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CAO Liqin  曹 麗琴

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… Alternative Names

Cao Liqin  曹 麗琴

SOU Reikin  曹 麗琴

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Researcher Number 60399475
Other IDs
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help 2023: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
2015 – 2022: 筑波大学, 国際統合睡眠医科学研究機構, 助教
2012: 公益財団法人東京都医学総合研究所, 基盤技術研究センター, 研究員
2010 – 2011: 独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, 国際特別研究員
Review Section/Research Field
Principal Investigator
Basic Section 42040:Laboratory animal science-related / Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related / Integrative animal science / Genetics/Genome dynamics
Except Principal Investigator
Integrative animal science
Keywords
Principal Investigator
遺伝学 / 脳・神経 / 神経発達障害 / マウス / 睡眠 / CDKL5 / 癲癇 / seizure / 精神疾患 / 恐怖感情 … More / 先天的恐怖 / in vivo imaging / 生体イメージング / 遺伝病 / 分子遺伝 / ミトコンドリア分離 / ボトルネック / ミトコンドリア … More
Except Principal Investigator
恐怖情動 / バイオリソース / モデルマウス / 精神障害 / 先天的恐怖 / フォワード・ジェネティックス Less
  • Research Projects

    (5 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (6 People)
  •  Unraveling the genetic modifier, and molecular and neural basis of intractable epilepsy in a mouse model of CDKL5 deficiency disorderPrincipal Investigator

    • Principal Investigator
      曹 麗琴
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Elucidate the neural mechanisms underlying sleep disturbances in neurodevelopmental disorders-focusing on CDKL5 deficiency disorder-Principal Investigator

    • Principal Investigator
      Cao Liqin
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
    • Research Institution
      University of Tsukuba
  •  Elucidate the molecular mechanisms of innate fear and its relation to mental disordersPrincipal Investigator

    • Principal Investigator
      Cao Liqin
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrative animal science
    • Research Institution
      University of Tsukuba
  •  Unveiling the molecular mechanism of innate fear using forward genetic screen approach

    • Principal Investigator
      LIU Qinghua
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Integrative animal science
    • Research Institution
      University of Tsukuba
  •  Study on mitochondrial bottleneck and diseasesPrincipal Investigator

    • Principal Investigator
      SOU Reikin
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genetics/Genome dynamics
    • Research Institution
      公益財団法人東京都医学総合研究所
      The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice2021

    • Author(s)
      Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai, Qinghua Liu
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 2648-2648

    • DOI

      10.1038/s41467-021-22914-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738, KAKENHI-PUBLICLY-19H05006, KAKENHI-PROJECT-18K06515, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-20K20578, KAKENHI-PUBLICLY-20H04849
  • [Journal Article] Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation2021

    • Author(s)
      Matsuo Tomohiko、Isosaka Tomoko、Hayashi Yuichiro、Tang Lijun、Doi Akihiro、Yasuda Aiko、Hayashi Mikio、Lee Chia-Ying、Cao Liqin、Kutsuna Natsumaro、Matsunaga Sachihiro、Matsuda Takeshi、Yao Ikuko、Setou Mitsuyoshi、Kanagawa Dai、Higasa Koichiro、Ikawa Masahito、Liu Qinghua、Kobayakawa Reiko、Kobayakawa Ko
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 2074-2074

    • DOI

      10.1038/s41467-021-22205-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06773, KAKENHI-PROJECT-20K06738, KAKENHI-PROJECT-18H02546, KAKENHI-PROJECT-20K09337, KAKENHI-PLANNED-20H05911, KAKENHI-PROJECT-19H03259, KAKENHI-PROJECT-20K07715, KAKENHI-PROJECT-20K09400, KAKENHI-PROJECT-21K09191, KAKENHI-PROJECT-19K16933, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-20K20578, KAKENHI-PUBLICLY-20H04849
  • [Journal Article] Hyper-Activation of mPFC Underlies Specific Traumatic Stress-Induced Sleep-Wake EEG Disturbances2020

    • Author(s)
      Tingting Lou, Jing Ma, Zhiqiang Wang, Yuka Terakoshi, Chia-Ying Lee, Greg Asher, Liqin Cao, Zhiyu Chen, Katsuyasu Sakurai, Qinghua Liu
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14 Pages: 883-883

    • DOI

      10.3389/fnins.2020.00883

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738, KAKENHI-PROJECT-19H03263, KAKENHI-PROJECT-18KK0070
  • [Journal Article] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors2018

    • Author(s)
      Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2041-2041

    • DOI

      10.1038/s41467-018-04324-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133, KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PUBLICLY-17H05583, KAKENHI-PUBLICLY-17H06048, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-16K07445, KAKENHI-PUBLICLY-17H05586, KAKENHI-PUBLICLY-18H04806, KAKENHI-PROJECT-16H02591, KAKENHI-PROJECT-18H02546, KAKENHI-PROJECT-18K19350, KAKENHI-PROJECT-18K06024
  • [Journal Article] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors2018

    • Author(s)
      Wang, Y., Cao, L., Lee, C-Y., et al.
    • Journal Title

      Nature Communications (accepted)

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Journal Article] Quantitative phosphoproteomic analysis of the molecular substrates of sleep need2018

    • Author(s)
      Z. Wang, J. Ma, C. Miyoshi, Y. Li, M Sato, Y. Ogawa, T. Lou, C. Ma, X. Gao, C. Lee, T. Fujiyama, X. Yang, S. Zhou, N. Hotta-Hirashima, D. Klewe-Nebenus, A. Ikkyu, M. Kakizaki, S. Kanno, L. Cao, S. Takahashi, J. Peng, Y. Yu, H. Funato, M. Yanagisawa, Q. Liu
    • Journal Title

      Nature

      Volume: 558 Issue: 7710 Pages: 435-439

    • DOI

      10.1038/s41586-018-0218-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133, KAKENHI-PROJECT-17K15592, KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PUBLICLY-17H05583, KAKENHI-PUBLICLY-17H06048, KAKENHI-PROJECT-17H04023, KAKENHI-PROJECT-18K06024, KAKENHI-ORGANIZER-15H05935
  • [Journal Article] High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.2012

    • Author(s)
      Cao, L.
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Journal Article] High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device2012

    • Author(s)
      Cao, L., Kobayakawa S., Yoshiki A., and Abe K
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Journal Article] The mode of mitochondrial DNA transmission in mammals: rapid segregation and bottleneck effect2010

    • Author(s)
      Shitara, H., Cao L., and Yonekawa H
    • Journal Title

      Cell Technology

      Volume: 29 Pages: 461-465

    • NAID

      40018784481

    • Data Source
      KAKENHI-PROJECT-22570009
  • [Journal Article] 哺乳動物におけるミトコンドリアDNAの遺伝様式:急調分離とボトルネック効果2010

    • Author(s)
      設楽浩志、曹麗琴、米川博通
    • Journal Title

      細胞工学

      Volume: 29 Pages: 461-465

    • Data Source
      KAKENHI-PROJECT-22570009
  • [Journal Article] High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device

    • Author(s)
      Cao, L., S.Kobayakawa, A.Yoshiki, K.Abe
    • Journal Title

      Plos One

      Volume: (accepted)(In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] Sleep disturbances in a mouse model of CDKL5 deficiency disorder2023

    • Author(s)
      Liqin Cao, Tingting Lou, Xin Zhang, Jing Ma, Zhiqiang Wang, Teruyuki Tanaka, Hiromasa Funato, Qinghua Liu, Masashi Yanagisawa
    • Organizer
      36th International Mammalian Genome conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738
  • [Presentation] Loss of CDKL5 in glutamatergic neurons results in disruptions of sleep/wake patterns in mice2023

    • Author(s)
      Liqin Cao
    • Organizer
      The 2nd CDKL5 Asia Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K05614
  • [Presentation] Loss of CDKL5 in excitatory neurons underlies sleep disturbances in CDD2023

    • Author(s)
      Liqin Cao
    • Organizer
      2023 CDKL5 Forum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K05614
  • [Presentation] Sleep disturbances in mice with a CDKL5 kinase-dead missense mutation, a novel mouse model of neurodevelopmental disorder2023

    • Author(s)
      Liqin Cao, Xin Zhang, Tingting Lou, Teruyuki Tanaka, Qinghua Liu, Hiromasa Funato, Masashi Yanagisawa
    • Organizer
      The 11th Annual WPI-IIIS Symposium ~Deciphering the Mysteries of Instinctive Behaviors~
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738
  • [Presentation] Natural history study of sleep disturbances in CDKL5 deficiency disorder mice2022

    • Author(s)
      Liqin Cao, Tingting Lou, Xin Zhang, Jing Ma, Zhiqiang Wang, Teruyuki Tanaka, Hiromasa Funato, Qinghua Liu, Masashi Yanagisawa
    • Organizer
      JST-CREST "Optobio" / WPI-IIIS Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738
  • [Presentation] The natural history of epilepsy in CDKL5 KO mouse models2022

    • Author(s)
      Liqin Cao
    • Organizer
      2022 CDKL5 Forum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738
  • [Presentation] Altered sleep architecture in CDKL5 KO mouse models & possible clinical applications2021

    • Author(s)
      Liqin Cao
    • Organizer
      2021 CDKL5 Forum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738
  • [Presentation] Sleep disturbances in young and older CDKL5 knockout mice2020

    • Author(s)
      Liqin Cao, Tingting Lou, Jing Ma, Zhiqang Wang, Teruyuki Tanaka, Qinghua Liu
    • Organizer
      2020 CDKL5 Forum
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06738
  • [Presentation] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors2019

    • Author(s)
      Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
    • Organizer
      Keystone Symposia, Mammalian Sensory System (C4)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] Identifying schizophrenia genes through a forward genetic screen in mice2019

    • Author(s)
      Liqin Cao, Daniela Klewe-Nebenius, Greg Asher, Takeshi Sakurai, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa, Qinghua Liu
    • Organizer
      Neuro2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] Sleep architecture in CDKL5 KO mouse2019

    • Author(s)
      Liqin Cao
    • Organizer
      2019 CDKL5 Forum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] Characterization of sleep architecture in CDKL5 knockout mice2019

    • Author(s)
      Liqin Cao, Jing Ma, Tingting Lou, Zhiqiang Wang, Qinghua Liu
    • Organizer
      The 8th Annual IIIS Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] Sleep disruptions in CDKL5 knockout mice2019

    • Author(s)
      Liqin Cao
    • Organizer
      CDKL5 ASIA Workshop 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] Psycho, a potential mouse model of schizophrenia2018

    • Author(s)
      Liqin Cao, Daniela Klewe-Nebenius, Greg Asher, Makito Sato, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa, Qinghua Liu
    • Organizer
      The 7th Annual IIIS International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors2018

    • Author(s)
      Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
    • Organizer
      The 7th Annual IIIS International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08133
  • [Presentation] High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.2012

    • Author(s)
      Cao, L.
    • Organizer
      The 26th Molossinus Symposium
    • Place of Presentation
      東京大学弥生講堂
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device2012

    • Author(s)
      Cao, L., Kobayakawa S., Yoshiki A., and Abe K
    • Organizer
      The 26^<th> Molossinus Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] In vivo imaging of subcellular structures, mitochondria and autophagosomes, in live mouse abdominal organs using a microstage device2012

    • Author(s)
      Cao, L. and Abe K
    • Organizer
      The 12^<th> Conference of Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      Tsukuba, Ibaraki, Japan
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] In vivo imaging of subcellular structures, mitochondria and autophagosomes, in live mouse abdominal organs using a microstage device.2012

    • Author(s)
      Cao, L.
    • Organizer
      The 12th Conference of Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      筑波大学国際会議室
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] Solid evidence proves that the mitochondrial bottleneck occurs without reduction of mitochondrial DNA molecules in early primordial germ cells of mice2011

    • Author(s)
      Cao, L., H.Shitara, M.Sugimoto, J.-I.Hayashi, K.Abe, H.Yonekawa
    • Organizer
      The eighth European Meeting on Mitochondrial Pathology
    • Place of Presentation
      Zaragoza, Spain
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] Solid evidence proves that the mitochondrial bottleneck occurs without reduction of mitochondrial DNA molecules in early primordial germ cells of mice2011

    • Author(s)
      Cao, L., Shitara H., Sugimoto M., Hayashi J.-I., Abe K., Yonekawa H
    • Organizer
      The eighth European Meeting on Mitochondrial Pathology (Euromit 8)
    • Place of Presentation
      Zaragoza, Spain
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] Intravital molecular imaging of cellular processes in live mice2010

    • Author(s)
      Cao, L., and Abe K. (invited speaker)
    • Organizer
      The 4^<th> congress of Asia federation of laboratory animal science
    • Place of Presentation
      Taipei, Taiwan
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] The mitochondrial DNA bottleneck in the germline cells of mammals2010

    • Author(s)
      Cao, L., Shitara H., Sugimoto M., Hayashi J.-I., Abe K., and Yonekawa H. (invited speaker)
    • Organizer
      Eastern Japanese animal embryo transfer workshop and animal genetics and reproduction seminar
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2010-12-13
    • Data Source
      KAKENHI-PROJECT-22570009
  • [Presentation] The mitochondrial DNA bottleneck in the germline cells of mammals2010

    • Author(s)
      Cao, L., H.Shitara, M.Sugimoto, J.-I.Hayashi, K.Abe, H.Yonekawa
    • Organizer
      Eastern Japanese animal embryo transfer workshop and animal genetics and reproduction seminar
    • Place of Presentation
      Tsukuba
    • Year and Date
      2010-12-13
    • Data Source
      KAKENHI-PROJECT-22570009
  • 1.  クレウエ・ネベニウス ダニエラ (60737667)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  LIU Qinghua (90723792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  KOBAYAKAWA Reiko (40372411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  YANAGISAWA Masashi (20202369)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  佐藤 牧人 (70743699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  松尾 朋彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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