IMAI HIROSHI 今井洋

… Alternative Names

IMAI Hiroshi 今井洋

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Researcher Number	60391869
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院理学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院理学研究科, 助教 2017 – 2021: 大阪大学, 理学研究科, 助教 2016: 中央大学, 理工学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Biophysics Except Principal Investigator Basic Section 28040:Nanobioscience-related / Basic Section 43040:Biophysics-related / Biophysics
Keywords	Principal Investigator ダイニン / クライオ電子顕微鏡 / 単粒子解析 / モータータンパク質 / 微小管 / 細胞骨格 / 分子モーター / 繊毛 / チューブリン / 構造解析 … More / 癌 / 脳神経疾患 / 電子顕微鏡 / 生物物理 / ナノバイオ / 構造生物学 / クライオ子線トモグラフィ / ナノマシーン … More Except Principal Investigator ナノバイオ / 分子操作 / 運動マシナリ / 高圧力顕微鏡 / 鞭毛 / 重合ダイナミクス / アロステリック制御 / 微小管 / 生物物理 / GTP / 核形成 / チューブリン / 核生成 / ネガティブ染色電子顕微鏡法 / 重合キネティクス / 臨界核 / GTPチューブリン Less

繊毛波形形成を担う繊毛・内腕ダイニン（特徴的な3種類）の構造基盤解明Principal Investigator
- Principal Investigator
  
  今井洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Osaka University
Visualizing the activation of flagellar beating at high-pressure.
- Principal Investigator
  
  西山雅祥
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kindai University
Verification of multiple conformations in GTP-tubulin
- Principal Investigator
  
  武藤悦子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Chuo University
チューブリン結合によるダイニン活性化の構造基盤の解明Principal Investigator
- Principal Investigator
  
  今井洋
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Osaka University
Mechanical control of rhythmic flagellar beating motions
- Principal Investigator
  
  Nishiyama Masayoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kindai University
Clarification of the coupling mechanism between polymerization and GTP hydrolysis by using tubulin mutant
- Principal Investigator
  
  Muto Etsuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Institute of Physical and Chemical Research
Interaction between two motor domains of cytoplasmic dynein stepping along microtubules revealed by cryo-electron microscopy.Principal Investigator
- Principal Investigator
  
  IMAI Hiroshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
  Chuo University

All 2024 2023 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] Handbook of Dynein (Second Edition)2019
- Author(s)
  Roberts, A., Toropova, K, and Imai, H. (Editor Hirose, K.)
- Total Pages
  32
- Publisher
  Jenny Stanford Publishing
- ISBN
  9814800015
- Data Source
  KAKENHI-PROJECT-16K07327
[Journal Article] Two different linker conformations of the cytoplasmic dynein motor domain in the presence of ADP2024
- Author(s)
  H. Imai, R. Kanazawa, R. Shimo-Kon, T. Kon
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 35
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06096
[Journal Article] Effects of high hydrostatic pressure to swimming sea urchin sperm flagella2023
- Author(s)
  H. Imai, M. Nishiyama, Y. Kaminoe, Y. Harada, T. Kon, S. Kamimura
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 35
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06096
[Journal Article] Dynamics of the Spontaneous Nucleation of Microtubules2023
- Author(s)
  IMAI Hiroshi、MUTO Etsuko
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 63 Issue: 6 Pages: 299-302
- DOI
  10.2142/biophys.63.299
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06096
[Journal Article] GTP-dependent formation of straight oligomers leads to nucleation of microtubules2020
- Author(s)
  Ayukawa Rie、Iwata Seigo、Imai Hiroshi、Kamimura Shinji、Hayashi Masahito、Ngo Kien Xuan、Minoura Itsushi、Uchimura Seiichi、Makino Tsukasa、Shirouzu Mikako、Shigematsu Hideki、Sekimoto Ken、Gigant Benoit、Muto Etsuko
- Journal Title
  
  bioRxiv
  
  Volume: －
- DOI
  10.1101/2020.03.05.979989
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03668, KAKENHI-PROJECT-16K07327
[Journal Article] Development of phase-contrast/dark-field microscopy with scanning laser illumination2019
- Author(s)
  Tsuyoshi Sato, Tomotaka Shirane, Yuuko Wada, Hiroshi Imai, Shinji Kamimura
- Journal Title
  
  Journal of the Institute of Science and Engineering, Chuo University
  
  Volume: 25 Pages: 93-103
- NAID
  120006870443
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07327
[Journal Article] 動物細胞に共通する細胞内の輸送システム2018
- Author(s)
  今井洋，昆隆英
- Journal Title
  
  生産と技術
  
  Volume: 70 Pages: 73-76
- NAID
  40021703280
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] 繊毛ダイニン・細胞質ダイニン・IFT ダイニンの構造的共通性と多様性2024
- Author(s)
  雷宜慈, 今井洋, 山本遼介, 下理恵子, 宮田知子, 梶村直子, 八木俊樹, 上村慎治, 光岡薫, 難波啓一, 昆隆英
- Organizer
  生体運動研究合同班会議2024
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] 繊毛微小管内部タンパク質 Rib43a は正常な繊毛運動と繊毛軸糸の物理的安定性に重要である2024
- Author(s)
  丹羽蘭丸, 山本遼介, 今井洋, 柴小菊, 八木俊樹, 稲葉一男, 昆隆英
- Organizer
  生体運動研究合同班会議2024
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] Two different linker conformations of the cytoplasmic dynein motor domain in the presence of ADP2023
- Author(s)
  H. Imai, R. Kanazawa, R. Shimo-Kon, T. Kon
- Organizer
  Cell Bio2023（アメリカ細胞生物学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] 電子顕微鏡単粒子解析法による繊毛ダイニン新規構造の解明2023
- Author(s)
  雷宜慈 1, 今井洋 1, 山本遼介 1,重兼拓実 1, 下理恵子 1, 上村慎治 2, 八木俊樹 3, 梶村直子 4, 光岡薫 4, 昆隆英 1 （1 大阪大学理学研究科, 2 中央大学理工学部, 3 県立広島大学生物資源科学部, 4 大阪大学超高圧電子顕微鏡センター）
- Organizer
  2023 年生体運動研究合同班会議
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] Effects of high hydrostatic pressure to swimming sea urchin sperm flagella2023
- Author(s)
  H. Imai, M. Nishiyama, Y. Kaminoe, Y. Harada, T. Kon, S. Kamimura
- Organizer
  Cell Bio2023（アメリカ細胞生物学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] New insights into the mechanism of dynein force generation2023
- Author(s)
  今井洋, 昆隆英
- Organizer
  第59回内藤コンファレンス
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] クライオ電子顕微鏡による 14 本から 16 本プロトフィラメント GMPCPP 微小管の構造解析2023
- Author(s)
  前嶋捷久, 岡本玲菜, 今井洋, 梶村直子, 光岡薫, 廣瀬未果, 加藤貴之, 成田哲博, 昆隆英
- Organizer
  第61回日本生物物理学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] Effects of high hydrostatic pressure to swimming sea urchin sperm flagella2023
- Author(s)
  Imai H., Nishiyama M., Kaminoe Y., Harada Y., Kon T., Kamimura S.
- Organizer
  2023 ASCB Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23190
[Presentation] 電子顕微鏡を利用した繊維状蛋白質の解離定数の新規測定法の開発2021
- Author(s)
  渡邊真人, 今井洋, 宮田知子, 牧野文信, 武藤悦子, Gerle Christoph, 光岡薫, 栗栖源嗣, 難波啓一, 昆隆英
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] ネガティブ染色電子顕微鏡法により明らかにされた繊毛ダイニンの新規構造2021
- Author(s)
  雷宜慈, 今井洋, 山本遼介, 下理恵子, 上村慎治, 八木俊樹, 梶村直子, 廣瀬未果, 加藤貴之, 光岡薫, 昆隆英
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06096
[Presentation] 微小管のX線繊維回折：チューブリン格子ラセン角の計測2019
- Author(s)
  上村慎治, 今井洋, 八木俊樹, 岩本裕之, Estevez-Galego, J., Lucena-Agell, D., Diaz, J.-F. & Hermida-Merino, D.
- Organizer
  2019年生体運動合同班会議
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] 微小管のX線繊維回折：チューブリン格子ラセン角の計測2019
- Author(s)
  上村慎治, 今井洋, 八木俊樹, 岩本裕之, Estevez-Galego, J., Lucena-Agell, D., Diaz, J.-F. & Hermida-Merino, D.
- Organizer
  2019年生体運動合同班会議
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] シャトネラ鞭毛停止運動と赤潮発生機構2019
- Author(s)
  成田大樹、和田祐子、中原美奈、鈴木雄大、田中昴輝、今井洋、上村慎治
- Organizer
  第39回エアロ・アクアバイオメカニズム学会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] Structural/functional analysis on MOT7, a novel light chain of ciliary dynein f/I1. 新規繊毛ダイニン軽鎖MOT7の構造機能解析2019
- Author(s)
  Ryosuke Yamamoto, Yuuhei Nakagiri, Osamu Kutomi, Hiroshi Imai, Chihong Song, Kazuyoshi Murata, Ken-ichi Wakabayashi, Takashi Ishikawa, Kazuo Inaba, Takahide Kon
- Organizer
  日本生物物理学会第57回年会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] A newly developed negative stain EM method for protein complexes at high protein concentration.2019
- Author(s)
  Hiroshi Imai, Takayuki Kato, Gerle Christoph, Etsuko Muto, Kaoru Mitsuoka, Genji Kurisu, Keiichi Namba Takahide Kon
- Organizer
  日本生物物理学会第57回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] Dynamic changes of tubulin dimer configurations on a scale of sub-second revealed by high flux X-ray fiber diffraction2019
- Author(s)
  Shinji Kamimura, Hiroshi Imai, Toshiki Yagi, Hiroyuki Iwamoto
- Organizer
  日本生物物理学会第57回年会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] 微小管内のチューブリン分子の安定性・可塑性・柔軟性を目安にした微細動態解析2019
- Author(s)
  上村慎治、今井洋、八木俊樹、岩本裕之
- Organizer
  日本動物学会・関東支部　第71回大会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] Cryo-electron tomography revealed localization of a novel ciliary dynein subunit, MOT7. クライオ電子線トモグラフィー法による新規に発見された繊毛ダイニンのサブユニットMOT7の局在決定2019
- Author(s)
  Ryosuke Yamamoto, Yuuhei Nakagiri, Osamu Kutomi, Hiroshi Imai, Chihong Song, Kazuyoshi Murata, Ken-ichi Wakabayashi, Takashi Ishikawa, Kazuo Inaba, Takahide Kon
- Organizer
  NIPS EM Workshop 2019 生理研研究会.
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] 微小管内のチューブリン分子の安定性・可塑性・柔軟性を目安にした微細動態解析2019
- Author(s)
  上村慎治、今井洋、八木俊樹、岩本裕之
- Organizer
  日本動物学会・関東支部　第71回大会
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] 高タンパク質濃度条件下のタンパク質複合体の構造を観察するための新規のネガティブ染色電子顕微鏡法2019
- Author(s)
  今井洋，中桐侑平，Gerle,C，武藤悦子，栗栖源嗣，昆隆英
- Organizer
  2019年生体運動合同班会議
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] A newly developed negative stain EM method for protein complexes at high protein concentration. 新規に開発した高濃度タンパク質のためのネガティブ染色電子顕微鏡法2019
- Author(s)
  Hiroshi Imai, Takayuki Kato, Gerle Christoph, Etsuko Muto, Kaoru Mitsuoka, Genji Kurisu, Keiichi Namba Takahide Kon
- Organizer
  日本生物物理学会第57回年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] ラフィド藻シャトネラの遊泳停止と赤潮発生機構2019
- Author(s)
  中原美奈、成田大樹、和田祐子、鈴木雄大、田中昂輝、今井洋、上村慎治
- Organizer
  日本動物学会・関東支部　第71回大会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] Dynamic changes of tubulin dimer configurations on a scale of sub-second revealed by high flux X-ray fiber diffraction2019
- Author(s)
  Shinji Kamimura, Hiroshi Imai, Toshiki Yagi, Hiroyuki Iwamoto
- Organizer
  日本生物物理学会第57回年会
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] 高タンパク質濃度条件下のタンパク質複合体の構造を観察するための新規のネガティブ染色電子顕微鏡法2019
- Author(s)
  今井洋，中桐侑平，Gerle,C，武藤悦子，栗栖源嗣，昆隆英
- Organizer
  2019年生体運動合同班会議
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] Cryo-EM observation of stepping patterns of cytoplasmic dynein on microtubules with new freezing conditions.2018
- Author(s)
  R. Kanazawa, H. Imai, T. Shioi, R. Shimo, R. Yamamoto, K. Mitsuoka, and T. Kon.
- Organizer
  日本生物物理学会　第56回年会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] A new negative staining EM method at high protein concentration for sample evaluation of cryo-EM single particle analysis.2018
- Author(s)
  H. Imai, E. Muto, T. Kon.
- Organizer
  生理研究会
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] 細胞内輸送の動力源の一つ・蛋白質「ダイニン」の不活性化状態と活性化状態の構造解析2018
- Author(s)
  今井洋
- Organizer
  大阪大学超高圧電子顕微鏡センター医学・生物系共同利用研究報告会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] Novel intermediate structures of cytoplasmic dynein between shutdown and active states.2018
- Author(s)
  T. Shioi, A. Fukunaga, R. Shimo, R. Yamamoto, H. Imai, and T. Kon.
- Organizer
  日本生物物理学会　第56回年会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] A new negative staining EM method at high protein concentration for sample evaluation of cryo-EM single particle analysis.2018
- Author(s)
  H. Imai, E. Muto, T. Kon.
- Organizer
  生理研究会
- Data Source
  KAKENHI-PROJECT-16K07327
[Presentation] Dynamic changes in microtubule structure observed on a time scale of seconds by X-ray fiber diffraction2018
- Author(s)
  Kamimura S, Imai H, Yagi T & Iwamoto H
- Organizer
  EMBL Symposium: Microtubules: From Atoms to Complex Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] How does cytoplasmic dynein stepping along microtubules look like?2017
- Author(s)
  今井洋
- Organizer
  International Wordkshop of Dynein 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03668
[Presentation] How does cytoplasmic dynein stepping along microtubules look like?2017
- Author(s)
  Hiroshi Imai and Takahide Kon
- Organizer
  Dynein 2017 International Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07327

1. Muto Etsuko (90373373)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Nishiyama Masayoshi (10346075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 八木俊樹 (40292833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 松浦宏治 (70443223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 上村慎治 (90177585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 佐藤裕公 (40545571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IMAI HIROSHI 今井 洋

IMAI Hiroshi 今井 洋

Research Projects

Research Products

Co-Researchers

繊毛波形形成を担う繊毛・内腕ダイニン（特徴的な3種類）の構造基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualizing the activation of flagellar beating at high-pressure.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Verification of multiple conformations in GTP-tubulin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

チューブリン結合によるダイニン活性化の構造基盤の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanical control of rhythmic flagellar beating motions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the coupling mechanism between polymerization and GTP hydrolysis by using tubulin mutant

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction between two motor domains of cytoplasmic dynein stepping along microtubules revealed by cryo-electron microscopy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Handbook of Dynein (Second Edition)2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Two different linker conformations of the cytoplasmic dynein motor domain in the presence of ADP2024

Author(s)

Journal Title

Data Source

[Journal Article] Effects of high hydrostatic pressure to swimming sea urchin sperm flagella2023

Author(s)

Journal Title

Data Source

[Journal Article] Dynamics of the Spontaneous Nucleation of Microtubules2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] GTP-dependent formation of straight oligomers leads to nucleation of microtubules2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of phase-contrast/dark-field microscopy with scanning laser illumination2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 動物細胞に共通する細胞内の輸送システム2018

Author(s)

IMAI HIROSHI 今井洋

IMAI Hiroshi 今井洋