Obama Takashi 小濱孝士

… Alternative Names

OBAMA Takashi 小濱孝士

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Researcher Number	60395647
Other IDs
Affiliation (Current)	2025: 昭和大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 昭和大学, 薬学部, 准教授 2014 – 2015: 昭和大学, 薬学部, 講師 2007 – 2014: 昭和大学, 薬学部, 助教 2005: Showa University, School of Pharmaceutical Sciences, Research, 薬学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 59040:Nutrition science and health science-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator リポタンパク質 / 動脈硬化症 / 酸化LDL / 血管内皮細胞 / 好中球細胞外トラップ / 血管炎症 / 好中球 / LDL / モノクローナル抗体 / HDL … More / 動脈硬化 / リピドミクス / 酸化ストレス / プロテオーム … More Except Principal Investigator 酸化LDL / LC-MS/MS / 動脈硬化症 / リポタンパク質 / 酸化ストレス / 質量分析 / リゾホスファチジルコリン / 酸化リン脂質 / リピドミクス / 細胞内脂肪滴 / 中間比重粒子 / PLIN2 / COPⅡ小胞 / Sar1 / NETs / 急性心筋梗塞 / HDL / 好中球細胞外トラップ / 急性心筋後続 / 酸化HDL / Lp-PLA2 / リゾPC / LCAT / 安定同位体標識 / 動脈硬化 / oxidative stress / mass spectrometry / apoE-knockout mouse / monoclonal antibody / atherosclerosis / oxidized LDL / LDL / アポEノックアウトマウス / モノクローナル抗体 / 歯肉溝滲出液 / PAF-AH / ELISA / 歯周病 / 糖尿病 / apoB / アクロレイン / 酸化ホスファチジルコリン / LPP / トランスジェリン / プロテオミクス / 血管平滑筋細胞 / apoEノックアウトマウス / 生体内酸化LDL / apoE-ノックアウトマウス / 血管平滑筋 / ペルオキシレドキシン / 非アルコール性脂肪肝炎 / アディポフィリン / 肝細胞 / 生活習慣病 / メタボリックシンドローム / 脂肪肝 / トリグリセリド / Aキナーゼ / グルカゴン / 脂肪酸 / ADRP Less

Effects of neutrophil extracellular traps and lipoproteins on the function of vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  小濱孝士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Showa University
Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.
- Principal Investigator
  
  板部洋之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Effects of oxidized lipoproteins on neutrophil extracellular trap formation followed by vascular inflammationPrincipal Investigator
- Principal Investigator
  
  Obama Takashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa University
Proinflammatory activity elicited by oxidized low-density lipoproteins and neutrophil extracellular trap formationPrincipal Investigator
- Principal Investigator
  
  Obama Takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Studies on process of generation and metabolism of oxidized LDL in vivo.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Sensitive measurement of oxidized phospholipids as markers of oxidative stress and diseases.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Isolation and comprehensive analysisi of constituents in oxidized low-density lipoprotein in vivoPrincipal Investigator
- Principal Investigator
  
  OBAMA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Generation of plasma oxidized LDL in the early stages of atherogenesis
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Analysis of modified low-density lipoproteins in plasma of myocardial infarctionPrincipal Investigator
- Principal Investigator
  
  OBAMA Takashi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Biological and pharmaceutical study on intracellular lipid droplets which are the key organelle to understand life style diseases.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Separation and analysis of oxidized low-density lipoprotein in vivo using immunological technique.
- Principal Investigator
  
  ITABE Hiroyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

[Book] 酸化ストレスの医学2008
- Author(s)
  小浜孝士, 板部洋之, 他80名
- Total Pages
  384
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19590076
[Journal Article] The oxidized lipoproteins in vivo: its diversity and behavior in the human circulation2023
- Author(s)
  Hiroyuki Itabe, Takashi Obama
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 6 Pages: 5747-5747
- DOI
  10.3390/ijms24065747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06617, KAKENHI-PROJECT-19K07069
[Journal Article] Behavior of intracellular lipid droplets during cell division in HuH7 hepatoma cells2023
- Author(s)
  Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Masahiro Chatani, Yuki Azetsu, Kosuke Kawaguchi, Tsuneo Imanaka, Hiroyuki Itabe
- Journal Title
  
  Exp Cell Res.
  
  Volume: 433 Issue: 2 Pages: 113855-113855
- DOI
  10.1016/j.yexcr.2023.113855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-22K06617, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-19KK0233
[Journal Article] Sar1 affects the localization of perilipin 2 to lipid droplets2022
- Author(s)
  Tomohiko Makiyama, Takashi Obama, Yuichi Watanabe, Hiroyuki Itabe
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 2 Issue: 12 Pages: 6366-6366
- DOI
  10.3390/ijms23126366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06617
[Journal Article] High-Density Lipoprotein Suppresses Neutrophil Extracellular Traps Enhanced by Oxidized Low-Density Lipoprotein or Oxidized Phospholipids2022
- Author(s)
  Ohinata Hitomi、Obama Takashi、Makiyama Tomohiko、Watanabe Yuichi、Itabe Hiroyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 22 Pages: 13992-13992
- DOI
  10.3390/ijms232213992
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07069
[Journal Article] Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein2021
- Author(s)
  Itabe Hiroyuki、Sawada Naoko、Makiyama Tomohiko、Obama Takashi
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 6 Pages: 655-655
- DOI
  10.3390/biomedicines9060655
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069
[Journal Article] Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins2020
- Author(s)
  Odanaka Hibiki、Obama Takashi、Sawada Naoko、Sugano Marika、Itabe Hiroyuki、Yamamoto Matsuo
- Journal Title
  
  Biological Research
  
  Volume: 53 Issue: 1 Pages: 3-3
- DOI
  10.1186/s40659-020-0271-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K19034
[Journal Article] Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Shinji Koba, Takashi Takaki, Sanju Iwamoto, Toshihiro Aiuchi, Rina Kato, Masaki Kikuchi, Yuji Hamazaki, Hiroyuki Itabe.
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051
[Journal Article] Neutrophils as a novel target of modified low-density lipoproteins and an accelerator of cardiovascular diseases.2020
- Author(s)
  Takashi Obama, Hiroyuki Itabe
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 21 Pages: 8312-8312
- DOI
  10.3390/ijms21218312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069
[Journal Article] Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins.2020
- Author(s)
  Naoko Sawada, Takashi Obama, Mirei Mizuno, Kiyoshi Fukuhara, Sanju Iwamoto, Toshihiro Aiuchi, Tomohiko Makiyama and Hiroyuki Itabe
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 11 Pages: 1045-1045
- DOI
  10.3390/antiox9111045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL.2020
- Author(s)
  Sawada Naoko、Obama Takashi、Koba Shinji、Takaki Takashi、Iwamoto Sanju、Aiuchi Toshihiro、Kato Rina、Kikuchi Masaki、Hamazaki Yuji、Itabe Hiroyuki
- Journal Title
  
  Journal of Lipid Research
  
  Volume: - Issue: 6 Pages: 816-829
- DOI
  10.1194/jlr.ra119000312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11426, KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069
[Journal Article] Evaluation of protein-protein interactions using an on-membrane digestion technique2019
- Author(s)
  Obama Takashi、Miyazaki Takuro、Aiuchi Toshihiro、Miyazaki Akira、Itabe Hiroyuki
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 149 Issue: 149 Pages: 149-149
- DOI
  10.3791/59733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K08590
[Journal Article] 動脈硬化とNETs：酸化LDLとの相乗的作用2019
- Author(s)
  小濱孝士、板部洋之
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 9 Pages: 304-310
- Data Source
  KAKENHI-PROJECT-19K07069
[Journal Article] Proteomics of human glomerulonephritis by laser microdissection and liquid chromatography‐tandem mass spectrometry2019
- Author(s)
  Kawata Naoto、Kang Dedong、Aiuchi Toshihiro、Obama Takashi、Yoshitake Osamu、Shibata Takanori、Takimoto Masafumi、Itabe Hiroyuki、Honda Kazuho
- Journal Title
  
  Nephrology
  
  Volume: 25 Issue: 4 Pages: 351-359
- DOI
  10.1111/nep.13676
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K07445, KAKENHI-PROJECT-16K11070, KAKENHI-PROJECT-19K08690
[Journal Article] Cooperative action of oxidized low-density lipoproteins and neutrophils on endothelial inflammatory responses through neutrophil extracellular trap formation2019
- Author(s)
  Obama Takashi、Ohinata Hitomi、Takaki Takashi、Iwamoto Sanju、Sawada Naoko、Aiuchi Toshihiro、Kato Rina、Itabe Hiroyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 1899-1899
- DOI
  10.3389/fimmu.2019.01899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07051, KAKENHI-PROJECT-19K07069, KAKENHI-PROJECT-19K07423
[Journal Article] Temporal and spatial changes of peroxiredoxin 2 levels in aortic media at very early stages of atherosclerotic lesion formation in apoE-knockout mice.2019
- Author(s)
  Kato R, Hayashi M, Aiuchi T, Sawada N, Obama T, Itabe H.
- Journal Title
  
  Free Radic Biol Med.
  
  Volume: 130 Pages: 348-360
- DOI
  10.1016/j.freeradbiomed.2018.10.458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08245, KAKENHI-PROJECT-18K06666
[Journal Article] Significance of oxidized low-density lipoprotein in body fluids as a marker related to diseased conditions.2018
- Author(s)
  Itabe Hiroyuki、Kato Rina、Sasabe Naoko、Obama Takashi、Yamamoto Matsuo
- Journal Title
  
  Curr Med Chem
  
  Volume: 25 Issue: 9 Pages: 1576-1593
- DOI
  10.2174/0929867325666180307114855
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08245, KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-19K07051
[Journal Article] Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth.2017
- Author(s)
  Moriya Y, Obama T, Aiuchi T, Sugiyama T, Endo Y, Koide Y, Noguchi E, Ishizuka M, Inoue M, Itabe H, Yamamoto M.
- Journal Title
  
  Journal of Clinical Periodontology
  
  Volume: 印刷中 Issue: 4 Pages: 353-362
- DOI
  10.1111/jcpe.12696
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-16K08245
[Journal Article] Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes.2015
- Author(s)
  Nimura S, Yamaguchi T, Ueda K, Kadokura K, Aiuchi T, Kato R, Obama T, Itabe H.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 467 Issue: 4 Pages: 906-912
- DOI
  10.1016/j.bbrc.2015.10.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-26460077
[Journal Article] 生体内酸化LDL中のバイオマーカー網羅的探索2015
- Author(s)
  小浜孝士、板部洋之
- Journal Title
  
  昭和学士会雑誌
  
  Volume: 75
- NAID
  130005108374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790087
[Journal Article] Tomohiro Yamaguchi, Noriyuki Fujikawa, Satomi Nimura, Yutaro Tokuoka, Sonoka Tsuda, Toshihiro Aiuchi, Rina Kato, Takashi Obama, Hiroyuki Itabe. Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation.2015
- Author(s)
  Yamaguchi T, Fujikawa N, Nimura S, Tokuoka Y, Tsuda S, Aiuchi T, Kato R, Obama T, Itabe H.
- Journal Title
  
  BBA - Molecular and Cell Biology of Lipids
  
  Volume: 1851 Issue: 10 Pages: 1285-1295
- DOI
  10.1016/j.bbalip.2015.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07944, KAKENHI-PROJECT-26460077
[Journal Article] Targeting Neutrophil: New Approach Against Hypertensive Cardiac Remodeling?2014
- Author(s)
  Obama T, Scalia R, Eguchi S
- Journal Title
  
  Hypertension
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790087
[Journal Article] Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase.2014
- Author(s)
  Takayanagi T, Crawford KJ, Kobayashi T, Obama T, Tsuji T, Elliott KJ, Hashimoto T, Rizzo V, Eguchi S
- Journal Title
  
  Clin Sci (Lond)
  
  Volume: 126 Issue: 11 Pages: 785-794
- DOI
  10.1042/cs20130660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790087
[Journal Article] The apolipoprotein B concentration in gingival crevicular fluid increases in patients with diabetes mellitus.2014
- Author(s)
  Noguchi E, Kato R, Ohno K, Mitsui A, Obama T, Hirano T, Itabe H, Yamamoto M.
- Journal Title
  
  Clinical Biochemistry
  
  Volume: 47 Issue: 1-2 Pages: 67-71
- DOI
  10.1016/j.clinbiochem.2013.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590094, KAKENHI-PROJECT-24790087
[Journal Article] Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein2014
- Author(s)
  Sasabe N, Keyamura Y, Obama T, Inoue N, Igarashi Y, Aiuchi T, Kato R, Yamaguchi T, Kuwata H, Iwamoto S, Miyazaki A, Hara S, Yoshikawa T, Itabe H
- Journal Title
  
  Lipids Health Dis
  
  Volume: 13 Issue: 1 Pages: 48-48
- DOI
  10.1186/1476-511x-13-48
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591341, KAKENHI-PROJECT-24590094, KAKENHI-PROJECT-24790087, KAKENHI-PROJECT-25293033
[Journal Article] Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?2014
- Author(s)
  Obama T, Eguchi S
- Journal Title
  
  Clin Sci (Lond)
  
  Volume: 127 Issue: 1 Pages: 15-17
- DOI
  10.1042/cs20140081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790087
[Journal Article] Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor-1α2014
- Author(s)
  Obama T, Takayanagi T, Kobayashi T, Bourne AM, Elliott KJ, Charbonneau M, Dubois CM, Eguchi S
- Journal Title
  
  Am J Hypertens
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790087
[Journal Article] Crucial role of perilipin-3 (TIP47) in formation of lipid droplets and PGE2 production in HL-60-derived neutrophils.2013
- Author(s)
  Nose F, Yamaguchi T, Kato R, Aiuchi T, Obama T, Hara S, Yamamoto M, Itabe H.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 8 Pages: 71542-71542
- DOI
  10.1371/journal.pone.0071542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790098, KAKENHI-PROJECT-24590094, KAKENHI-PROJECT-24790087, KAKENHI-PUBLICLY-25116720
[Journal Article] The dynamics of oxidized LDL during atherogenesis2011
- Author(s)
  Itabe H, Obama T, Kato R.
- Journal Title
  
  J. Lipids
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] The dynamics of oxidized LDL during atherogenesis2011
- Author(s)
  Itabe H, Obama T, Kato R
- Journal Title
  
  Journal of Lipids Article ID
  
  Pages: 418313-418313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Oxidized low-density lipo-protein induced periodontal inflammation is associated with up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells2011
- Author(s)
  Nagahama Y, Obama T, Usui M, Kanazawa Y, Iwamoto S, Suzuki K, Miyazaki A, Yamaguchi T, Yamamoto M, Itabe H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 413(4) Pages: 566-571
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice : Suppression of lipin-1 and -2 in the glycerol-3-phosphate2011
- Author(s)
  Takashi Obama, et al
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 8 Pages: 22917-22917
- DOI
  10.1371/journal.pone.0022917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073, KAKENHI-PROJECT-22500390, KAKENHI-PROJECT-23790098
[Journal Article] The dynamics of oxidized LDL during atherogenesis.2011
- Author(s)
  Itabe H、 Obama T, Kato R.
- Journal Title
  
  J.Lipids
  
  Volume: 2(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver.2011
- Author(s)
  Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H.
- Journal Title
  
  J lipid Res. 51
  
  Pages: 2571-2580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] The dynamics of oxidized LDL during atherogenesis2011
- Author(s)
  Hiroyuki Itabe, Takashi Obama, Rina Kato
- Journal Title
  
  Journal of Lipids
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Dietary cholesterol reduces plasma triacyl-glycerol in apolipoprotein E-null mice : Suppression of lipin-1 and-2 in the glycerol-3-phosphate pathway2011
- Author(s)
  Obama T, Nagaoka S, Akagi K, Kato R, Horiuchi N, Horai N, Aiuchi T, Arata S, Yamaguchi T, Watanabe M, Itabe H.
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Oxidized low-density lipoproteins increases IL-8 production in human gingival epithelial cell line Ca9-222010
- Author(s)
  Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M.
- Journal Title
  
  Periodont. Res
  
  Volume: 45(4) Pages: 488-495
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Immunoprecipitation and LC-MS/MS analysis of human oxidized low-density lipoprotein from plasma2010
- Author(s)
  Takashi Obama, Masaki Kikuchi, Takayuki Shiraiwa, Rina Kato, Hiroyuki Itabe
- Journal Title
  
  Chemistry and Physics of Lipids
  
  Volume: 163S
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Oxidized Low-Density Lipoproteins enhances IL-8 production in Human Gingival Epithelial Cells2010
- Author(s)
  Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M
- Journal Title
  
  Journal of Periodontal Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver2010
- Author(s)
  Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H.
- Journal Title
  
  J. Lipid Res
  
  Volume: 51(9) Pages: 2571-2580
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Oxidized low-density lipoproteins increases IL-8 production in human gingival epithelial cell line Ca9-22.2010
- Author(s)
  Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M.
- Journal Title
  
  J.Periodont.Res.
  
  Volume: 46 Pages: 488-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Immunoprecipitation and LC-MS/MS analysis of human oxidized low-density lipoprotein from plasma2010
- Author(s)
  Obama T, Kikuchi M, Shiraiwa T, Kato R, Itabe H
- Journal Title
  
  Chemistry and Physics of Lipids 163S
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Oxidized Low-Density Lipoproteins enhances IL-8 production in Human Gingival Epithelial Cells2010
- Author(s)
  Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 45 Pages: 488-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Oxidized Low-Density Lipoproteins enhances IL-8 production in Human Gingival Epithelial Cells2010
- Author(s)
  Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M
- Journal Title
  
  J Period Res. 45
  
  Pages: 488-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Immunohistochemical detection of 13(R)-hydroxyoctadecadienoic acid in atherosclerotic plaques of human carotid arteries using a novel specific antibody.2010
- Author(s)
  Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H.
- Journal Title
  
  J.Lipid Res.
  
  Volume: 51 Pages: 2571-2580
- NAID
  130000142919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice2009
- Author(s)
  Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, Itabe H.
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol
  
  Volume: 29(1) Pages: 33-39
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice2009
- Author(s)
  Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, Itabe H.
- Journal Title
  
  Arterioscler.Thromb.Vasc.Biol. 29
  
  Pages: 33-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Transient Increase in Plasma Oxidized LDL During the Progression of Atherosclerosis in Apolipoprotein E Knockout Mice.2009
- Author(s)
  Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, Itabe H.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 29
  
  Pages: 33-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790092
[Journal Article] Oxidized low-density lipoproteins increases IL-8 production in human gingival epithelial cell line Ca9-222009
- Author(s)
  Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M.
- Journal Title
  
  J.Periodont.Res.
  
  Pages: 4-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590073
[Journal Article] Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice.2009
- Author(s)
  Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, Itabe H.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 29
  
  Pages: 33-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590076
[Journal Article] Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice2009
- Author(s)
  Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, and Itabe H.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 29(1)
  
  Pages: 33-39
- Data Source
  KAKENHI-PROJECT-19590076
[Journal Article] A tryrosine kinase inhibitor,β-hydroxyisovalerylshikonin,inducepoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity2008
- Author(s)
  Kajimoto S, Horie M, Manabe H, Masuda Y, Shibayama-lmazu T, Nakajo S, Xiang Feng Gong, Obama T, Itabe H, Nakaya K.
- Journal Title
  
  BBA-Molecular Basis of Disease. 1782
  
  Pages: 41-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590076
[Journal Article] Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS2007
- Author(s)
  Obama T, Kato R, Masuda Y, Takahashi K, Aiuchi T, and Itabe H.
- Journal Title
  
  Proteomics 7
  
  Pages: 2132-2141
- Data Source
  KAKENHI-PROJECT-19590076
[Journal Article] Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS2007
- Author(s)
  Obama T, Kato R, Masuda Y, Takahashi K, Aiuchi T, Itabe H.
- Journal Title
  
  Proteomics 7
  
  Pages: 2132-2141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590076
[Patent] タンパク質又はペプチドをスルホン酸誘導体化する方法、及びタンパク質又はペプチドのアミノ酸配列を決定する方法2010
- Inventor(s)
  小濱孝士、山口実、九山浩樹、安藤英治
- Industrial Property Rights Holder
  株式会社島津製作所
- Acquisition Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-21790092
[Patent] タンパク質又はペプチドをスルホン酸誘導体化する方法、及びタンパク質又はペプチドのアミノ酸配列を決定する方法2010
- Inventor(s)
  小濱孝士, 他3名
- Industrial Property Rights Holder
  島津製作所
- Acquisition Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-21790092
[Patent] タンパク質又はペプチドのスルホン酸誘導体化されたN末端ペプチドフラグメントを質量分析する方法2010
- Inventor(s)
  乗岡茂巳、山口実、九山浩樹、小濱孝士、安藤英治、中澤隆、上山憲一、岡村高明
- Industrial Property Rights Holder
  株式会社島津製作所
- Acquisition Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21790092
[Patent] Methods for derivatizing protein or peptide with sulfonic acid groups2009
- Inventor(s)
  小濱孝士, 他7名
- Industrial Property Rights Holder
  島津製作所
- Acquisition Date
  2009-08-25
- Data Source
  KAKENHI-PROJECT-21790092
[Patent] Methods for derivatizing protein or peptide with sulfonic acid groups2009
- Inventor(s)
  乗岡茂巳、山口実、九山浩樹、小濱孝士、安藤英治、中澤隆、上山憲一、岡村高明
- Industrial Property Rights Holder
  株式会社島津製作所
- Acquisition Date
  2009-08-25
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] Involvement of high-density lipoprotein in oxidatively modified forms of low-density lipoproteins in human circulation.2020
- Author(s)
  H. Itabe, N. Sawada T. Obama, S.
- Organizer
  SFRR-India 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] Oxidatively modified low-density lipoproteins enhance endothelial inflammatory responses through accelerated neutrophil extracellular trap formation2019
- Author(s)
  Takashi Obama, Naoko Sawada, Toshihiro Aiuchi, Rina Kato and Hiroyuki Itabe
- Organizer
  The 9th SFRR-Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07069
[Presentation] 安定同位体リピドミクスを利用したLDL-HDL間の酸化PC代謝解析2019
- Author(s)
  澤田直子、小濱孝士、福原潔、水野美麗、巖本三壽、相内敏弘、板部洋之
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] Structure and compositional analysis of oxidized low-density lipoproteins present in plasma from healthy subjects and patients with atherosclerosis2019
- Author(s)
  Naoko Sawada, Takashi Obama, Sanju Iwamoto, Shinji Koba, Toshihiro Aiuchi, Rina Kato, Hiroyuki Itabe
- Organizer
  The 9th Biennial Meeting of Society for Free Radical Research-Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07051
[Presentation] 血管内皮細胞の炎症誘導における好中球細胞外トラップと酸化LDLの関与」　日本薬学会第138年会2018
- Author(s)
  小浜孝士、池田葵、今井瑞菜、上田晃輝、門倉夏林、髙橋江里奈、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化症患者血漿中の酸化LDLの分離とその性状解析2018
- Author(s)
  澤田直子、小浜孝士、巖本三壽、木庭新治、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] HL-60由来好中球の好中球細胞外トラップ形成と酸化LDL：ミエロペルオキシダーゼ放出に対する影響2018
- Author(s)
  中村美沙季、綾部かれん、小濱孝士、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 好中球細胞外トラップ形成への酸化LDLの関与と血管内皮細胞の炎症応答2018
- Author(s)
  小濱孝士、綾部かれん、大日方瞳、大矢夏菜、栗原徹、須賀日咲子、高林衿花、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 動脈硬化初期病変進展過程における抗酸化タンパク質Peroxiredoxin 2及びThioredoxin低下による平滑筋細胞の酸化ストレス亢進2018
- Author(s)
  加藤里奈、嶋崎萌夏、小澤雪乃、知念良憲、渡辺窓香、上當明徳、高田紫苑、相内敏弘、澤田直子、小浜孝士、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 好中球細胞外トラップと酸化LDLによるヒト血管内皮細胞での炎症誘導2018
- Author(s)
  伊藤沙恵、大矢夏菜、須賀日咲子、小濱孝士、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 好中球細胞外トラップと酸化LDLによるヒト血管内皮細胞の形態変化2018
- Author(s)
  森谷拓海、高林衿花、小濱孝士、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] HL-60由来好中球の好中球細胞外トラップ形成と酸化LDL：DNA放出に対する影響2018
- Author(s)
  清水優花、大日方瞳、栗原徹、小濱孝士、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 血管内皮細胞の炎症誘導における好中球細胞外トラップと酸化LDLの関与2018
- Author(s)
  小濱孝士、池田葵、今井瑞菜、上田晃輝、門倉夏林、髙橋江里奈、澤田直子、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 安定同位体リピドミクスを用いたHDLによるLDL酸化抑制機構の解析2017
- Author(s)
  笹部直子、小浜孝士、増田しおり、髙田夏鈴、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 歯肉溝滲出液中の酸化LDLと歯周病に伴う炎症について2017
- Author(s)
  石塚元規、板部洋之、加藤里奈、守屋佑美、山本松男、笹部直子、小濱孝士
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] HDLによるLDL中の酸化PC代謝の安定同位体リピドミクスを用いた解析2017
- Author(s)
  笹部直子、小浜孝士、増田しおり、高田夏鈴、櫻井彩伽、長谷川拓也、福原潔、水野美麗、相内敏弘、加藤里奈、板部洋之
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化初期病変進展過程における平滑筋細胞の酸化ストレス上昇と形質変化の関係性2017
- Author(s)
  加藤里奈、嶋﨑萌夏、鈴木花菜、小澤雪乃、知念良憲、渡辺窓香、相内敏弘、笹部直子、小浜孝士、板部洋之
- Organizer
  第49回日本動脈硬化学会・学術集会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 安定同位体リピドミクスを用いたHDLによるLDL酸化抑制機構の解析2017
- Author(s)
  笹部直子、小濱孝士、増田しおり、髙田夏鈴、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 歯肉溝滲出液中の酸化LDLと歯周病に伴う炎症について2017
- Author(s)
  石塚元規、板部洋之、加藤里奈、守屋佑美、山本松男、笹部直子、小浜孝士
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] 動脈硬化進展初期過程における平滑筋細胞のPerxoiredoxin 2低下による酸化ストレス亢進と形質変化2017
- Author(s)
  加藤里奈、嶋﨑萌夏、鈴木花菜、小澤雪乃、知念良憲、渡辺窓香、相内敏弘、笹部直子、小浜孝士、板部洋之
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト血漿からの酸化LDL分離と脂質酸化による性状の変化2016
- Author(s)
  小濱孝士、笹部直子、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  にぎわい交流館AU（秋田）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] ヒト血漿から分離した酸化LDLに含まれる酸化リン脂質と変性タンパク質の解析2016
- Author(s)
  笹部直子、小濱孝士、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京）
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] ヒト血漿からの酸化LDL分離と脂質酸化による性状の変化2016
- Author(s)
  小浜孝士、笹部直子、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト血漿から分離した酸化LDLに含まれる酸化リン脂質と変性タンパク質の解析2016
- Author(s)
  笹部直子、小浜孝士、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  衛生薬学・環境トキシロジーフォーラム2016
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト血漿から分離した酸化LDLのリン脂質プロファイルとリポタンパク質の酸化変性2016
- Author(s)
  小濱孝士、笹部直子、井上望、橋本哲弥、久保祐貴、巖本三壽、相内敏弘、加藤里奈、板部洋之
- Organizer
  日本過酸化脂質・抗酸化物質学会　第24回年会
- Place of Presentation
  東北大学片平さくらホール（仙台）
- Data Source
  KAKENHI-PROJECT-16K08245
[Presentation] 安定同位体リピドミクスによる酸化LDL-HDL間の脂質利モデリングの解析2016
- Author(s)
  増田しおり、高田夏鈴、小浜孝士、相内敏弘、加藤里奈、山口智広、板部洋之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] Reduced expression of peroxiredoxin 2 in smooth muscle cells at the onset of atherogenesis in apoE-knockout mice.2015
- Author(s)
  Itabe H, Kato R, Hayashi M, Obama T, Aiuchi T, Yamaguchi T.
- Organizer
  11th International Congress on Coronary Artery Disease
- Place of Presentation
  フローレンス
- Year and Date
  2015-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07944
[Presentation] ヒト血漿中から分離した変性 LDL の酸化変性とリン脂質分子種の解析2014
- Author(s)
  笹部直子 ,和田暁 ,梅宮大貴 ,佐々木愛紗 ,小浜孝士 ,相内敏弘, 加藤里奈 ,山口智広 ,板部洋之
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Vascular Smooth Muscle ADAM17 Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation but not Hypertension in Mice2014
- Author(s)
  Obama T, Takayanagi T, Kobayashi T, Hashimoto T, Eguchi S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Lucca, Italy
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Caveolin-1 is Critical for Abdominal Aortic Aneurysm Induced by Angiotensin II2013
- Author(s)
  Obama T, Crawford KJ, Tsuji T, Takayanagi T, Rizzo V, Eguchi S
- Organizer
  AHA Scientific Sessions
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Caveolin-1 is Critical for Abdominal Aortic Aneurysm Induced by Angiotensin II2013
- Author(s)
  Obama T, Takayanagi T, Crawford KJ, Kobayashi T, Rizzo V, Eguchi S
- Organizer
  High Blood Pressure Research
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Separation and characterization of oxidized LDL from human plasma2012
- Author(s)
  Itabe H, Obama T, Koba S, Aiuchi T, Kato R, Yamaguchi T
- Organizer
  International Conferernce on Biochemistry of Lipids
- Place of Presentation
  Banff, Canada
- Data Source
  KAKENHI-PROJECT-24590094
[Presentation] 生体内で生成する酸化LDLの性状と質量分析法による酸化脂質の分析2012
- Author(s)
  小浜孝士, 他
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590073
[Presentation] 酸化LDL中の酸化修飾リポタンパク質のLC-MS/MS解析2012
- Author(s)
  守谷瑠梨子、伊藤綾花、小浜孝士、相内敏弘、加藤里奈、山口智広、板部洋之
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  昭和大学薬学部（東京）
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿からの酸化LDLの分離と酸化脂質の分子種解析2012
- Author(s)
  小浜孝士、楠ノ瀬雄也、髙橋あい理、加納明日香、田辺佳那子、木庭新治、濱嵜裕司、小林洋一、相内敏弘、加藤里奈、山口智広、板部洋之
- Organizer
  第13回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  日本薬学会長井記念ホール（東京）
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Characterization of oxidized phospholipids and cholesterol esters in human oxidized low-density lipoproteins by LC-ESI-MS/MS2012
- Author(s)
  小浜孝士、髙橋あい理、楠ノ瀬雄也、加納明日香、田辺佳那子、濱嵜裕司、加藤里奈、相内敏弘、山口智広、木庭新治、小林洋一、板部洋之
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Immunoprecipitation and LC-MS/MS analysis of human oxidized low-density lipoprotein from plasma2012
- Author(s)
  Hiroyuki Itabe , Takashi Obama, Airi Takahashi, Yuya Kusunose, Toshihiro Aiuchi, Rina Kato, Tomohiro Yamaguchi
- Organizer
  53rd International Conference on the Bioscience of Lipids
- Place of Presentation
  Banff Centre (Banff Alberta, Canada)
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿から分離した酸化LDLに存在する酸化脂質の網羅的解析2012
- Author(s)
  小浜孝士、髙橋あい理、楠ノ瀬雄也、木庭新治、濱嵜裕司、小林洋一、相内敏弘、加藤里奈、山口智広、板部洋之
- Organizer
  第54回日本脂質生化学会
- Place of Presentation
  九州大学医学部百年講堂（福岡）
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] 生体内酸化LDLに現れる特異的脂質成分の解析2012
- Author(s)
  井上望、増子幸志、小浜孝士、相内敏弘、加藤里奈、山口智広、板部洋之
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  昭和大学薬学部（東京）
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-knockout mice : Suppression of lipin-1 and lipi-2 in the glycerol-3-2011
- Author(s)
  小浜孝士, 他
- Organizer
  第43回日本動脈硬化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590073
[Presentation] 冠動脈疾患患者の血中に存在する酸化LDLの性状解析2011
- Author(s)
  小浜孝士, 他
- Organizer
  第53回日本脂質生化学会
- Place of Presentation
  東京・湯島
- Data Source
  KAKENHI-PROJECT-21590073
[Presentation] 生体内で生じた酸化LDLの脂質過酸化物による修飾2011
- Author(s)
  小濱孝士、白岩誉裕希、楠ノ瀬雄也、加藤里奈、山口智広、板部洋之
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] 生体内で生じた酸化LDLの脂質過酸化物による修飾2011
- Author(s)
  小浜孝士、白岩誉裕希、楠ノ瀬雄也、加藤里奈、山口智広、板部洋之
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] 動脈硬化の発症と大動脈組織の脂質過酸化物沈着2010
- Author(s)
  林暢孝、加藤里奈、宮越由佳、天日雅行、小濱孝士、山口智広、板部洋之
- Organizer
  第11回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] Immunoprecipitation and LC-MS/MS analysis of human oxidized low-density lipoprotein from plasma2010
- Author(s)
  Obama T, Kikuchi M, Shiraiwa T, Kato R, Itabe H
- Organizer
  51st International Conference on the Bioscience of Lipids
- Place of Presentation
  Bilbao, Spain
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] apoEノックアウトマウス大動脈の動脈硬化初期段階における脂質過酸化物の出現2010
- Author(s)
  林暢孝、加藤里奈、宮越由佳、天日雅行、荒田悟、小濱孝士、山口智広、板部洋之
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] MLTC-1ライディッヒ細胞における脂肪滴局在タンパク質のプロテオミクス2010
- Author(s)
  藤川典之、山口智広、津田園佳、徳岡雄太郎、長澤充、小浜孝士、加藤里奈、板部洋之
- Organizer
  第54回日本薬学会関東支部会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21590073
[Presentation] 肝トリグリセリド合成の制御機構の解析～コレステロール摂取によるlipin発現の抑制2010
- Author(s)
  小浜孝士、赤城和貴、長岡彩香、堀内尚美、加藤里奈、山口智広、渡辺光博、板部洋之
- Organizer
  第52回日本脂質生化学会
- Place of Presentation
  伊香保温泉
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PROJECT-21590073
[Presentation] 動脈硬化の発症と大動脈組織の脂質過酸化物沈着2010
- Author(s)
  林暢孝、加藤里奈、宮越由佳、天日雅行、小浜孝士、山口智広、板部洋之
- Organizer
  第11回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21590073
[Presentation] コレステロールにより変動するマウス肝のTG合成・VLDL形成の制御2009
- Author(s)
  赤木和貴、長岡彩香、小浜孝士、加藤里奈、板部洋之
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ボートアイランド
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] 肝トリグリセリド合成の制御機構の解析～コレステロール摂取によるlipin発現の抑制2009
- Author(s)
  小濱孝士、赤木和貴、長岡彩香、堀内尚美、加藤里奈、山口智広、板部洋之
- Organizer
  第52回日本脂質生化学会
- Place of Presentation
  群馬
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] Oxidized low-density lipoproteins enhances IL-8 production in human gingival epithelial cell line Ca9-222009
- Author(s)
  Suzuki K, Obama T, Sakiyama Y, Usui M, Kato R, Yamamoto M, Itabe H
- Organizer
  4th International Conference on Phospholipase A2 and Lipid Mediator (PLM2009)
- Place of Presentation
  学術総合センター
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] 食餌性コレステロールによるapoE-KOマウスのトリグリセリド代謝変動解析2009
- Author(s)
  赤木和貴、長岡彩香、小浜孝士、加藤里奈、板部洋之
- Organizer
  第10回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  長井記念ホール
- Data Source
  KAKENHI-PROJECT-21790092
[Presentation] 動脈硬化の初期過程においてパーオキシレドキシンと-平滑筋型アクチンの発現が低下した平滑筋細胞はMCP-1が誘導される
- Author(s)
  加藤里奈、林暢孝、鈴木裕之、三井敦、松井浩志、宮越由佳、天日雅行、相内敏弘、笹部直子、小浜孝士、山口智広、板部洋之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] OxPC/lysoPC profiles in oxidized LDL separated from in human circulating plasma
- Author(s)
  Itabe H, Sasabe N, Obama T, Inoue N, Aiuchi T, Kato R, Koba S, Yamaguchi T
- Organizer
  PLM2015
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿中からの酸化LDL分離とリン脂質プロファイルの解析
- Author(s)
  小浜孝士、笹部直子、井上望、相内敏弘、木庭新治、加藤里奈、山口智広、板部洋之
- Organizer
  第２６回ビタミンＥ研究会
- Place of Presentation
  北里大学薬学部（東京）
- Year and Date
  2015-01-09 – 2015-01-10
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿中酸化LDLのリン脂質プロファイル
- Author(s)
  板部洋之、笹部直子、井上望、相内敏弘、木庭新治、加藤里奈、小浜孝士、山口智広
- Organizer
  第67回日本酸化ストレス学会
- Place of Presentation
  同志社大学今出川キャンパス（京都）
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] 酸化LDL生成時におけるリン脂質プロファイルの経時変化とLp-PLA2の役割
- Author(s)
  笹部直子、毛谷村由佳、小浜孝士、井上望、増子幸志、五十嵐優、相内敏弘、加藤里奈、山口智広、桑田浩、原俊太郎、吉川智博、板部洋之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（神戸）他
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿中から分離した酸化LDLのapoB変性とリン脂質分子種の解析
- Author(s)
  笹部直子、小浜孝士、矢澤快、大坪茉莉子、羽田幸代、井上望、相内敏弘、木庭新治、加藤里奈、山口智広、板部洋之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590094
[Presentation] 動脈硬化の初発反応の探索:中膜平滑筋の peroxiredoxin2 の発現低下と MCP-1 発現亢進
- Author(s)
  加藤里奈、林暢孝、鈴木裕之、三井敦、松井浩志、宮越由佳、天日雅行、相内敏弘、笹部直子、小浜孝士、山口智広、板部洋之
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] パーオキシレドキシン2 の発現が低下した脱分化型平滑筋細胞による初期動脈硬化の進展促進
- Author(s)
  加藤里奈、林暢孝、鈴木裕之、三井敦、松井浩志、宮越由佳、天日雅行、相内敏弘、笹部直子、小浜孝士、山口智広、板部洋之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（神戸）他
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿中の酸化LDLの性状　～質量分析計を用いた脂質プロファイルの検討～
- Author(s)
  笹部直子、○板部洋之、井上望、和田暁、梅宮大貴、佐々木愛紗、相内敏弘、加藤里奈、小浜孝士、山口智広
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24590094
[Presentation] 酸化LDL生成時におけるリン脂質プロファイルの経時変化とLp-PLA2の役割
- Author(s)
  笹部直子、毛谷村由佳、○小浜孝士、井上望、増子幸志、五十嵐優、相内敏弘、加藤里奈、山口智広、桑田浩、原俊太郎、吉川智博、板部洋之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590094
[Presentation] ヒト血漿中の酸化LDLの性状～質量分析計を用いた脂質プロファイルの検討～
- Author(s)
  笹部直子、板部洋之、井上望、和田暁、梅宮大貴、佐々木愛紗、相内敏弘、加藤里奈、小浜孝士、山口智広
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24790087
[Presentation] ヒト血漿中から分離した酸化LDL のapoB 変性とリン脂質分子種の解析
- Author(s)
  笹部直子、小浜孝士、矢澤快、大坪茉利子、羽田幸代、井上望、相内敏弘、木庭新治、加藤里奈、山口智広、板部洋之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（神戸）他
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24790087

1. ITABE Hiroyuki (30203079)

# of Collaborated Projects: 9 results

# of Collaborated Products: 84 results
2. KATO Rina (30392400)

# of Collaborated Projects: 6 results

# of Collaborated Products: 54 results
3. 牧山智彦 (60733102)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 笹部直子 (50643566)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. IWAMOTO Sanju (50176567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. TAKAHASHI Katsuhiko (80307066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. KOBAYASHI Yoichi (70158905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIYAZAKI Akira (70253721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 木庭新治 (20276546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 山口智広 (50347530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. 高木孝士 (10774820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 渡邉雄一 (70792729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. NOGUCHI Emiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 畔津佑季

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 茶谷昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Obama Takashi 小濱 孝士

OBAMA Takashi 小濱 孝士

Research Projects

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Co-Researchers

Effects of neutrophil extracellular traps and lipoproteins on the function of vascular endothelial cellsPrincipal Investigator

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Novel approach to search for factors regulating intracellular lipid droplet formation based o Sar1b function.

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Oxidatively modified high-density lipoprotein: its roles in vessel wall tissues and mechanism of its generation.

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Effects of oxidized lipoproteins on neutrophil extracellular trap formation followed by vascular inflammationPrincipal Investigator

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Proinflammatory activity elicited by oxidized low-density lipoproteins and neutrophil extracellular trap formationPrincipal Investigator

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Studies on process of generation and metabolism of oxidized LDL in vivo.

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Sensitive measurement of oxidized phospholipids as markers of oxidative stress and diseases.

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Isolation and comprehensive analysisi of constituents in oxidized low-density lipoprotein in vivoPrincipal Investigator

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Generation of plasma oxidized LDL in the early stages of atherogenesis

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Analysis of modified low-density lipoproteins in plasma of myocardial infarctionPrincipal Investigator

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Biological and pharmaceutical study on intracellular lipid droplets which are the key organelle to understand life style diseases.

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Separation and analysis of oxidized low-density lipoprotein in vivo using immunological technique.

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[Book] 酸化ストレスの医学2008

Author(s)

Total Pages

Obama Takashi 小濱孝士

OBAMA Takashi 小濱孝士