ohnishi Hidenori、Ogawa Takenori
- Journal Title
  
  Otology & Neurotology
  
  Volume: 43 Issue: 7 Pages: 712-719
- DOI
  10.1097/mao.0000000000003552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-20K18307, KAKENHI-PROJECT-20K09688
[Journal Article] A case of VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) with decreased oxidative stress levels after oral prednisone and tocilizumab treatment2022
- Author(s)
  Tozaki Nagie、Tawada Chisato、Niwa Hirofumi、Mizutani Yoko、Shu En、Kawase Aki、Miwa Yuki、Ohnishi Hidenori、Sasai Hideo、Miyako Keisuke、Hosokawa Junichi、Kato Ayaka、Kobayashi Kazuhiro、Miyazaki Tatsuhiko、Shirakami Yohei、Shimizu Masahito、Iwata Hiroaki
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 9 Pages: 1046820-1046820
- DOI
  10.3389/fmed.2022.1046820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K06999
[Journal Article] An adult case of suspected A20 haploinsufficiency mimicking polyarteritis nodosa2022
- Author(s)
  Niwano Tomoko、Hosoya Tadashi、Kadowaki Saori、Toyofuku Etsushi、Naruto Takuya、Shimizu Masaki、Ohnishi Hidenori、Koike Ryuji、Morio Tomohiro、Imai Kohsuke、Yoshida Masayuki、Yasuda Shinsuke
- Journal Title
  
  Rheumatology
  
  Volume: 61 Issue: 11 Pages: e337-e340
- DOI
  10.1093/rheumatology/keac308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07770
[Journal Article] Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-192022
- Author(s)
  Eto S, Nukui Y, Tsumura M, Nakagama Y, Kashimada K, Mizoguchi Y, Utsumi T, Taniguchi M, Sakura F, Noma K, Yoshida Y, Ohshimo S, Nagashima S, Okamoto K, Endo A, Imai K, Kanegane H, Ohnishi H, Hirata S, Sugiyama E, Shime N, Ito M, Ohge H, Kido Y, Bastard P, Casanova JL, Ohara O, Tanaka J, Morio T, Okada S
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 42 Issue: 7 Pages: 1360-1370
- DOI
  10.1007/s10875-022-01308-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K07887, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-20K17460, KAKENHI-PROJECT-23K24302
[Journal Article] Successful treatment of a novel type I interferonopathy due to a de novo PSMB9 gene mutation with a Janus kinase inhibitor2021
- Author(s)
  Kataoka S, Kawashima N, Okuno Y, Muramatsu H, Miwata S, Narita K, Hamada M, Murakami N, Taniguchi R, Ichikawa D, Kitazawa H, Suzuki K, Nishikawa E, Narita A, Nishio N, Yamamoto H, Fukasawa Y, Kato T, Yamamoto H, Natsume J, Kojima S, Nishio I, Taketani T, Ohnishi H, Tahakashi Y.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: - Issue: 2 Pages: 639-644
- DOI
  10.1016/j.jaci.2021.03.010
- NAID
  120007192018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08155, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-19K17357, KAKENHI-PROJECT-19K08297, KAKENHI-PROJECT-19K08319, KAKENHI-PROJECT-21K00249, KAKENHI-PROJECT-21K07770
[Journal Article] Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT32021
- Author(s)
  Tanita Kay、Sakura Fumiaki、Nambu Ryusuke、Tsumura Miyuki、Imanaka Yusuke、Ohnishi Hidenori、Kato Zenichiro、Pan Jie、Hoshino Akihiro、Suzuki Koji、Yasutomi Motoko、Umetsu Shuichiro、Okada Chizuru、Takagi Masatoshi、Imai Kohsuke、Ohara Osamu、Muise Alexo M.、Okada Satoshi、Morio Tomohiro、Kanegane Hirokazu
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: - Issue: 4 Pages: 780-790
- DOI
  10.1007/s10875-021-00975-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-20J10721
[Journal Article] Hematopoietic Cell Transplantation Ameliorates Autoinflammation in A20 Haploinsufficiency2021
- Author(s)
  Shiraki, M. Williams, E. Yokoyama, N. Shinoda, K. Nademi, Z. Matsumoto, K. Nihira, H. Honda, Y. Izawa, K. Nishikomori, R. Slatter, M. A. Cant, A. J. Gennery, A. R. Ohnishi, H. Kanegane, H.
- Journal Title
  
  J Clin Immunol
  
  Volume: 41 Issue: 8 Pages: 1954-1956
- DOI
  10.1007/s10875-021-01124-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-21K07770
[Journal Article] A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency2021
- Author(s)
  Qin Tao、Jia Yanjun、Liu Yuhang、Dai Rongxin、Zhou Lina、Okada Satoshi、Tsumura Miyuki、Ohnishi Hidenori、Kato Zenichiro、Kanegane Hirokazu、Sun Xiulian、Zhao Xiaodong
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 517544-517544
- DOI
  10.3389/fimmu.2020.517544
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08249, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18KK0228
[Journal Article] Functional analysis of novel A20 variants in patients with atypical inflammatory diseases2021
- Author(s)
  Kadowaki S, Hashimoto K, Nishimura T, Kashimada K, Kadowaki T, Kawamoto N, Imai K, Okada S, Kanegane H, Ohnishi H.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 23 Issue: 1 Pages: 52-52
- DOI
  10.1186/s13075-021-02434-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K07840
[Journal Article] An infant with X-linked anhidrotic ectodermal dysplasia with immunodeficiency presenting with Pneumocystis pneumonia: A case report.2021
- Author(s)
  Toyohara M, Kajiho Y, Toyofuku E, Takahashi C, Owada K, Kanda S, Harita Y, Ohnishi H, Wada T, Imai K, Kanegane H, Morio T, Oka A
- Journal Title
  
  Clin Case Rep
  
  Volume: 9 Issue: 11
- DOI
  10.1002/ccr3.5093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08584, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K07861
[Journal Article] Case of Muckle-Wells syndrome with erythema dominantly infiltrated by lymphocytes.2021
- Author(s)
  Kadowaki S, Kimura T, Shiraki M, Mizutani Y, Nakama M, Kobayashi K, Suzui N, Kawamoto N, Ohnishi H, Seishima M.
- Journal Title
  
  J Dermatol.
  
  Volume: 48 Issue: 2
- DOI
  10.1111/1346-8138.15686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840
[Journal Article] A20 Haploinsufficiency in East Asia2021
- Author(s)
  Kadowaki Tomonori、Kadowaki Saori、Ohnishi Hidenori
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 780689-780689
- DOI
  10.3389/fimmu.2021.780689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07770
[Journal Article] Case Report: Analysis of Preserved Umbilical Cord Clarified X-Linked Anhidrotic Ectodermal Dysplasia With Immunodeficiency in Deceased, Undiagnosed Uncles2021
- Author(s)
  Inaba Satoshi、Aizawa Yuta、Miwa Yuki、Imai Chihaya、Ohnishi Hidenori、Kanegane Hirokazu、Saitoh Akihiko
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 786164-786164
- DOI
  10.3389/fimmu.2021.786164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08317, KAKENHI-PROJECT-21K07770
[Journal Article] Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency2021
- Author(s)
  Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, M.H, K.A, M.T, H.S, K.N, K.S, H.Y, I.K, N.R, T.M, Y.Y, T.S, O.T, O.T, K.T, S.I, F.Y, W.N, I.Y, K.K, O.S, T.T, N.K, M.S, Y.K, Kaisho T
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 0-0
- DOI
  10.1038/s41467-021-27085-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-19K08754, KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-20K17405
[Journal Article] IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation2020
- Author(s)
  Nishimura Shiho、Kobayashi Yoshiyuki、Ohnishi Hidenori、Moriya Kunihiko、Tsumura Miyuki、Sakata Sonoko、Mizoguchi Yoko、Takada Hidetoshi、Kato Zenichiro、Sancho-Shimizu Vanessa、Picard Capucine、Irani Sarosh R.、Ohara Osamu、Casanova Jean-Laurent、Puel Anne、Ishikawa Nobutsune、Okada Satoshi、Kobayashi Masao
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 41 Issue: 1 Pages: 125-135
- DOI
  10.1007/s10875-020-00885-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-19H03613, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18K07847, KAKENHI-PROJECT-18K15716, KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-21K07791
[Journal Article] The IL1RN Mutation Creating the Most-Upstream Premature Stop Codon Is Hypomorphic Because of a Reinitiation of Translation.2020
- Author(s)
  Moriya K, Kadowaki S, Nakano T, Akarcan SE, Kutukculer N, Aksu G, Sasahara Y, Kure S, Ohnishi H, Casanova JL, Puel A, Fukao T.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 40 Issue: 4 Pages: 643-645
- DOI
  10.1007/s10875-020-00770-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-19K23819
[Journal Article] Haploinsufficiency of A20 with a novel mutation of deletion of exons 2-3 of TNFAIP3.2020
- Author(s)
  Shimizu Maho、Matsubayashi Tadashi、Ohnishi Hidenori、Nakama Mina、Izawa Kazushi、Honda Yoshitaka、Nishikomori Ryuta
- Journal Title
  
  Modern Rheumatology
  
  Volume: e-pub Issue: 2 Pages: 1-5
- DOI
  10.1080/14397595.2020.1719595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-19K17293, KAKENHI-PROJECT-19K08299
[Journal Article] Immunophenotyping of A20 haploinsufficiency by multicolor flow cytometry.2020
- Author(s)
  Kadowaki T, Ohnishi H, Kawamoto N, Kadowaki S, Hori T, Nishimura K, Kobayashi C, Shigemura T, Ogata S, Inoue Y, Hiejima E, Izawa K, Matsubayashi T, Matsumoto K, Imai K, Nishikomori R, Ito S, Kanegane H, Fukao T.
- Journal Title
  
  Clin Immunol.
  
  Volume: 216 Pages: 108441-108441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840
[Journal Article] Impetigo herpetiformis with a CARD14 Thr79Ile variant successfully treated with granulocyte and monocyte adsorption apheresis.2020
- Author(s)
  Fujii Kento、Takahashi Tomoko、Matsuyama Kanako、Fujii Asami、Mizutani Yoko、Ohnishi Hidenori、Seishima Mariko
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47 Issue: 3
- DOI
  10.1111/1346-8138.15241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18K16056
[Journal Article] Immunologic Effects of Sirolimus in Patients With Vascular Anomalies.2019
- Author(s)
  Nozawa Akifumi、Ozeki Michio、Yasue Shiho、Endo Saori、Kawamoto Norio、Ohnishi Hidenori、Fumino Shigehisa、Furukawa Taizo、Tajiri Tatsuro、Maekawa Takanobu、Fujino Akihiro、Souzaki Ryota、Fukao Toshiyuki
- Journal Title
  
  Journal of Pediatric Hematology/Oncology
  
  Volume: e-pub Issue: 5 Pages: 1-1
- DOI
  10.1097/mph.0000000000001650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-19K09053, KAKENHI-PROJECT-19H03719, KAKENHI-PROJECT-17K11517, KAKENHI-PROJECT-17K11518, KAKENHI-PROJECT-18K15704
[Journal Article] An innate interaction between IL-18 and the propeptide that inactivates its precursor form2019
- Author(s)
  Naotaka Tsutsumi, Ayumi Yokota, Takeshi Kimura, Zenichiro Kato, Toshiyuki Fukao, Masahiro Shirakawa, Hidenori Ohnishi & Hidehito Tochio
- Journal Title
  
  Scientific Reportsvolume
  
  Volume: 9 Issue: 1 Pages: 6160-6160
- DOI
  10.1038/s41598-019-42661-5
- NAID
  120007006235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10025, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-19K08249, KAKENHI-PROJECT-18K19297
[Journal Article] Autosomal dominant Hashimoto’s thyroiditis with a mutation in <i>TNFAIP3</i>2019
- Author(s)
  Hori Tomohiro、Ohnishi Hidenori、Kadowaki Tomonori、Kawamoto Norio、Matsumoto Hideki、Ohara Osamu、Fukao Toshiyuki
- Journal Title
  
  Clinical Pediatric Endocrinology
  
  Volume: 28 Issue: 3 Pages: 91-96
- DOI
  10.1297/cpe.28.91
- NAID
  130007681720
- ISSN
  0918-5739, 1347-7358
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07840
[Journal Article] Prominent Dermal Langerhans Cells in an Omenn Syndrome Patient With a Novel Mutation in the IL2RG Gene2019
- Author(s)
  Ibusuki Atsuko、Nishikawa Takuro、Hiraki Tsubasa、Okano Tsubasa、Imai Kohsuke、Kanegane Hirokazu、Ohnishi Hidenori、Kato Zenichiro、Fujii Kazuyasu、Tanimoto Akihide、Kawano Yoshifumi、Kanekura Takuro
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 46 Issue: 11 Pages: 1019-1023
- DOI
  10.1111/1346-8138.15054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18K08272, KAKENHI-PROJECT-19K08249, KAKENHI-PROJECT-19K08777, KAKENHI-PROJECT-17K10099
[Journal Article] The Long-Term Efficacy of Cochlear Implantation for Hearing Loss in Muckel-Wells Syndrome.2019
- Author(s)
  Ogawa B, Aoki M, Ohnishi H, Ohashi T, Hayashi H, Kuze B, Ito Y.
- Journal Title
  
  J Int Adv Otol.
  
  Volume: 15 Issue: 3 Pages: 454-458
- DOI
  10.5152/iao.2019.6871
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-17K16902
[Journal Article] Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD882018
- Author(s)
  Uno Masatoshi、Watanabe-Nakayama Takahiro、Konno Hiroki、Akagi Ken-ichi、Tsutsumi Naotaka、Fukao Toshiyuki、Shirakawa Masahiro、Ohnishi Hidenori、Tochio Hidehito
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 87 Pages: 12318-12321
- DOI
  10.1039/c8cc06480f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840
[Journal Article] Gain-of-function IKBKB mutation causes human combined immune deficiency2018
- Author(s)
  Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G,et al.
- Journal Title
  
  J Exp Med
  
  Volume: 215 Issue: 11 Pages: 2715-2724
- DOI
  10.1084/jem.20180639
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-17K10112, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18KK0228, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16H05355
[Journal Article] Hypoallergenic casein hydrolysate for peptide-based oral immunotherapy in cow's milk allergy2018
- Author(s)
  Ueno HM, Kato T, Ohnishi H, Kawamoto N, Kato Z, Kaneko H, Kondo N, Nakano T.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 142 Issue: 1 Pages: 330-333
- DOI
  10.1016/j.jaci.2018.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-16K10024
[Journal Article] IKBA S32 Mutations Underlie Ectodermal Dysplasia with Immunodeficiency and Severe Noninfectious Systemic Inflammation2018
- Author(s)
  Moriya K, Sasahara Y, Ohnishi H, Kawai T, Kanegane H.
- Journal Title
  
  J Clin Immunol
  
  Volume: 38 Issue: 5 Pages: 543-545
- DOI
  10.1007/s10875-018-0522-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K07840
[Journal Article] A Japanese family case with juvenile onset Behçet's disease caused by TNFAIP3 mutation2017
- Author(s)
  Ohnishi H, Kawamoto N, Seishima M, Ohara O, Fukao T.
- Journal Title
  
  Allergol. Int.
  
  Volume: 66 Issue: 1 Pages: 146-148
- DOI
  10.1016/j.alit.2016.06.006
- NAID
  130005308497
- ISSN
  1323-8930, 1440-1592
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461576
[Journal Article] Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants2016
- Author(s)
  Kagawa R, Fujiki R, Tsumura M, Sakata S, Nishimura S,Itan Y, Kong XF, Kato Z, Ohnishi H, Hirata O, Saito S, Ikeda M,Baghdadi JE, Bousfiha A, Fujiwara K, Oleastro M, Yancoski J,Perez L, Danielian S, Ailal F, Takada H, Hara T, Anne Puel A, Boisson-Dupuis S, Bustamante J, Casanova JL, Ohara O, Okada S, Masao Kobayashi M.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: － Issue: 1 Pages: 232-241
- DOI
  10.1016/j.jaci.2016.09.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461576, KAKENHI-PROJECT-15K21189, KAKENHI-PROJECT-16K10025, KAKENHI-PROJECT-17K10112, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-15K09655, KAKENHI-PROJECT-16K15528
[Journal Article] Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome Treated with Granulocyte and Monocyte Adsorption Apheresis.2016
- Author(s)
  Mizutani Y, Okano T, Takahashi T, Ohnishi H, Ohara O, Sano A, Seishima M.
- Journal Title
  
  Acta Derm Venereol.
  
  Volume: － Issue: 2 Pages: 275-276
- DOI
  10.2340/00015555-2507
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461576, KAKENHI-PROJECT-15K08094, KAKENHI-PROJECT-15K19686
[Journal Article] Selective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes.2016
- Author(s)
  Shingo Sotoma, Jun Iimura, Ryuji Igarashi, Koichiro M. Hirosawa, Hidenori Ohnishi, Shin Mizukami, Kazuya Kikuchi, Takahiro K. Fujiwara, Masahiro Shirakawa and Hidehito Tochio
- Journal Title
  
  Nanomaterials
  
  Volume: 6 Issue: 4 Pages: 56-56
- DOI
  10.3390/nano6040056
- NAID
  120005848250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461576, KAKENHI-PUBLICLY-15H01212, KAKENHI-PUBLICLY-26115707, KAKENHI-PROJECT-24685028, KAKENHI-PUBLICLY-15H00818, KAKENHI-PUBLICLY-15H01636, KAKENHI-PROJECT-15H03120
[Journal Article] IgGサブクラス欠損症およびIgA欠損症2015
- Author(s)
  大西秀典, 金子英雄
- Journal Title
  
  小児内科
  
  Volume: 47 Pages: 718-721
- Data Source
  KAKENHI-PROJECT-26461576
[Journal Article] Familial Mediterranean fever variant with repeated atypical skin eruptions2015
- Author(s)
  Takahashi T, Fujisawa T, Kimura M, Ohnishi H, Seishima M
- Journal Title
  
  J Dermatol
  
  Volume: 42 Issue: 9 Pages: 903-905
- DOI
  10.1111/1346-8138.12929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08094, KAKENHI-PROJECT-26461576, KAKENHI-PROJECT-15K19686
[Journal Article] Mondini dysplasia with recurrent bacterial meningitis caused by three different pathogens.2015
- Author(s)
  Shikano H, Ohnishi H, Fukutomi H, Ito K, Morimoto M, Teramoto T, Aoki M, Nishihori T, Akeda Y, Oishi K, Fukao T.
- Journal Title
  
  Pediatr Int.
  
  Volume: 57 Issue: 6 Pages: 1192-1195
- DOI
  10.1111/ped.12731
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461576
[Journal Article] Merkel cell polyomavirus-positive Merkel cell carcinoma in a patient with epidermodysplasia verruciformis2015
- Author(s)
  Mizuno Y, et al. 8名
- Journal Title
  
  Acta Derm Venereol
  
  Volume: 95 Issue: 1 Pages: 98-99
- DOI
  10.2340/00015555-1868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590185, KAKENHI-PROJECT-26461576, KAKENHI-PROJECT-15K08094
[Journal Article] The structural basis for receptor recognition of human interleukin-182014
- Author(s)
  Naotaka Tsutsumi, Takeshi Kimura, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Takahiro Yamamoto, Xiaobing Zuo, Katsumi Maenaka, Enoch Y. Park, Naomi Kondo, Masahiro Shirakawa, Hidehito Tochio and Zenichiro Kato
- Journal Title
  
  Nat. Commun.
  
  Volume: 5 5340 Issue: 1 Pages: 1-13
- DOI
  10.1038/ncomms6340
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J02660, KAKENHI-PLANNED-22121007, KAKENHI-PUBLICLY-25112514, KAKENHI-PROJECT-25461588, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-26461576, KAKENHI-PROJECT-26711004
[Journal Article] Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes2014
- Author(s)
  Takeshi Kimura, Naotaka Tsutsumi, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Naomi Kondo, Masahiro Shirakawa, Zenichiro Kato and Hidehito Tochio
- Journal Title
  
  Acta Crystallogr. Sect. F Struct. Biol. Commun.
  
  Volume: 70 Issue: 10 Pages: 1351-1356
- DOI
  10.1107/s2053230x14016926
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J02660, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-26461576, KAKENHI-PROJECT-26711004
[Journal Article] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes2014
- Author(s)
  Yamamoto T, Tsutsumi N, Tochio H, Ohnishi H, Kubota K, Kato Z, Shirakawa M, Kondo N
- Journal Title
  
  Mol Immunol
  
  Volume: 58(1) Pages: 66-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] A complement factor B mutation in a large kindred with atypical hemolytic uremic syndrome.2014
- Author(s)
  Funato M, Uemura O, Ushijima K, Ohnishi H, Orii K, Kato Z, Yamakawa S, Nagai T, Ohara O, Kaneko H, Kondo N.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 34 Issue: 6 Pages: 691-695
- DOI
  10.1007/s10875-014-0058-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461576
[Journal Article] Clinical and genetic characterization of Japanese sporadic cases of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome from a single medical center in Japan.2014
- Author(s)
  Kubota K, Ohnishi H, Teramoto T, Kawamoto N, Kasahara K, Ohara O, Kondo N.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 34 Issue: 5 Pages: 584-593
- DOI
  10.1007/s10875-014-0043-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860854, KAKENHI-PROJECT-26461576
[Journal Article] Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease.2014
- Author(s)
  Tamura K, Matsubara K, Ishiwada N, Nishi J, Ohnishi H, Suga S, Ihara T, Chang B, Akeda Y, Oishi K
- Journal Title
  
  Vaccine
  
  Volume: 32 Pages: 1444-1450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.2014
- Author(s)
  Yamamoto T, Tsutsumi N, Tochio H, Ohnishi H, Kubota K, Kato Z, Shirakawa M, Kondo N.
- Journal Title
  
  Mol Immunol
  
  Volume: 58(1) Issue: 1 Pages: 66-76
- DOI
  10.1016/j.molimm.2013.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23115004, KAKENHI-PROJECT-23791161, KAKENHI-PUBLICLY-25112514, KAKENHI-PROJECT-25860854
[Journal Article] Autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency caused by a novel NFKBIA mutation, p.Ser36Tyr, presents with mild ectodermal dysplasia and non-infectious systemic inflammation.2013
- Author(s)
  Yoshioka T, Nishikomori R, Hara J, Okada K, Hashii Y, Okafuji I, Nodomi S, Kawai T, Izawa K, Ohnishi H, Yasumi T, Nakahata T, Heike T.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 33 Issue: 7 Pages: 1165-1174
- DOI
  10.1007/s10875-013-9924-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] In vitro analysis of the functional effects of an NLRP3 G809S variant with the co-existence of MEFV haplotype variants in atypical autoinflammatory syndrome2013
- Author(s)
  Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N
- Journal Title
  
  J Clin Immunol
  
  Volume: 33(2) Pages: 325-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] In vitro analysis of the functional effects of an NLRP3 G809S variant with the co-existence of MEFV haplotype variants in atypical autoinflammatory syndrome.2013
- Author(s)
  Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N
- Journal Title
  
  J Clin Immunol
  
  Volume: 33 Pages: 325-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Pediatric allergy and immunology in Japan2013
- Author(s)
  Ebisawa M, Nishima S, Ohnishi H, Kondo N
- Journal Title
  
  Pediatr Allergy Immunol
  
  Volume: 24(7) Pages: 704-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency caused by a novel NFKBIA mutation, p.Ser36Tyr, presents with mild ectodermal dysplasia and non-infectious systemic inflammation2013
- Author(s)
  Yoshioka T, Nishikomori R, Hara J, Okada K, Hashii Y, Okafuji I, Nodomi S, Kawai T, Izawa K, Ohnishi H, Yasumi T, Nakahata T, Heike T
- Journal Title
  
  J Clin Immunol
  
  Volume: 33(7) Pages: 1165-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Pediatric allergy and immunology in Japan.2013
- Author(s)
  Ebisawa M, Nishima S, Ohnishi H, Kondo N.
- Journal Title
  
  Pediatr Allergy Immunol.
  
  Volume: 24 Issue: 7 Pages: 704-714
- DOI
  10.1111/pai.12117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD882012
- Author(s)
  Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N
- Journal Title
  
  PLoS One
  
  Volume: 7(6)
- NAID
  120005540726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Characterization of NLRP3 variants in Japanese cryopyrin-associated periodic syndrome patients2012
- Author(s)
  Ohnishi H, Teramoto T, Iwata H, Kato Z, Kimura T, Kubota K, Nishikomori R, Kaneko H, Seishima M, Kondo N
- Journal Title
  
  J Clin Immunol
  
  Volume: 32(2) Pages: 221-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling2012
- Author(s)
  Nada M, Ohnishi H, Tochio H, Kato Z, Kimura T, Kubota K, Yamamoto T, Kamatari YO, Tsutsumi N, Shirakawa M, Kondo N
- Journal Title
  
  Mol Immunol
  
  Volume: 52(3-4) Pages: 108-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Structural property of soybean protein P34 and specific IgE response to recombinant P34 in patients with soybean allergy2012
- Author(s)
  Morita H, Kaneko H, Ohnishi H, Kato Z, Kubota K, Yamamoto T, Matsui E, Teramoto T, Fukao T, Kasahara K, Kondo N
- Journal Title
  
  Int J Mol Med
  
  Volume: 29(2) Pages: 153-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Characterization of NLRP3 Variants in Japanese Cryopyrin-Associated Periodic Syndrome Patients.2012
- Author(s)
  Ohnishi H, Teramoto T, Iwata H, Kato Z, Kimura T, Kubota K, Nishikomori R, Kaneko H, Seishima M, Kondo N.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 32 Pages: 221-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Structural property of soybean protein P34 and specific IgE response to recombinant P34 in patients with soybean allergy.2012
- Author(s)
  Morita H, Kaneko H, Ohnishi H, Kato Z, Kubota K, Yamamoto T, Matsui E, Teramoto T, Fukao T, Kasahara K, Kondo N.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 29 Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] A rapid screening method to detect autosomal-dominant ectodermal dysplasia with immune deficiency syndrome.2012
- Author(s)
  Ohnishi H, Miyata R, Suzuki T, Nose T, Kubota K, Kato Z, Kaneko H, Kondo N.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 129 Pages: 578-580
- NAID
  10030801132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism.2012
- Author(s)
  Hori T, Ohnishi H, Teramoto T, Tsubouchi K, Naiki T, Hirose Y, Ohara O, Seishima M, Kaneko H, Fukao T, Kondo N.
- Journal Title
  
  J Clin Immunol
  
  Volume: 32 Pages: 1213-1220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling2012
- Author(s)
  Nada M, Ohnishi H, Tochio H, Kato Z, Kimura T, Kubota K, Yamamoto T, Kamatari YO, Tsutsumi N, Shirakawa M, Kondo N.
- Journal Title
  
  Mol Immunol.
  
  Volume: 52 Pages: 108-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism2012
- Author(s)
  Hori T, Ohnishi H, Teramoto T, Tsubouchi K, Naiki T, Hirose Y, Ohara O, Seishima M, Kaneko H, Fukao T, Kondo N
- Journal Title
  
  J Clin Immunol
  
  Volume: 32(6) Pages: 1213-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.2012
- Author(s)
  Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N.
- Journal Title
  
  PLoS One
  
  Volume: 7
- NAID
  120005540726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] A rapid screening method to detect autosomal-dominant ectodermal dysplasia with immune deficiency syndrome2012
- Author(s)
  Ohnishi H, Miyata R, Suzuki T, Nose T, Kubota K, Kato Z, Kaneko H, Kondo N
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 129(2) Pages: 578-80
- NAID
  10030801132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Antigen-specific immune response to endotoxin-free recombinant P34.2011
- Author(s)
  Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N.
- Journal Title
  
  Allergy
  
  Volume: (E Pub)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.2011
- Author(s)
  An Y, Ohnishi H, Matsui E, Funato M, Kato Z, Teramoto T, Kaneko H, Kimura T, Kubota K, Kasahara K, Kondo N.
- Journal Title
  
  Int J Mol Med. 27(6)
  
  Pages: 795-801
- NAID
  120006341946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Antigen-specific immune response to endotoxin-free recombinant P342011
- Author(s)
  Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N.
- Journal Title
  
  .Allergy.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.2011
- Author(s)
  Yang An, Hidenori Ohnishi, Eiko Matsui, Michinori Funato, Zenichiro Kato, Takahide Teramoto, Hideo Kaneko, Takeshi Kimura, Kazuo Kubota, Kimiko Kasahara, Naomi Kondo.
- Journal Title
  
  Int J Mol Med
  
  Volume: 27 Pages: 795-801
- NAID
  120006341946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Refractory chronic pleurisy caused by Helicobacter equorum-like bacterium in a patient with X-linked agammaglobulinemia2011
- Author(s)
  Funato M, Kaneko H, Ohkusu K, Sasai H, Kubota K, Ohnishi H, Kato Z, Fukao T, Kondo N
- Journal Title
  
  J Clin Microbiol
  
  Volume: 49(9) Pages: 3432-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] 皮膚症状からみた自己炎症性症候群2011
- Author(s)
  大西秀典、寺本貴英、久保田一生、清島真理子、近藤直実
- Journal Title
  
  小児皮膚科学会雑誌
  
  Volume: 30 Pages: 11-16
- NAID
  10029837057
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Refractory chronic pleurisy caused by Helicobacter equorum-like bacterium in a patient with X-linked agammaglobulinemia.2011
- Author(s)
  Funato M, Kaneko H, Ohkusu K, Sasai H, Kubota K, Ohnishi H, Kato Z, Fukao T, Kondo N.
- Journal Title
  
  J Clin Microbiol.
  
  Volume: 49 Pages: 3432-3435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791161
[Journal Article] Interleukin-17 expression in the urticarial rash of familial cold autoinflammatory syndrome : a case report.2010
- Author(s)
  Yamauchi A, Iwata H, Ohnishi H, Teramoto T, Kondo N, Seishima M.
- Journal Title
  
  Br J Dermatol
  
  Volume: 163 Pages: 1351-1353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Efficacy of the slow dose-up method for specific oral tolerance induction in children with cow's milk allergy : comparison with reported protocols.2010
- Author(s)
  Kaneko H, Teramoto T, Kondo M, Morita H, Ohnishi H, Orii K, Matsui E, Kondo N.
- Journal Title
  
  J Investig Allergol Clin Immunol. 20(6)
  
  Pages: 538-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Efficacy of the slow dose-up method for specific oral tolerance induction in children with cow's milk allergy : comparison with reported protocols.2010
- Author(s)
  Kaneko H, Teramoto T, Kondo M, Morita H, Ohnishi H, Orii K, Matsui E, Kondo N.
- Journal Title
  
  J Investig Allergol Clin Immunol
  
  Volume: 20 Pages: 538-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Prediction of the pathogenesis of the mutation in MeCP2 C-terminal domain.2010
- Author(s)
  Kato Z, Ohnishi H, Kimura T, Kondo N.
- Journal Title
  
  Brain Dev. 32(2)
  
  Pages: 169-169
- NAID
  10027213098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] (1)H, (13)C, and (15)N resonance assignment of the TIR domain of human MyD88.2010
- Author(s)
  Ohnishi H, Tochio H, Kato Z, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
- Journal Title
  
  Biomol NMR Assign.
- NAID
  120002709551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88.2010
- Author(s)
  Ohnishi H, Tochio H, Kato Z, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
- Journal Title
  
  Biomol NMR Assign. 4(2)
  
  Pages: 123-125
- NAID
  120002709551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Mutation in the Q28SDD31SD site, but not in the two SQ sites of the survival of motor neuron protein, affects its foci formation.2010
- Author(s)
  Aoki Y, Fukao T, Zhang G, Ohnishi H, Kondo N.
- Journal Title
  
  Int J Mol Med
  
  Volume: 26 Pages: 667-671
- NAID
  120006341937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Mutation in the Q28SDD31SD site, but not in the two SQ sites of the survival of motor neuron protein, affects its foci formation.2010
- Author(s)
  Aoki Y, Fukao T, Zhang G, Ohnishi H, Kondo N.
- Journal Title
  
  Int J Mol Med. 26(5)
  
  Pages: 667-671
- NAID
  120006341937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Interleukin-17 expression in the urticarial rash of familial cold autoinflammatory syndrome : a case report.2010
- Author(s)
  Yamauchi A, Iwata H, Ohnishi H, Teramoto T, Kondo N, Seishima M.
- Journal Title
  
  Br J Dermatol. 163(6)
  
  Pages: 1351-1353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 自然免疫系の障害による原発性免疫不全症の最近の動向2009
- Author(s)
  徳見哲司、大西秀典、金子英雄、加藤善一郎、近藤直実
- Journal Title
  
  アレルギー 58
  
  Pages: 19-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 免疫不全とアレルギー-特に,自然免疫系の分子のタンパク構造生物学的視点から-2009
- Author(s)
  近藤直実、大西秀典、加藤善一郎、松井永子、木村豪、徳見哲司、森田秀行、金子英雄、寺本貴英
- Journal Title
  
  日本小児アレルギー学会誌 23
  
  Pages: 203-211
- NAID
  10026284582
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.2009
- Author(s)
  Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
- Journal Title
  
  Proc Natl Acad Sci USA. 106
  
  Pages: 10260-10265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 自然免疫の分子機構に基づいた自己炎症性症候群の診断へのアプローチ2009
- Author(s)
  大西秀典、加藤善一郎、寺本貴英、舩戸道徳、金子英雄、深尾敏幸、近藤直実
- Journal Title
  
  アレルギー 58
  
  Pages: 1502-1512
- NAID
  110007482487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.2009
- Author(s)
  Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
- Journal Title
  
  Proc Natl Acad Sci USA. 106(25)
  
  Pages: 10260-10265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 感染症・免疫異常の臨床遺伝学2009
- Author(s)
  近藤直実、大西秀典、徳見哲司、金子英雄、加藤善一郎
- Journal Title
  
  小児科臨床 1
  
  Pages: 77-82
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.2008
- Author(s)
  Bai C, Matsui E, Ohnishi H, Kimata K, Kasahara K, Kaneko H, Kato Z, Fukao T, Kondo N.
- Journal Title
  
  Int J Mol Med. 21(2)
  
  Pages: 139-144
- NAID
  120006340784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Hypothermia augments NF-kappaB activity and the production of IL-12 and IFN-gamma.2008
- Author(s)
  Arai T, Kaneko H, Ohnishi H, Matsui E, Fukao T, Kawamoto N, Kasahara K, Kondo N.
- Journal Title
  
  Allergol Int. 57(4)
  
  Pages: 331-338
- NAID
  10025108414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 小児気管支喘息患児と親又は保護者のQOL調査票簡易改訂版2008(GIFU)2008
- Author(s)
  近藤直実, 平山耕一郎, 松井永子, 寺本貴英, 金子英雄, 深尾敏幸, 折居建治, 川本美奈子, 舩戸道徳, 大西秀典, 川本典生, 森田秀行, 木村豪, 名田匡利, 徳見哲司, 堀友博, 渡邊倫子
- Journal Title
  
  アレルギー 57
  
  Pages: 1022-1033
- NAID
  110006884769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] A novel polymorphism,E254K,in the 5-lipoxygenase gene associated with bronchial asthma2008
- Author(s)
  Bai C, Matsui E, Ohnishi H, Kimata K, Kasahara K, Kaneko H, Kato Z, Fukao T, Kondo N
- Journal Title
  
  International Journal of Molecular Medicine 21
  
  Pages: 139-144
- NAID
  120006340784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17790699
[Journal Article] 小児インフルエンザにおける麻黄湯の効果と治療の選択についての検討2008
- Author(s)
  福富悌, 金子英雄, 大西秀典, 笠原貴美子, 近藤直実
- Journal Title
  
  漢方と免疫・アレルギー 27
  
  Pages: 22-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Expression, Purification and Structural Analysis of Human IL-18 Binding Protein : A Potent Therapeutlic Molecule for Allergy2008
- Author(s)
  T Kimura, Z Kato, H Ohnishi, H Tochio, M Shirakawa, N Kondo
- Journal Title
  
  Allergol Int 57
  
  Pages: 367-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Hypothermia Augments NF-kappaB Activity and the Production of IL-12 and IFN-gamma2008
- Author(s)
  T Arai, H Kaneko, H Ohnishi, E Matsui, T Fukao, N Kawamoto, K Kasahara, N Kondo
- Journal Title
  
  Allergol Int 57
  
  Pages: 331-338
- NAID
  10025108414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 分子生物学的アプローチの臨床へのインパクトIL-18及びシグナル伝達系タンパク質構造解析に基づく創薬へのアプローチ2008
- Author(s)
  大西秀典, 加藤善一郎, 李愛蓮, 木村豪, 名田匡利, 徳見哲司, 相馬和佳, 松井永子, 金子英雄, 近藤直実, 杤尾豪人, 白川昌宏
- Journal Title
  
  日本小児アレルギー学会誌 22
  
  Pages: 63-70
- NAID
  10027854539
- Data Source
  KAKENHI-PROJECT-17790699
[Journal Article] Expression, purification and structural analysis of human IL-18 binding protein : a potent therapeutic molecule for allergy.2008
- Author(s)
  Kimura T, Kato Z, Ohnishi H, Tochio H, Shirakawa M, Kondo N.
- Journal Title
  
  Allergol Int. 57(4)
  
  Pages: 367-376
- NAID
  10025108541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] 免疫寛容誘導のための食物アレルギー主要抗原タンパクの基礎的検討2008
- Author(s)
  森田秀行、金子英雄、大西秀典、近藤應、松井永子、深尾敏幸、近藤直実
- Journal Title
  
  日本小児アレルギー学会誌 22
  
  Pages: 233-238
- NAID
  10026940238
- Data Source
  KAKENHI-PROJECT-20790723
[Journal Article] Development of fluorescence linked immunosorbent assay (FLISA) for high throughput screening (HTS) of interferon-gamma2006
- Author(s)
  Eiji Matsukuma, Zenichiro Kato, Kentaro Omoya, Kazuyuki Hashimoto, Ailian Li, Yutaka Yamamoto, Hidenori Ohnishi, et al.
- Journal Title
  
  Allergology International (In press)
- Data Source
  KAKENHI-PROJECT-17790699
[Journal Article] Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder2005
- Author(s)
  Hashimoto K, Kato Z, Nagase T, Shimozawa N, Kuwata K, Omoya K, Li A, Matsukuma E, Yamamoto Y, Ohnishi H, et al.
- Journal Title
  
  PEDIATRIC RESEARCH 58・2
  
  Pages: 263-269
- Data Source
  KAKENHI-PROJECT-17790699
[Patent] インターロイキン-18活性阻害剤2016
- Inventor(s)
  大西秀典、木村豪、加藤善一郎、杤尾豪人、堤尚孝、横田歩
- Industrial Property Rights Holder
  京都大学、岐阜大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-12-09
- Overseas
- Data Source
  KAKENHI-PROJECT-26461576
[Patent] インターロイキン－１８活性阻害剤2015
- Inventor(s)
  杤尾豪人、堤尚孝、横田歩、大西秀典、木村豪、加藤善一郎
- Industrial Property Rights Holder
  杤尾豪人、堤尚孝、横田歩、大西秀典、木村豪、加藤善一郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-242091
- Filing Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-26461576
[Patent] 変異導入MyD88蛋白によるToll様受容体/インターロイキン18シグナルの特異的制御法2008
- Inventor(s)
  近藤直実、加藤善一郎、大西秀典、白川昌宏、杤尾豪人
- Industrial Property Rights Holder
  岐阜大学、京都大学
- Filing Date
  2008-07-31
- Overseas
- Data Source
  KAKENHI-PROJECT-20790723
[Patent] 変異導入MyD88蛋白によるToll様受容体/インターロイキーン18シグナルの特異的制御法2008
- Inventor(s)
  近藤直実、加藤善一郎、大西秀典、白川昌宏、栃尾豪人
- Industrial Property Rights Holder
  岐阜大学、京都大学
- Filing Date
  2008-07-31
- Overseas
- Data Source
  KAKENHI-PROJECT-20790723
[Patent] 変異導入MyD88蛋白によるToll様受容体/インターロイキン18シグナルの特異的制御法2007
- Inventor(s)
  近藤直実, 加藤善一郎, 大西秀典, 栃尾豪人, 白川昌宏
- Industrial Property Rights Holder
  国立大学法人岐阜大学, 国立大学法人京都大学
- Industrial Property Number
  2007-200776
- Filing Date
  2007-08-01
- Data Source
  KAKENHI-PROJECT-17790699
[Presentation] 自己炎症性疾患up to date 20232023
- Author(s)
  大西秀典
- Organizer
  日本リウマチ学会総会・学術集会 (第67回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] 免疫異常疾患における小児科と歯科・口腔外科のクロストーク2023
- Author(s)
  大西秀典
- Organizer
  日本小児歯科学会中部地方会大会(第42回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] A20ハプロ不全症の全国疫学調査2023
- Author(s)
  大西秀典, 白木真由香, 三輪友紀, 門脇紗織, 門脇朋範
- Organizer
  日本小児リウマチ学会学術集会(第32回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] 希少遺伝子変異と免疫疾患　自己炎症性疾患　炎症性腸疾患(IBD)を呈する疾患を中心として2023
- Author(s)
  大西秀典
- Organizer
  日本臨床免疫学会総会(第51回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] 原発性免疫不全症の新生児マススクリーニングの現状について2023
- Author(s)
  大西秀典
- Organizer
  日本小児感染症学会総会・学術集会(第55回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] 自己炎症性疾患 PFAPAその鑑別疾患（HA20、高IgD症候群など）.2022
- Author(s)
  大西秀典
- Organizer
  日本小児感染症学会学術集会(第54回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] PIGS遺伝子変異を認めた先天性GPI欠損症の1例 A case of congenital GPI deficiency with PIGS gene mutation.2022
- Author(s)
  足立美穂、久保田一生、山本崇裕、才津浩智、村上良子、大西秀典
- Organizer
  第64回　日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K02709
[Presentation] 免疫不全症を伴う遺伝性自己炎症性疾患2022
- Author(s)
  大西秀典
- Organizer
  日本免疫不全・自己炎症学会総会(第5回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] 自己炎症性症候群の現状の把握、未来に向けてのメッセージ　自己炎症性症候群の新規疾患.2022
- Author(s)
  大西秀典
- Organizer
  日本小児リウマチ学会総会・学術集会(第31回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] Monogenic VasculitisとしてのA20ハプロ不全症2021
- Author(s)
  大西秀典
- Organizer
  日本小児リウマチ学会総会・学術集会(第30回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] 先天性免疫異常症におけるJAK阻害剤の適応と最近の話題2021
- Author(s)
  大西秀典
- Organizer
  日本小児リウマチ学会総会・学術集会(第30回)
- Data Source
  KAKENHI-PROJECT-21K07770
[Presentation] A case of novel identified proteasome-related autoinflammation and immunodeficiency syndrome caused by PSMB9 mutation.2019
- Author(s)
  Ohnishi H., Kataoka S., Muramatsu H., Kadoi E., Kanazawa N., Okada S., Honda Y., Izawa K., Nishikomori R., Taketani T., Hamazaki J., Murata S., Takahashi Y., Fukao T.
- Organizer
  The 10th Biannual Meeting of the International Society of Systemic Auto-Inflammatory Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07840
[Presentation] The clinical and immunological profiles of haploinsufficiency of A20 in Japan.2019
- Author(s)
  Ohnishi H., Kadowaki T., Kawamoto N., Hori T., Nishimura K., Kobayashi C., Shigemura T., Ogata S., Inoue Y., Kawai T., Hiejima E., Izawa K., Matsubayashi T., Takagi M., Imai K., Nishikomori R., Ito S., Heike T., Ohara O., Morio T, Kanegane H., Fukao T.
- Organizer
  The 10th Biannual Meeting of the International Society of Systemic Auto-Inflammatory Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07840
[Presentation] What PID to suspect when a child present with difficult to treat mycobacterial infections?2019
- Author(s)
  Ohnishi H.
- Organizer
  The 15th Congress of Asian Society for Pediatric Research (ASPR)
- Invited
- Data Source
  KAKENHI-PROJECT-18K07840
[Presentation] 自己炎症性疾患の診断と治療およびイラリスの適正使用2018
- Author(s)
  大西秀典
- Organizer
  日本小児リウマチ学会総会・学術集会(第28回)
- Data Source
  KAKENHI-PROJECT-18K07840
[Presentation] Anti-NMDA receptor encephalitis associate with IRAK4 deficiency.2018
- Author(s)
  Nishimura S, Kobayashi Y, Tsumura M, Ishikawa N, Ohnishi H, Takada H, Sancho-Shimizu V, Moriya K, Anne P, Capucine P, Irani S, Casanova JL, Okada S, Kobayashi M.
- Organizer
  ESID 2018 (European Society for Immunodeficiencies)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07840
[Presentation] Molecular analysis of signal transduction pathway of IL-18, related with allergic condition2012
- Author(s)
  Hidenori Ohnishi, Zenichiro Kato, Takeshi Kimura, Kazuo Kubota, Takahiro Yamamoto, Naomi Kondo
- Organizer
  The 22nd Congress of Interasma Japan / North Asia
- Place of Presentation
  Fukuoka Japan
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] The functional assessments of mutational effect of human IRAK4 and MyD88 gene2012
- Author(s)
  Hidenori Ohnishi, Naotaka Tsutsumi, Takahiro Yamamoto, Hidehito Tochio, Zenichiro Kato, Kazuo Kubota, Masahiro Shirakawa, Naomi Kondo
- Organizer
  APAPARI 2012
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] Characterization of NLRP3 Variants in Japanese Cryopyrin-associated Periodic Syndrome Patients2012
- Author(s)
  Hidenori Ohnishi, Takahide Teramoto, Zenichiro Kato, Kazuo Kubota, Hideo Kaneko, and Naomi Kondo
- Organizer
  UTOIMMUNITY 2012(第8回国際自己免疫疾患学会)
- Place of Presentation
  Granada, Spain
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] Gene polymorphisms in innate immune signaling pathways associated with allergic disease2011
- Author(s)
  Hidenori Ohnishi
- Organizer
  Asia Pacific Association of Pediatric Allergy, Respirology and Immunology 2011 (APAPARI 2011), 48th Annual Meeting of Japanese Society of Pediatric Allergy and Clinical Immunoligy (48th JSPACI)
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] IRAK4ミスセンス遺伝子変異の病的意義の判定方法2011
- Author(s)
  大西秀典、山本崇裕、加藤善一郎、近藤直実
- Organizer
  日本免疫学会(第40回)
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] 自然免疫不全症の構造生物学的病態解析2011
- Author(s)
  大西秀典、加藤善一郎、安陽、松井永子、木村豪、名田匡利、久保田一生、山本崇裕、金子英雄、近藤直実
- Organizer
  日本小児科学会(第114回)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] インターロイキン18 シグナル伝達経路の分子生物学的解析2011
- Author(s)
  大西秀典
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] Gene polymorphisms in innate immune signaling pathways associated with allergic disease2011
- Author(s)
  Ohnishi H
- Organizer
  Asia Pacific Association of Pediatric Allergy, Respirology and Immunology2011 (APAPARI 2011) 48th Annual Meeting of Japanese Society of Pediatric Allergy and Clinical Immunoligy (48 th JSPACI)
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] フローサイトメーターによるスクリーニング法で診断された新規遺伝子変異を有するIκBα欠損症の1男児例2011
- Author(s)
  大西秀典、加藤善一郎、金子英雄、近藤直実、宮田理英、鈴木智典、能勢統一郎
- Organizer
  春期日本アレルギー学会(第23回)
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] 自然免疫不全症の病態解明と診断手順について2011
- Author(s)
  大西秀典
- Organizer
  第6回岐阜小児アレルギー・喘息研究会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23791161
[Presentation] 乳児栄養の役割:母乳・人工乳2010
- Author(s)
  大西秀典、金子英雄、森田秀行、川本美奈子、松井永子、加藤善一郎、近藤直実
- Organizer
  第113回日本小児科学会学術集会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] The genetic variations of the MyD88 adaptor protein like (Mal) are associated with allergic diseases in Japanese population.2010
- Author(s)
  Hidenori Ohnishi, Yang An, Eiko Matsui, Zenichiro Kato, Hideo Kaneko, Naomi Kondo.
- Organizer
  The 20th Interasma Japan/North Asia.
- Place of Presentation
  Tokyo.
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] The LPS induced enhancement of IL-1β and IL-18 production is a useful tool for diagnosis of familial cold inflammatory syndrome (FCAS).2010
- Author(s)
  Hidenori Ohnishi, Takahide Teramoto, Zenichiro Kato, Hideo Kaneko, Ryuta Nishikomori, Naomi Kondo.
- Organizer
  Autoinflammation 2010.
- Place of Presentation
  Amsterdam, Netherlands.
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 自然免疫不全症(MyD88欠損症,IRAK4欠損症)の構造生物学的解析2010
- Author(s)
  大西秀典、加藤善一郎、安陽、松井永子、金子英雄、近藤直実
- Organizer
  第60回日本アレルギー学会秋期学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] The LPS induced enhancement of IL-1β and IL-18 production is a useful tool for diagnos is of familial cold inflammatory syndrome (FCAS).2010
- Author(s)
  Hidenori Ohnishi, Takahide Teramoto, Zenichiro Kato, Hideo Kaneko, Ryuta Nishikomori, Naomi Kondo.
- Organizer
  Autoinflammation 2010
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Structural basis for the innate immune deficiency syndrome.2010
- Author(s)
  Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Takeshi Kimura, Masatoshi Nada, Kazuo Kubota, Masahiro Shirakawa, Naomi Kondo.
- Organizer
  The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2010
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] A conserved interaction mode between MyD88 and distinct membrane-sorting adaptors in TLR4 and IL-18 signaling.2010
- Author(s)
  H.Ohnishi, H.Tochio, Z.Kato, T.Kimura, T.Funasaka, R.W.Wong, M.Shirakawa, N.Kondo.
- Organizer
  14th International Congress of Immunology.
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 自然免疫異常症の構造生物学的解析2010
- Author(s)
  大西秀典、加藤善一郎、木村豪、久保田一生、金子英雄、近藤直実、堤尚孝、杤尾豪人、白川昌宏
- Organizer
  第46回中部小児科学会
- Place of Presentation
  金沢
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Structural basis for the interactions of the MyD88 TIR domain in TLR4 signaling.2010
- Author(s)
  Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Takeshi Kimura, Naomi Kondo, Masahiro Shirakawa.
- Organizer
  World wide magnetic resonance conference 2010
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 最近、当科で診断した自己炎症性症候群の7例について2010
- Author(s)
  大西秀典、寺本貴英、加藤善一郎、松井永子、金子英雄、近藤直実、岩田浩明、加納宏行
- Organizer
  第三回日本免疫不全症研究会
- Place of Presentation
  東京
- Year and Date
  2010-01-30
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] The genetic variations of the MyD88 adaptor protein like (Ma1) are associated with allergic diseases in Japanese population.2010
- Author(s)
  Hidenori Ohnishi, Yang An, Eiko Matsui, Zenichiro Kato, Hideo Kaneko, Naomi Kondo.
- Organizer
  The 20th Interasma Japan/North Asia
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 自然免疫異常症、アレルギー疾患病態解明に向けたプロテオミクス的手法の応用2010
- Author(s)
  大西秀典、加藤善一郎、木村豪、安陽、久保田一生、松井永子、金子英雄、近藤直実
- Organizer
  第47回日本小児アレルギー学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Structural basis for the innate immune deficiency syndrome.2010
- Author(s)
  Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Takeshi Kimura, Masatoshi Nada, Kazuo Kubota, Masahiro Shirakawa, Naomi Kondo.
- Organizer
  The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2010.
- Place of Presentation
  Singapore.
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Structural basis for the interactions of the MyD88 TIR domain in TLR4 signaling.2010
- Author(s)
  Hidenori Ohnishi, Hidehito Tochio, ZenichiroKato, Takeshi Kimura, Naomi Kondo, Masahiro Shirakawa.
- Organizer
  World wide magnetic resonance conference 2010.
- Place of Presentation
  Florence, Italy.
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] A conserved interaction mode between MyD88 and distinct membrane-sorting adaptors in TLR4 and IL-18 signaling.2010
- Author(s)
  H.Ohnishi, H.Tochio, Z.Kato, T.Kimura, T.Funasaka, R.W.Wong, M.Shirakawa, N.Kondo.
- Organizer
  14th International Congress of Immunology.
- Place of Presentation
  Kobe.
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 化膿性細菌感染に関与するToll様受容体の細胞内シグナル伝達機構の構造生物学的解析2009
- Author(s)
  大西秀典, 加藤善一郎, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 金子英雄, 近藤直実
- Organizer
  第12回岐阜小児感染症懇話会
- Place of Presentation
  岐阜
- Year and Date
  2009-02-07
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 化膿性細菌感染に関与するToll様受容体の細胞内シグナル伝達機構の構造生物学的解析2009
- Author(s)
  大西秀典, 加藤善一郎, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 金子英雄, 近藤直実
- Organizer
  第二回日本免疫不全症研究会
- Place of Presentation
  東京
- Year and Date
  2009-01-31
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 自己炎症性症候群の包括的診断フローチャート(GIFU)に基づくCINCA症候群の診断例について2009
- Author(s)
  大西秀典、寺本貴英、川本典生、木村豪、加藤善一郎、金子英雄、深尾敏幸、近藤直実
- Organizer
  第21回日本アレルギー学会春季臨床大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 化膿性細菌感染に関与するToll様受容体の細胞内シグナル伝達機構の構造生物学的解析2009
- Author(s)
  大西秀典, 加藤善一郎, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 金子英雄, 近藤直実
- Organizer
  第112回日本小児科学会学術集会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 家族性寒冷自己炎症症候群(FCAS)の分子生物学的解析2009
- Author(s)
  大西秀典、寺本貴英、近藤直実、岩田浩明、青山裕美
- Organizer
  第59回日本アレルギー学会秋季学術大会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] MyD88免疫不全症におけるシグナル伝達機構の構造生物学的基盤解析2009
- Author(s)
  加藤善一郎, 大西秀典, 木村豪, 徳見哲司, 名田匡利, 長屋聡一郎, 金子英雄, 近藤直実
- Organizer
  第二回日本免疫不全症研究会
- Place of Presentation
  東京
- Year and Date
  2009-01-31
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 当科で経験したCIAS1遺伝子異常症4例の分子生物学的解析2009
- Author(s)
  大西秀典、寺本貴英、加藤善一郎、木村豪、近藤直実、岩田浩明、青山裕美
- Organizer
  第46回日本小児アレルギー学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] アダプター分子MyD88のタンパク構造・機能解析とその創薬に向けた応用2008
- Author(s)
  大西秀典, 加藤善一郎, 李愛蓮, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 相馬和佳, 近藤直実
- Organizer
  第111回日本小児科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 食物アレルギーにおけるβ-ラクトグロブリンおよび大豆P34分解ペプチドの臨床応用2008
- Author(s)
  森田秀行, 金子英雄, 大西秀典, 近藤應, 松井永子, 深尾敏幸, 近藤直実
- Organizer
  第20回日本アレルギー学会春季臨床大会
- Place of Presentation
  東京
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] グラム陽性菌感染に関与するTLRとアダプター分子間相互作用の構造生物学的解析とその臨床応用2008
- Author(s)
  徳見哲司, 大西秀典, 加藤善一郎, 木村豪, 名田匡利, 金子英雄, 近藤直実
- Organizer
  第44回中部日本小児科学会
- Place of Presentation
  富山
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 食物アレルギーにおけるβ-ラクトグロブリンおよび大豆P34の分解ペプチドの臨床応用2008
- Author(s)
  森田秀行, 金子英雄, 大西秀典, 近藤應, 川本美奈子, 松井永子, 深尾敏幸, 近藤直実
- Organizer
  第111回日本小児科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-04-27
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 大豆アレウギー寛容誘導を目的とするP34抗原修飾ペプチド作製に向けたBおよびT細胞反応性エピトープの解析2008
- Author(s)
  森田秀行, 金子英雄, 大西秀典, 加藤善一郎, 松井永子, 深尾敏幸, 近藤直実
- Organizer
  第58回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Molecular Analyses Of Interaction Between Myd88-Adaptor- Like And The Other TIR Proteins In Toll-Like Receptor Signaling2008
- Author(s)
  Tokumi T, Ohnishi H, Kimura T, Kaneko H, Kondo N
- Organizer
  Joint Singapore Paediatric Congress & APAPARI Meeting 2008
- Place of Presentation
  ンンガポール
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] リポペプチドを認識するTLRとアダプター分子間相互作用の構造生物学的解析2008
- Author(s)
  名田匡利, 大西秀典, 加藤善一郎, 李愛蓮, 徳見哲司, 相馬和佳, 金子英雄, 近藤直実
- Organizer
  第111回日本小児科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-04-27
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 牛乳アレルギーにおける経口免疫寛容誘導食品の作成. ミニシンポジウム4食物アレルギー診療の新しい展開2008
- Author(s)
  金子英雄, 森田秀行, 大西秀典, 近藤應, 川本美奈子, 松井永子, 深尾敏幸, 加藤晴彦, 中埜拓, 近藤直実
- Organizer
  第45回日本小児アレルギー学会
- Place of Presentation
  横浜
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] TLR4とIL-18シグナル伝達におけるMyD88と細胞膜誘導性アダプター分子の相互作用様式の解析2008
- Author(s)
  大西秀典, 近藤直実
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 母乳中のサイトカイン, 食物抗原とアレルギー発症との関連についての検討2008
- Author(s)
  川本美奈子, 大西秀典, 川本典生, 森田秀行, 深尾敏幸, 金子英雄, 松井永子, 笠原貴美子, 近藤直実
- Organizer
  第111回日本小児科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-04-27
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 母乳中のサイトカイン, 食物抗原とアレルギー発症との関連について2008
- Author(s)
  川本美奈子, 大西秀典, 川本典生, 森田秀行, 深尾敏幸, 金子英雄, 松井永子, 笠原貴美子, 近藤直実
- Organizer
  第20回日本アレルギー学会春季臨床大会
- Place of Presentation
  東京
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 構造解析・臨床応用へ向けたIL-18結合タンパク大量発現系の構築2008
- Author(s)
  木村豪, 加藤善一郎, 大西秀典, 李愛蓮, 近藤直実
- Organizer
  第111回日本小児科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 細菌感染に関与するTLRの細胞内シグナル伝達機構の構造生物学的解析とその臨床応用2008
- Author(s)
  大西秀典, 加藤善一郎, 福富悌, 木村豪, 名田匡利, 徳見哲司, 長屋聡一郎, 松井永子, 金子英雄, 近藤直実
- Organizer
  第40回日本小児感染症学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Molecular analyses of protein-protein interactions of intra-cellular signaling in innate immunity. (英語口演)2008
- Author(s)
  T Tokumi, H Ohnishi, Z Kato, S Nagaya, H Kaneko, N Kondo
- Organizer
  第111回日本小児科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] Expression, Purification and Structural Analysis of Human IL-18 Binding Protein : A Potent Therapeutic Molecule for Allergy2008
- Author(s)
  Kimura T, Kato Z, Ohnishi H, Tokumi T, Tochio H, Shirakawa M, Konodo N
- Organizer
  Joint Singapore Paediatric Congress & APAPARI Meeting 2008
- Place of Presentation
  ンンガポール
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 構造解析・臨床応用へ向けたIL-18結合タンパク大量発現系の構築2008
- Author(s)
  木村豪, 加藤善一郎, 大西秀典, 李愛蓮, 近藤直実
- Organizer
  第20回日本アレルギー学会春季臨床大会
- Place of Presentation
  東京
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 母乳栄養とアレルギー疾患発症との関連について. シンポジウム3環境因子がアレルギー疾患の発症に及ぼす影響と発症予防の可能性について2008
- Author(s)
  川本美奈子, 大西秀典, 川本典生, 森田秀行, 松井永子, 金子英雄, 寺本貴英, 深尾敏幸, 白木誠, 岩砂眞一, 近藤直実
- Organizer
  第45回日本小児アレルギー学会
- Place of Presentation
  横浜
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 脊髄性筋萎縮症の病態解析〜SMNタンパクのリン酸化に関する研究〜2008
- Author(s)
  青木雄介, 深尾敏幸, 大西秀典, 折居建治, 近藤直実
- Organizer
  第50回日本小児神経学会総会
- Place of Presentation
  東京
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] TLRシグナル伝達に関わるアダプター分子Malの機能解析とその臨床応用2008
- Author(s)
  徳見哲司, 大西秀典, 加藤善一郎, 長屋聡一郎, 木村豪, 名田匡利, 金子英雄, 近藤直実
- Organizer
  第58回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2008-11-27
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] アレルギー発症にかかわる分子の構造学的解明と臨床応用2008
- Author(s)
  大西秀典, 加藤善一郎, 木村豪, 徳見哲史, 福富悌, 近藤直実
- Organizer
  第45回日本小児アレルギー学会
- Place of Presentation
  横浜
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-20790723
[Presentation] 分子生物学的アプローチの臨床へのインパクトIL-18及びシグナル伝達系タンパク質構造解析に基づく創薬へのアプローチ2007
- Author(s)
  大西秀典, 加藤善一郎, 李愛蓮, 木村豪, 名田匡利, 相馬和佳, 松井永子, 金子英雄, 近藤直実, 杤尾豪人, 白川昌宏
- Organizer
  第44回日本小児アレルギー学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-17790699
[Presentation] 免疫アレルギー病態における細胞内シグナル伝達機構のタンパク構造学的解析2007
- Author(s)
  大西秀典, 加藤善一郎, 李愛蓮, 名田匡利, 相馬和佳, 近藤直実
- Organizer
  第110回日本小児科学会学術集会
- Place of Presentation
  京都国際会館
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-17790699
[Presentation] 温度変化がサイトカイン産生に及ぼす影響2007
- Author(s)
  新井隆広, 金子英雄, 川本典生, 笠原貴美子, 大西秀典, 松井永子, 近藤直実
- Organizer
  第110回日本小児科学会学術集会
- Place of Presentation
  京都国際会館
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-17790699
[Presentation] MyD88タンパク立体構造解析による新規シグナル伝達制御分子の開発2007
- Author(s)
  大西秀典, 加藤善一郎, 李愛蓮, 名田匡利, 相馬和佳, 松井永子, 金子英雄, 近藤直実, 杤尾豪人, 白川昌宏
- Organizer
  第57回日本アレルギー学会秋季学術大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-17790699
[Presentation] アダプター分子MyD88の構造生物学的機能解析と臨床応用への展望2007
- Author(s)
  名田匡利, 大西秀典, 相馬和佳, 李愛蓮, 加藤善一郎, 金子英雄, 近藤直実, 杤尾豪人, 白川昌宏
- Organizer
  第19回日本アレルギー学会春季臨床大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-06-11
- Data Source
  KAKENHI-PROJECT-17790699

1. 足立美穂 (10440356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 堀田亮 (10733074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山本眞由美 (40313879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. TOCHIO HIDEHITO

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. KIMURA TAKESHI

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATO Taichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. OKADA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
8. TSUMURA Miyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. OHARA Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. IZAWA Kazushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. IMAI Kohsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. IMAI Chihaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山本英範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 金澤伸雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 加藤光広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 西小森隆太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 久保田一生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 加藤善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 神田祥一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 藤澤智美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 清島眞理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 濱崎純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 金兼弘和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Onishi Hidenori 大西 秀典

Ohnishi Hidenori 大西 秀典

OHNISHI Hidenori 大西 秀典

Research Projects

Research Products

Co-Researchers

The research of the pathophysiology of type I interferonopathy with disease-specific iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発達障害を有する大学生の頻度・特徴・介入の有効性を明らかにし支援モデルを構築する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of in vitro functional assay system for the genetic variants in inherited autoinflammatory diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The protein structure determination of IL-36 related molecules and their clinical application.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The structural analysis of the onset mechanism of cryopyrin-associated periodic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of immune-modulate molecule using the binding specificity of Toll-Interleukin-1 receptor domainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The structure based drug design for controlling the innate immune response and interleukin-18 signaling.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

自然免疫・獲得免疫スイッチング機構の構造生物学的解析に基づく抗アレルギー薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] メバロン酸キナーゼ欠損症別冊日本臨床先天代謝異常症候群(第2版)上2012

Author(s)

Publisher

Data Source

[Book] 自己炎症性疾患・自然免疫不全症の病因・病態と診断フローチャート自己炎症性疾患・自然免疫不全症とその近縁疾患2012

Author(s)

Publisher

Data Source

[Book] 免疫異常疾患に対する免疫療法と抗体療法-その3-自己炎症性疾患に対する生物学的製剤アレルギー疾患の免疫療法と分子標的治療2012

Author(s)

Publisher

Data Source

[Book] 原発性免疫不全症の概念と分類,および自己炎症性疾患・自然免疫不全症・近縁疾患の位置づけ自己炎症性疾患・自然免疫不全症とその近縁疾患2012

Author(s)

Publisher

Data Source

[Book] Castleman病自己炎症性疾患・自然免疫不全症とその近縁疾患2012

Author(s)

Publisher

Data Source

[Book] 慢性皮膚粘膜カンジダ症(STAT1異常症)自己炎症性疾患・自然免疫不全症とその近縁疾患2012

Author(s)

Publisher

Data Source

[Book] 自然免疫不全症総論自己炎症性疾患・自然免疫不全症とその近縁疾患2012

Author(s)

Onishi Hidenori 大西秀典

Ohnishi Hidenori 大西秀典

OHNISHI Hidenori 大西秀典