Takaesu Giichi 高江洲義一

… Alternative Names

Researcher Number	60403995
Other IDs
Affiliation (Current)	2020: 琉球大学, 熱帯生物圏研究センター, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 琉球大学, 熱帯生物圏研究センター, 准教授 2013 – 2015: 琉球大学, 医学(系)研究科(研究院), 助教 2009: Kyushu University, 医学部, 講師 2007 – 2008: Kyushu University, Medical Institute of Bioregulation, Assistant Professor 2006: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Bacteriology (including mycology) / Cell biology / Experimental pathology / Basic Section 49070:Immunology-related Except Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology)
Keywords	Principal Investigator 自然免疫 / マクロファージ / 細胞死 / TAK1 / TAB1 / TAB2 / Tax / 炎症 / オートファジー / TAK1-binding proteins … More Except Principal Investigator 結核菌 / マクロファージ / インフラマゾーム / 感染防御 / 感染防御・制御 / 炎症 / IL-17 / IL-23 / IL-1β / 3型免疫応答 / 結核 / 肺 / IL-17A / γδ T細胞 / 肉芽腫 / ミトコンドリア / 免疫抑制 Less

結核菌によるミトコンドリア障害と免疫抑制の分子基盤と治療への応用Ongoing
- Principal Investigator
  
  松崎吾朗
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
結核菌感染肺における「3型免疫応答」の多元的防御機構の解明Ongoing
- Principal Investigator
  
  梅村正幸
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  University of the Ryukyus
結核菌感染におけるTAB3の役割Principal InvestigatorOngoing
- Principal Investigator
  
  高江洲義一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  University of the Ryukyus
Molecular mechanisms of cell death in macrophages and foam cellsPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of the Ryukyus
Elucidation of caspase-1 activation inhivition mechanism by Vibrio parahaemolyticus effector VopQ
- Principal Investigator
  
  HIGA Naomi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  University of the Ryukyus
A novel regulatory mechanism of cell death in macrophagesPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  University of the Ryukyus
Cross-regulatory mechanisms of innate immunity and autophagyPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
Mechanisms for negative regulation ofTAK1/MAPKKK in innate immune responsesPrincipal Investigator
- Principal Investigator
  
  TAKAESU Giichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University

All 2020 2019 2018 2017 2016 2015 2014 2009 2008 2006

All Journal Article Presentation

[Journal Article] TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation2014
- Author(s)
  Morioka, S., Broglie, P., Omori, E., Ikeda, Y., Takaesu, G. Matsumoto, K., and Ninomiya-Tsuji, J.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 204 Pages: 607-623
- DOI
  10.1083/jcb.201305070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24112510, KAKENHI-PROJECT-25860322
[Journal Article] Activated macrophage survival is coordinated by TAK1 binding proteins2014
- Author(s)
  Mihaly SR, Morioka S, Ninomiya-Tsuji J, Takaesu G
- Journal Title
  
  PLOS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0094982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860322
[Journal Article] An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.2009
- Author(s)
  Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G.
- Journal Title
  
  Biochem Biophys Res Commun. 381(3)
  
  Pages: 412-417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.2009
- Author(s)
  Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A.
- Journal Title
  
  J Immunol. 182(10)
  
  Pages: 5929-5937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.2009
- Author(s)
  Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A.
- Journal Title
  
  Immunity. 30(3)
  
  Pages: 372-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4, 5-biphosphate hydrolysis.2009
- Author(s)
  Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A.
- Journal Title
  
  Oncogene. 28(8)
  
  Pages: 1076-1088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.2008
- Author(s)
  Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T.
- Journal Title
  
  J Biol Chem. 283(25)
  
  Pages: 17003-17008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] STAT6 Inhibits TGF-betal-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.2008
- Author(s)
  Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T.
- Journal Title
  
  J Biol Chem. 283(22)
  
  Pages: 14955-14962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor(TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.2008
- Author(s)
  Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A.
- Journal Title
  
  J-Biol Chem 283(49)
  
  Pages: 33858-33864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.2008
- Author(s)
  Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T.
- Journal Title
  
  J Biol Chem. 283(52)
  
  Pages: 36211-36220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790376
[Journal Article] Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo2006
- Author(s)
  Takaesu, Giichi, et. al.
- Journal Title
  
  Journal of Cell Biology 175・3
  
  Pages: 383-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.2006
- Author(s)
  Minoda Y, Saeki K, Aki D, Takaesu G, Yoshimura A. et al.
- Journal Title
  
  Biochem Biophys Res Commun. 344(3)
  
  Pages: 1023-30
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] TGF-betal suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.2006
- Author(s)
  Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A. et al.
- Journal Title
  
  Genes Cells. 11(8)
  
  Pages: 871-82
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.2006
- Author(s)
  Lu Y, Fukuyama S, Yoshida R, Yoshimura A, Takaesu G. et al.
- Journal Title
  
  J Biol Chem. 281(48)
  
  Pages: 36683-90
- Data Source
  KAKENHI-PROJECT-18570180
[Journal Article] Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo2006
- Author(s)
  Takaesu, Giichi, et. al.
- Journal Title
  
  Journal of Cell, Biology 175-3
  
  Pages: 383-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570180
[Presentation] A molecular mechanism of IL-1β inhibition by mycobacterial effector protein2020
- Author(s)
  Tomomi Kurane, Kazuko Sawada, Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2020
- Author(s)
  藏根友美、澤田和子、高江洲義一、梅村正幸、松崎吾朗
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌のエフェクタータンパク質Zmp1と相互作用する宿主側分子の同定とその機能解析2020
- Author(s)
  高江洲義一、梅村正幸、松崎吾朗
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] Identification and functional analysis of a host protein targeted by mycobacterial effector Zmp12020
- Author(s)
  Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] マイコバクテリア病原因子Zmp1の自然免疫およびT細胞免疫応答への影響2019
- Author(s)
  梅村正幸、木村倫和、岩橋晃平、藏根友美、照屋尚子、中山真彰、大原直也、高江洲義一、松崎吾朗
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2019
- Author(s)
  藏根友美, 澤田和子, 高江洲義一, 梅村正幸, 松﨑吾朗
- Organizer
  第30回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] Effects of zinc metalloprotease-1 on innate and Th1/Th17 immunity during lung mycobacterial infection.2019
- Author(s)
  Msayuki Umemura, Naoko Teruya, Giichi Takaesu, Naoya Ohara, Goro Matsuzaki
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2019
- Author(s)
  高江洲義一, 藏根友美, 澤田和子, 梅村正幸, 松﨑吾朗
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] Mechanism of mycobacteria specific IL-17A production of BCG infected lung-derived TcR γδ T cells.2019
- Author(s)
  Masayuki Umemura, Mio Iimura, Tomomi Kurane, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第43回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌エフェクタータンパク質によるIL-1β産生阻害の分子機序2019
- Author(s)
  高江洲義一、藏根友美、澤田和子、梅村正幸、松崎吾朗
- Organizer
  第60回日本熱帯医学会大会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌が賛成するエフェクター分子の作用機序の解明とそれに基づく宿主免疫増強型の結核治療法の開発2019
- Author(s)
  高江洲義一、藏根友美、、澤田和子、梅村正幸、松崎吾朗
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] A molecular mechanism of IL-1β inhibition by mycobacterial effector protein.2019
- Author(s)
  Tomomi Kurane, Kazuko Sawada, Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 病原因子Zmp1欠損マイコバクテリアによるT細胞免疫応答への影響2019
- Author(s)
  梅村正幸, 藏根友美, 中山真彰, 大原直也, 高江洲義一, 松﨑吾朗
- Organizer
  第84回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] マイコバクテリア病原因子Zmp1の自然免疫およびT細胞免疫応答への影響2019
- Author(s)
  梅村正幸, 木村倫和, 岩橋晃平, 照屋尚子, 藏根友美, 中山真彰, 大原直也, 高江洲義一, 松﨑吾朗
- Organizer
  第60回日本熱帯医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] BCG感染肺由来TcR γδ T細胞の抗原特異的IL-17A産生メカニズムの解明2019
- Author(s)
  梅村正幸, 飯村澪,　高江洲義一, 松﨑吾朗
- Organizer
  第30回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 自然免疫およびT細胞免疫応答へのBCG由来病原因子Zmp1の影響2018
- Author(s)
  梅村正幸,　木村倫和, 岩橋晃平, 照屋尚子, 高江洲義一, 松﨑吾朗
- Organizer
  第29回日本生体防御学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] マイコバクテリア感染肺に誘導されるIL-17A産生細胞の多様性2018
- Author(s)
  梅村正幸, 儀間香南子, 高江洲義一, 中江進, 岩倉洋一郎, 松﨑吾朗
- Organizer
  第83回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] A molecular mechanism of inflammasome suppression by mycobacterial virulence factor2018
- Author(s)
  高江洲義一、藏根友美、梅村正幸、松﨑吾朗
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌の分泌タンパク質Zmp1によるIL-1b産生阻害の分子機序2018
- Author(s)
  藏根友美、高江洲義一、梅村正幸、松﨑吾朗
- Organizer
  第71回日本細菌学会九州支部総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] 結核菌の分泌タンパク質Zmp1によるIL-1β産生阻害機序2018
- Author(s)
  高江洲義一, 藏根友美, 平安座啓, 山田綾太郎, 梅村正幸, 松﨑吾朗
- Organizer
  第29回日本生体防御学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] Effects of mycobacteria-derived zinc-dependent metalloprotease-1 (Zmp1) on innate and T-cell immune response.2018
- Author(s)
  Masayuki Umemura, Giichi Takaesu, Goro Matsuzaki
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] 結核菌の分泌タンパク質Zmp1によるIL-1b産生阻害機序2018
- Author(s)
  高江洲義一、藏根友美、平安座啓、山田綾太郎、梅村正幸、松﨑吾朗
- Organizer
  第２９回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07179
[Presentation] A mycobacterial virulence factor Zmp1 interferes with NLRP3 inflammasome activation by targeting host mitochondrial protein.2018
- Author(s)
  Giichi Takaesu, Tomomi Kurane, Masayuki Umemura, Goro Matsuzaki
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07117
[Presentation] TAK1-binding protein 2 (TAB2) negatively regulates the processing of pro-interleukin-1b2017
- Author(s)
  Giichi Takaesu, Masayuki Umemura, Goro Matsuzaki, Toshihiko Suzuki
- Organizer
  OIST & Univ. Ryukyus Joint Symposium 2017
- Data Source
  KAKENHI-PROJECT-15K08429
[Presentation] TAB2はマクロファージの細胞死とIL-1bの産生を負に制御する2016
- Author(s)
  高江洲義一、松﨑吾朗、鈴木敏彦
- Organizer
  第27回　日本生体防御学会学術総会
- Place of Presentation
  九州大学病院キャンパスコラボステーションI（福岡県福岡市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-15K08429
[Presentation] TAK1-binding protein 2 (TAB2) negatively regulates the processing of pro-interleukin-1beta2015
- Author(s)
  高江洲義一、仲宗根昇、トーマ・クラウディア、比嘉直美、鈴木敏彦
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-15K08429
[Presentation] TAK1 Kinase Complex Regulates Macrophage Survival2014
- Author(s)
  高江洲　義一
- Organizer
  Keystone Symposium, "The Chemistry and Biology of Cell Death"
- Place of Presentation
  米国ニューメキシコ州サンタフェ市
- Data Source
  KAKENHI-PROJECT-25860322
[Presentation] TAK1-binding protein 2 (TAB2)may negatively regulate basal autophagy2009
- Author(s)
  高江洲義一、吉村昭彦
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20790376
[Presentation] TAK1-binding protein 2(TAB2) may negatively regulate basal autophagy.2009
- Author(s)
  高江洲義一
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-20790376
[Presentation] TAK1-binding protein 2 (TAB2) is essential for cell division2008
- Author(s)
  高江洲義一
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20790376
[Presentation] TAK1-binding protein 2(TAB2)is essential for cell division.2008
- Author(s)
  高江洲義一、吉村昭彦
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20790376

1. 梅村正幸 (90359985)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. 松崎吾朗 (30229455)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
3. HIGA Naomi (70457688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUZUKI Toshihiko (10292848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松永哲郎 (00723206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 松本壮吉 (30244073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松本邦弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takaesu Giichi 高江洲 義一

TAKAESU Giichi 高江洲 義一

Research Projects

Research Products

Co-Researchers

結核菌によるミトコンドリア障害と免疫抑制の分子基盤と治療への応用Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

結核菌感染肺における「3型免疫応答」の多元的防御機構の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

結核菌感染におけるTAB3の役割Principal InvestigatorOngoing

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Molecular mechanisms of cell death in macrophages and foam cellsPrincipal Investigator

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Elucidation of caspase-1 activation inhivition mechanism by Vibrio parahaemolyticus effector VopQ

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A novel regulatory mechanism of cell death in macrophagesPrincipal Investigator

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Cross-regulatory mechanisms of innate immunity and autophagyPrincipal Investigator

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Mechanisms for negative regulation ofTAK1/MAPKKK in innate immune responsesPrincipal Investigator

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[Journal Article] TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation2014

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[Journal Article] Activated macrophage survival is coordinated by TAK1 binding proteins2014

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[Journal Article] An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.2009

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[Journal Article] A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.2009

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[Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.2009

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[Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4, 5-biphosphate hydrolysis.2009

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[Journal Article] Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.2008

Takaesu Giichi 高江洲義一

TAKAESU Giichi 高江洲義一