SHIMIZU Dai 清水大

Researcher Number	60400503
Other IDs
Affiliation (based on the past Project Information) *help	2022 – 2023: 秋田大学, 医学系研究科, 准教授 2018 – 2023: 秋田大学, 医学部附属病院, 講師 2014 – 2017: 秋田大学, 医学部, 講師 2012 – 2013: 秋田大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords	Principal Investigator 癌免疫療法 / 母児免疫寛容 Except Principal Investigator ヒト未受精卵 / micro RNA / DNA架橋修復 / アルキル化剤 / 未成熟卵子 / 白金製剤 / 免疫療法 / がん微小環境 … More / ゲノム編集 / がん免疫療法 / コンディショナルゲノム編集 / iPS細胞 / 細胞診液状検体 / 次世代シーケンサー / TP53変異 / 漿液性癌 / 発現タンパく質 / 胚選別 / 発現タンパク質 / タイムラプス / 発育挙動 / NA-K ATPase / 胚盤胞 / Na-K ATPase / タイトジャンクション / TE / ICM / 胚細胞 / in vivo / 免疫学的異系移植 / キメラ / 免疫寛容機構 / マイクロキメリズム / ﾘﾝﾊﾟ節転移 / ﾘﾝﾊﾟ管侵襲 / リンパ節転移 / リンパ管侵襲 / CRP単一塩基多型 / 子宮体癌 Less

がん微小環境特異的コンディショナルゲノム編集による新規がん免疫療法の樹立
- Principal Investigator
  
  牧野健一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Akita University
白金製剤による未成熟卵子の成熟・分裂能への影響とDNA２本鎖架橋の修復機能の解明
- Principal Investigator
  
  佐藤敏治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Akita University
子宮内膜細胞診用液状検体の遺伝子検査を用いた漿液性腺癌検診の確立
- Principal Investigator
  
  佐藤敏治
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Akita University
Cell biological significance of the remarkable construction of the human blastocyst called collapse
- Principal Investigator
  
  KUMAZAWA Yukiyo
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Akita University
Acquired tolerance during pregnency, a challenge towards the application to oncology/transplantation
- Principal Investigator
  
  TERADA YUKIHIRO
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Akita University
Establishment of novel immunotherapy against gynecologic cancer based on the mechanism of maternal-fetal immune tolerance.Principal Investigator
- Principal Investigator
  
  Shimizu Dai
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Akita University
Association between CRP single nucleotide polymorphisms and lymphatic invasion, lymph node metastasis in endometrial cancer
- Principal Investigator
  
  FUJIMOTO Toshio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Akita University

All 2020 2019 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] 遺伝性乳癌卵巣癌に対する当院での診療体制構築と展望．2020
- Author(s)
  菅原多恵、佐藤直樹、有明千賀、三浦康子、牧野健一、佐藤敏治、清水大、寺田幸弘
- Journal Title
  
  秋田県産科婦人科学会誌
  
  Volume: 25 Pages: 11-15
- NAID
  40022243617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09795
[Journal Article] An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array2019
- Author(s)
  Tamura Daisuke、Maeda Daichi、Sato Toshiharu、Sugawara Tae、Shirasawa Hiromitsu、Shimizu Dai、Sato Naoki、Goto Akiteru、Terada Yukihiro
- Journal Title
  
  Genes, Chromosomes and Cancer
  
  Volume: 59 Issue: 3 Pages: 209-213
- DOI
  10.1002/gcc.22817
- NAID
  120007089058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07433, KAKENHI-PROJECT-19K07454, KAKENHI-PROJECT-19K09795
[Journal Article] Food intake affects sperm-egg fusion through the GIP/PSG17 axis in mice.2017
- Author(s)
  Tatsunori Shimizu, Takehiro Sato, Katsushi Tsukiyama, Hiroki Fujita, Shunsuke Kato, Manabu Hoizumi, Hiromitsu Shirasawa, Takuma Narita, Yukihiro Terada, Yutaka Seino, Yoichiro Yamada
- Journal Title
  
  Endocrinology
  
  Volume: - Issue: 7 Pages: 2134-2144
- DOI
  10.1210/en.2016-1861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20170, KAKENHI-PROJECT-16K15699
[Journal Article] Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women.2017
- Author(s)
  Tanaka H,Shirasawa H,Shimizu D,Sato N,Ooyama N,Takahashi O,Terada Y
- Journal Title
  
  J Obstet Gynaecol Res
  
  Volume: 43 Pages: 1597-1601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15699
[Journal Article] 子宮体癌におけるリンチ症候群のスクリーニング戦略.2017
- Author(s)
  菅原多恵，佐藤直樹，加藤彩，髙橋和江，清水大，佐藤敏治，牧野健一，木藤正彦，田村大輔，寺田幸弘
- Journal Title
  
  日本家族性腫瘍学会誌
  
  Volume: 16 Pages: 44-49
- NAID
  130005665563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15699
[Journal Article] Clinical characteristics of Lynch-like cases collaterally classified by Lynch syndrome identification strategy using universal screening in endometrial cancer2017
- Author(s)
  Takahashi K,Sato N,Sugawara T,Kato A,Sato T,Shimizu D,Tamura D,Kito M,Makino K,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Terada Y
- Journal Title
  
  Gynecologic Oncology
  
  Volume: 147 Issue: 2 Pages: 388-395
- DOI
  10.1016/j.ygyno.2017.08.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11127, KAKENHI-PROJECT-17K11216, KAKENHI-PROJECT-16K15699
[Journal Article] Cesarean scar caseating granuloma: A case of vesicouterine fistula 30 years after cesarean section.2016
- Author(s)
  Ｓato T,Sato N,Takahashi K,Kito M,Sugawara T,Kato A,Makino K,Shimizu D,Terada Y
- Journal Title
  
  Clinical Case Reports
  
  Volume: 4 Issue: 8 Pages: 721-724
- DOI
  10.1002/ccr3.607
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15699
[Journal Article] Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients.2016
- Author(s)
  Kato A,Sato N,Sugawara T,Takahashi K,Kito M,Makino K,Sato T,Shimizu D,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Kumagai J,Terada Y
- Journal Title
  
  Am J Surg Pathol
  
  Volume: 40 Issue: 6 Pages: 770-776
- DOI
  10.1097/pas.0000000000000606
- NAID
  120006364339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11127, KAKENHI-PROJECT-16K15699
[Journal Article] Efficient Screening Strategy for Lynch Syndrome in Japanese Endometrial Cancer2015
- Author(s)
  Sugawara T, Sato N, Shimizu D, Sato T, Makino K, Kito M, Tamura D, Kato A, Terada Y
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 235 Issue: 2 Pages: 117-125
- DOI
  10.1620/tjem.235.117
- NAID
  130004822436
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592501, KAKENHI-PROJECT-24659721, KAKENHI-PROJECT-25861466, KAKENHI-PROJECT-25861467
[Journal Article] Impact of adjuvant chemotherapy for stage I ovarian carcinoma with intraoperative tumor capsule rupture.2015
- Author(s)
  Shimizu D, Sato N, Sato T, Makino K, Kito M, Shirasawa H, Kumagai J, Terada Y.
- Journal Title
  
  J Obstet Gynaecol Res
  
  Volume: 41 Issue: 3 Pages: 432-439
- DOI
  10.1111/jog.12551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861466, KAKENHI-PROJECT-25861467
[Presentation] 孤立性に存在し、腸間膜・腹膜と広汎に癒着を認めたextra ovarian endometoriomaの1例2020
- Author(s)
  白澤弘光，熊澤由紀代，佐藤亘，富樫嘉津恵，尾野夏紀，久木元詩央香，清水大，佐藤敏治，三浦康子，菅原多恵，佐藤直樹，寺田幸弘
- Organizer
  第41回日本エンドメトリオーシス学会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] オラパリブ療法中に汎血球減少と肺真菌症が発生した再発卵巣癌の2例.2020
- Author(s)
  小野有紀，佐藤直樹，菅原多恵，三浦康子，牧野健一，佐藤敏治，清水大，寺田幸弘
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] 認知の遅れたリンチ症候群関連子宮体癌の一例2020
- Author(s)
  1）菅原多恵，佐藤直樹，金子恵菜実，牧野健一，佐藤敏治，清水大，寺田幸弘
- Organizer
  第23回東北家族性腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] 認知の遅れたリンチ症候群関連子宮体癌の一例2020
- Author(s)
  菅原多恵，佐藤直樹，金子恵菜実，牧野健一，佐藤敏治，清水大，寺田幸弘
- Organizer
  第23回東北家族性腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] 術前に子宮頸部上皮内病変と診断され、円錐切除が施行された症例の転帰～LEEP の適応条件の検討～2019
- Author(s)
  佐藤敏治，佐藤直樹，吉川諒子，金子恵菜実，田村大輔，菅原多恵，三浦康子，清水大，寺田幸弘
- Organizer
  第71回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] 子宮アデノマトイド腫瘍と免疫抑制薬の相関2019
- Author(s)
  田村大輔，吉川涼子，金子恵菜実，菅原多恵，三浦康子, ，佐藤敏治，清水大，佐藤直樹，寺田幸弘
- Organizer
  第71回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] 費用対効果に優れたリンチ症候群関連子宮体癌のスクリーニング戦略2019
- Author(s)
  菅原多恵，佐藤直樹，加藤彩，髙橋和江，金子恵菜実，吉川諒子，田村大輔,三浦康子，佐藤敏治,清水大，寺田幸弘
- Organizer
  第71回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K09795
[Presentation] 臨床進行期Ⅰ期の卵巣粘液癌における後腹膜リンパ節郭清の省略条件．2016
- Author(s)
  佐藤敏治，佐藤直樹，髙橋和江，木藤正彦，牧野健一，清水大，寺田幸弘
- Organizer
  第68回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K15699
[Presentation] 子宮体癌におけるリンチ症候群の臨床分布とその識別法〜360例の検討〜2015
- Author(s)
  菅原多恵,佐藤直樹,田村大輔,木藤正彦,牧野健一,佐藤敏治,清水大,寺田幸弘
- Organizer
  第67回日本産科婦人科学会学術講演会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-04-12
- Data Source
  KAKENHI-PROJECT-24592501
[Presentation] 外陰部リンパ管拡張症に合併した血管線維腫の1 例
- Author(s)
  牧野健一，清水大，木藤正彦，菅原多恵，佐藤敏治，佐藤直樹，寺田幸弘
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25861467
[Presentation] 若年で発症し，卵巣腫瘍との鑑別が困難であった結腸間膜原発血管周皮腫（hemangiopericytoma）の1 症例
- Author(s)
  菅原多恵，木藤正彦，牧野健一，佐藤敏治，清水大，佐藤直樹，寺田幸弘
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25861467
[Presentation] 子宮魚
- Author(s)
  木藤正彦，佐藤直樹，清水大，佐藤敏治，牧野健一，菅原多恵，寺田幸弘
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25861467
[Presentation] 会陰部に発育した消化管間質腫瘍（GIST）の1例
- Author(s)
  木藤正彦，牧野健一，上野真侑，菅原多恵，佐藤敏治，清水大，佐藤直樹，寺田幸弘
- Organizer
  第62回北日本産科婦人科学会
- Place of Presentation
  ホテル金沢
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25861467

1. SATO Toshiharu (70636183)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. SATO Naoki (40447199)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. 牧野健一 (20714330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. FUJIMOTO Toshio (20375249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TERADA YUKIHIRO (10260431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. KUMAZAWA Yukiyo (70400504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐藤亘 (10726441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高橋和政 (60791910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 三浦広志 (80375302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 菅原多恵 (40566163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 白澤弘光 (60598019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 後藤明輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 前田大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU Dai 清水 大

Research Projects

Research Products

Co-Researchers

がん微小環境特異的コンディショナルゲノム編集による新規がん免疫療法の樹立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

白金製剤による未成熟卵子の成熟・分裂能への影響とDNA２本鎖架橋の修復機能の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

子宮内膜細胞診用液状検体の遺伝子検査を用いた漿液性腺癌検診の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell biological significance of the remarkable construction of the human blastocyst called collapse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Acquired tolerance during pregnency, a challenge towards the application to oncology/transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel immunotherapy against gynecologic cancer based on the mechanism of maternal-fetal immune tolerance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Association between CRP single nucleotide polymorphisms and lymphatic invasion, lymph node metastasis in endometrial cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 遺伝性乳癌卵巣癌に対する当院での診療体制構築と展望．2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Food intake affects sperm-egg fusion through the GIP/PSG17 axis in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women.2017

Author(s)

Journal Title

Data Source

[Journal Article] 子宮体癌におけるリンチ症候群のスクリーニング戦略.2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Clinical characteristics of Lynch-like cases collaterally classified by Lynch syndrome identification strategy using universal screening in endometrial cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cesarean scar caseating granuloma: A case of vesicouterine fistula 30 years after cesarean section.2016

Author(s)

Journal Title

DOI

SHIMIZU Dai 清水大