ASAI Akira 浅井章良

Researcher Number	60381737
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 静岡県立大学, 薬学研究院, 教授 2017: 静岡県立大学, 大学院薬学研究科, 教授 2016: 静岡県立大学, 薬学研究院, 教授 2011 – 2015: 静岡県立大学, 薬学研究科(研究院), 教授 2014: 静岡県立大学, 大学院薬学研究科, 教授 2012: 静岡県立大学, 大学院・創薬探索センター, 教授
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Tumor therapeutics / Chemical biology Except Principal Investigator Basic Section 55020:Digestive surgery-related / Applied health science / Drug development chemistry / Tumor biology
Keywords	Principal Investigator がん免疫療法 / 免疫チェックポイント / 抗がん剤 / ドラッグデザイン / 併用効果 / PD-L1 / SH2 / STAT3 / 転写制御因子 / キメラ化合物 … More / ハイブリッド化合物 / ドッキングシミュレーション / スクリーニング / がん免疫 / 腫瘍微小環境 / TDO / IDO / キヌレニン / トリプトファン / 抗がん物質 / キナーゼ / 抗がん / IDO1 / シグナル伝達 / アルキル化剤 / 転写因子 / DNAアルキル化剤 / がん … More Except Principal Investigator 細胞輸注療法 / 細胞傷害性T細胞 / 腫瘍殺傷 / T細胞 / 腫瘍免疫 / ワクチン / キラーT細胞 / 抗原欠損バリアント / 養子免疫療法 / 加齢・老化 / キヌレン酸 / キヌレニン / ストレス / うつ / 認知機能 / 筋萎縮 / 老化 / 加齢 / クアトロフェニル / 二量等価体 / ファゴサイトーシス / ホスファチジルセリン / アクチン / dynasore / 遊走 / 浸潤 / がん / ダイナミン Less

独自のがん免疫療法シーズに基づく二重機能性キメラ化合物の開発Principal Investigator
- Principal Investigator
  
  浅井章良
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Shizuoka
Basic drug discovery research aimed at developing new combination cancer immunotherapiesPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cells
- Principal Investigator
  
  Muraoka Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
Basic research for development of IDO/TDO dual inhibitors as new immuno-oncology drugsPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Whether reduction of skeletal muscle function causes deterioration of cognitive function or depression symptoms
- Principal Investigator
  
  Miura Shinji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  University of Shizuoka
Molecular basis for the development of novel STAT3 inhibitorsPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  University of Shizuoka
Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing property
- Principal Investigator
  
  SHUTO satoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
A novel mode of action of DNA alkylating anticancer agentsPrincipal Investigator
- Principal Investigator
  
  ASAI AKIRA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  University of Shizuoka
The role of dynamin in actin dynamics: Development of anticancer drugs inhibiting dynamin function
- Principal Investigator
  
  ABE Tadashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Okayama University

[Book] 創薬における化合物ライブラリーとスクリーニングの関係と概要2019
- Author(s)
  浅井章良
- Total Pages
  7
- Publisher
  情報機構
- ISBN
  9784865021806
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models2023
- Author(s)
  Takahashi Hiroyuki、Miyoshi Nao、Murakami Hisashi、Okamura Yuta、Ogo Naohisa、Takagi Akimitsu、Muraoka Daisuke、Asai Akira
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 7 Pages: 2473-2482
- DOI
  10.1007/s00262-023-03440-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling2022
- Author(s)
  Araki Toshihiro、Watanabe Yuuki、Okada Yusuke、Murakami Hisashi、Ogo Naohisa、Asai Akira
- Journal Title
  
  Experimental Cell Research
  
  Volume: 413 Issue: 2 Pages: 113079-113079
- DOI
  10.1016/j.yexcr.2022.113079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis.2022
- Author(s)
  Yanagimura N, Takeuchi S, Fukuda K, Arai S, Tanimoto A, Nishiyama A, Ogo N, Takahashi H, Asai A, Watanabe S, Kikuchi T, Yano S.
- Journal Title
  
  NPJ Precis Oncol
  
  Volume: 6 Issue: 1 Pages: 11-11
- DOI
  10.1038/s41698-022-00254-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0019, KAKENHI-PROJECT-19H03665, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-20K08516, KAKENHI-PROJECT-23K20323
[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022
- Author(s)
  Dotsu Yosuke、Muraoka Daisuke、Ogo Naohisa、Sonoda Yudai、Yasui Kiyoshi、Yamaguchi Hiroyuki、Yagita Hideo、Mukae Hiroshi、Asai Akira、Ikeda Hiroaki
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 2 Pages: e003958-e003958
- DOI
  10.1136/jitc-2021-003958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-21H02990
[Journal Article] Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase2022
- Author(s)
  Yoshioka Saeko、Ikeda Tomonori、Fukuchi Sogo、Kawai Yurika、Ohta Katsumi、Murakami Hisashi、Ogo Naohisa、Muraoka Daisuke、Takikawa Osamu、Asai Akira
- Journal Title
  
  International Journal of Tryptophan Research
  
  Volume: 15
- DOI
  10.1177/11786469221138456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation2021
- Author(s)
  Sawada Jun-ichi、Matsuno Kenji、Ogo Naohisa、Asai Akira
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 193 Pages: 114789-114789
- DOI
  10.1016/j.bcp.2021.114789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-20K06969
[Journal Article] A Brief Update on STAT3 Signaling: Current Challenges and Future Directions in Cancer Treatment2021
- Author(s)
  Keisuke Taniguchi、Momomi Tsugane、Akira Asai
- Journal Title
  
  Journal of Cellular Signaling
  
  Volume: 2 Issue: 3 Pages: 181-194
- DOI
  10.33696/signaling.2.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substitued Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery2021
- Author(s)
  Kenta Hayami, Yuichi Kuboki, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun-Ichi Haruta , Kenichi Murai, Hiromichi Fujioka, Akira Asai, Mitsuhiro Arisawa
- Journal Title
  
  Heterocycles
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Identification of a Novel Indoleamine 2,3-Dioxygenase Inhibitor Bearing an Eight-Membered Ring Fused Indole Scaffold and Its Structure-Activity Relationship2021
- Author(s)
  Ayuta Yamaguchi, Shinsuke Inuki, Katsumi Ohta, Shinya Oishi, Akira Asai, Hiroaki Ohno
- Journal Title
  
  Heterocycles
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Design, synthesis, and evaluation of a novel prodrug, a S-trityl--cysteine derivative targeting kinesin spindle protein2021
- Author(s)
  Fukai Ryota、Ogo Naohisa、Ichida Taiki、Yamane Masayoshi、Sawada Jun-ichi、Miyoshi Nao、Murakami Hisashi、Asai Akira
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 215 Pages: 113288-113288
- DOI
  10.1016/j.ejmech.2021.113288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-20K06969
[Journal Article] Towards the Inhibition of Protein-Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives2020
- Author(s)
  Mori Matteo、Gilardoni Ettore、Regazzoni Luca、Pedretti Alessandro、Colombo Diego、Parkinson Gary、Asai Akira、Meneghetti Fiorella、Villa Stefania、Gelain Arianna
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 15 Pages: 3509-3509
- DOI
  10.3390/molecules25153509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity2020
- Author(s)
  Suzuki Yumiko、Otake Ayana、Ueno Satoshi、Hayashi Kensuke、Ishii Hirosuke、Miyoshi Nao、Kuroiwa Kenta、Tachikawa Masashi、Fujimaki Yuki、Nishiyama Kotaro、Manabe Kei、Yamazaki Ryuta、Asai Akira
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 11 Issue: 6 Pages: 1287-1291
- DOI
  10.1021/acsmedchemlett.0c00119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07083, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-18K06587
[Journal Article] STX‐0119, a novel STAT3 dimerization inhibitor, prevents fibrotic gene expression in a mouse model of kidney fibrosis by regulating Cxcr4 and Ccr1 expression2020
- Author(s)
  Makitani Kouki、Ogo Naohisa、Asai Akira
- Journal Title
  
  Physiological Reports
  
  Volume: 8 Issue: 20
- DOI
  10.14814/phy2.14627
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Antitumor activity of a novel oral STAT3 inhibitor YHO-17012020
- Author(s)
  Fukiko Nishisaka, Keisuke Taniguchi, Momomi Tsugane, Genya Hirata, Akimitsu Takagi, Naoyuki Asakawa, Akinobu Kurita, Hiroyuki Takahashi, Naohisa Ogo, Yoshiyuki Shishido, Akira Asai
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 5 Pages: 1774-1784
- DOI
  10.1111/cas.14369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance2019
- Author(s)
  Muraoka Daisuke、Seo Naohiro、Hayashi Tae、Tahara Yoshiro、Fujii Keisuke、Tawara Isao、Miyahara Yoshihiro、Okamori Kana、Yagita Hideo、Imoto Seiya、Yamaguchi Rui、Komura Mitsuhiro、Miyano Satoru、Goto Masahiro、Sawada Shin-ichi、Asai Akira、Ikeda Hiroaki、Akiyoshi Kazunari、Harada Naozumi、Shiku Hiroshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 3 Pages: 1278-1294
- DOI
  10.1172/jci97642
- NAID
  120006987781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07222, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-18K19474, KAKENHI-PROJECT-16H06369, KAKENHI-PROJECT-16K07168
[Journal Article] Identification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors.2019
- Author(s)
  Yamane M, Sawada JI, Ogo N, Ohba M, Ando T, Asai A.Yamane M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 519 Issue: 3 Pages: 505-511
- DOI
  10.1016/j.bbrc.2019.09.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-18H02559
[Journal Article] Discovery of a New STAT3 Inhibitor Acting on the Linker Domain2019
- Author(s)
  Tatsuya Koseki, Naoya Suehiro, Yoshiaki Masuda, Nao Miyoshi, Daisuke Muraoka, Naohisa Ogo, Akira Asai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 5 Pages: 792-800
- DOI
  10.1248/bpb.b18-00992
- NAID
  130007641492
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.2019
- Author(s)
  Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y.
- Journal Title
  
  Immunol Lett.
  
  Volume: 216 Pages: 43-50
- DOI
  10.1016/j.imlet.2019.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-17K07209
[Journal Article] Modeling of aluminum-induced malate secretion by pharmacological approach in Arabidopsis: involvement of lipid signaling2019
- Author(s)
  Wu Liujie、Sadhukhan Ayan、Kobayashi Yuriko、Ogo Naohisa、Tokizawa Mutsutomo、Agrahari Raj Kishan、Ito Hiroki、Iuchi Satoshi、Kobayashi Masatomo、Asai Akira、Koyama Hiroyuki
- Journal Title
  
  Journal of Experimental Botany
  
  Volume: - Issue: 12 Pages: 3329-3342
- DOI
  10.1093/jxb/erz179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative2019
- Author(s)
  Sawada Jun-ichi、Ishii Hirosuke、Matsuno Kenji、Sato Masayuki、Suzuki Yumiko、Asai Akira
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 96 Issue: 5 Pages: 609-618
- DOI
  10.1124/mol.119.116624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08371, KAKENHI-PROJECT-18K06587, KAKENHI-PROJECT-18H02559
[Journal Article] Exploring the Biological Activity of a Library of 1,2,5-Oxadiazole Derivatives Endowed With Antiproliferative Activity2018
- Author(s)
  GELAIN ARIANNA、MORI MATTEO、MENEGHETTI FIORELLA、PORTA FEDERICA、BASILE LIVIA、MARVERTI GAETANO、ASAI AKIRA、HYERACI MARIAFRANCESCA、GARC?A-ARG?EZ A?DA NELLY、VIA LISA DALLA、GUCCIONE SALVATORE、VILLA STEFANIA
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 1 Pages: 135-144
- DOI
  10.21873/anticanres.13089
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity2018
- Author(s)
  Fukuda Miwa、Sasaki Tomomi、Hashimoto Tomoko、Miyachi Hiroyuki、Waki Minoru、Asai Akira、Takikawa Osamu、Ohno Osamu、Matsuno Kenji
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 17 Pages: 2846-2849
- DOI
  10.1016/j.bmcl.2018.07.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] 新薬のためのコンセプトデザイン2017
- Author(s)
  浅井章良
- Journal Title
  
  Biophilia
  
  Volume: 66 Pages: 22-28
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Inhibition of STAT3 by Anticancer Drug Bendamustine2017
- Author(s)
  Iwamoto K, Uehara Y, Inoue Y, Taguchi K, Muraoka D, Ogo N, Matsuno K, Asai A.
- Journal Title
  
  PLoS One
  
  Volume: １２ Issue: 1 Pages: e0170709-e0170709
- DOI
  10.1371/journal.pone.0170709
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity2017
- Author(s)
  Hato SV, Figdor CG, Takahashi S, Pen AE, Halilovic A, Bol KF, Vasaturo A, Inoue Y, de Haas N, Verweij D, Van Herpen CML, Kaanders JH, van Krieken JHJM, Van Laarhoven HWM, Hooijer GKJ, Punt CJA, Asai A, de Vries IJM, Lesterhuis WJ.
- Journal Title
  
  Oncotarget
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell Line2017
- Author(s)
  Miyata H, Ashizawa T, Iizuka A, Kondou R, Nonomura C, Sugino T, Urakami K, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K, Akiyama Y.
- Journal Title
  
  Cancer Genomics Proteomics
  
  Volume: １４ Issue: 1 Pages: 83-91
- DOI
  10.21873/cgp.20021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430166, KAKENHI-PROJECT-16K08727
[Journal Article] Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain2017
- Author(s)
  Gabriele E, Ricci C, Ferri N, Asai A, Sparatorea A
- Journal Title
  
  J Enzyme Inhib Med Chem
  
  Volume: ３２ Issue: 1 Pages: 337-344
- DOI
  10.1080/14756366.2016.1252757
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] An in vivo active 1,2,5-oxadiazole Pt(II) complex: a promising anticancer agent endowed with STAT3 inhibitory properties2017
- Author(s)
  Porta F, Facchetti G, Ferri N, Gelain A, Meneghetti F, Villa S, Barlocco D, Masciocchi D, Asai A, Miyoshi N, Marchianò S, Kwon BM, Gandin V, Marzano C, Rimoldi I.
- Journal Title
  
  Eur J Med Chem
  
  Volume: １３１ Pages: 196-206
- DOI
  10.1016/j.ejmech.2017.03.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach2015
- Author(s)
  Poli G, Gelain A, Porta F, Asai A, Martinelli A, Tuccinardi T
- Journal Title
  
  J Enzyme Inhib Med Chem
  
  Volume: Aug26 Issue: 6 Pages: 1-7
- DOI
  10.3109/14756366.2015.1079184
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] がんの免疫逃避機構を標的とする新しい抗がん剤の開発2015
- Author(s)
  浅井章良
- Journal Title
  
  化学工業
  
  Volume: 66 Pages: 13-21
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Ureido-pyridazinone derivatives: Insights into the structural and conformational properties for STAT3 inhibition2015
- Author(s)
  Meneghetti F, Villa S, Masciocchi D, Barlocco D, Toma L, Han DC, Kwon BM, Ogo N, Asai A, Legnani L, Gelain A
- Journal Title
  
  Eur J Org Chem
  
  Volume: 22 Issue: 22 Pages: 4907-4912
- DOI
  10.1002/ejoc.201500599
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line2014
- Author(s)
  Ashizawa T, Akiyama Y, Miyata H, Iizuka A, Komiyama M, Kume A, Omiya M, Sugino T, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K
- Journal Title
  
  Int J Oncol.
  
  Volume: 411-8 Issue: 1 Pages: 411-418
- DOI
  10.3892/ijo.2014.2439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281, KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-25430166, KAKENHI-PROJECT-26430166
[Journal Article] Modeling, synthesis and NMR characterization of novel chimera compounds targeting STAT32014
- Author(s)
  Silvia Dell'Orto, Daniela Masciocchi, Stefania Villa, Fiorella Meneghetti, Giuseppe Celentano, Daniela Barlocco, Diego Colombo, Laura Legnani, Lucio Toma, Yoon Jung Jeon, Byoung-Mog Kwon, Akira Asai, Arianna Gelain
- Journal Title
  
  Med. Chem. Commun.
  
  Volume: ５ Issue: 11 Pages: 1651-1657
- DOI
  10.1039/c4md00177j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430166
[Journal Article] Synthesis, structure.activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors2013
- Author(s)
  Masciocchi D, Gelain A, Porta F, Meneghetti F, Pedretti A, Celentano G, Barlocco D, Legnani L, Toma L, Kwon B, Asai A, Villa S
- Journal Title
  
  Med Chem Commun.
  
  Volume: 4 Pages: 1181-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins2013
- Author(s)
  5) Takakuma K, Ogo N, Uehara Y, Takahashi S, Miyoshi N, Asai A
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 8 Pages: e71646-e71646
- DOI
  10.1371/journal.pone.0071646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma2013
- Author(s)
  Ashizawa T, Miyata H, Iizuka A, Komiyama M, Oshita C, Kume A, Nogami M, Yagoto M, Ito I, Oishi T, Watanabe R, Mitsuya K, Matsuno K, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A, Nakasu Y, Yamaguchi K, Akiyama Y
- Journal Title
  
  Int J Oncol.
  
  Volume: 43 Pages: 219-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins2013
- Author(s)
  Takakuma K, Ogo N, Uehara Y, Takahashi S, Miyoshi N, Asai A
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] 創薬研究における点と線2013
- Author(s)
  浅井章良、小郷尚久
- Journal Title
  
  ドラッグライクとドラッガブルの接点を探る細胞工学
  
  Volume: 32 Pages: 644-648
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma2013
- Author(s)
  Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi Yasuto Akiyama
- Journal Title
  
  International Journal of Oncology
  
  Volume: 43 Issue: 1 Pages: 219-227
- DOI
  10.3892/ijo.2013.1916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390028, KAKENHI-PROJECT-23510281, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-24659048
[Journal Article] Synthesis, structure–activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors2013
- Author(s)
  7) Masciocchi D, Gelain A, Porta F, Meneghetti F, Pedretti A, Celentano G, Barlocco D, Legnani L, Toma L, Kwon B, Asai A, Villa S.
- Journal Title
  
  Med Chem Commun
  
  Volume: 4 Issue: 8 Pages: 1181-1188
- DOI
  10.1039/c3md00095h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors2012
- Author(s)
  Masciocchi D, Villa S, Meneghetti F, Pedretti A, Barlocco D, Legnani L, Toma L, Kwon B, Nakano S, Asai A, Gelain A
- Journal Title
  
  Med Chem Commun.
  
  Volume: 3 Pages: 592-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Identification of novel kynurenine production-inhibiting benzenesulfonamide derivatives in cancer cells2012
- Author(s)
  Nakano S, Takai K, Isaka Y, Takahashi S, Unno Y, Ogo N, Matsuno K, Takikawa O, Asai A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 556-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] 創薬標的としての転写因子 STAT32012
- Author(s)
  浅井章良、松野研司
- Journal Title
  
  ファルマシア
  
  Volume: 48 Pages: 673-677
- NAID
  110009901124
- Data Source
  KAKENHI-PROJECT-23510281
[Journal Article] Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors2012
- Author(s)
  Daniela Masciocchi, Stefania Villa, Fiorella Meneghetti, Alessandro Pedretti, Daniela Barlocco, Laura Legnani, Lucio Toma, Byoung-Mog Kwon, Shintaro Nakano, Akira Asai, Arianna Gelain
- Journal Title
  
  Med. Chem. Commun
  
  Volume: 3 Issue: 5 Pages: 592-599
- DOI
  10.1039/c2md20018j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281
[Patent] ガン免疫療法においてIDO1阻害剤と併用する薬剤を選択する方法、及びIDO1阻害剤と併用する薬剤とを含むガン免疫療法用組成物2023
- Inventor(s)
  浅井章良、小郷尚久、村上央、三好奈央、中川貴之、加藤大貴
- Industrial Property Rights Holder
  静岡県公立大学法人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-219833
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21H02609
[Patent] リンパ球機能亢進剤、リンパ球介在型がん治療法の治療剤との併用剤、及びリンパ球のミトコンドリア機能亢進剤2021
- Inventor(s)
  浅井章良、小郷尚久、池田裕明、村岡大輔、道津洋介
- Industrial Property Rights Holder
  浅井章良、小郷尚久、池田裕明、村岡大輔、道津洋介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-203972
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02609
[Patent] IDO/TDO阻害剤2018
- Inventor(s)
  浅井章良、小郷尚久、村岡大輔、滝川修、河邊拓己、佐藤卓治
- Industrial Property Rights Holder
  浅井章良、小郷尚久、村岡大輔、滝川修、河邊拓己、佐藤卓治
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02559
[Patent] 抗浸潤薬の新規スクリーニング法および抗浸潤剤2012
- Inventor(s)
  山田浩司、竹居孝二、道上宏之、松井秀樹、浅井章良
- Industrial Property Rights Holder
  山田浩司、竹居孝二、道上宏之、松井秀樹、浅井章良
- Industrial Property Number
  2012-137489
- Filing Date
  2012-06-19
- Data Source
  KAKENHI-PROJECT-22501013
[Patent] フルボキサミンを配合することを特徴とする分子標的型抗癌剤(特に抗脳腫瘍治療薬剤:第二医薬品用途)2012
- Inventor(s)
  道上宏之、林圭一郎、松井秀樹、山田浩司、竹居孝二、宮地弘幸、浅井章良
- Industrial Property Rights Holder
  道上宏之、林圭一郎、松井秀樹、山田浩司、竹居孝二、宮地弘幸、浅井章良
- Industrial Property Number
  2012-263317
- Filing Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-22501013
[Presentation] 免疫チェックポイント分子を標的とした低分子化合物の探索2024
- Author(s)
  林弘信、永岡菜、楳野幸人、車田千春、渡邉未来、市田泰輝、村上央、小郷尚久、浅井章良
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] Development of cancer immunotherapy that overcomes tumor heterogeneity2024
- Author(s)
  Hiroaki Ikeda, Daisuke Ehara, Kiyoshi Yasui, Daisuke Muraoka, Hiromitsu Yoneda, Sachiko Okamoto, Yasunori Amaishi, Hiroyuki Murota, Akira Asai
- Organizer
  The 1st International Symposium on Cancer Immunology and Immunotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] BTLA-HVEM 結合阻害化合物スクリーニング系の構築2023
- Author(s)
  楳野幸人、村上央、小郷尚久、浅井章良
- Organizer
  第69回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 新規 IDO1/TDO 二重阻害剤の創製－イソチオウレア誘導体の合成と構造活性相関－2023
- Author(s)
  小郷尚久、田島和明、河合佑里香、太田克美、三好奈央、村上央、滝川修、佐藤卓治、河邊拓己、浅井章良
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] キヌレニン経路の亢進による腫瘍微小環境の免疫学的変化2023
- Author(s)
  河合佑里香、加藤壮一郎、三好奈央、村上央、小郷尚久、浅井章良
- Organizer
  第69回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍微小環境におけるトリプトファン代謝酵素が引き起こす免疫抑制機構の解析2023
- Author(s)
  村上央、小郷尚久、村岡大輔、浅井章良
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] キヌレニン経路の亢進による腫瘍微小環境の免疫学的変化と阻害薬による効果2023
- Author(s)
  河合佑里香、村上央、太田克美、三好奈央、小郷尚久、浅井章良
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] S -trityl-L-cysteine 誘導体と酵素切断リンカーコンジュゲートの合成と評価2023
- Author(s)
  村瀬啓輔、市田泰輝、小郷尚久、村上央、浅井章良
- Organizer
  第69回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 新規 IDO1/TDO 二重阻害化合物の発見と構造活性相関研究2023
- Author(s)
  小郷尚久、田島和明、河合佑里香、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] TIGIT-CD155結合阻害化合物スクリーニング系の構築2022
- Author(s)
  永岡菜、村上央、小郷尚久、浅井章良
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] マウス腫瘍微小環境におけるIDO1の抗腫瘍免疫抑制機能の解析2022
- Author(s)
  河合佑里香、村上央、太田克美、三好奈央、小郷尚久、浅井章良
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] がん免疫療法を指向した新規 IDO1/TDO 二重阻害化合物の探索2022
- Author(s)
  小郷尚久、田島和明、河合佑里香、吉岡紗衣子、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本トリプトファン研究会第41回学術集会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 新規IDO1/TDO二重阻害化合物の構造活性相関研究2022
- Author(s)
  田島和明、渡部美都、石原桃子、野中智陽、河合佑里香、吉岡紗衣子、太田克美、村上央、小郷尚久、浅井章良
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] Novel STAT3 inhibitor, YHO-1701 enhances the antitumor effect of anti-PD-1 antibody2022
- Author(s)
  Hiroyuki Takahashi, Hisashi Murakami, Naohisa Ogo, Daisuke Muraoka, Akimitsu Takagi, Akira Asai
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] ミトコンドリア電子伝達系を介してT細胞の活性化閾値を改善する新基軸代謝化合物を用いたがん免疫療法の開発2022
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎　寛、池田裕明
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] マウストリプトファン代謝酵素安定発現細胞株の作製と性状解析2021
- Author(s)
  河合佑里香、村上央、小郷尚久、村岡大輔、浅井章良
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] The compound activating mitochondrial respiration leads PD-1 blockade efficacy even in a low immunogenic tumor2021
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Yudai Sonoda, Naohisa Ogo, Akira Asai, Hideo Yagita, Hiroshi Mukae, Hiroaki Ikeda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] CTLA-4安定発現細胞の作製と抗体によるCTLA-4阻害作用の解析2021
- Author(s)
  村上央、渡邉未来、小郷尚久、浅井章良
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 低分子化合物によるミトコンドリア機能の制御は、不十分な抗原刺激下における T 細胞をも活性化し、抗 PD-1 抗体療法の有効性を導く2021
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎寛、池田裕明
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] Discovery of novel cysteine derivatives to improve selectivity and targeting to cancer cells using in silico modeling2021
- Author(s)
  Naohisa Ogo, Hisashi Murakami, Akira Asai
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] STAT3 inhibition suppresses adaptive survival of ALK-rearanged cancer cells via transcriptional modulation of apoptosis2021
- Author(s)
  Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Akihiro Nishiyama, Naohisa Ogo, Akira Asai, Seiji Yano
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] がん免疫療法を指向した新規IDO1阻害化合物の設計と合成2020
- Author(s)
  小郷尚久、野仲智陽、石原桃子、渡部美都、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本トリプトファン研究会第39回学術集会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Discovery of novel isothiourea derivatives as potent dual inhibitors of IDO1 and TDO2020
- Author(s)
  Naohisa Ogo, Daisuke Muraoka, Takayuki Ando , Akira Asai
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] がん免疫療法を指向した新規IDO1阻害化合物の設計、合成と構造活性相関2020
- Author(s)
  小郷尚久、野中智陽、石原桃子、渡部美都、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] 海洋シアノバクテリア由来新規キヌレニン産生阻害剤の構造解析および生物活性2020
- Author(s)
  大野修、佐々木智未、人見悠毅、中風奈々恵、浅井章良、滝川修、松野研司
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Low molecular weight compound enhancing NF-kB signaling augments the T cell activation and anti-tumor immune response2020
- Author(s)
  Daisuke Muraoka, Yosuke Dotsu, Yudai Sonoda, Naohisa Ogo, Akira Asai, Hiroaki Ikeda
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Low molecular compound promotes tumor antigen recognition and enhances the effector function of tumor infiltrating lymphocytes in cancer-bearing mouse model2019
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Yudai Sonoda , Akira Asai , Hiroshi Mukae, Hiroaki Ikeda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] 生体分子レジデンスを制御する小分子の探索2019
- Author(s)
  浅井章良
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] 低分子化合物による抗原認識能の向上作用の機構解明と大腸癌マウスモデルにおける腫瘍浸潤T 細胞への影響の解析2019
- Author(s)
  道津洋介、村岡大輔、園田祐大、浅井章良、迎寛、池田裕明
- Organizer
  第23 回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] がん免疫療法を指向したSBDDによる新規IDO1阻害化合物の探索2019
- Author(s)
  小郷尚久、野仲智陽、石原桃子、渡部美都、太田克美、村上央、滝川修、浅井章良
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] SBDDによる新規IDO1阻害化合物の合成と構造活性相関研究2019
- Author(s)
  野仲智陽、小郷尚久、渡部美都、石原桃子、太田克美、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Foxp3阻害化合物の探索及び作用機序解析2018
- Author(s)
  園田祐大、小郷尚久、安藤隆幸、村岡大輔、浅井章良
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Targeting the tryptophan metabolism pathway for cancer immunotherapy2018
- Author(s)
  浅井章良
- Organizer
  International Convention of the Pharmaceutical Society of Korea
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Discovery of isothiourea derivatives as novel inhibitors of IDO and TDO2018
- Author(s)
  浅井章良
- Organizer
  15th International Society for Tryptophan Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] 生体分子レジデンスの制御と創薬2018
- Author(s)
  浅井章良
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] KIS-154, a FOXO1 inhibitor, is one of the candidate compounds to prevent skeletal muscle atrophy.2017
- Author(s)
  Watanabe, Y., Nakagawa, T., Morita, A., Ogo, N., Asai, A., Kamei, Y., and Miura, S.
- Organizer
  The 22nd Shizuoka Forum on Health and Longevity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K13047
[Presentation] Foxo1を標的とした筋萎縮抑制化合物の探索2017
- Author(s)
  渡辺優衣、中川匠、守田昭仁、小郷尚久、浅井章良、亀井康富、三浦進司
- Organizer
  第71回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K13047
[Presentation] テモゾロミド耐性神経膠芽腫細胞に対するSTAT3阻害剤とmTOR阻害剤との併用抗腫瘍効果2017
- Author(s)
  芦澤忠、飯塚明、浅井章良、山口建、秋山康人
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2017-10-06
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] ビスベンゾキノン誘導体によるSTAT3阻害作用の生化学的解析2016
- Author(s)
  小跡竜也, 小郷尚久, 田口今日子, 増田吉昭, 浅井章良
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] 神経膠芽腫におけるTDO発現制御シグナルの解析2015
- Author(s)
  池田智則、海野雄加、小郷尚久、浅井章良
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] Cyclisation of Benzylisothiourea Provided Kynurenine Production Inhibitor without Indoleamine 2,3-Dioxygenase Inhibition2015
- Author(s)
  Fukuda　M, Miyachi　H, Waki　M, Asai　A, Takikawa　O, Matsuno　K
- Organizer
  EFMC-ASMC'15 6th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
- Place of Presentation
  Rehovot
- Year and Date
  2015-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] 恒常的にIDO1を発現するヒトがん細胞株の同定と解析2015
- Author(s)
  福地壮吾、池田智則、海野雄加、小郷尚久、浅井章良
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] IDOを標的とした新規免疫調節化合物の合成と構造活性相関2015
- Author(s)
  渡部美都、小郷尚久、高井一成、太田克美、松野研司、滝川修、浅井章良
- Organizer
  第20回静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] STAT3転写活性に対するベンダムスチンの阻害作用2014
- Author(s)
  岩本一徳、上原裕、海野雄加、小郷尚久、浅井章良
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] Identification of a novle STAT3 inhibitors structurally related to the oxadiazole derivative MD772013
- Author(s)
  5. Daniela Masciocchi, Stefania Villa, Federica Porta, Daniela Barlocco, Fiorella Meneghetti, Byoung-Mog Kwon, Akira Asai, Arianna Gelain
- Organizer
  XXII National Meeting on Medicinal Chemistry
- Place of Presentation
  ローマ
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] Platinum-based cancer chemotherapeutics inhibit STAT signaling by blocking the SH2 domain2013
- Author(s)
  W. Joost Lesterhuis, Stanleyson V. Hat2, Carl G. Figdor, Susumu Takahashi, Cornelis J.A. Punt, Akira Asai, I. Jolanda M. De Vries
- Organizer
  AACR Annual Meeting 2013
- Place of Presentation
  Washington, DC
- Year and Date
  2013-04-08
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] STATファミリー阻害剤探索のための新規マルチプレックスアッセイ系の開発2013
- Author(s)
  髙熊万之、小郷尚久、上原裕、高橋進、三好奈央、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第8回年会
- Place of Presentation
  東京
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] 神経膠芽腫患者由来のがん性幹細胞の増殖に及ぼすSTAT3阻害剤STX-0119の効果2013
- Author(s)
  芦澤忠、飯塚明、小宮山優、浅井章良、山口建、秋山靖人
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] STATファミリー阻害剤探索のための新規マルチプレックスアッセイ系の開発2013
- Author(s)
  2. 髙熊万之、小郷尚久、上原裕、高橋進、三好奈央、浅井章良
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] 静岡県における化合物ライブラリーシステムの構築2012
- Author(s)
  小郷尚久、鈴木紳之、大場舞、小和田和宏、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] PLATINUM-BASED CANCER CHEMOTHERAPEUTICS DIRECTLY INTERACT WITH STAT PROTEINS AND INHIBIT SIGNALING BY BLOCKING THE SH2 DOMAIN2012
- Author(s)
  Stanleyson V. Hato, Carl G. Figdor, Susumu Takahashi, Anja E. Pen, Cornelis J.A. Punt, Akira Asai, I. Jolanda M. de Vries, W. Joost Lesterhuis
- Organizer
  11th International Symposium on Platinum Coordination Compounds inCancer Chemotherapy
- Place of Presentation
  Verona
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] New STAT3 inhibitors2012
- Author(s)
  Arianna Gelain, Daniela Masciocchi, Stefania Villa, Fiorella Meneghetti, Alessandro1 Pedretti, Daniela Barlocco, Laura Legnani, Lucio Toma, Byoung-Mog Kwon, Shintaro Nakano, Akira Asai
- Organizer
  identification of a lead 21st National Meeting on Medicinal Chemistry
- Place of Presentation
  Palermo
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] MERGED STRUCTURES AS NEW STAT3 INHIBITORS: THE "CHIMERA" COMPOUNDS2012
- Author(s)
  Arianna Gelain, Daniela Masciocchi, Stefania Villa, Fiorella Meneghetti, Alessandro Pedretti, Daniela Barlocco, Laura Legnani, Lucio Toma, Byoung-Mog Kwon, Shintaro Nakano, Akira Asai
- Organizer
  22nd International Symposium on Medicinal Chemistry
- Place of Presentation
  Berlin
- Year and Date
  2012-09-05
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] In silicoスクリーニングによるSTAT3阻害剤の探索2011
- Author(s)
  増田吉昭、室谷歩、高橋理、横田川高峰、古谷利夫、松野研司、上原裕、大川原正、大塚雅巳、小郷尚久、芦澤忠、秋山靖人、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第6回年会
- Place of Presentation
  東京
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] Novel STAT3 inhibitors: Development of 1,2,5-oxadiazoles for anticancer therapy
- Author(s)
  Federica Porta, Arianna Gelain, Daniela Masciocchi, Fiorella Meneghetti, Daniela Barlocco, Nicola Ferri, B-M Kwon, Akira Asai and Stefania Villa
- Organizer
  EFMC-ISMC 2014
- Place of Presentation
  Lisbon
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] テモゾロミド耐性神経膠芽細胞腫に対するSTAT3阻害剤STX-0119のin vitro及びin vivo抗腫瘍効果
- Author(s)
  芦澤忠、飯塚明、小宮山優、浅井章良、山口建、秋山靖人
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] Platinum-based cancer chemotherapeutics inhibit STAT signaling by blocking the SH2 domain
- Author(s)
  W. Joost Lesterhuis, Stanleyson V. Hato, Carl G. Figdor, Susumu Takahashi, Cornelis J.A. Punt, Akira Asai, I. Jolanda M. De Vries
- Organizer
  American Association for Cancer Research Annual Meeting 2013
- Place of Presentation
  Washington, DC (USA)
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] Blocking STAT3 signaling in cancer: Synthesis of new potential inhibitors bearing the pyridazinone moiety
- Author(s)
  FiorellaI Meneghetti, Silvia Dell'orto, Stefania Villa, Daniela Masclocchi, Ariana Gelain, Daniela Barlocco, Laura Legnani, Byoung-Mog Kwon, Akira Asai
- Organizer
  EFMC-ISMC 2014
- Place of Presentation
  Lisbon
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] Platinum-based cancer chemotherapeutics directly interact with STAT proteins and inhibit signaling by blocking the SH2 domain
- Author(s)
  Stanleyson V. Hato, Carl G. Figdor, Susumu Takahashi, Anja E. Pen, Cornelis J.A. Punt, Akira Asai, I. Jolanda M. de Vries, W. Joost Lesterhuis
- Organizer
  11th International Symposium on Platinum Coordination Compounds in Cancer
- Place of Presentation
  Verona (Italy)
- Data Source
  KAKENHI-PROJECT-23510281
[Presentation] 静岡県におけるアカデミア創薬の実践
- Author(s)
  浅井章良
- Organizer
  創薬懇話会2014
- Place of Presentation
  岐阜
- Year and Date
  2014-07-09 – 2014-07-10
- Invited
- Data Source
  KAKENHI-PROJECT-26430166
[Presentation] Merged structures as new STAT3 inhibitors: the “chimera” compounds
- Author(s)
  Arianna Gelain, Daniela Masciocchi, Stefania Villa, Fiorella Meneghetti, Alessandro Pedretti, Daniela Barlocco, Laura Legnani, Lucio Toma, Byoung-Mog Kwon, Shintaro Nakano, Akira Asai
- Organizer
  22nd International Symposium on Medicinal Chemistry
- Place of Presentation
  Berlin (Germany)
- Data Source
  KAKENHI-PROJECT-23510281

1. Muraoka Daisuke (20608955)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. 小郷尚久 (20501307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 37 results
3. ABE Tadashi (60423282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMADA Hiroshi (80325092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. WATANABE Masami (70444677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHUTO satoshi (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUKUDA Hayato (30434450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUDA Tadashi (20212219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Miura Shinji (10342932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KAMEI YASUTOMI (70300829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. UNNO KEIKO (10106437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOSHIDA TAKUYA (80622448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 守田昭仁 (40239653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 池田裕明 (40374673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 安井潔 (50372777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. SATO TOMOKI

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SENOO NANAMI

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ISHINO MAYU

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 林謙介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 阿部貴志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 安藤隆幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 大塚雅巳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 芦澤忠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 松野研司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ASAI Akira 浅井 章良

Research Projects

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独自のがん免疫療法シーズに基づく二重機能性キメラ化合物の開発Principal Investigator

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Basic drug discovery research aimed at developing new combination cancer immunotherapiesPrincipal Investigator

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Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cells

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Basic research for development of IDO/TDO dual inhibitors as new immuno-oncology drugsPrincipal Investigator

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Whether reduction of skeletal muscle function causes deterioration of cognitive function or depression symptoms

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Molecular basis for the development of novel STAT3 inhibitorsPrincipal Investigator

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Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing property

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A novel mode of action of DNA alkylating anticancer agentsPrincipal Investigator

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The role of dynamin in actin dynamics: Development of anticancer drugs inhibiting dynamin function

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[Book] 創薬における化合物ライブラリーとスクリーニングの関係と概要2019

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[Journal Article] Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models2023

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[Journal Article] Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling2022

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[Journal Article] STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis.2022

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[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022

ASAI Akira 浅井章良