yoshimoto keitaro 吉本敬太郎

… Alternative Names

YOSHIMOTO Keitaro 吉本敬太郎

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Researcher Number	60392172
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院総合文化研究科, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 東京大学, 大学院総合文化研究科, 准教授 2012 – 2015: 東京大学, 総合文化研究科, 准教授 2010 – 2012: 東京大学, 大学院・総合文化研究科, 准教授 2007 – 2009: 筑波大学, 大学院・数理物質科学研究科, 講師 2006: 理研, 研究員 2006: 筑波大学, 大学院数理物質科学研究科, 講師 2005: 独立行政法人理化学研究所, 前田バイオ工学研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Analytical chemistry / Transformative Research Areas, Section (II) / Basic Section 34020:Analytical chemistry-related Except Principal Investigator Transformative Research Areas, Section (II) / Basic Section 34020:Analytical chemistry-related / Biomedical engineering/Biomaterial science and engineering / Science and Engineering / Science and Engineering / Biomedical engineering/Biological material science
Keywords	Principal Investigator 核酸 / アプタマー / バイオセンサー / 血液凝固疾患 / 分子進化工学 / 核酸アプタマー / 創薬 / 合成高分子 / 幹細胞 / 三次元培養 … More / 機械学習 / 診断 / 精密合成高分子 / 核酸医薬 / 低分子薬 / トロンビン / 高感度分析 / 血液凝固 / 分子認識化学 / 核酸科学 / 低分子化合物 / 蛍光 / RNA / DNA / キャピラリー電気泳動 / 分離化学 / 核酸化学 / 細胞塊 / マイクロデバイス / バイオ分析 / メカノバイオロジー / 誘電泳動 / 細胞分析 / バイオ界面 / 肝毒性評価 / ポリｲｵﾝコンプレックス / 高分子 / 判別分析 / マイクロ / 細胞チップ / 分化 / 酵素 / secretome / 分泌液 / マイクロパタン / 細胞培養 / 磁性粒子 / 細胞培養皿 / 細胞分離 / 遺伝子診断 / 水素結合 / 構造解析 / 希土類錯体 / エネルギー移動発光 / 蛍光識別 / 遺伝子診断・解析 / ランタノイド錯体 / 分子認識 … More Except Principal Investigator 分子認識 / ポリマーブラシ / PEG / バイオナノ粒子 / バイオインターフェース / センサー / 免疫沈降 / ELISA / 表面プラズモン共鳴 / ナノ酵素 / 免疫診断 / ナノ診断 / ラジカル重合 / アプタマー / 高分子合成 / 創薬 / 均一高分子 / 分子進化工学 / 制御ラジカル重合 / プラスチック抗体 / 精密高分子 / 高分子進化 / 細胞 / タンパク質 / アプタマー選抜 / 次世代シーケンシング / クラスタリング / 機械学習 / in vitro選抜 / キャピラリー電気泳動 / DNAアプタマー / 分析科学 / 生体材料 / 再生医療 / イムノアッセイ / DNAチップ / 抗体 / PEG混合ブラシ / ソフト界面 / 密生層 / 血液透析 / 血液活性化抑 / 細胞分化抑制 / ポリエチレングリコール / 表面コーティング / 安定ラジカル / 活性酸素 / 酸化ストレス / SPR / XPS / DDS / 遺伝子治療 / 遺伝子診断 / オリゴ核酸 / RNA精製 / PCR / ストレプトアビジン / ブラシ / ハイブリッド密生層 Less

精密高分子と核酸との共進化と創薬Principal Investigator
- Principal Investigator
  
  吉本敬太郎
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
核酸アプタマーと機械学習を利用する血液凝固因子欠損症の高精度迅速診断Principal Investigator
- Principal Investigator
  
  吉本敬太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  The University of Tokyo
Development of next-generation pharmaceuticals through evolutionary engineering of p recision polymers
- Principal Investigator
  
  星野友
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyushu University
Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methodsPrincipal Investigator
- Principal Investigator
  
  吉本敬太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Functional DNA aptamer selection by capillary electrophoresis
- Principal Investigator
  
  Saito Shingo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  Saitama University
Introduction and evaluation of micro beads-assisted capillary electrophoresis for nucleic acid aptamer selection systemsPrincipal Investigator
- Principal Investigator
  
  Yoshimoto Keitaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  The University of Tokyo
Development of DEP device for analysis of mechanobiology that affects cell function and differentiationPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Keitaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Analytical chemistry
- Research Institution
  The University of Tokyo
Development of next-generation technologies for bone-cartilage regeneration on the basis of Raman profiling for regenerated bones and cartilages
- Principal Investigator
  
  Yamamoto Masaya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tohoku University
  Kyoto University
Development of theree-dimentional cell culture chip for drug screeningPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Keitaro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Analytical chemistry
- Research Institution
  The University of Tokyo
Development of functional cell array for long-term survival and recovery of tissuesPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Keitaro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Analytical chemistry
- Research Institution
  The University of Tokyo
Construction of Densely Packed Hybrid Biointerfase
- Principal Investigator
  
  NAGASAKI Yukio
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  University of Tsukuba
Development of hydrogen-bonding lanthanide complex that recognizes nucleic acid base and Its application for the determination of DNA sequencePrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Keitaro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Analytical chemistry
- Research Institution
  University of Tsukuba
遺伝子センシングを可能とするバイオナノ粒子の材料設計
- Principal Investigator
  
  長崎幸夫
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  University of Tsukuba
Bionanosensing based on Bio-frontier Surface
- Principal Investigator
  
  NAGASAKI Yukio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
核酸の光機能化に基づく新規バイオセンサーの開発と細胞分析基板技術への応用Principal Investigator
- Principal Investigator
  
  吉本敬太郎
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Analytical chemistry
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 生物工学会誌2015
- Author(s)
  冨田峻介, 吉本敬太郎
- Total Pages
  4
- Publisher
  生物工学会
- Data Source
  KAKENHI-PROJECT-24350037
[Book] Design of Highly Functional Antiferritin-Immunolatex by Hybridization of Antiferritin/Mixed-PEG Polymers onto Polystyrene Submicroparticles2010
- Author(s)
  Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto, Yukio Nagasaki
- Total Pages
  15
- Publisher
  Biomaterials : ACS Symposium Series
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Proficiently partitioning of bioactive peptide-ssDNA conjugates by microbead-assisted capillary electrophoresis (MACE)2024
- Author(s)
  Matsuo Muneyuki、Wakui Koji、Inami Yuuki、Furukawa Akihiro、Sato Seiji、Yoshimoto Keitaro
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 687 Pages: 115452-115452
- DOI
  10.1016/j.ab.2023.115452
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide2023
- Author(s)
  Troisi Romualdo、Napolitano Valeria、Rossitto Emanuele、Osman Waleed、Nagano Masanobu、Wakui Koji、Popowicz Grzegorz?M、Yoshimoto Keitaro、Sica Filomena
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 16 Pages: 8880-8890
- DOI
  10.1093/nar/gkad634
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice2023
- Author(s)
  Masanobu Nagano , Kazuki Kubota , Asuka Sakata , Rei Nakamura , Toru Yoshitomi , Koji Wakui , Keitaro Yoshimoto
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: - Pages: 762-772
- DOI
  10.1016/j.omtn.2023.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06450, KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Evaluation of G-quartet-forming deoxyguanines in antiparallel G-quadruplexes using optical spectroscopy and deoxyguanine-to-deoxythymidine scanning2022
- Author(s)
  Nagano Masanobu、Nakano Sosuke、Yoshimoto Keitaro
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 658 Pages: 114903-114903
- DOI
  10.1016/j.ab.2022.114903
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Discovery of a Highly Specific Anti-methotrexate (MTX) DNA Aptamer for Antibody-Independent MTX Detection2022
- Author(s)
  Nagano Masanobu、Toda Takumi、Makino Kurumi、Miki Hiroko、Sugizaki Yoshiaki、Tomizawa Hideyuki、Isobayashi Atsunobu、Yoshimoto Keitaro
- Journal Title
  
  Analytical Chemistry
  
  Volume: 94 Issue: 49 Pages: 17255-17262
- DOI
  10.1021/acs.analchem.2c04182
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05049
[Journal Article] Design Strategy of Short Antidote Sequence for Bivalent aptamer: Rapid Neutralization of High Anticoagulant Thrombin-Binding DNA Aptamer Linked M08 with HD222021
- Author(s)
  Yoshitomi Toru、Wakui Koji、Miyakawa Masato、Yoshimoto Keitaro
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02002
[Journal Article] Accelerated Discovery of Potent Bioactive anti‐TNFα Aptamers by Microbead‐Assisted Capillary Electrophoresis (MACE)‐SELEX2021
- Author(s)
  Nagano Masanobu、Oguro Takumi、Sawada Ryo、Yoshitomi Toru、Yoshimoto Keitaro
- Journal Title
  
  ChemBioChem
  
  Volume: 22 Issue: 23 Pages: 3341-3347
- DOI
  10.1002/cbic.202100478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02002
[Journal Article] Single‐Round DNA Aptamer Selection by Combined Use of Capillary Electrophoresis and Next Generation Sequencing: An Aptaomics Approach for Identifying Unique Functional Protein‐Binding DNA Aptamers2021
- Author(s)
  Saito Shingo、Sakamoto Toshiki、Tanaka Naoki、Watanabe Ryo、Kamimura Takuya、Ota Kazuki、Riley Kathryn R.、Yoshimoto Keitaro、Tasaki‐Handa Yuiko、Shibukawa Masami
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 27 Issue: 39 Pages: 10058-10067
- DOI
  10.1002/chem.202100177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02740
[Journal Article] Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity2020
- Author(s)
  Yoshitomi Toru、Hayashi Misako、Oguro Takumi、Kimura Keiko、Wayama Fumiya、Furusho Hitoshi、Yoshimoto Keitaro
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 19 Pages: 1145-1152
- DOI
  10.1016/j.omtn.2019.12.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02002
[Journal Article] Programmable RNA detection with a fluorescent RNA aptamer using optimized three-way junction formation2019
- Author(s)
  Furuhata Yuichi、Kobayashi Mizuki、Maruyama Ryo、Sato Yusuke、Makino Kurumi、Michiue Tatsuo、Yui Hiroharu、Nishizawa Seiichi、Yoshimoto Keitaro
- Journal Title
  
  RNA
  
  Volume: 25 Issue: 5 Pages: 590-599
- DOI
  10.1261/rna.069062.118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02002, KAKENHI-PROJECT-19K15720
[Journal Article] Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX2019
- Author(s)
  Wakui Koji、Yoshitomi Toru、Yamaguchi Akane、Tsuchida Maho、Saito Shingo、Shibukawa Masami、Furusho Hitoshi、Yoshimoto Keitaro
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 16 Pages: 348-359
- DOI
  10.1016/j.omtn.2019.03.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02002, KAKENHI-PROJECT-16K16398
[Journal Article] Screening of DNA Signaling Aptamer from Multiple Candidates Obtained from SELEX with Next-generation Sequencing2019
- Author(s)
  YOSHITOMI Toru、WAYAMA Fumiya、KIMURA Keiko、WAKUI Koji、FURUSHO Hitoshi、YOSHIMOTO Keitaro
- Journal Title
  
  Anal. Sci.
  
  Volume: 35 Issue: 1 Pages: 113-116
- DOI
  10.2116/analsci.18SDN05
- NAID
  130007554959
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2019-01-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02002, KAKENHI-PROJECT-16K16398
[Journal Article] High Enrichment of Nucleobase-modified Aptamers in Early Selection Rounds by Microbeads-assisted Capillary Electrophoresis SELEX2019
- Author(s)
  WAKUI Koji、ABE Akihito、YOSHITOMI Toru、FURUSHO Hitoshi、YOSHIMOTO Keitaro
- Journal Title
  
  Anal. Sci.
  
  Volume: 35 Issue: 5 Pages: 585-588
- DOI
  10.2116/analsci.18SDN04
- NAID
  130007644236
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2019-05-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02002
[Journal Article] Estimation of G-quartet-forming guanines in parallel-type G-quadruplexes by optical spectroscopy measurements of their single-nucleobase substitution sequences2018
- Author(s)
  Maruyama Ryo、Makino Kurumi、Yoshitomi Toru、Yui Hiroharu、Furusho Hitoshi、Yoshimoto Keitaro
- Journal Title
  
  The Analyst
  
  Volume: 143 Issue: 17 Pages: 4022-4026
- DOI
  10.1039/c8an01131a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02002, KAKENHI-PROJECT-16K16398
[Journal Article] Osteogenic Lineage Commitment of Adipose-Derived Stem Cells Is Predetermined by Three-Dimensional Cell Accumulation on Micropatterned Surface2017
- Author(s)
  Yuichi Furuhata, Toru Yoshitomi, Yuka Kikuchi, Miho Sakao, and Keitaro Yoshimoto
- Journal Title
  
  Applied Materials and Interfaces
  
  Volume: 9 Issue: 11 Pages: 9339-9347
- DOI
  10.1021/acsami.6b15688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J06585, KAKENHI-PROJECT-15K13721, KAKENHI-PROJECT-16K16398
[Journal Article] Alternation of Gene Expression Levels in Mesenchymal Stem Cells by Applying Positive Dielectrophoresis2016
- Author(s)
  J. Yoshioka, T. Yoshitomi, T. Yasukawa, K. Yoshimoto
- Journal Title
  
  Anal. Sci.
  
  Volume: 32 Issue: 11 Pages: 1213-1216
- DOI
  10.2116/analsci.32.1213
- NAID
  130005277931
- ISSN
  0910-6340, 1348-2246
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04169, KAKENHI-PROJECT-26288071, KAKENHI-PROJECT-15K13721, KAKENHI-PROJECT-16K14023, KAKENHI-PROJECT-16K16398
[Journal Article] Small Spheroids of Adipose-Derived Stem Cells with Time-Dependent Enhancement of IL-8 and VEGF-A Secretion2016
- Author(s)
  Furuhata, Y., Kikuchi, Y., Tomita, S., Yoshimoto, K.
- Journal Title
  
  Genes to Cells
  
  Volume: 21(12) Issue: 12 Pages: 1380-1386
- DOI
  10.1111/gtc.12448
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K13721, KAKENHI-PROJECT-16K14043
[Journal Article] Enzymatic fingerprinting of structurally similar homologous proteins using polyion complex library constructed by tuning PEGylated polyamine functionalitiesion2014
- Author(s)
  Tomita, S., Soejima, T., Shiraki, K., Yoshimoto, K.
- Journal Title
  
  Analyst
  
  Volume: 139(23) Issue: 23 Pages: 6100-6103
- DOI
  10.1039/c4an01398k
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24350037, KAKENHI-PROJECT-26810074
[Journal Article] Polyion complex libraries possessing naturally occurring differentiation for pattern-based protein discrimination.2013
- Author(s)
  Shunsuke Tomita, Keitaro Yoshimoto
- Journal Title
  
  Chemical Communications
  
  Volume: 49 Issue: 88 Pages: 10430-10432
- DOI
  10.1039/c3cc45640d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08921, KAKENHI-PROJECT-24350037
[Journal Article] Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array2012
- Author(s)
  Yutaka Ikeda, Tomoko Jomura, Umeko Horiuchi, Junko Saeki, Keitaro Yoshimoto, Takeshi Ikeya, Yukio Nagasaki
- Journal Title
  
  Colloid and Surface, B, Biointerface
  
  Volume: 97 Pages: 97-100
- DOI
  10.1016/j.colsurfb.2012.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011, KAKENHI-PROJECT-21240050, KAKENHI-PROJECT-24659920
[Journal Article] Long-term survival and functional maintenance of hepatocytes by using a microfabricated cellarray2012
- Author(s)
  Ikeda, Y., Jomura, T., Horiuchi, U., Saeki, J., Yoshimoto, K., Ikeya, T., Nagasaki, Y
- Journal Title
  
  Colloids and Surfaces B : Biointerfaces
  
  Pages: 97-100
- Data Source
  KAKENHI-PROJECT-22750066
[Journal Article] Development of a high-performance immunolatex based on "soft landing" antibody immobilization mechanism2012
- Author(s)
  Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto and Yukio Nagasaki
- Journal Title
  
  Colloid and Surface B: Biointreface
  
  Volume: Vol.99 Pages: 45-52
- DOI
  10.1016/j.colsurfb.2011.09.040
- NAID
  120007137228
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011, KAKENHI-PROJECT-21240050, KAKENHI-PROJECT-24659920
[Journal Article] Long-term survival and functional maintenance of hepatocytes by using a microfabricated cellarray2012
- Author(s)
  Ikeda, Y., Jomura, T., Horiuchi, U., Saeki, J., Yoshimoto. K. Ikeya, T., Nagasaki, Y.,
- Journal Title
  
  Colloids and Surfaces B : Biointerfaces
  
  Volume: 97 Pages: 97-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24350037
[Journal Article] High PEGylation Efficiency of Pentaethylenehexamine-end Poly(ethyleneglycol) (mPEG-N6) for Active-ester Surface2012
- Author(s)
  Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto and Yukio Nagasaki
- Journal Title
  
  Colloid and Surface B: Biointerface
  
  Volume: 92 Issue: 2 Pages: 25-29
- DOI
  10.4155/tde.11.153
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011, KAKENHI-PROJECT-21240050, KAKENHI-PROJECT-22659008, KAKENHI-PROJECT-24659920
[Journal Article] Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed-poly(ethylene glycol) tethered-chain Layer2011
- Author(s)
  Kubota, M., Yoshimoto, K., Yuan, X., Nagasaki, Y
- Journal Title
  
  Polymer Journal
  
  Volume: 43 Pages: 493-496
- NAID
  10028221047
- Data Source
  KAKENHI-PROJECT-22750066
[Journal Article] Improvement of the Thermal Stability of Streptavidin Immobilized on Magnetic Beads by the Construction of a Mixed-poly(ethylene glycol) Tethered-chain Layer2011
- Author(s)
  Kubota Masaki, Yoshimoto Keitaro, Yuan Xiaofei, Nagasaki Yukio
- Journal Title
  
  Polymer Journal in press
- NAID
  10028221047
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly (ethylene glycol) tethered-chain layer2011
- Author(s)
  Masaki Kubota, Keitaro Yoshimoto, Yuan Xiaofei, Yukio Nagasaki
- Journal Title
  
  Polymer Journal
  
  Volume: 43 Issue: 5 Pages: 493-496
- DOI
  10.1038/pj.2011.5
- NAID
  10028221047
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011, KAKENHI-PROJECT-21240050, KAKENHI-PROJECT-22659008
[Journal Article] Improvement of the Thermal Stability of Streptavidin Immobilized on Magnetic Beads by the Construction of a Mixed-poly(ethylene glycol) Tethered-chain Layer2011
- Author(s)
  Kubota, M., Yoshimoto, K., Yuan, X.,Nagasaki,Y.
- Journal Title
  
  Polymer Journal
  
  Volume: 43 Pages: 493-496
- NAID
  10028221047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750066
[Journal Article] Improvement of the thermal stability of streptavidin immobilized on magnetic beads by the construction of a mixed poly(ethylene glycol) tethered-chain layer2011
- Author(s)
  Masaki Kubota, Keitaro Yoshimoto, Yuan Xiaofei, Yukio Nagasaki
- Journal Title
  
  Polymer Journal
  
  Volume: 43 Pages: 493-496
- NAID
  10028221047
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Direct Observation of Adsorption-Induced Inactivation of Antibody Fragments Surrounded by Mixed-PEG Layer on a Gold Surface2010
- Author(s)
  Yoshimoto Keitaro, Nishio Motohiko, Sugasawa Hiroaki, Nagasaki Yukio
- Journal Title
  
  Journal of the American Chemical Society 132(23)
  
  Pages: 7982-7989
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Direct Observation of Adsorption-Induced Inactivation of Antibody Fragments Surrounded by Mixed-PEG Layer on a Gold Surface2010
- Author(s)
  Yoshimoto Keitaro, Nishio Motohiko, Sugasawa Hiroaki, Nagasaki Yukio
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 132(23) Pages: 7982-7989
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Improving the Heat Resistance of Ribonuclease A by the Addition of Poly(N,N-diethylaminoethyl methacrylate)-graft-poly(ethylene glycol) (PEAMA-g-PEG)2010
- Author(s)
  Ganguli Sumon, Keitaro Yoshimoto, Tomita Shunsuke, Sakuma Hiroshi, Matsuoka Tsuneyoshi, Shiraki Kentaro, Nagasaki Yukio
- Journal Title
  
  Macromolecular Bioscience
  
  Volume: 10(8) Pages: 853-859
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Luminescence-based Cotorimetric Discrimination of Single-nucleotide Transversions by the Combined Use of the Derivatives of DOTA-conjugated Naphthyridine and Its Terbium Complex2009
- Author(s)
  厚見宙志、吉本敬太郎、齋藤伸吾、大熊盛也、前田瑞夫、長崎幸夫
- Journal Title
  
  Tetrahedron Letters 50
  
  Pages: 2177-2180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750055
[Journal Article] Influence of substituent modifications on the binding of 2-amino-1, 8-naphthyridines to cytosine opposite an AP site in DNA duplexes : Thermodynamic characterization2009
- Author(s)
  佐藤雄介、西澤精一、吉本敬太郎、清野武博、森田幸太郎、寺前紀夫
- Journal Title
  
  Nucleic Acid Research 37
  
  Pages: 1411-1422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750055
[Journal Article] High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface : High Sensitive Ferritin Immunodiagnostics.2009
- Author(s)
  Yuan X, Yoshimoto K, Nagasaki Y
- Journal Title
  
  Analytical Chemistry 81(4)
  
  Pages: 1549-1556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Inverted Pattern Formation of Cell Microarrays on Poly(ethylene glycol)(PEG)Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains.2009
- Author(s)
  Yoshimoto Keitaro, Ichino Masahiro, Nagasaki Yukio
- Journal Title
  
  Lab on a Chip 9
  
  Pages: 1286-1289
- NAID
  120007138167
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface : High Sensitive Ferritin Immunodiagnostics.2009
- Author(s)
  Yuan Xiaofei, Yoshimoto Keitaro, Nagasaki Yukio
- Journal Title
  
  Analytical Chemistry 81(4)
  
  Pages: 1549-1556
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Inverted Pattern Formation of Cell Microarrays on Poly(ethylen glycol) (PEG) Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains2009
- Author(s)
  Yoshimoto Keitaro, Ichino Masahiro, Nagasaki Yukio
- Journal Title
  
  Lab on a Chip 9
  
  Pages: 1286-1289
- NAID
  120007138167
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Luminescence-based Colorimetric Discrimination of Single-nucleotide Transversions by the Combined Use of the Derivatives of DOTA-conjugated Naphthyridine and Its Terbium Complex2009
- Author(s)
  厚見宙志、吉本敬太郎、齋藤伸吾、大熊盛也、前田瑞夫、長崎幸夫
- Journal Title
  
  Tetrahedron Letters 50
  
  Pages: 2177-2180
- NAID
  120007138274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750055
[Journal Article] Influence of substituent modifications on the binding of 2-amino-1, 8-naphthyridines to cytosine opposite an AP site in DNA duplexes: Thermodynamic characterization2009
- Author(s)
  佐藤雄介、西澤精一、吉本敬太郎、清野武博、森田幸太郎、寺前紀夫
- Journal Title
  
  Nucleic Acid Research 37
  
  Pages: 1411-1422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750055
[Journal Article] Efficient Inhibition of Interfacial Nonspecific Interaction to Create Practically Utilizable High Ferritin-Response Immunolatex2009
- Author(s)
  Yuan Xiaofei, Fabregat Dolca, Yoshimoto Keitaro, Nagasaki Yukio
- Journal Title
  
  Analytical Chemistry 81
  
  Pages: 10097-10105
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Spheroid Array of Fetal Mouse Liver Cells Constructed on a PEG-gel Micropatterned Surface : Upregulation of Hepatic Functions by Co-Culture with Nonparenchymal Liver Cells.2009
- Author(s)
  Kojima Ryota, Yoshimoto Keitaro, Miyoshi Hirotoshi, Nagasaki Yukio
- Journal Title
  
  Lab on a Chip 9
  
  Pages: 1991-1993
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine] Modified Gold Surfaces Fabricated by the "Grafting to" Method : Comparison of its Protein Resistance with Poly(ethylene glycol)Modified Gold Surfaces.2009
- Author(s)
  Yoshimoto Keitaro, Hirase Takumi, Madsen Jeppe, Armes Steven P., Nagasaki Yukio
- Journal Title
  
  Macromolecular Rapid Communication 30(24)
  
  Pages: 2136-2140
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Studies on the Adsorption Property and Structure of Polyamine-Ended Poly(ethylene glycol)Derivatives on a Gold Surface by Surface Plasmon Resonance and Angle-resolved X-ray Photoelectron Spectroscopy.2009
- Author(s)
  Yoshimoto Keitaro, Nozawa Makiko, Matsumoto Shinya, Echigo Takuya, Nemoto Seiko, Hatta Tamao, Nagasaki Yukio
- Journal Title
  
  Langmuir 25(20)
  
  Pages: 12243-12249
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Regulation of Lysozyme Activity Based on Thermotolerant Protein/Smart Polymer Complex Formation2009
- Author(s)
  Ganguli Sumon, Yoshimoto Keitaro, Tomita Shunsuke, Sakuma Hiroshi, Matsuoka Tsuneyoshi, Shiraki Kentaro, Nagasak Yukio
- Journal Title
  
  Journal of the American Chemical Society accepted
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Binding Enhancement of Antigen-Functionalized PEGylated Gold Nanoparticles onto Antibody-Immobilized Surface by Increasing the Functionalized Antigen using α-sulfanyl-ω -amino-PEG.2008
- Author(s)
  Yoshimoto Keitaro, Hoshino Yuki, Ishii Takehiko, Nagasaki Yukio
- Journal Title
  
  Chemical Communications
  
  Pages: 5369-5371
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Binding Enhancement of Antigen-Functionalized PEGylated Gold Nanoparticles onto Antibody-Immobilized Surface by Increasing the Functionalized Antigen using α-sulfanyl-ω-amino-PEG.2008
- Author(s)
  Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y
- Journal Title
  
  Chemical Communications
  
  Pages: 5369-5371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Completely Dispersible PEGylated Gold Nanoparticles Under Physiolo gical Conditions : Modification of Gold Nanoparticles With Precisely Controlled PEGbnolvamine2008
- Author(s)
  吉本敬太郎、長崎幸夫、他
- Journal Title
  
  Langmuir 24
  
  Pages: 5010-5017
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Completely Dispersible PEGylafed Gold Nanoparticles Under Physiological Conditions: Modification of Gold Nanoparticles With Precisely Controlled PEG-b-polyamine.2008
- Author(s)
  宮本大輔、大石基、吉本敬太郎、長崎幸夫、他
- Journal Title
  
  Langmuir 24
  
  Pages: 5010-5017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Facile Construction of Sulfanyl-terminated Poly(ethylene glycol)-brushed Layer on a Gold Surface for Protein Immobilization by the Combined Use of Sulfanyl-Ended Telechelic and Semi-Telechelic Poly(ethylene glycol)s.2008
- Author(s)
  Yoshimoto Keitaro, Hirase Takumi, Nemoto Seiko, Hatta Tamao, Nagasaki Yukio
- Journal Title
  
  Langmuir 24
  
  Pages: 9623-9629
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20106011
[Journal Article] Immobilization and Hybridization Behavior of DNA on Poly (ethylene glycol)-block-Poly [2-(N, N-dimethylamino) ethyl methacrylate]-modified Gold Surfaces2007
- Author(s)
  Yoshimoto Keitaro, Matsumoto Shinya, Asakawa Ryosuke, Uchida Katsumi, Ishii Takehiko, Nagasaki Yukio
- Journal Title
  
  Chemistry Letters 36
  
  Pages: 1444-1445
- NAID
  10020011799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Immobilization and Hybridization Behavior of DNA on Poly(ethylene glycol)-block-Poly[2-(N,N-dimethylamino)ethyl methacrylate]-Modified Gold Surfaces2007
- Author(s)
  吉本敬太郎、長崎幸夫、他
- Journal Title
  
  Chemistry Letter 36
  
  Pages: 1444-1445
- NAID
  10020011799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200033
[Journal Article] Immobilization and Hybridization Behavior of DNA on Poly(ethyleneglycol)-block-Poly[2-(N,N-dimethylamino)ethyl methacrylate]-Modified Gold Surfaces2007
- Author(s)
  吉本敬太郎、長崎幸夫, 他
- Journal Title
  
  Chemistry Letter 36
  
  Pages: 1444-1445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021007
[Journal Article] Assignment of hydrogen-bond structure in a ligand-nucleobase complex inside duplex DNA : Combined use of quantum chemical calculations and ^<15>N NMR experiments2005
- Author(s)
  K.Yoshimoto
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 255-256
- Data Source
  KAKENHI-PROJECT-17750079
[Journal Article] Long-termsurvival and functionalmaintenance of hepatocytes by using amicrofabricatedcellarray
- Author(s)
  Ikeda Y., Jomura T., Horiuchia U., Saekia J., Yoshimoto, K., Ikeya T., Nagasaki, Y
- Journal Title
  
  Colloids and Surfaces B : Biointerfaces
  
  Volume: (掲載決定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750066
[Patent] 核酸アプタマー2019
- Inventor(s)
  吉本、吉冨、和久井、古性、齋藤、宮内
- Industrial Property Rights Holder
  吉本、吉冨、和久井、古性、齋藤、宮内
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02002
[Patent] 解毒剤2018
- Inventor(s)
  吉本、吉冨、和久井、古性
- Industrial Property Rights Holder
  吉本、吉冨、和久井、古性
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-231878
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02002
[Patent] 免疫ラテックス粒子及びその製造方法2009
- Inventor(s)
  長崎幸夫, 吉本敬太郎, 原暁非, Dolca Fabrigat
- Industrial Property Rights Holder
  筑波大学
- Filing Date
  2009-01-16
- Data Source
  KAKENHI-PLANNED-20106011
[Patent] 混合ポリエチレングリコールと抗体が共固定化された表面を所有する免疫ラテックス粒子及びその製造方法2009
- Inventor(s)
  長崎幸夫, 原暁非, 吉本敬太
- Industrial Property Rights Holder
  筑波大学
- Filing Date
  2009-01-16
- Data Source
  KAKENHI-PROJECT-18200033
[Patent] 混合ポリエチレングリコールと抗体が共固定化された表面を所有する免疫ラテックス粒子及びその製造方法2009
- Inventor(s)
  長崎幸夫, 原暁非, 吉本敬太郎
- Industrial Property Rights Holder
  国立大学法人筑波大学
- Industrial Property Number
  2009-007846
- Filing Date
  2009-01-16
- Data Source
  KAKENHI-PROJECT-18200033
[Patent] 混合ポリエチレングリコールと抗体が共固定化された表面を所有する免疫ラテックス粒子及びその製造方法2009
- Inventor(s)
  長崎幸夫, 原暁非, 吉本敬太郎
- Industrial Property Rights Holder
  筑波大学
- Filing Date
  2009-01-16
- Data Source
  KAKENHI-PLANNED-20106011
[Presentation] 診断薬・治療薬としての二重特異性DNAアプタマー2023
- Author(s)
  吉本敬太郎
- Organizer
  Cheminas48
- Invited
- Data Source
  KAKENHI-PLANNED-22H05049
[Presentation] Therapeutic and Diagnostic Agents Based on Bispecific Aptamers Constructed by Natural DNA Aptamers Identified by MACE-SELEX2023
- Author(s)
  Keitaro Yoshimoto
- Organizer
  2023 KSBB Fall Meeting and International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05049
[Presentation] 診断・治療薬としての二重特異性DNAアプタマー2023
- Author(s)
  吉本敬太郎
- Organizer
  第116回応用化学セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-22H05049
[Presentation] アンタゴニストおよびアゴニスト型DNAアプタマーの医療応用を目指して2022
- Author(s)
  吉本敬太郎
- Organizer
  第18回基礎医学教育協議会合同講演会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] 血液疾患に対する核酸アプタマー治療薬2022
- Author(s)
  吉本敬太郎
- Organizer
  第17回ナノ・バイオメディカル学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05049
[Presentation] 血液疾患に対する核酸アプタマー治療薬2022
- Author(s)
  吉本敬太郎
- Organizer
  第17回ナノ・バイオメディカル学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-22H05047
[Presentation] アンタゴニストおよびアゴニスト型DNAアプタマーの医療応用を目指して2022
- Author(s)
  吉本敬太郎
- Organizer
  第18回基礎医学教育協議会合同講演会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05049
[Presentation] Reguration of Cellar Functions by Nucleic Acid Aptamers2021
- Author(s)
  吉本敬太郎
- Organizer
  Pacifichem 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 新規な分離技術を導入した分子進化工学的手法 MACE-SELEX で獲得した DNA アプタマーの機能2021
- Author(s)
  吉本敬太郎
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 新規な分離科学を取り入れた分子進化工学的手法の構築 -同手法で獲得したアンタゴニスト型核酸分子の機能-2020
- Author(s)
  吉本敬太郎
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 血液凝固因子を標的とする中和可能な核酸アプタマーの設計2020
- Author(s)
  吉本敬太郎
- Organizer
  第69回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 血液凝固因子を標的とする中和可能な核酸アプタマーの設計2020
- Author(s)
  吉本敬太郎
- Organizer
  第69回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] Rapidly Neutralizable and High Anticoagulant DNA Aptamer Discovered by MACE-SELEX2020
- Author(s)
  吉本敬太郎
- Organizer
  Pittcon 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 分子認識能をもつ核酸“核酸アプタマー”の医療・創薬分野への挑戦2020
- Author(s)
  吉本敬太郎
- Organizer
  九州大学先導物質化学研究所講演会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] Anti-coagulant activity of DNA aptamer and its neutralization by antidote single stranded DNA2020
- Author(s)
  吉本敬太郎
- Organizer
  第42回日本血栓止血学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] Anti-coagulant activity of DNA aptamer and its neutralization by antidote single stranded DNA2020
- Author(s)
  吉本敬太郎
- Organizer
  第42回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 新規な分離科学を取り入れた分子進化工学的手法の構築 -同手法で獲得したアンタゴニスト型核酸分子の機能-2020
- Author(s)
  吉本敬太郎
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 構造誘起に基づく分子認識機能を有するトロンビン結合型DNAアプタマーのCE選抜2019
- Author(s)
  坂本寿樹，半田友衣子，吉本敬太郎，渋川雅美，齋藤伸吾
- Organizer
  第39回キャピラリー電気泳動シンポジウム
- Data Source
  KAKENHI-PROJECT-19H02740
[Presentation] 立体構造変化に基づいた分子認識機能を有するトロンビン結合型DNAアプタマーの電気泳動選抜2019
- Author(s)
  坂本寿樹，半田友衣子，吉本敬太郎，渋川雅美，齋藤伸吾
- Organizer
  日本分析化学会第68年会
- Data Source
  KAKENHI-PROJECT-19H02740
[Presentation] Functions of DNA aptamers discovered by improved SELEX2019
- Author(s)
  吉本敬太郎
- Organizer
  3rd International symposium on Nanoarchitectonics for Mechanobiology, March 8th 2019 (NIMS, Tsukuba, Ibaraki)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] MACE/NGS-SELEXで発見されたトロンビンアプタマーの抗凝固活性と中和2019
- Author(s)
  吉本敬太郎
- Organizer
  日本化学会第99春季年会特別企画 “核酸分析・機能創出の新展開”, 2019年3月19日, （甲南大学, 神戸, 兵庫）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] キャピラリー電気泳動と大規模配列解析に基づくPC-9細胞結合型アプタマーの1ラウンド選抜2019
- Author(s)
  田中直樹，半田友衣子，渋川雅美，菅沼雅美，吉本敬太郎，齋藤伸吾
- Organizer
  日本分析化学会第68年会
- Data Source
  KAKENHI-PROJECT-19H02740
[Presentation] toehold 導入型核酸アプタマーによる中和制御可能な抗凝固製剤2019
- Author(s)
  吉本敬太郎
- Organizer
  日本薬学会第139年会一般シンポジウム “生体分子骨格リデザインで挑む次世代創薬研究”, 2019年3月22日, （幕張メッセ, 幕張, 千葉）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 1ラウンドCE選抜と大規模配列解析に基づく細胞結合型DNAアプタマー獲得法の開発2019
- Author(s)
  田中直輝，半田友衣子，渋川雅美，吉本敬太郎，菅沼雅美，齋藤伸吾
- Organizer
  第39回キャピラリー電気泳動シンポジウム
- Data Source
  KAKENHI-PROJECT-19H02740
[Presentation] 立体構造の異なるランダムDNAサブライブラリーを用いるトロンビン結合型アプタマー選抜2019
- Author(s)
  坂本寿樹，吉本敬太郎，渋川雅美，齋藤伸吾
- Organizer
  第79回分析化学討論会
- Data Source
  KAKENHI-PROJECT-19H02740
[Presentation] マイクロ粒子支援型キャピラリー電気泳動 SELEX で獲得した抗トロンビンアプタマーの抗凝固能2018
- Author(s)
  吉本敬太郎
- Organizer
  第38回キャピラリー電気泳動シンポジウム (SCE2018), 2018年12月6日（I-siteなんば大阪府立大学, 大阪, 大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] MACE-SELEX により選抜された抗トロンビン DNA アプタマーの抗凝固作用2018
- Author(s)
  吉本敬太郎
- Organizer
  バイオメディカル研究部門セミナー, 2018年1月30日（産業技術総合研究所, つくば, 茨城）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] DNAアプタマー選抜における分離・洗浄工程の重要性：微粒子導入型キャピラリー電気泳動の導入効果2018
- Author(s)
  吉本敬太郎
- Organizer
  日本分析化学会第67年会, 2018年7月30日（東京大学生産技術研究所, 駒場, 東京）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 核酸アプタマー選抜実験系（SELEX）における分離・洗浄工程の重要性2018
- Author(s)
  吉本敬太郎
- Organizer
  第２回中分子×IT×創薬ビジネス研究会, 2018年5月31日（川崎市産業振興会館, 川崎, 神奈川）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 分子標的薬のスクリーニング実験における分離・洗浄工程の重要性 ~ 核酸アプタマースクリーニングを例に~2018
- Author(s)
  吉本敬太郎
- Organizer
  甲南大学 Science Live Ticket Series Part 36, 2018年11月20日（甲南大学, 神戸, 兵庫）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 分子認識型核酸（核酸アプタマー）選抜実験における分離・洗浄工程の重要性2018
- Author(s)
  吉本敬太郎
- Organizer
  平成30年度第1回奨励会特別研究会, 2018年7月30日（東京大学生産技術研究所, 駒場, 東京）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02002
[Presentation] 脂肪幹細胞の分化誘導における新機軸の提案：マイクロパタン培養皿を利用する細胞蓄積量の精密制御2017
- Author(s)
  古旗　祐一、吉冨　徹、菊池　有夏、坂尾　美帆、吉本　敬太郎
- Organizer
  第２６回インテリジェント材料・システムシンポジウム
- Place of Presentation
  TWINS（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-15K13721
[Presentation] 鋸型電極の誘電泳動を利用する細胞の分離・凝集・力覚分析用デバイスの開発2016
- Author(s)
  吉岡純矢、安川智之、吉本敬太郎
- Organizer
  第76回分析化学討論会
- Place of Presentation
  岐阜薬科大学（岐阜県岐阜市）
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K13721
[Presentation] Dielectrophoresis device as an analytical tool for applying mechanical stimuli to cell2016
- Author(s)
  Junya Yoshioka, Toru Yoshitomi, Tomoyuki Yasukawa, Keitaro Yoshimoto
- Organizer
  JASIS RSC Tokyo International Conference
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K13721
[Presentation] Development of evaluation device for physical stimulation to cell based on dielectrophoresis2016
- Author(s)
  YOSHIOKA, Junya; YASUKAWA, Tomoyuki; YOSHIMOTO, Keitaro
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学京田辺キャンパス（京田辺市、京都府）
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K13721
[Presentation] Dielectrophoresis device with saw-shaped electrode as a tool for applying mechanical stress to cell2016
- Author(s)
  Junya Yoshioka, Toru Yoshitomi, Tomoyuki Yasukawa, Keitaro Yoshimoto
- Organizer
  2nd International Symposium on Nanoarchitectonics for Mechanobiology
- Place of Presentation
  国際ナノアーキテクトニクス研究拠点（茨城県つくば市）
- Year and Date
  2016-07-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K13721
[Presentation] 高分子界面を用いる生体機能制御2014
- Author(s)
  吉本　敬太郎
- Organizer
  第47回研究会：主題バイオマテリアル
- Place of Presentation
  京都大学東京品川オフィス（東京都港区）
- Year and Date
  2014-06-04
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 酵素/高分子電解質複合体ライブラリアレイを用いるタンパク質の交差反応型蛍光センシング法の開発2013
- Author(s)
  横山沙樹、冨田峻介、吉本敬太郎
- Organizer
  日本分析化学会第６２年会
- Place of Presentation
  近畿大学、大阪府東大阪市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] Upregulation of Differentiation Efficiency Using 3D Cell Culture Microenvironment Constructed by Adhesion-Controlled　Micro-Patterned Surface2013
- Author(s)
  Yuka Kikuchi, Keitaro Yoshimoto
- Organizer
  The 4th Asian Biomaterial Congress
- Place of Presentation
  The Hong Kong University, Hong Kong, CHINA
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] PEG 修飾マイクロパタン表面における脂肪幹細胞の高機能化2013
- Author(s)
  菊池有夏、高橋秀治、吉本敬太郎
- Organizer
  第６２回高分子討論会
- Place of Presentation
  金沢大学、石川県金沢市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 3D Microenvironmental Regulation of Cultured Cell Using Micropatterned Techniques2013
- Author(s)
  Keitaro Yoshimoto
- Organizer
  ICBS2013
- Place of Presentation
  つくば国際会議場(茨城)
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 酵素/PEG化高分子電解質複合体ライブラリを利用するパターン認識に基づくタンパク質判別法2013
- Author(s)
  冨田峻介、吉本敬太郎
- Organizer
  第23回日本MRS年次大会
- Place of Presentation
  横浜市開港記念館、神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] マイクロパタンスフェロイド培養法を用いる脂肪幹細胞の高機能化：未分化状態および骨芽細胞分化時における三次元培養環境の効果／Spheroid Culture Using Micro-patterned Surface Leads to Upregulation of Cellar Functions in Adipose Derived Stem Cell on Differentiated and Undifferentiated State2013
- Author(s)
  菊池有夏、鈴木秀幸、佐藤守俊、高橋秀治、吉本敬太郎
- Organizer
  SCE2013　第33回キャピラリー電気泳動シンポジウム
- Place of Presentation
  東京大学、東京都文京区・日本女子大学、東京都文京区
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] マイクロパタンを用いる脂肪幹細胞の三次元化：骨芽細胞スフェロイドチップの構築2013
- Author(s)
  菊池有夏、吉本敬太郎
- Organizer
  日本分析化学会第73回分析化学討論会
- Place of Presentation
  北海道大学、北海道函館市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] Polyion complexes as a novel receptor library for a pattern　recognition based protein discrimination2013
- Author(s)
  Shunsuke Tomita, Keitaro Yoshimoto
- Organizer
  RSC-TIC2013
- Place of Presentation
  幕張メッセ、千葉県千葉市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 酵素/高分子電解質複合体ライブラリアレイを用いるタンパク質の交差反応型蛍光センシング2013
- Author(s)
  横山沙樹、冨田峻介、吉本敬太郎
- Organizer
  第23回日本MRS年次大会
- Place of Presentation
  横浜市開港記念館、神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] パターン認識に基づく酵素/荷電性ブロックコポリマー複合体ライブラリ―を利用する血漿タンパク質判別法の開発2013
- Author(s)
  冨田峻介、吉本敬太郎
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん分化会館, 鳥取県鳥取市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] Enzyme/PEGylated polyelectrolyte complexes: Novel receptor library　based on naturally occurring differentiation for plasma protein　identification2013
- Author(s)
  Shunsuke Tomita, Keitaro Yoshimoto
- Organizer
  The 4th Asian Biomaterial Congress
- Place of Presentation
  The Hong Kong University, Hong Kong, CHINA
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 酵素/PEG化高分子電解質複合体ライブラリを用いるパターン認識に基づく血漿タンパク質センシング法の開発2013
- Author(s)
  冨田峻介、吉本敬太郎
- Organizer
  日本分析化学会第73回分析化学討論会
- Place of Presentation
  北海道大学、北海道函館市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] Effect of 3D Cell Culture Environment using Hydrogel Micro-Patterned Surface on Cell Differentiation2012
- Author(s)
  Keitaro Yoshimoto
- Organizer
  IUMRS-ICEM 2012
- Place of Presentation
  パシフィコ横浜(神奈川)(依頼講演)
- Year and Date
  2012-09-27
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 高分子修飾表面の界面力-生体高分子・細胞に与える不思議な環境2012
- Author(s)
  吉本敬太郎
- Organizer
  第12回表面力セミナー
- Place of Presentation
  東北大学
- Year and Date
  2012-03-03
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] 3D Cell Co-culture System on Hydrogel Micro-Patterned Surface Fabricated by Photolithography2012
- Author(s)
  K., Yoshimoto, R., Kojima, E., Takahashi, M., Ichino, H., Miyoshi, and Yukio Nagasaki
- Organizer
  International Conference of Photopolymer Science and Technology (ICPST)
- Place of Presentation
  千葉大学(千葉)(依頼講演)
- Year and Date
  2012-06-27
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] マイクロパタンを用いた脂肪幹細胞の三次元化および機能解析2012
- Author(s)
  Y., Kikuchi, H., Suzuki, M., Sato, S., Takahashi, K, Yoshimoto.
- Organizer
  第64回日本生物工学会大会
- Place of Presentation
  神戸国際会議場(兵庫)
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 3D CULTURE SYSTEM ON A MICRO PATTERNED SURFACE FOR MPROVED DIFFERENTIATION CAPABILITIES OF ADIPOSE DERIVED STEM CELLS2012
- Author(s)
  Y., Kikuchi, H., Suzuki, M., Sato, S., Takahashi. and K., Yoshimoto,
- Organizer
  RSC Tokyo International Conference
- Place of Presentation
  幕張メッセ(千葉)
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] Upregulation of Cellar Function Using 3D Cell Culture Microenvironment Constructed by Adhesion-Controlled Micro-Patterned Surface2012
- Author(s)
  Keitaro Yoshimoto
- Organizer
  ソフトインターフェース SISYS2012
- Place of Presentation
  産業技術総合研究所(つくば市)(依頼講演)
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 培養細胞の構造制御と高機能化-細胞も3Dの時代2011
- Author(s)
  吉本敬太郎
- Organizer
  第12回機能構造と分析化学シンポジウム
- Place of Presentation
  東北大学
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] 3D Cell Co-culture System on Hydrogel Micro-Patterned Surface2011
- Author(s)
  吉本敬太郎
- Organizer
  MRS Fall Meeting
- Place of Presentation
  ボストン(アメリカ)(招待講演)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] 3D Cell Co-culture System on Hydrogel Micro-Patterned Surface2011
- Author(s)
  Keitaro Yoshimoto
- Organizer
  MRS Fall Meeting
- Place of Presentation
  Boston, USA
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] 分子認識の選択性を高めるソフト界面設計2011
- Author(s)
  吉本敬太郎,長崎幸夫
- Organizer
  日本分析化学会第60年会
- Place of Presentation
  名古屋大学
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] Fab'/mixed-PEG co-immobilized gold surface-The role of a PEG tethered layer in molecular recognition events-2011
- Author(s)
  Yukio Nagasaki, Motohiko Nishio, Keitaro Yoshimoto
- Organizer
  ICTF15
- Place of Presentation
  Fukuoka
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] Structural Analysis and Molecular Recognition Behavior of Bio-macromolecular/Polymer Hybrid Interface2011
- Author(s)
  Keitaro Yoshimoto
- Organizer
  ICAS2011
- Place of Presentation
  Kyoto International Conference Center, Kyoto, Japan
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] Surface engineering of antibody/PEG hybrid for design of high-performance immunolatex2010
- Author(s)
  Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto, Yukio Nagasaki
- Organizer
  IVC-18/ICN+T2010/ICSS-14/VASSCAA-5
- Place of Presentation
  Beijing, China.
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PLANNED-20106011
[Presentation] Design of antibody/PEG hybrid biointerface for obtaining high-performance immunolatex2010
- Author(s)
  Xiaofei Yuan, Dolca Fabregat, Keitaro Yoshimoto, Yukio Nagasaki
- Organizer
  Gordon Research Conferences(GRC)-Biointerface Science
- Place of Presentation
  Les Diablerets, Switzerland.
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PLANNED-20106011
[Presentation] 生体高分子構造の空間制御に基づく高性能診断法の開発2010
- Author(s)
  吉本敬太郎
- Organizer
  日本分析化学会第59年会
- Place of Presentation
  東北大学
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] 胎生肝細胞の長期培養と分化誘導法2010
- Author(s)
  吉本敬太郎,小島綾太,長崎幸夫
- Organizer
  第59回高分子学会年次大会
- Place of Presentation
  横浜
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22750066
[Presentation] Synthesis of Functionalized Naphthyridine Derivatives and Its Application for Fluorescence-Based Colorimetric Discriminatio n of Single Nucleotide Transversion International Symposium on atomic technology2009
- Author(s)
  厚見宙志、吉本敬太郎、齋藤伸吾、大熊盛也、前田瑞夫、長崎幸夫
- Organizer
  International Symposium on atomic technol ogy (ISAT3) 3rd Polyscale Technology Wo rkshop(PTW3)
- Place of Presentation
  Tokyo Internaitional Exchange Center, Tokyo ,Japan
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-20750055
[Presentation] Synthesis of Functionalized Naphthyridine Derivatives and Its Application for Fluorescence-Based Colorimetric Discrimination of Single Nucleotide Transversion International Symposium on atomic technology2009
- Author(s)
  厚見宙志、吉本敬太郎、齋藤伸吾、大熊盛也、前田瑞夫、長崎幸夫
- Organizer
  International Symposium on atomic technology (ISAT3) 3rd Polyscale Technology Workshop(PTW3)
- Place of Presentation
  Tokyo Internaitional Exchange Center(Tokyo、Japan)
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-20750055
[Presentation] PEG/PAMA/ssDNA 共固定化修飾金表面の構築とSPRによる一塩基多型の検出2008
- Author(s)
  松本慎哉, 吉本敬太郎, 長崎幸夫
- Organizer
  Biacore Symposium Japan 2008. d-11
- Place of Presentation
  品川プリンスホテル (国内)
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-18200033
[Presentation] Density Controlled PEG/Biomacromolecule Co-Immobilized Gold Surface as an Intelligent Sensor Platform2008
- Author(s)
  Keitaro Yoshimoto
- Organizer
  First International Symposium on Interdisciplinary Materials Science
- Place of Presentation
  Tsukuba International Congress Center (EPOCHAL TSUKUBA), (国際会議口頭)
- Year and Date
  2008-03-15
- Data Source
  KAKENHI-PROJECT-18200033
[Presentation] Enzyme/PEGylated polyelectrolte complexes library for pattern-based protein discrimination
- Author(s)
  Shunsuke Tomita, Keitaro Yoshimoto
- Organizer
  東京大学生命科学シンポジウム
- Place of Presentation
  東京大学伊藤国際学術研究センター、東京都文京区
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 非天然型三次元ニッチ形式に基づく脂肪幹細胞の機能制御に関する研究
- Author(s)
  吉本敬太郎
- Organizer
  再生医学・再生医療の先端融合的共同研究拠点
- Place of Presentation
  京都大学再生医科学研究所、京都府京都市
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 直交型四重極電極を用いた誘電泳動による迅速な細胞凝集体の作製
- Author(s)
  守島　麻、　安川　智之、　吉本　敬太郎、　水谷文雄
- Organizer
  第74回分析化学討論会
- Place of Presentation
  日本大学工学部（福島県郡山市）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 三次元化脂肪幹細胞の機能評価：マイクロパタン培養が創傷治療関連遺伝子に及ぼす影響
- Author(s)
  古旗　祐一、　吉本　敬太郎
- Organizer
  第74回分析化学討論会
- Place of Presentation
  日本大学工学部（福島県郡山市）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 規則性多孔体を利用した酵素利用技術の開発
- Author(s)
  吉本　敬太郎
- Organizer
  平成２６年度　東日本分析若手交流会
- Place of Presentation
  鶴岡メタボロームクラスター　レクチャーホール（山形県鶴岡市）
- Year and Date
  2014-07-11 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] Cell-based analysis and cell diagnostics using polymer chemistry
- Author(s)
  吉本　敬太郎
- Organizer
  日本分析化学会第６３年会　第１回アジア分析科学シンポジウム
- Place of Presentation
  広島大学（広島県広島市）
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-24350037
[Presentation] 3-D construction of adipose derived stem cells cultured on a microfabricated surface : effects on stemness and differentiation
- Author(s)
  菊池有夏、吉本敬太郎
- Organizer
  東京大学生命科学シンポジウム
- Place of Presentation
  東京大学伊藤国際学術研究センター、東京都文京区
- Data Source
  KAKENHI-PROJECT-24350037

1. NAGASAKI Yukio (90198309)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
2. OISHI Motoi (90419242)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. GEN Gyouhi (60422185)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MIYAMOTO Daisuke (30392145)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. TOMITA Shunsuke (50726817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. Saito Shingo (60343018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. TAKAHASHI Shuji (90447318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. Yamamoto Masaya (10332735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 堀口諭吉 (50609758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 安川智之 (40361167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 田畑泰彦 (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉冨徹 (20585799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 半田友衣子 (20586599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 星野友 (40554689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 澤田敏樹 (20581078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小出裕之 (60729177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 坂田飛鳥 (90528457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 松尾宗征 (90869025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 長野正展 (00771619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. TASAKI Yuiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

yoshimoto keitaro 吉本 敬太郎

YOSHIMOTO Keitaro 吉本 敬太郎

Research Projects

Research Products

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精密高分子と核酸との共進化と創薬Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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核酸アプタマーと機械学習を利用する血液凝固因子欠損症の高精度迅速診断Principal Investigator

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Development of next-generation pharmaceuticals through evolutionary engineering of p recision polymers

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Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methodsPrincipal Investigator

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Functional DNA aptamer selection by capillary electrophoresis

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Introduction and evaluation of micro beads-assisted capillary electrophoresis for nucleic acid aptamer selection systemsPrincipal Investigator

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Development of DEP device for analysis of mechanobiology that affects cell function and differentiationPrincipal Investigator

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Development of next-generation technologies for bone-cartilage regeneration on the basis of Raman profiling for regenerated bones and cartilages

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Development of theree-dimentional cell culture chip for drug screeningPrincipal Investigator

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Development of functional cell array for long-term survival and recovery of tissuesPrincipal Investigator

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Construction of Densely Packed Hybrid Biointerfase

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Development of hydrogen-bonding lanthanide complex that recognizes nucleic acid base and Its application for the determination of DNA sequencePrincipal Investigator

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遺伝子センシングを可能とするバイオナノ粒子の材料設計

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yoshimoto keitaro 吉本敬太郎

YOSHIMOTO Keitaro 吉本敬太郎