YAMAWAKI Hideyuki 山脇英之

Researcher Number	60399607
Other IDs
Affiliation (Current)	2025: 北里大学, 獣医学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2024: 北里大学, 獣医学部, 教授 2013: 北里大学, 獣医学部, 准教授 2007 – 2008: Kitasato University, 獣医学部, 講師 2006: 北里大学, 獣医畜産学部, 講師 2005: 国立循環器病センター(研究所), 疫学部, 室長
Review Section/Research Field	Principal Investigator Veterinary medical science / General pharmacology / Basic Section 42020:Veterinary medical science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Keywords	Principal Investigator 薬理学 / 病態 / 循環器 / 細胞外小胞 / 高血圧 / 動脈硬化 / 血管内皮細胞 / 糖尿病 / 多臓器連関 / 高血圧症 … More / エクソソーム / 血行力学 / シーアストレス / 臓器連関 / 心血管病 / 循環器系疾患 / アディポサイトカイン / 循環器疾患 / 血管 / シグナル伝達 / 糖尿病高血圧 / 血管内皮 / 血管平滑筋 / 脈管生理学 / 炎症 / 細胞内情報伝達 Less

Research Projects
(7 results)
Research Products
(84 results)

細胞外小胞を介したshear stressによる新たな動脈硬化制御機構の解明Principal Investigator
- Principal Investigator
  
  山脇英之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Kitasato University
Elucidation of novel mechanisms of essential hypertension development: focus on exosomePrincipal Investigator
- Principal Investigator
  
  山脇英之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kitasato University
Mechanisms of adipocytokine control of cardiovascular diseases through the regulation of multi organ networkPrincipal Investigator
- Principal Investigator
  
  Yamawaki Hideyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kitasato University
Exploring the whole mechanisms of adipocytokine regulation of atherosclerosisPrincipal Investigator
- Principal Investigator
  
  Yamawaki Hideyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kitasato University
Spatiotemporal exploration of vascular inflammation during the development of atherosclerosisPrincipal Investigator
- Principal Investigator
  
  YAMAWAKI Hideyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Kitasato University
Mechanisms of diabetic large vascular dysfunction : Focus on vascular contractilityPrincipal Investigator
- Principal Investigator
  
  YAMAWAKI Hideyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kitasato University
糖尿病性血管内皮障害におけるP2X7レセプターの役割Principal Investigator
- Principal Investigator
  
  山脇英之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kitasato University
  National Cardiovascular Center Research Institute

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 2008 2006 2005 Other

All Journal Article Presentation

[Journal Article] Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain2020
- Author(s)
  Yamamoto A, Matsumoto K, Hori K, Kameshima S, Yamaguchi N, Okada S, Okada M, and Yamawaki H
- Journal Title
  
  Pflugers Archiv - Eur J Physiol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03918
[Journal Article] Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats2020
- Author(s)
  Omori A, Goshima M, Kakuda C, Kodama T, Otani K, Okada M, and Yamawaki H
- Journal Title
  
  Pflugers Archiv - Eur J Physiol
  
  Volume: 472 Issue: 3 Pages: 335-342
- DOI
  10.1007/s00424-019-02345-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03918
[Journal Article] Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats2017
- Author(s)
  Sakamoto Yuzaburo、Kameshima Satoshi、Kakuda Chiharu、Okamura Yuta、Kodama Tomoko、Okada Muneyoshi、Yamawaki Hideyuki
- Journal Title
  
  Pflugers Arch-Eur J Physiol
  
  Volume: 469 Issue: 11 Pages: 1425-1432
- DOI
  10.1007/s00424-017-2043-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03918
[Journal Article] Adipocytokine, progranulin augments acetylcholine-induced nitric oxide-mediated relaxation through the increases of cGMP production in rat isolated mesenteric artery2017
- Author(s)
  Kazama K, Hoshino K, Kodama T, Okada M, and Yamawaki H
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: 219 Issue: 4 Pages: 781-789
- DOI
  10.1111/apha.12739
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292175
[Journal Article] Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 42017
- Author(s)
  Okamura Y, Otani K, Sekiguchi A, Kogane T, Kakuda C, Sakamoto Y, Kodama T, Okada M, and Yamawaki H
- Journal Title
  
  Pflugers Arch-Eur J Physiol
  
  Volume: 印刷中 Issue: 9 Pages: 1177-1188
- DOI
  10.1007/s00424-017-1976-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292175
[Journal Article] Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats.2016
- Author(s)
  3.Kameshima S, Sakamoto Y, Okada M, and Yamawaki H.
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: 217 Issue: 2 Pages: 120-129
- DOI
  10.1111/apha.12636
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25292175
[Journal Article] Is novel adipocytokine, omentin, a therapeutic target for obesity-related hypertension?2015
- Author(s)
  Kazama K, Okada M, Yamawaki H
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 145 Issue: 2 Pages: 65-69
- DOI
  10.1254/fpj.145.65
- NAID
  130004827719
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J03703, KAKENHI-PROJECT-25292175
[Journal Article] Chemerin promotes proliferation and migration of vascular smooth muscle and increases mouse blood pressure.2015
- Author(s)
  Kunimoto H, Kazama K, Takai M, Oda M, Okada M, and Yamawaki H.
- Journal Title
  
  Am J Physiol-Heart and Circulatory Physiology
  
  Volume: 309 Issue: 5 Pages: H1017-H1028
- DOI
  10.1152/ajpheart.00820.2014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292175
[Journal Article] A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through anti-oxidative mechanism2014
- Author(s)
  Kazama K, Okada M, Yamawaki H
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: (in press) Issue: 12 Pages: H1714-H1719
- DOI
  10.1152/ajpheart.00048.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J03703, KAKENHI-PROJECT-25292175
[Journal Article] A novel adipocytokine, omentin, inhibits monocrotaline-induced pulmonary arterial hypertension in rats2014
- Author(s)
  Kazama K, Okada M, Yamawaki H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 452 (1) Issue: 1 Pages: 142-146
- DOI
  10.1016/j.bbrc.2014.08.070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J03703, KAKENHI-PROJECT-25292175
[Journal Article] Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells.2014
- Author(s)
  Usui T, Naruo A, Okada M, Hayabe Y, and Yamawaki H.
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: In Press Issue: 2 Pages: 385-394
- DOI
  10.1111/apha.12249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25660233, KAKENHI-PROJECT-26850182
[Journal Article] Vaspin prevents methylglyoxal-induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation.2013
- Author(s)
  Phalitakul S, Okada M, Hara Y, and Yamawaki H.
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: 209 Issue: 3 Pages: 212-219
- DOI
  10.1111/apha.12139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25292175
[Journal Article] Methylglyoxal Inhibits Smooth Muscle Contraction in Isolated Blood Vessels.2009
- Author(s)
  Mukohda M, Yamawaki H, Nomura H, Okada M, and Hara Y.
- Journal Title
  
  J Pharmacol Sci 109
  
  Pages: 305-310
- NAID
  10025734753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790195
[Journal Article] Glyoxal causes inflammatory injury in human endothelial cells2008
- Author(s)
  H. Yamawaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790195
[Journal Article] Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells.2008
- Author(s)
  Yamawaki H, Saito K, Okada M, and Hara Y.
- Journal Title
  
  Am J Physiol Cell Physiol 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790195
[Journal Article] Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel.2008
- Author(s)
  Nomura H, Yamawaki H, Mukohda M, Okada M, and Hara Y.
- Journal Title
  
  J Pharmacol Sci 108
  
  Pages: 258-265
- NAID
  10024592922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790195
[Journal Article] Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells2008
- Author(s)
  H. Yamawaki
- Journal Title
  
  Am J Physiol Cell Physiol 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790195
[Journal Article] Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium.2008
- Author(s)
  Baden T, Yamawaki H, Saito K, Mukohda M, Okada M, and Hara Y.
- Journal Title
  
  Biochem Biophys Res Commun 373
  
  Pages: 253-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790195
[Journal Article] Cytotoxicity of water soluble fullerene in vascular endothelial cells.2006
- Author(s)
  Yamawaki H, Iwai N.
- Journal Title
  
  Am J Physiol Cell Physiol. (印刷中)
- Data Source
  KAKENHI-PROJECT-17790176
[Journal Article] Cytotoxicity of water soluble fullerene in vascular endothelial cells.2006
- Author(s)
  H YAMAWAKI, NIWAI
- Journal Title
  
  American Journal of Physiology Cell Physiology. 290・(6)
- Data Source
  KAKENHI-PROJECT-17790176
[Journal Article] Mechanisms underlying nano-sized air-pollution-mediated progression of atherosclerosis : carbon black causes cytotoxic injury/inflammation and inhibits cell growth in vascular endothelial cells.2006
- Author(s)
  Yamawaki H, Iwai N.
- Journal Title
  
  Circ J. 70・(1)
  
  Pages: 129-140
- Data Source
  KAKENHI-PROJECT-17790176
[Journal Article] Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptro-2 in endothelial cells : angiotensin II type 1 receptor-independent effects of EXP3179.2005
- Author(s)
  Watanabe T, Suzuki J, Yamawaki H, Sharma VK, Sheu SS, Berk BC.
- Journal Title
  
  Circulation. 112・(12)
  
  Pages: 1798-1805
- Data Source
  KAKENHI-PROJECT-17790176
[Journal Article] Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum.2005
- Author(s)
  Murata T, Suzuki N, Yamawaki H, Sato K, Hori M, Karaki H, Ozaki H.
- Journal Title
  
  Eur J Pharmacol. 15・(1-3)
  
  Pages: 134-141
- Data Source
  KAKENHI-PROJECT-17790176
[Journal Article] KlK1 as one of genes contributing to hypertension in Dahl salt-sensitive rat.2005
- Author(s)
  Iwai N, Yasui N, Naraba H, Tago N, Yamawaki H, Sumiya H.
- Journal Title
  
  Hypertension. 45・(5)
  
  Pages: 947-953
- Data Source
  KAKENHI-PROJECT-17790176
[Presentation] Chemerin/CMKLR1 in the brain of spontaneously hypertensive rats mediates systemic　hypertension2021
- Author(s)
  Yamamoto　A， Yamaguchi N， Okada S， Otani K， Okada M，and Yamawaki H
- Organizer
  The 94th annual Meeting of the Japanese Pharmacological Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] アディポサイトカインchemerin-9による中枢性血圧制御を介した本態性高血圧症の病態機序2020
- Author(s)
  山本篤範、松本拳悟、亀島聡、山口奈緒子、岡田尚志郎、岡田宗善、山脇英之
- Organizer
  第30回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] Chemerin-9がラット摘出心房筋の収縮及び心拍数に及ぼす影響2020
- Author(s)
  飯田広人、兒玉朋子、大谷紘資、岡田宗善、山脇英之
- Organizer
  第163回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] Effects of chemerin-9 on contractility of isolated pulmonary artery from pulmonary artery hypertensive rat2019
- Author(s)
  Omori A, Kodama T, Goshima M, Kakuda C, Okada M, and Yamawaki H
- Organizer
  The 93rd annual Meeting of the Japanese Pharmacological Society
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] アディポサイトカインchemerin-9のラット急性脳室内投与による昇圧作用の機序2019
- Author(s)
  山本篤範、松本拳悟、亀島聡、山口奈緒子、岡田尚志郎、岡田宗善、山脇英之
- Organizer
  第32回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] Chemerin-9急性脳室内投与によるラット全身血圧上昇のメカニズム2019
- Author(s)
  山本篤範、松本拳悟、亀島聡、山口奈緒子、岡田尚志郎、岡田宗善、山脇英之
- Organizer
  第162回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] 正常及び肺高血圧症モデルラットの摘出肺動脈におけるアディポサイトカインchemerin-9の収縮作用2019
- Author(s)
  大森彩帆、兒玉朋子、五島真、角田千春、岡田宗善、山脇英之
- Organizer
  第32回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure via CMKLR1 in rats2019
- Author(s)
  Yamamoto A, Matsumoto K, Kameshima S, Yamaguchi N, Okada S, Okada M, and Yamawaki H
- Organizer
  The 93rd annual Meeting of the Japanese Pharmacological Society
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] モノクロタリン誘発ラット肺高血圧症モデル摘出肺動脈に及ぼすchemerin-9の影響.2018
- Author(s)
  五島真, 兒玉朋子, 角田　千春, 岡田　宗善, 山脇　英之.
- Organizer
  第31回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] The effects of acute intracerebroventricular injection of chemerin-9 on systemic blood pressure in rats.2018
- Author(s)
  Matsumoto K, Kameshima S, Hori K, Okada M, and Yamawaki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] ラットの中枢性血圧制御に及ぼすchemerin-9の影響.2018
- Author(s)
  松本拳悟, 亀島聡, 堀貴子, 山口奈緒子, 岡田宗善, 山脇英之.
- Organizer
  第31回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] Chemerin-9-induced contraction of isolated pulmonary artery is enhanced in monocrotaline-induced pulmonary hypertensive rat.2018
- Author(s)
  Goshima M, Kakuda C, Okada M, and Yamawaki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] 肺高血圧症・右心不全に対する新規の創薬・治療ターゲットの探索2017
- Author(s)
  山脇英之
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Invited
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Chemerin活性断片chemerin-9はラット心線維芽細胞の遊走を促進する2017
- Author(s)
  相良鮎美，岡田宗善，山脇英之
- Organizer
  第30回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] 脳組織内HDAC4の高血圧症及び合併症における役割2017
- Author(s)
  堀貴子, 亀島聡, 佐藤由紀乃, 兒玉朋子, 松本拳悟, 杉山真言, 上野俊治, 黒瀬陽平, 岡田宗善, 山脇英之
- Organizer
  第30回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] アディポサイトカインomentinが自然発症高血圧ラットの高血圧と合併症の病態に及ぼす影響2017
- Author(s)
  佐藤由紀乃, 亀島聡, 坂本雄三郎, 堀貴子, 兒玉朋子, 岡田宗善, 山脇英之
- Organizer
  第30回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] アディポサイトカインomentinが自然発症高血圧ラットの病態に及ぼす影響2017
- Author(s)
  佐藤由紀乃, 亀島聡, 坂本雄三郎, 堀貴子, 兒玉朋子, 岡田宗善, 山脇英之
- Organizer
  第160回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] 脳卒中易発性自然発症高血圧ラットSHRSP脳組織内HDAC4の役割2017
- Author(s)
  堀貴子, 亀島聡, 佐藤由紀乃, 兒玉朋子, 杉山真言, 上野俊治, 黒瀬陽平, 岡田宗善, 山脇英之
- Organizer
  第160回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03918
[Presentation] Effects of chemerin, an adipocytokine, on contractility of rat isolated pulmonary artery.2016
- Author(s)
  Kakuda C, Kazama K, Okada M, and Yamawaki H.
- Organizer
  The 89th Annual Meeting of The Japanese Pharmacological Society.
- Place of Presentation
  Pacifico Yokohama (Kanagawa prefecture, Yokohama city)
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] A fatty-acid binding protein 4 inhibitor prevents proliferation, migration and inflammatory responses in vascular smooth muscle cells2016
- Author(s)
  Okamura Y, Sekiguchi A, Kogane T, Kakuda C, Sakamoto Y, Okada M, and Yamawaki H
- Organizer
  American Heart Association Scientific Session 2016
- Place of Presentation
  ERNEST MORIAL CONVENTION CENTER (New Orleans, LA, USA)
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] 脂肪酸結合タンパク質4阻害薬が自然発症高血圧ラットの病態に及ぼす影響2016
- Author(s)
  岡村勇汰, 坂本雄三郎, 角田千春, 兒玉朋子, 風間恭輔, 岡田宗善, 山脇英之
- Organizer
  第29回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学白金キャンパス（東京都港区）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Effect of vaspin, an adipocytokine, on the progression of monocrotaline-induced pulmonary arterial hypertension.2016
- Author(s)
  Sakamoto Y, Kameshima S, Okada M, and Yamawaki H.
- Organizer
  The 89th Annual Meeting of The Japanese Pharmacological Society.
- Place of Presentation
  Pacifico Yokohama (Kanagawa prefecture, Yokohama city)
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカインchemerinのラット摘出肺動脈における収縮作用の機序2016
- Author(s)
  角田千春, 風間恭輔, 岡田宗善, 山脇英之
- Organizer
  第29回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学白金キャンパス（東京都港区）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] An FABP4 inhibitor suppresses inflammatory response of vascular smooth muscle cells.2016
- Author(s)
  Okamura Y, Sekiguchi A, Sakamoto Y, Kodama T, Kazama K, Okada M, and Yamawaki H.
- Organizer
  The 89th Annual Meeting of The Japanese Pharmacological Society.
- Place of Presentation
  Pacifico Yokohama (Kanagawa prefecture, Yokohama city)
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカインvaspinによるモノクロタリン誘発肺高血圧症の病態抑制の機序2016
- Author(s)
  坂本雄三郎, 亀島聡, 角田千春, 岡村勇汰, 岡田宗善, 山脇英之
- Organizer
  第29回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学白金キャンパス（東京都港区）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカインvaspinの高血圧症の病態と摘出血管反応性に及ぼす影響.2015
- Author(s)
  亀島聡、山田研祐、坂本雄三郎、森田知佳、岡田宗善、山脇英之.
- Organizer
  第158回日本獣医学会学術集会.
- Place of Presentation
  北里大学十和田キャンパス（青森県十和田市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] 新規アディポサイトカインomentinは糖代謝産物methylglyoxalによる血管内皮細胞死を抑制する.2015
- Author(s)
  風間恭輔、加藤亮、岡田宗善、山脇英之.
- Organizer
  第28回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学相模原キャンパス（神奈川県相模原市）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Progranulinはラット摘出腸間膜動脈において内皮依存性弛緩反応を増強する.2015
- Author(s)
  星野和真、岡田宗善、山脇英之.
- Organizer
  第28回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学相模原キャンパス（神奈川県相模原市）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカイン vaspin は抗酸化及び抗炎症作用を介して自然発症高血圧ラットにおける血圧上昇を抑制する.2015
- Author(s)
  亀島聡、坂本雄三郎，岡田宗善、山脇英之.
- Organizer
  第25回日本循環薬理学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] New frontier in vascular biology.2015
- Author(s)
  Yamawaki H.
- Organizer
  The 88th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Nagoya Congress Center (Nagoya city)
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Progranulinが血管内皮細胞における炎症性反応に及ぼす影響.2015
- Author(s)
  富野里櫻子、篠原健大、岡田宗善、山脇英之.
- Organizer
  第28回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学相模原キャンパス（神奈川県相模原市）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] 新規アディポサイトカインomentinの心血管病に対する作用メカニズムに関する研究.2015
- Author(s)
  風間恭輔、岡田宗善、山脇英之.
- Organizer
  第158回日本獣医学会学術集会 (獣医学奨励賞受賞講演).
- Place of Presentation
  北里大学十和田キャンパス（青森県十和田市）
- Year and Date
  2015-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Effects of progranulin, an adipocytokine on contractility of rat isolated mesenteric artery.2015
- Author(s)
  Hoshino K, Yamada K, Okada M, and Yamawaki H.
- Organizer
  The 88th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Nagoya Congress Center (Nagoya city)
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] 脂肪酸結合タンパク質4が血管平滑筋細胞における炎症反応に及ぼす影響.2015
- Author(s)
  岡村勇汰、関口晃弘、岡田宗善、山脇英之.
- Organizer
  第28回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学相模原キャンパス（神奈川県相模原市）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Brain-derived neurotrophic factor (BDNF) stimulates proliferation of vascular smooth muscle cells2015
- Author(s)
  Otani K, Okada M, Yamawaki H.
- Organizer
  The 88th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Nagoya Congress Center (Nagoya city)
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] 新規アディポサイトカインvaspinの自然発症高血圧ラットにおける高血圧症進展に及ぼす影響.2015
- Author(s)
  亀島聡、坂本雄三郎，岡田宗善、山脇英之.
- Organizer
  第28回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学相模原キャンパス（神奈川県相模原市）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Visceral adipose tissue-derived serine protease inhibitor prevents the development of hypertension through the Inhibition of vascular remodeling via anti-oxidative mechanisms in spontaneously hypertensive rats.2015
- Author(s)
  Kameshima S, Sakamoto Y, Okada M, and Yamawaki H.
- Organizer
  AHA Hypertension 2015
- Place of Presentation
  Omni Shoreham Hotel (Washington DC, USA)
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカインchemerinは血管平滑筋細胞の増殖及び遊走の促進を介して昇圧をおこす2014
- Author(s)
  國本秀瑞垂、高井瑞穂、岡田宗善、山脇英之
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] 脂肪酸結合タンパク質fatty acid binding protein(FABP)4は血小板由来増殖因子PDGF- BBによる血管平滑筋細胞の遊走及び増殖を促進する2014
- Author(s)
  関口晃弘、風間恭輔、岡田宗善、山脇英之
- Organizer
  第157回日本獣医学会学術集会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] A novel adipocytokine, omentin, prevents monocrotaline-induced pulmonary arterial hypertension in rats.2014
- Author(s)
  Kazama K, Okada M, and Yamawaki H.
- Organizer
  HBPR Scientific Sessions 2014
- Place of Presentation
  Hilton San Francisco Union Square (San Francisco, CA, USA)
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Methylglyoxal enhances sodium nitroprusside-induced relaxation in isolated blood vessel2009
- Author(s)
  向田昌司、山脇英之、岡田宗善、原幸男
- Organizer
  第82回日本薬理学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19790195
[Presentation] メチルグリオキサルのラット動脈標本収縮性に及ぼす影響2008
- Author(s)
  向田昌司、山脇英之、野村秀美、岡田宗善、原幸男
- Organizer
  第59回日本薬理学会北部会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-19790195
[Presentation] Mechanisms underlying the vasodilating effects of pioglitazonein isolated blood vessel2008
- Author(s)
  H. Yamawaki
- Organizer
  The 81st Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790195
[Presentation] テルミサルタンはメチルグリオキサルが引き起こすヒト血管内皮細胞におけるアポトーシスを抑制する2008
- Author(s)
  馬殿達也、山脇英之、斎藤和晃、向田昌司、岡田宗善、原幸男
- Organizer
  第146回日本獣医学会
- Place of Presentation
  宮崎大学
- Data Source
  KAKENHI-PROJECT-19790195
[Presentation] 糖代謝物質の血管内皮障害作用機序の検討2008
- Author(s)
  山脇英之、斎藤和晃、馬殿達也、向田昌司岡田宗善、原幸男
- Organizer
  第59回日本薬理学会北部会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-19790195
[Presentation] 糖変性物質メチルグリオキサルの血管反応性におよぼす影響2008
- Author(s)
  山脇英之
- Organizer
  第145回日本獣医学会学術集会
- Place of Presentation
  麻布大学
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790195
[Presentation] Nesfatin-1, a novel adipocytokine, stimulates proliferation of vascular smooth muscle cells
- Author(s)
  Hayabe Y, Usui T, Okada M, and Yamawaki H.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] 新規アディポサイトカインomentinは平滑筋細胞の遊走を抑制する
- Author(s)
  風間　恭輔、岡田　宗善、山脇　英之
- Organizer
  北里大学第26回バイオサイエンスフォーラム
- Place of Presentation
  北里大学(神奈川県相模原市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカインchemerinは血管平滑筋細胞の増殖及び遊走を促進する
- Author(s)
  國本秀瑞垂、高井瑞穂、岡田宗善、山脇英之
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Omentin prevents early inflammatory responses in aorta of high fat-fed mice
- Author(s)
  Kazama K, Okada M, and Yamawaki H.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Brain-derived neurotrophic factor promotes angiogenesis via oxidative stress in human vascular endothelial cells: Implication for atherogenesis?
- Author(s)
  Hideyuki Yamawaki
- Organizer
  第39回日本微小循環学会総会（AKPS研究集会共催）
- Place of Presentation
  北里大学(東京都港区）
- Invited
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] Effects of fatty acid-binding protein(FABP)4 on proliferation of vascular smooth muscle cell
- Author(s)
  Sekiguchi A, Kazama K, Okada M, and Yamawaki H.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] Brain-derived neurotrophic factor (BDNF)は酸化ストレス産生を介して血管新生を促進する
- Author(s)
  臼井達哉、成尾明浩、岡田宗善、山脇英之
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜大学(岐阜県岐阜市)
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] Vascular effects of novel adipocytokines: implication for pathogenesis of obesity-related hypertension
- Author(s)
  Yamawaki H
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Brain-derived neurotrophic factor (BDNF)による血管新生制御メカニズムの解明
- Author(s)
  臼井達哉、成尾明浩、岡田宗善、山脇英之
- Organizer
  北里大学第26回バイオサイエンスフォーラム
- Place of Presentation
  北里大学(神奈川県相模原市)
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] Effects of vaspin, an adipocytokine on contractility of rat isolated mesenteric artery
- Author(s)
  Yamada K, Morita T, Okada M, and Yamawaki H.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] Effects of fatty acid-binding protein (FABP)4 on proliferation of vascular smooth muscle cell
- Author(s)
  Sekiguchi A, Kazama K, Okada M, and Yamawaki H.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] アディポサイトカインchemerinは血管平滑筋細胞の増殖及び遊走を促進する
- Author(s)
  國本秀瑞垂、高井瑞穂、岡田宗善、山脇英之
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-25660233
[Presentation] Nesfatin-1, a novel adipocytokine, stimulates proliferation of vascular smooth muscle cells
- Author(s)
  Hayabe Y, Usui T, Okada M, and Yamawaki H.
- Organizer
  The 87th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  東北大学(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-25292175
[Presentation] A Novel Adipocytokine, Omentin Prevents Vascular Smooth Muscle　Cell Migration By Inhibiting O2-/p38/HSP27 Pathway
- Author(s)
  Kyosuke Kazama, Muneyoshi Okada, Hideyuki Yamawaki
- Organizer
  HBPR2013
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25292175

YAMAWAKI Hideyuki 山脇 英之

Research Projects

Research Products

細胞外小胞を介したshear stressによる新たな動脈硬化制御機構の解明Principal Investigator

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Elucidation of novel mechanisms of essential hypertension development: focus on exosomePrincipal Investigator

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Mechanisms of adipocytokine control of cardiovascular diseases through the regulation of multi organ networkPrincipal Investigator

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Exploring the whole mechanisms of adipocytokine regulation of atherosclerosisPrincipal Investigator

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Spatiotemporal exploration of vascular inflammation during the development of atherosclerosisPrincipal Investigator

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Mechanisms of diabetic large vascular dysfunction : Focus on vascular contractilityPrincipal Investigator

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糖尿病性血管内皮障害におけるP2X7レセプターの役割Principal Investigator

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[Journal Article] Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain2020

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[Journal Article] Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats2020

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[Journal Article] Visceral adipose tissue-derived serine protease inhibitor prevents the development of monocrotaline-induced pulmonary arterial hypertension in rats2017

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[Journal Article] Adipocytokine, progranulin augments acetylcholine-induced nitric oxide-mediated relaxation through the increases of cGMP production in rat isolated mesenteric artery2017

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[Journal Article] Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 42017

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[Journal Article] Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats.2016

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[Journal Article] Is novel adipocytokine, omentin, a therapeutic target for obesity-related hypertension?2015

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YAMAWAKI Hideyuki 山脇英之