Takaesu Giichi 高江洲義一

… Alternative Names

TAKAESU Giichi 高江洲義一

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Researcher Number	60403995
Other IDs
Affiliation (Current)	2025: 琉球大学, 熱帯生物圏研究センター, 准教授
Affiliation (based on the past Project Information) *help	2025: 琉球大学, 熱帯生物圏研究センター, 准教授 2016 – 2023: 琉球大学, 熱帯生物圏研究センター, 准教授 2013 – 2015: 琉球大学, 医学(系)研究科(研究院), 助教 2009: Kyushu University, 医学部, 講師 2007 – 2008: Kyushu University, Medical Institute of Bioregulation, Assistant Professor 2006: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Experimental pathology / Cell biology / Bacteriology (including mycology) / Immunology Except Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology)
Keywords	Principal Investigator マクロファージ / 自然免疫 / インフラマソーム / 炎症 / Tax / TAB2 / TAB1 / TAK1 / 細胞死 / 感染症 … More / Zmp1 / NLRP3 / IL-1beta / 電子伝達系 / ミトコンドリア / インターロイキン(IL)-1β / 結核菌 / 泡沫細胞 / LPS / ネクロプトーシス / IL-1b / サイトカイン / DAMP / TNF / Proteome / HTLV- 1 / Ubiquitin / Negative regulation / Inflammatory cytokines / Toll-like receptor (TLR) / Innate Immunity / TLR / キナーゼ / プロテオーム / HTLV-1 / ユビキチン / 負の制御 / 炎症性サイトカイン / Toll-like receptor(TLR) / TAK1-binding proteins / オートファジー … More Except Principal Investigator 結核菌 / 結核 / 病原因子 / IL-17A / IL-1β / 3型免疫応答 / interleukin-1β / 肺 / TCR γδ T細胞 / interleukin-17 / マクロファージ / 結核ワクチン / Zmp1 / 炎症性サイトカイン / ワクチン / IFN-γ / TCR γδT細胞 / interleukin-17A / BCG / Zinc metalloprotease / interleukine-1β / interleukine-17A / 肺胞上皮細胞 / インターロイキン－17 / 免疫抑制 / ミトコンドリア / インフラマソーム / 肉芽腫 / γδ T細胞 / IL-23 / IL-17 / TcR γδT細胞 / interleukin-23 / 炎症 / 感染防御・制御 / 感染防御 / インフラマゾーム Less

結核菌の病原因子Zmp1による炎症性サイトカイン遺伝子の発現制御機構の解明
- Principal Investigator
  
  松崎吾朗
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
Elucidation of the mechanism of type 3 immune response in Mycobacterium tuberculosis-infected lungs and development of anti-tuberculosis vaccine strategies
- Principal Investigator
  
  梅村正幸
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
Analysis of type 3 immune responses against M. tuberculosis infection and application to boost vaccine
- Principal Investigator
  
  梅村正幸
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
Analysis of molecular mechanism of mitochondrial damage and immune suppression induced by Mycobacterium tuberculosis
- Principal Investigator
  
  Matsuzaki Goro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
Analysis of multiple defense mechanisms of "type 3 immune response" in mycobacteria infected lungs
- Principal Investigator
  
  Umemura Masayuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
A role of TAB3 in host defense against mycobacterial infectionPrincipal Investigator
- Principal Investigator
  
  Takaesu Giichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  University of the Ryukyus
Molecular mechanisms of cell death in macrophages and foam cellsPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of the Ryukyus
Elucidation of caspase-1 activation inhivition mechanism by Vibrio parahaemolyticus effector VopQ
- Principal Investigator
  
  HIGA Naomi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  University of the Ryukyus
A novel regulatory mechanism of cell death in macrophagesPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  University of the Ryukyus
Cross-regulatory mechanisms of innate immunity and autophagyPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
Mechanisms for negative regulation ofTAK1/MAPKKK in innate immune responsesPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2009 2008 2006

All Journal Article Presentation

[Journal Article] GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.2022
- Author(s)
  Kurane, T., Matsunaga, T., Ida, T., Sawada, K., Nishimura, A., Fukui, M., Umemura, M., Nakayama, M., Ohara, N., Matsumoto, S., Akaike, T., Matsuzaki, G., Takaesu, G.
- Journal Title
  
  FASEB Journal
  
  Volume: 36 Issue: 1
- DOI
  10.1096/fj.202101074rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07117, KAKENHI-PROJECT-20K21496, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-20H03487, KAKENHI-PROJECT-19K07554, KAKENHI-PROJECT-20K05930, KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-21K05504, KAKENHI-PROJECT-21K07028, KAKENHI-PROJECT-21K09842, KAKENHI-PROJECT-17H06170
[Journal Article] Activated macrophage survival is coordinated by TAK1 binding proteins2014
- Author(s)
  Mihaly SR, Morioka S, Ninomiya-Tsuji J, Takaesu G
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 4 Pages: e94982-e94982
- DOI
  10.1371/journal.pone.0094982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860322
[Journal Article] TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation2014
- Author(s)
  Morioka, S., Broglie, P., Omori, E., Ikeda, Y., Takaesu, G. Matsumoto, K., and Ninomiya-Tsuji, J.
- Journal Title
  
  J, Cell. Biol.
  
  Volume: 204 Issue: 4 Pages: 607-623
- DOI
  10.1083/jcb.201305070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24112510, KAKENHI-PROJECT-25860322
[Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.2009
- Author(s)
  Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A.
- Journal Title
  
  Immunity. 30(3)
  
  Pages: 372-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.2009
- Author(s)
  Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A.
- Journal Title
  
  J Immunol. 182(10)
  
  Pages: 5929-5937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.2009
- Author(s)
  Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G.
- Journal Title
  
  Biochem Biophys Res Commun. 381(3)
  
  Pages: 412-417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4, 5-biphosphate hydrolysis.2009
- Author(s)
  Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A.
- Journal Title
  
  Oncogene. 28(8)
  
  Pages: 1076-1088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.2008
- Author(s)
  Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T.
- Journal Title
  
  J Biol Chem. 283(25)
  
  Pages: 17003-17008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] STAT6 Inhibits TGF-betal-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.2008
- Author(s)
  Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T.
- Journal Title
  
  J Biol Chem. 283(22)
  
  Pages: 14955-14962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.2008
- Author(s)
  Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T.
- Journal Title
  
  J Biol Chem. 283(52)
  
  Pages: 36211-36220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor(TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.2008
- Author(s)
  Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A.
- Journal Title
  
  J-Biol Chem 283(49)
  
  Pages: 33858-33864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo2006
- Author(s)
  Takaesu, Giichi, et. al.
- Journal Title
  
  Journal of Cell Biology 175・3
  
  Pages: 383-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.2006
- Author(s)
  Minoda Y, Saeki K, Aki D, Takaesu G, Yoshimura A. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 344(3)
  
  Pages: 1023-30
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] TGF-betal suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.2006
- Author(s)
  Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A. et al.
- Journal Title
  
  Genes Cells. 11(8)
  
  Pages: 871-82
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.2006
- Author(s)
  Lu Y, Fukuyama S, Yoshida R, Yoshimura A, Takaesu G. et al.
- Journal Title
  
  J Biol Chem. 281(48)
  
  Pages: 36683-90
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo2006
- Author(s)
  Takaesu, Giichi, et. al.
- Journal Title
  
  Journal of Cell, Biology 175-3
  
  Pages: 383-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570180
[Presentation] マイコバクテリア感染によって誘導されるサイトカイン産生におけるGRIM-19の新規役割2023
- Author(s)
  高江洲義一，梅村正幸，松崎吾朗
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] Zinc metalloprotease (Zmp) 1欠損BCGの追加接種による肺炎誘導のメカニズム2023
- Author(s)
  梅村正幸、渡久地ジュリ亜、吉里真誼、下忠義継、高江洲義一、松﨑吾朗
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 1.Effect of zinc metalloprotease 1-deficient BCG vaccination in protective immunity to pulmonary tuberculosis2023
- Author(s)
  Masasyuki Umemura, Masayori Yoshisato, Ryusei Shimotada, Julia Toguchi, Giichi Takaesu, Goro Matsuzaki
- Organizer
  JSICR/MMCB 2023 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] Elucidation of pneumonia-inducing mechanism by additional inoculation of Zinc metalloprotease 1-deficient Mycobacterium tuberculosis variant BCG2023
- Author(s)
  Masayuki Umemura, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] Zinc metalloprotease(Zmp)1欠損BCGの追加接種による肺炎誘導メカニズムの解明2023
- Author(s)
  梅村正幸，渡久地ジュリ亜，吉里真誼，下忠龍生，高江洲義一，松崎吾朗
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] マイコバクテリア感染によって誘導されるサイトカイン産生におけるGrio19の新規役割2023
- Author(s)
  高江洲義一、梅村正幸、松﨑吾朗
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌Zmp1によるIL-1β産生抑制の分子機構2023
- Author(s)
  松﨑吾朗、高江洲義一
- Organizer
  第96回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] Zmp1欠損Mycobacterium tuberculosis var. BCG接種による抗結核防御応答2023
- Author(s)
  梅村正幸, 吉里真誼, 下忠龍生, 渡久地ジュリ亜, 高江洲義一, 松崎吾朗
- Organizer
  第34回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] Effect of Zmp1-deficient BCG vaccination in protective immunity to pulmonary tuberculosis2022
- Author(s)
  Masayuki Umemura, Masayori Yoshisato, Ryusei Shimotada, Julia Toguchi, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] マイコバクテリア感染肺におけるTCRVγ6 γδT細胞の検出2022
- Author(s)
  梅村正幸、波多野晋也、下忠龍生、吉里真、渡久地ジュリ亜、高江洲義一、吉開康信、松﨑吾朗
- Organizer
  第33回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] A novel role of GRIM-19 in cytokine production upon mycobacterial infection2022
- Author(s)
  Giichi Takaesu, Tomomi Kurane, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌のエフェクタータンパク質Zmp1と会合する宿主E3ユビキチンリガーゼの機能解析2022
- Author(s)
  高江洲義一、Nguen Huong Minh、梅村正幸、松﨑吾朗
- Organizer
  第33回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] マイコバクテリアの産生する病原因子Zinc Metalloprotease 1（Zmp1）による炎症性サイトカインIL-1β産生抑制の分子機構2022
- Author(s)
  松﨑吾朗, 藏根友美, 梅村正幸, 大原直也, 高江洲義一
- Organizer
  第33回日本比較免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] Effect of Zmp1-deficient BCG vaccination in protective immunity to pulmonary tuberculosis2022
- Author(s)
  Masasyuki Umemura, Masayori Yoshisato, Ryusei Shimotada, Julia Toguchi, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] A novel role of GRIM-19 in cytokine production in macrophages upon mycobacterial infection2022
- Author(s)
  Giichi Takaesu, Tomomi Kurane, Masayuki Umemura, Goro Matsuzaki.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌のエフェクタータンパク質Zmp1と会合する宿主E3ユビキチンリガーゼの機能解析2022
- Author(s)
  高江洲義一, Nguen Huong Minh, 梅村正幸, 松崎吾朗
- Organizer
  第33回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] TAB2とTAB3はTLR刺激に応答したサイトカイン産生に必須である2022
- Author(s)
  Tanveer Ali、松﨑吾朗、高江洲義一
- Organizer
  第33回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] マイコバクテリアの産生する病原因子Zinc Metalloprotease 1（Zmp1）による炎症性サイトカインIL-1β産生抑制の分子機構2022
- Author(s)
  松﨑吾朗、藏根友美、梅村正幸、大原直也、高江洲義一
- Organizer
  第３３回日本比較免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] マイコバクテリア感染肺におけるTCRVγ6+ γδ T細胞の検出2022
- Author(s)
  梅村正幸, 畑野晋也, 下忠龍生, 吉里真誼, 渡久地ジュリ亜, 高江洲義一, 吉開泰信, 松崎吾朗
- Organizer
  第33回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2021
- Author(s)
  藏根友美，高江洲義一，澤田和子，梅村正幸，松﨑吾朗
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌のエフェクタータンパク質Zmp1と会合する宿主E3ユビキチンリガーゼの機能解析2021
- Author(s)
  高江洲義一, Nguen Huong Minh, 梅村正幸, 松﨑吾朗
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] The effect of the deletion of the mycobacterial virulence factor Zmp1 on protective immunity2021
- Author(s)
  Masasyuki Umemura, Sohkichi Matsumoto, Tomomi Kurane, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌に対する生体防御と炎症性サイトカイン2021
- Author(s)
  松﨑吾朗, 藏根友美, 梅村正幸, 高江洲義一
- Organizer
  第32回日本生体防御学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2021
- Author(s)
  藏根友美, 高江洲義一, 松永哲郎, 井田智章, 澤田和子, 梅村正幸, 赤池孝章, 松﨑吾朗
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2021
- Author(s)
  藏根友美, 高江洲義一, 松永哲郎, 井田智章, 澤田和子, 梅村正幸, 赤池孝章, 松﨑吾朗
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質Zmp1と会合するGRIM-19の機能解析2021
- Author(s)
  藏根友美, 松永哲郎, 井田智章, 澤田和子, 梅村正幸, 赤池孝章, 松﨑吾朗, 高江洲義一
- Organizer
  第5回抗酸菌研究会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌に対する生体防御と炎症性サイトカイン2021
- Author(s)
  松﨑吾朗, 藏根友美, 梅村正幸, 高江洲義一
- Organizer
  第32回日本生体防御学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌由来病原因子Zmp1欠損の感染防御への影響2021
- Author(s)
  梅村正幸、松本宗吉、藏根友美、高江洲義一、松﨑吾朗
- Organizer
  第32回日本生体防御学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌エフェクタータンパク質Zmp1と会合するGRIM-19の機能解析2021
- Author(s)
  藏根友美, 松永哲郎, 井田智章, 澤田和子, 梅村正幸, 赤池孝章, 松﨑吾朗, 高江洲義一
- Organizer
  第5回抗酸菌研究会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation2021
- Author(s)
  Tomomi Kurane, Masayuki Umemura, Masaaki Nakayama, Naoya Ohara, Goro Matsuzaki, Giichi Takaesu
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌エフェクター蛋白質によるIL-1β産生阻害の分子機序2021
- Author(s)
  藏根友美、松永哲郎、井田智章、澤田和子、梅村正幸、赤池孝章、松﨑吾朗、高江洲義一
- Organizer
  九州微生物研究フォーラム2021
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] The effect of the deletion of the mycobacterial virulence factor Zmp1 on protective immunity2021
- Author(s)
  Masasyuki Umemura, Sohkichi Matsumoto, Tomomi Kurane, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] The effect of the deletion of the mycobacterial virulence factor Zmp1 on protective immunity2021
- Author(s)
  Masayuki Umemura, Sohkichi Matsumoto, Tomomi Kurane, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌のエフェクタータンパク質Zmp1と会合する宿主E3ユビキチンリガーゼの機能解析2021
- Author(s)
  高江洲義一, Nguen Huong Minh, 梅村正幸, 松﨑吾朗
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌エフェクター蛋白質によるIL-1β産生阻害の分子機序2021
- Author(s)
  藏根友美、高江洲義一、松永哲郎、井田智章、澤田和子、梅村正幸、赤池孝章、松﨑吾朗
- Organizer
  第32回日本生体防御学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌のエフェクター蛋白質Zmp1と会合する宿主E3ユビキチンリガーゼの機能解析2021
- Author(s)
  高江洲義一、Nguen Huong Minh、梅村正幸、松﨑吾朗
- Organizer
  第32回日本生体防御学会総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌由来病原因子Zmp1欠損の感染防御への影響2021
- Author(s)
  梅村正幸, 松本壮吉, 藏根友美, 高江洲義一, 松﨑吾朗
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07028
[Presentation] 結核菌由来病原因子Zmp1欠損の感染防御への影響2021
- Author(s)
  梅村正幸, 松本壮吉, 藏根友美, 高江洲義一, 松﨑吾朗
- Organizer
  第32回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質によるIL-1beta産生阻害の分子機序2021
- Author(s)
  藏根友美、高江洲義一、澤田和子、梅村正幸、松﨑吾朗
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌由来のエフェクタータンパク質によるIL-1β産生阻害の分子機序2020
- Author(s)
  高江洲義一、藏根友美、澤田和子、西村明、松永哲郎、井田智章、梅村正幸、赤池孝章、松﨑吾朗．
- Organizer
  第３１回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03487
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2020
- Author(s)
  藏根友美、澤田和子、高江洲義一、梅村正幸、松崎吾朗
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌由来のエフェクタータンパク質によるIL-1β産生阻害の分子機序2020
- Author(s)
  高江洲義一，藏根友美，澤田和子，西村明，松永哲郎，井田智章，梅村正幸，赤池孝章，松﨑吾朗
- Organizer
  第31回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌由来のエフェクタータンパク質によるIL-1beta産生阻害の分子機序2020
- Author(s)
  高江洲義一、藏根友美、松永哲郎、井田智章、澤田和子、梅村正幸、赤池孝章、松﨑吾朗
- Organizer
  第31回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] Identification and functional analysis of a host protein targeted by mycobacterial effector Zmp12020
- Author(s)
  Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] A molecular mechanism of IL-1b inhibition by mycobacterial effector protein2020
- Author(s)
  Tomomi Kurane, Kazuko Sawada, Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] A molecular mechanism of IL-1β inhibition by mycobacterial effector protein2020
- Author(s)
  Tomomi Kurane, Kazuko Sawada, Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌のエフェクタータンパク質Zmp1と相互作用する宿主側分子の同定とその機能解析2020
- Author(s)
  高江洲義一、梅村正幸、松崎吾朗
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] Mechanism of mycobacteria specific IL-17A production of BCG infected lung-derived TcR γδ T cells.2019
- Author(s)
  Masayuki Umemura, Mio Iimura, Tomomi Kurane, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第43回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] Effects of zinc metalloprotease-1 on innate and Th1/Th17 immunity during lung mycobacterial infection.2019
- Author(s)
  Msayuki Umemura, Naoko Teruya, Giichi Takaesu, Naoya Ohara, Goro Matsuzaki
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] マイコバクテリア病原因子Zmp1の自然免疫およびT細胞免疫応答への影響2019
- Author(s)
  梅村正幸、木村倫和、岩橋晃平、藏根友美、照屋尚子、中山真彰、大原直也、高江洲義一、松崎吾朗
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] BCG感染肺由来TcR γδ T細胞の抗原特異的IL-17A産生メカニズムの解明2019
- Author(s)
  梅村正幸, 飯村澪,　高江洲義一, 松﨑吾朗
- Organizer
  第30回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 病原因子Zmp1欠損マイコバクテリアによるT細胞免疫応答への影響2019
- Author(s)
  梅村正幸, 藏根友美, 中山真彰, 大原直也, 高江洲義一, 松﨑吾朗
- Organizer
  第84回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2019
- Author(s)
  藏根友美, 澤田和子, 高江洲義一, 梅村正幸, 松﨑吾朗
- Organizer
  第30回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] マイコバクテリア病原因子Zmp1の自然免疫およびT細胞免疫応答への影響2019
- Author(s)
  梅村正幸, 木村倫和, 岩橋晃平, 照屋尚子, 藏根友美, 中山真彰, 大原直也, 高江洲義一, 松﨑吾朗
- Organizer
  第60回日本熱帯医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌が賛成するエフェクター分子の作用機序の解明とそれに基づく宿主免疫増強型の結核治療法の開発2019
- Author(s)
  高江洲義一、藏根友美、、澤田和子、梅村正幸、松崎吾朗
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2019
- Author(s)
  高江洲義一、藏根友美、澤田和子、梅村正幸、松崎吾朗
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] A molecular mechanism of IL-1β inhibition by mycobacterial effector protein.2019
- Author(s)
  Tomomi Kurane, Kazuko Sawada, Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2019
- Author(s)
  高江洲義一, 藏根友美, 澤田和子, 梅村正幸, 松﨑吾朗
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌の分泌タンパク質Zmp1によるIL-1b産生阻害機序2018
- Author(s)
  高江洲義一、藏根友美、平安座啓、山田綾太郎、梅村正幸、松﨑吾朗
- Organizer
  第２９回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] Effects of mycobacteria-derived zinc-dependent metalloprotease-1 (Zmp1) on innate and T-cell immune response.2018
- Author(s)
  Masayuki Umemura, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] A mycobacterial virulence factor Zmp1 interferes with NLRP3 inflammasome activation by targeting host mitochondrial protein.2018
- Author(s)
  Giichi Takaesu, Tomomi Kurane, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] A molecular mechanism of inflammasome suppression by mycobacterial virulence factor2018
- Author(s)
  高江洲義一、藏根友美、梅村正幸、松﨑吾朗
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌の分泌タンパク質Zmp1によるIL-1β産生阻害機序2018
- Author(s)
  高江洲義一, 藏根友美, 平安座啓, 山田綾太郎, 梅村正幸, 松﨑吾朗
- Organizer
  第29回日本生体防御学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 自然免疫およびT細胞免疫応答へのBCG由来病原因子Zmp1の影響2018
- Author(s)
  梅村正幸,　木村倫和, 岩橋晃平, 照屋尚子, 高江洲義一, 松﨑吾朗
- Organizer
  第29回日本生体防御学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌の分泌タンパク質Zmp1によるIL-1b産生阻害の分子機序2018
- Author(s)
  藏根友美、高江洲義一、梅村正幸、松﨑吾朗
- Organizer
  第71回日本細菌学会九州支部総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] マイコバクテリア感染肺に誘導されるIL-17A産生細胞の多様性2018
- Author(s)
  梅村正幸, 儀間香南子, 高江洲義一, 中江進, 岩倉洋一郎, 松﨑吾朗
- Organizer
  第83回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] TAK1-binding protein 2 (TAB2) negatively regulates the processing of pro-interleukin-1b2017
- Author(s)
  Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki, Toshihiko Suzuki
- Organizer
  OIST & Univ. Ryukyus Joint Symposium 2017
- Data Source
  KAKENHI-PROJECT-15K08429
[Presentation] TAB2はマクロファージの細胞死とIL-1bの産生を負に制御する2016
- Author(s)
  高江洲義一、松﨑吾朗、鈴木敏彦
- Organizer
  第27回　日本生体防御学会学術総会
- Place of Presentation
  九州大学病院キャンパスコラボステーションI（福岡県福岡市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-15K08429
[Presentation] TAK1-binding protein 2 (TAB2) negatively regulates the processing of pro-interleukin-1beta2015
- Author(s)
  高江洲義一、仲宗根昇、トーマ・クラウディア、比嘉直美、鈴木敏彦
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-15K08429
[Presentation] TAK1 Kinase Complex Regulates Macrophage Survival2014
- Author(s)
  高江洲　義一
- Organizer
  Keystone Symposium, "The Chemistry and Biology of Cell Death"
- Place of Presentation
  米国ニューメキシコ州サンタフェ市
- Data Source
  KAKENHI-PROJECT-25860322
[Presentation] TAK1-binding protein 2 (TAB2)may negatively regulate basal autophagy2009
- Author(s)
  高江洲義一、吉村昭彦
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20790376
[Presentation] TAK1-binding protein 2(TAB2) may negatively regulate basal autophagy.2009
- Author(s)
  高江洲義一
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20790376
[Presentation] TAK1-binding protein 2(TAB2)is essential for cell division.2008
- Author(s)
  高江洲義一、吉村昭彦
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20790376
[Presentation] TAK1-binding protein 2 (TAB2) is essential for cell division2008
- Author(s)
  高江洲義一
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20790376

1. Umemura Masayuki (90359985)

# of Collaborated Projects: 6 results

# of Collaborated Products: 65 results
2. Matsuzaki Goro (30229455)

# of Collaborated Projects: 6 results

# of Collaborated Products: 67 results
3. HIGA Naomi (70457688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUZUKI Toshihiko (10292848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松永哲郎 (00723206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 松本壮吉 (30244073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 瀬戸真太郎 (50383203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松本邦弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takaesu Giichi 高江洲 義一

TAKAESU Giichi 高江洲 義一

Research Projects

Research Products

Co-Researchers

結核菌の病原因子Zmp1による炎症性サイトカイン遺伝子の発現制御機構の解明

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Elucidation of the mechanism of type 3 immune response in Mycobacterium tuberculosis-infected lungs and development of anti-tuberculosis vaccine strategies

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Analysis of type 3 immune responses against M. tuberculosis infection and application to boost vaccine

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Analysis of molecular mechanism of mitochondrial damage and immune suppression induced by Mycobacterium tuberculosis

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Analysis of multiple defense mechanisms of "type 3 immune response" in mycobacteria infected lungs

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A role of TAB3 in host defense against mycobacterial infectionPrincipal Investigator

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Molecular mechanisms of cell death in macrophages and foam cellsPrincipal Investigator

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Elucidation of caspase-1 activation inhivition mechanism by Vibrio parahaemolyticus effector VopQ

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A novel regulatory mechanism of cell death in macrophagesPrincipal Investigator

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Cross-regulatory mechanisms of innate immunity and autophagyPrincipal Investigator

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Mechanisms for negative regulation ofTAK1/MAPKKK in innate immune responsesPrincipal Investigator

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[Journal Article] GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation.2022

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Data Source

[Journal Article] Activated macrophage survival is coordinated by TAK1 binding proteins2014

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DOI

Takaesu Giichi 高江洲義一

TAKAESU Giichi 高江洲義一