SHIMIZU Hajime 清水一

Researcher Number	60398873
Affiliation (based on the past Project Information) *help	2012 – 2015: 日本医科大学, 付置研究所, その他 2014: 日本医科大学, 老人病研究所, マネージメントサポートスタッフ 2012: 日本医科大学, 老人病研究所, マネージメントサポートスタッフ 2010 – 2011: 日本医科大学, 老人病研究所, マネージメントサポートスタッフ 2010: 日本医科大学, 老人病研究所, マネジメントサポートスタッフ 2009: 日本医科大学, 老人病研究所, 研究技術主幹
Review Section/Research Field	Principal Investigator Plastic surgery Except Principal Investigator Plastic surgery / Emergency medicine
Keywords	Principal Investigator micrpRNA / コラーゲン / IL-6 / 線維化 / microRNA / ケロイド Except Principal Investigator 分子標的治療 / microRNA / 骨癒合遷延 / Non union … More / Bone union / Bone healing / MicroRNA / micro RNA / TGFB1 / マーカー / サイトカイン / 骨癒合 / BMP2 / TGF-β1 / 骨癒合マーカー / 偽関節 / 骨折治療 / frizzled4 / ROR2 / frizzeld4 / wound healing / keloid pathogenesis / β-catenin / Wnt signaling / keloid / Wnt signal-related genes / EMT / beta-catenin / Wnt5a / Keloid pathogenesis / 新しい分子治療 / c-Ab1 / 皮膚線維芽細胞 / 皮膚 / 線維芽細胞 / c-Abl / ケロイド Less

Elucidation of Wnt5a signal transduction mechanism(s) in keloid and application of molecular targeted therapy
- Principal Investigator
  
  GHAZIZADEH MOHAMMAD
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Nippon Medical School
Establishment and onset mechanism
- Principal Investigator
  
  HARA YOSHIAKI
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Nippon Medical School
The mechanisms of transcriptional regulation by microRMAs in relation to COLIA2 promotor region in keloidPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Hajime
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Nippon Medical School
Establishment of new molecular therapy of keloid and elucidation of mechanism of development by inhibition of cAbl tyrosine kinase
- Principal Investigator
  
  GHAZIZADEH M. (GHAZIZADEH MOHAMMAD Ghazizadeh)
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Nippon Medical School

All 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Identification and characterization of Wnt signaling pathway in keloid pathogenesis2013
- Author(s)
  Shinichi Igota,Mamiko Tosa,Masahiro Murakami,Seiko Egawa,Hajime Shimizu, Hiko Hyakusoku,Mohammad Ghazizadeh
- Journal Title
  
  Int J Med Sci
  
  Volume: 10(4) Pages: 344-354
- Data Source
  KAKENHI-PROJECT-22592003
[Journal Article] Identification and characterization of Wnt signaling pathway in keloid pathogenesis2013
- Author(s)
  Shinichi Igota, Mamiko Tosa, Masahiro Murakami, Seiko Egawa, Hajime Shimizu, Hiko Hyakusoku, Mohammad Ghazizadeh
- Journal Title
  
  International Journal of Medical Sciences
  
  Volume: 10 Issue: 4 Pages: 344-354
- DOI
  10.7150/ijms.5349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592722
[Journal Article] Interphase cytogenetic analysis of non-mucinous and mucinous adenocarcinoma with bronchioloalveolar pattern2012
- Author(s)
  Hajime Shimizu,Takashi Sugino,Hideki Chiba.
- Journal Title
  
  Fukushima.J Med.Sci
  
  Volume: 58,1 Pages: 66-74
- Data Source
  KAKENHI-PROJECT-22592003
[Journal Article] Pathogenic Mechanisms Shared between Psoriasis and Cardiovascular Disease2010
- Author(s)
  Ghazizadeh R, Shimizu H, Tosa M, Ghazizadeh M.
- Journal Title
  
  Int J Med Sci
  
  Volume: 7(5) Pages: 284-289
- DOI
  10.7150/ijms.7.284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592297
[Journal Article] Pathogenic Mechanisms shared between Psoriasis and cardiovascular disease2010
- Author(s)
  Ghazizadeh R,Shimizu H,Tosa M, Ghazizadeh M
- Journal Title
  
  Int J Med Sci
  
  Volume: 19;7(5) Pages: 284-289
- Data Source
  KAKENHI-PROJECT-22592003
[Journal Article] Interaction betweenβ-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer's disease2009
- Author(s)
  Shimizu H, Ghazizadeh M, Sato S, Oguro T, Kawanami O.
- Journal Title
  
  J Clin Neurosci
  
  Volume: 16(2) Issue: 2 Pages: 277-282
- DOI
  10.1016/j.jocn.2008.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] MicroRNA expression profiles in keloid and normal dermal fibroblasts2012
- Author(s)
  Hajime Shimizu,Shinichi Igota,MamikoTosa,Seiko Egawa,Mohammad Ghazizadeh
- Organizer
  第37回日本研究皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of a Wnt/ss-catenin canonical signaling pathway in keloid pathogenesis2012
- Author(s)
  Mohammad Ghazizadeh,Seiko Egawa, Hajime Shimizu,Shinichi Igota,Mamiko Tosa
- Organizer
  第37回日本研究皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Potential involvement of the stem cell factor (SCF) receptor c-kit in keloid pathogenesis2012
- Author(s)
  Mohammad Ghazizadeh, Seiko Egawa, Hajime Shimizu, Shinichi Igota, Mamiko Tosa
- Organizer
  第１１１回日本皮膚科学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24592722
[Presentation] Potential involvement of the stem cell factor receptor c-kit in keloid Pathogenesis2012
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu, Seiko Egawa, Mamiko Tosa
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Characterization of Wnt signaling pathway in keloid pathogenesis.2012
- Author(s)
  Mohammad Ghazizadeh,Seiko Egawa, Hajime Shimizu,Shinichi Igota, Mamiko Tosa
- Organizer
  65 th International Conference on Tissue Science and Engineering
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of a Wnt/beta-catenin canonical signaling pathway in keloid pathogenesis2012
- Author(s)
  Mohammad Ghazizadeh, Seiko Egawa, Hajime Shimizu, Shinichi Igota, Mamiko Tosa
- Organizer
  日本研究皮膚科学会第３７回年次学術大会総会
- Place of Presentation
  那覇
- Data Source
  KAKENHI-PROJECT-24592722
[Presentation] Potential involvement of the stem cell factor receptor c-kit in keloid pathogenesis2012
- Author(s)
  Mohammad Ghazizadeh,Hajime Shimizu, Seiko Egawa,Mamiko Tosa
- Organizer
  第110回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] 顔面の組織欠損に対する再建方法の検討2011
- Author(s)
  伊吾田慎一、ガジザデモハマッド、土佐眞美子、清水一、枝川聖子、岩切致、村上正洋、小川令、百束比古
- Organizer
  第3回日本創傷外科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] ケロイド発症の病因に関与するmicroRNA遺伝子について2011
- Author(s)
  清水一、土佐眞美子、ガジザデモハマッド
- Organizer
  第25回日本皮膚外科学会総会
- Place of Presentation
  富山
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Involvement of Wnt signaling pathway in abnormal wound healing2011
- Author(s)
  Mohammad Ghazizadeh,Hajime Shimizu, Shinichi Igota,Seiko Egawa,Mamiko Tosa
- Organizer
  第3回日本創傷外科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of Wnt signaling pathway in keloid pathogenesis2011
- Author(s)
  伊吾田慎一、清水一、ガジザデモハマッド
- Organizer
  第20回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Characterization of Wnt signaling pathway in keloidpathogenesis2011
- Author(s)
  Tomoyo Ueno,Shinichi Igota,Mamiko Tosa,Seiko Egawa,Hajime Shimizu, Mohammad Ghazizadeh
- Organizer
  第79回日本医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Targeting the Wnt signaling pathwain keloid2011
- Author(s)
  Mohammad Ghazizadeh, Shinichi Igota, Hajime Shimizu, Seiko Egawa, Mamiko Tosa
- Organizer
  第26回日本皮膚外科学会総会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Involvement of Wnt signaling pathway in keloid pathogenesis2011
- Author(s)
  伊吾田慎一、土佐眞美子、枝川聖子、清水一、村上正洋、百束比古、ガジザデモハマッド
- Organizer
  第20回日本形成外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Characterization of Wnt signaling pathway in keloid pathogenesis2011
- Author(s)
  Tomoyo Ueno, Hajime Shimizu, Mohammad Ghazizadeh
- Organizer
  第79回日本医科大学医学会総会
- Place of Presentation
  東京
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Characterization of Wnt signaling pathway in keloid pathogenesis2011
- Author(s)
  Tomoyo Ueno, Mamiko Tosa, Hajime Shimizu, Mohammad Ghazizadeh
- Organizer
  第79回日本医科大学医学会総会
- Place of Presentation
  東京
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Targeting the Wnt signaling Pathway in keloid2011
- Author(s)
  Mohammad Ghazizadeh,Shinichi Igota, Hajime Shimizu,Seiko Egawa,Mamiko Tosa
- Organizer
  第26回日本皮膚外科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of Wnt signaling pathway in keloid pathogenesis2011
- Author(s)
  伊吾田慎一、土佐眞美子、清水一、村上正洋、ガジザデモハマッド
- Organizer
  第20回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Targeting the Wnt signaling pathway in keloid2011
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu, Mamiko Tosa
- Organizer
  第26回日本皮膚外科学会総会
- Place of Presentation
  富山
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] ケロイド発症の病因に関与するmicroRNA遺伝子について2011
- Author(s)
  清水一、土佐眞美子、ガジザデモハマッド
- Organizer
  第25回日本皮膚外科学会総会
- Place of Presentation
  富山
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Targeting the Wnt signaling pathway in keloid2011
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第26回日本皮膚外科学会総会
- Place of Presentation
  富山
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] ケロイド発症の病因に関与するmicroRNA遺伝子について2011
- Author(s)
  清水一土佐眞美子、伊吾田慎一、枝川聖子、ガジザデモハマッド
- Organizer
  第26回日本皮膚外科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of Wnt signaling pathway in abnormal wound healing2011
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第3回日本創傷外科学会総会
- Place of Presentation
  札幌
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of Wnt signaling pathway in abnormal wound healing2011
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu, Shinichi Igota
- Organizer
  第3回日本創傷外科学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Inhibition of non-small cell lung cancer cells by a Src family-specific tyrosine kinase inhibitor.2010
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] チロシンキナーゼインヒビターPD173955による非小細胞肺癌細胞株の増殖抑制効果の検討2010
- Author(s)
  清水一、モハマッドガジザデ
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Inhibition of keloid fibroblast cell growth by a Src family-specific tyrosine kinase inhibitor2010
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu、Seiko Egawa, Mamiko Tosa
- Organizer
  第25回日本皮膚外科学会総会
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Inhibition of keloid fibroblast cell growth by a Src family-specific tyrosine kinase inhibitor2010
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第25回日本皮膚外科学会総会
- Place of Presentation
  大分
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Inhibition of keloid fibroblast cell growth by a Src family-specific tyrosine kinase inhibitor2010
- Author(s)
  Mohammad Ghazizadeh,Hajime Shimizu、Seiko Egawa, Mamko Tosa
- Organizer
  第25回日本皮膚外科学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Inhibition of non-small cell lung cancer cells by a Src family-specific tyrosine kinase inhibitor2010
- Author(s)
  Mohammad Ghazizadeh,Hajime Shimizu, Hideki Chiba
- Organizer
  第69回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] チロシンキナーゼインヒビターPD173955による非小細胞肺癌細胞株の増殖抑制効果の検討2010
- Author(s)
  清水一、モハマッドガジザデ、枝川聖子、千葉英樹
- Organizer
  第51回日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] チロシンキナーゼインヒビターPD173955による非小細胞肺癌細胞株の増殖抑制効果の検討2010
- Author(s)
  清水一、モハマッドガジザデ
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Inhibition of Keloid fibroblast cell growth by a Src family-specific tyrosine kinase inhibitor2010
- Author(s)
  Mohammed Ghazizadeh, Hajime Shimizu
- Organizer
  第25回日本研究皮膚外科学会総会
- Place of Presentation
  大分
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Inhibition of non-small cell lung cancer cells by a Src family-specific tyrosine kinase inhibitor.2010
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Effect of imatinib mesylate(STI571) on keloid fibroblast cell functions2009
- Author(s)
  Ghazizadeh M, Shimizu H, Tosa M, Egawa Seiko, Murakami M
- Organizer
  The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-21592297
[Presentation] Potential Involvement of the Stem Cell Factor Receptor c-kit in Keloid Pathogenesis
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第110回日本皮膚科学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Characterization of Wnt signaling pathway in Keloid Pathogenesis
- Author(s)
  Mohammad Ghazizadeh,Hajime Shimizu
- Organizer
  65th International conference on tissue science and engineering
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] Involvement of a Wnt/β-catenin Canonical Signaling Pathway in Keloid Pathogenesis
- Author(s)
  Mohammad Ghazizadeh, Hajime Shimizu
- Organizer
  第37回日本研究皮膚科学会総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-22592003
[Presentation] MicroRNA Expression Profiles in Keloid and Normal Dermal Fibroblasts
- Author(s)
  Hajime Shimizu, Mohammad Ghazizadeh
- Organizer
  第37回日本研究皮膚科学会総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-22592003

1. GHAZIZADEH M. (30190979)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TOSA Mamiko (30301568)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
3. MURAKAMI Masahiro (00239500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. HARA YOSHIAKI (20386197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KUNIHIRO MASHIKO (70165695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 金恩京 (10312068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ガジザデモハマッド

# of Collaborated Projects: 0 results

# of Collaborated Products: 45 results

SHIMIZU Hajime 清水 一

Research Projects

Research Products

Co-Researchers

Elucidation of Wnt5a signal transduction mechanism(s) in keloid and application of molecular targeted therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment and onset mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of transcriptional regulation by microRMAs in relation to COLIA2 promotor region in keloidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new molecular therapy of keloid and elucidation of mechanism of development by inhibition of cAbl tyrosine kinase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification and characterization of Wnt signaling pathway in keloid pathogenesis2013

Author(s)

Journal Title

Data Source

[Journal Article] Identification and characterization of Wnt signaling pathway in keloid pathogenesis2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interphase cytogenetic analysis of non-mucinous and mucinous adenocarcinoma with bronchioloalveolar pattern2012

Author(s)

Journal Title

Data Source

[Journal Article] Pathogenic Mechanisms Shared between Psoriasis and Cardiovascular Disease2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathogenic Mechanisms shared between Psoriasis and cardiovascular disease2010

Author(s)

Journal Title

Data Source

[Journal Article] Interaction betweenβ-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer's disease2009

Author(s)

Journal Title

DOI

Data Source

[Presentation] MicroRNA expression profiles in keloid and normal dermal fibroblasts2012

Author(s)

Organizer

Data Source

[Presentation] Involvement of a Wnt/ss-catenin canonical signaling pathway in keloid pathogenesis2012

Author(s)

Organizer

Data Source

[Presentation] Potential involvement of the stem cell factor (SCF) receptor c-kit in keloid pathogenesis2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Potential involvement of the stem cell factor receptor c-kit in keloid Pathogenesis2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Characterization of Wnt signaling pathway in keloid pathogenesis.2012

Author(s)

Organizer

Data Source

[Presentation] Involvement of a Wnt/beta-catenin canonical signaling pathway in keloid pathogenesis2012

Author(s)

Organizer

SHIMIZU Hajime 清水一