NAKAMURA Jun 中村淳

Researcher Number	60404175
Affiliation (based on the past Project Information) *help	2017: 佐賀大学, 医学部, 客員研究員 2011 – 2016: 佐賀大学, 医学部, 助教 2014: 佐賀大学, 医学部医学科, 助教
Review Section/Research Field	Principal Investigator Digestive surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator 低酸素 / 胃癌 / TFF1 / ROS / HIF-1α / マイトファジー / 生存 / 再発マーカー / 予後マーカー / 転移 … More / 浸潤 / TFF3 / バイオマーカー / メチル化 / 大腸癌 / TFF family / 浸潤能 / DNAメチル化 … More Except Principal Investigator 胃癌 / 低酸素環境 / HIF-1a / HIF-1α / リンパ管新生 / 腹膜播種 / ANGPTNL4 / LOXL2 / 低酸素誘導因子 / 細胞周期 / アノイキス / ANGPTL4 / スキルス胃癌 / 低酸素刺激 / HIF-1 / Warburg効果 / 治療モデル / アポトーシス / 活性酸素 / インスリン / グルコース / ワールブルグ効果 / エピゲノム / 低酸素 Less

A novel mechanism increasing gastric cancer aggressiveness via impaired mitophagyPrincipal Investigator
- Principal Investigator
  
  Nakamura Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Establishment of novel drug therapy targetting Warburg effect in gastric cancer
- Principal Investigator
  
  Kitajima Yoshihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Investigation of peritoneal dissemination mechanism through trans-vessel route in scirrhous gastric cancer
- Principal Investigator
  
  Ikeda Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
New Therapeutic Strategy using TFF1 protein for Gastrointestinal CancerPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Jun
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
Molecular target therapy induced by hypoxia for scirrhous gastric cancer.
- Principal Investigator
  
  KOGA Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
TFF1 targeting therapeutic strategy for dissemination of gastric cancerPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Jun
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Promising immunotherapies for esophageal cancer.2017
- Author(s)
  Tanaka T, Nakamura J, Noshiro H.
- Journal Title
  
  Expert Opin Biol Ther.
  
  Volume: 17 Issue: 6 Pages: 723-733
- DOI
  10.1080/14712598.2017.1315404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines.2017
- Author(s)
  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 11127-11127
- DOI
  10.1038/s41598-017-11769-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.2017
- Author(s)
  Wakiyama K, Kitajima Y, Tanaka T, Kaneki M, Yanagihara K, Aishima S, Nakamura J, Noshiro H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 12653-12653
- DOI
  10.1038/s41598-017-12929-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.2016
- Author(s)
  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H
- Journal Title
  
  Oncol Lett.
  
  Volume: 11 Issue: 2 Pages: 1026-1034
- DOI
  10.3892/ol.2015.4011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia2016
- Author(s)
  Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K, Noshiro H.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 4 Pages: 1379-90
- DOI
  10.3892/ijo.2016.3359
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10103
[Journal Article] The value of TFF3 expression in predicting the long-term outcome and early recurrence of colorectal cancer.2015
- Author(s)
  Morito K, Nakamura J, Kitajima Y, Kai K, Tanaka T, Kubo H, Miyake S, Noshiro H.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 46 Issue: 2 Pages: 563-568
- DOI
  10.3892/ijo.2014.2755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861201
[Journal Article] Methylation-mediated Gene Silencing as Biomarkers of Gastric Cancer : A Review2014
- Author(s)
  Nakamura J, Tanaka T, Kitajima Y, Noshiro H, Miyazaki K.
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 20 Issue: 34 Pages: 11991-12006
- DOI
  10.3748/wjg.v20.i34.11991
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861201
[Journal Article] HIF-1a is a crucial factor in the development of peritoneal dissemination via natural metastatic rouites in scirrhous gastric cancer2013
- Author(s)
  Miyake S, Kitajima Y, Nakamura J, Kai K, Yanagihara K et al
- Journal Title
  
  Int J Oncol
  
  Volume: 43 Issue: 5 Pages: 1431-1440
- DOI
  10.3892/ijo.2013.2068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462025, KAKENHI-PROJECT-25462026
[Journal Article] Loss of trefoil factor 1 (TFF1) is regulated by DNA methylation and is an independent predictive factor for a poor survival in advanced gastric cancer2013
- Author(s)
  Tomokazu Tanaka
- Journal Title
  
  International Journal of Oncology
  
  Volume: 42 Issue: 3 Pages: 894-902
- DOI
  10.3892/ijo.2013.1759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791548, KAKENHI-PROJECT-25861201
[Journal Article]2013
- Author(s)
  T Tanaka, J Nakamura, et al
- Journal Title
  
  Int J Oncol
  
  Volume: 42 Pages: 894-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] Warburg効果をターゲットとした胃癌に対する新規薬物療法：HIF1α阻害剤YC-1+GI療法の機序解析と臨床応用への可能性2017
- Author(s)
  脇山幸大、北島吉彦、田中智和、金木正夫、中村淳、柳原五吉、能城浩和
- Organizer
  日本外科学定期学術集会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 腫瘍内8OHdGは進行大腸癌における予後予測因子となりうる2017
- Author(s)
  北川浩、北島吉彦、中村淳、田中智和、古賀靖大、真鍋達也、能城浩和
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] Mieap発現欠失による低酸素環境下ミトコンドリア品質管理機構の破綻と胃癌悪性度増強機序2017
- Author(s)
  奥山桂一郎、北島吉彦、田中智和、中村淳、北川浩、江川紀幸、柳原五吉、中村康之、荒川博文、能城浩和
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低用量YC-1+GI療法によるWarburg効果をターゲットとした胃癌に対する新規薬物療法2017
- Author(s)
  脇山幸大、北島吉彦、田中智和、金木正夫、柳原五吉、相島慎一、中村淳、能城浩和
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] Mieap発現欠失による低酸素環境下ミトコンドリア品質管理機構の破綻と胃癌悪性度増強機序2017
- Author(s)
  奥山桂一郎、北島吉彦、田中智和、志田雅明、馬場耕一、脇山幸大、佐藤博文、北川　浩、中村　淳、能城浩和
- Organizer
  日本外科学定期学術集会
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] Mieap発現欠失による低酸素環境下ミトコンドリア品質管理機構の破綻と胃癌悪性度増強機序2017
- Author(s)
  奥山桂一郎、北島吉彦、田中智和、志田雅明、馬場耕一、脇山幸大、佐藤博文、北川　浩、中村　淳、能城浩和
- Organizer
  第117回日本外科学会定期学術集会
- Place of Presentation
  横浜
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素誘導性マイトファジーの破綻介したスキルス胃癌細胞の高悪性性度獲得機序についての新知見2016
- Author(s)
  志田雅明、北島吉彦、中村淳、馬塲耕一、脇山幸大
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素環境下でマイトファジーは胃癌細胞の細胞増殖と浸潤能に寄与する2016
- Author(s)
  奥山佳一郎、北島吉彦、志田雅明、中村淳、脇山幸大、佐藤博文、馬塲耕一、柳原五吉、能城浩和
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] マイトファジー機構の破綻により、胃癌細胞株の悪性度は増強する2015
- Author(s)
  志田雅明、北島吉彦、中村淳、柳原五吉、能城浩和
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] マイトファジー機構の破綻により，ROS HIF 1α 経路が活性化され，胃癌浸潤能が増強される2015
- Author(s)
  志田雅明、北島吉彦、中村淳、柳原五吉、能城浩和
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 低酸素誘導性マイトファジーの破綻を介したスキルス胃癌細胞の高悪性度獲得機序についての新知見2015
- Author(s)
  志田雅明、北島吉彦、中村淳、柳原五吉、能城浩和
- Organizer
  第3回がんと代謝研究会
- Place of Presentation
  金沢
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K10103
[Presentation] 大腸癌の予後マーカーとしてのTFF3発現に関する検討2014
- Author(s)
  中村淳
- Organizer
  第114回日本外科学会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25861201
[Presentation] スキルス胃癌の腹膜播種はHIF-1あにより活性化されるリンパ管新生を介した遠隔転移である2013
- Author(s)
  三宅修輔、北島吉彦、中村　淳、柳原五吉、田中智和、馬場耕一　他
- Organizer
  第24回日本消化器癌発生学会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] スキルス胃癌の腹膜播種はHIF-1aにより活性化されるリンパ管新生を介した遠隔転移である。2013
- Author(s)
  三宅修輔、北島吉彦、中村　淳、柳原五吉、田中智和　他
- Organizer
  第24回日本消化器癌発生学会総会
- Place of Presentation
  石川県立音楽堂
- Data Source
  KAKENHI-PROJECT-25462026
[Presentation] 進行胃癌におけるTFF1発現の意義とその制御機構2013
- Author(s)
  田中智和、中村淳
- Organizer
  第85回日本胃癌学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 胃癌におけるTFF1 のメチル化と浸潤および生存への影響2013
- Author(s)
  中村淳
- Organizer
  第113回日本外科学会
- Place of Presentation
  福岡国際会議場ほか
- Data Source
  KAKENHI-PROJECT-25861201
[Presentation] Trefoil factor 1 (TFF1) is silenced by DNA methylation, and associated with a T factor and prognosis in gastric cancer2012
- Author(s)
  中村淳
- Organizer
  第71回　日本癌学会
- Place of Presentation
  ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] Trefoil factor 1 (TFF1) is silenced by DNA methylation, and associated with a T factor and prognosis in gastric cancer2012
- Author(s)
  中村淳
- Organizer
  第71回日本癌学会
- Place of Presentation
  ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 進行胃癌の予後マーカーとしてのTFF1発現意義と発現制御機構に関する検討2012
- Author(s)
  田中智和、中村淳
- Organizer
  第112 日本外科学会
- Place of Presentation
  幕張メッセ、ホテルニューオータニ幕張
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] Trefoil factor 1 (TFF1) is silenced by DNA methylation, and associated with a poor prognosis in advanced gastric cancer.2011
- Author(s)
  田中智和、中村淳
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 胃癌における新規癌抑制遺伝子TFF1の発現調節および臨床的意義2011
- Author(s)
  中村淳
- Organizer
  第66回日本消化器外科学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 胃癌における新規癌抑制遺伝子TFF1の発現調節および臨床的意義2011
- Author(s)
  中村淳ほか
- Organizer
  第66回　日本消化器外科学会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] Trefoil factor 1 (TFF1) is silenced by DNA methylation, and associated with a poor prognosis in advanced gastric cancer.2011
- Author(s)
  田中智和、中村淳ほか
- Organizer
  第70回　日本癌学会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 進行胃癌の予後におけるTFF1発現の意義2011
- Author(s)
  田中智和、中村淳
- Organizer
  第111回日本外科学会定期学術集会
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 進行胃癌の予後におけるTFF1発現の意義とその制御機構2011
- Author(s)
  田中智和、中村淳ほか
- Organizer
  第22回　日本消化器癌発生学会
- Place of Presentation
  ホテルニューオータニ佐賀
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] 進行胃癌の予後におけるTFF1発現の意義とその制御機構2011
- Author(s)
  田中智和、中村淳
- Organizer
  第22回日本消化器癌発生学会
- Place of Presentation
  ホテルニューオータニ佐賀
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] ANGPTL4とLOXL2はスキルス胃癌腹膜転移の発生における候補遺伝子の可能性がある
- Author(s)
  馬塲耕一、北島吉彦、三宅修輔、中村淳、柳原五吉、田中智和、池田貯、能城浩和
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591947
[Presentation] ANGPTL4とLOXL2はスキルス胃癌における腹膜転移の候補遺伝子の可能性がある
- Author(s)
  馬塲耕一、北島吉彦、三宅修輔、中村淳、柳原吾吉、田中智和、志田雅明、脇山幸大、池田貯、能城浩和
- Organizer
  第25回日本消化器癌発生学会総会
- Place of Presentation
  福岡
- Year and Date
  2014-11-13 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-24591947
[Presentation] The value of TFF3 expression in predicting the long-term outcome and early recurrence of colorectal cancer
- Author(s)
  中村淳
- Organizer
  第73回　日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25861201
[Presentation] 低酸素環境下のエネルギー代謝変容に着眼した新たな胃癌薬物治療の可能性
- Author(s)
  北島吉彦、田中智和、三宅修輔、中村　淳、宮崎耕治、能城浩和
- Organizer
  第２回がんと代謝研究会
- Place of Presentation
  東京理科大葛飾キャンパス
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25462025
[Presentation] スキルス胃癌の腹膜播種はHIF-1αにより増強されるリンパ管を介した遠隔転移である
- Author(s)
  三宅修輔、北島吉彦、中村淳、甲斐敬太、柳原五吉、田中智和、馬塲耕一、宮﨑耕治、能城浩和、井手貴雄、古賀靖大、宮﨑耕治、能城浩和
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-24591947
[Presentation] 進行胃癌の予後におけるTFF1発現の意義
- Author(s)
  田中智和、中村淳ほか
- Organizer
  第111回　日本外科学会定期学術集会
- Place of Presentation
  紙上開催
- Data Source
  KAKENHI-PROJECT-23791548
[Presentation] ANGPTL4とLOXL2はスキルス胃癌腹膜転移の発生における候補遺伝子である
- Author(s)
  馬場耕一、北島吉彦、三宅修輔、中村　淳、柳原五吉、池田　貯　他
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25462026

1. KITAJIMA Yoshihiko (30234256)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. KOGA Yasuo (30555090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MIYAKE Shusuke (70726893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Ikeda Osamu (70523124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

NAKAMURA Jun 中村 淳

Research Projects

Research Products

Co-Researchers

A novel mechanism increasing gastric cancer aggressiveness via impaired mitophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel drug therapy targetting Warburg effect in gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of peritoneal dissemination mechanism through trans-vessel route in scirrhous gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New Therapeutic Strategy using TFF1 protein for Gastrointestinal CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular target therapy induced by hypoxia for scirrhous gastric cancer.

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TFF1 targeting therapeutic strategy for dissemination of gastric cancerPrincipal Investigator

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[Journal Article] Promising immunotherapies for esophageal cancer.2017

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[Journal Article] Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines.2017

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[Journal Article] Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.2017

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[Journal Article] Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer.2016

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[Journal Article] Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia2016

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[Journal Article] The value of TFF3 expression in predicting the long-term outcome and early recurrence of colorectal cancer.2015

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[Journal Article] Methylation-mediated Gene Silencing as Biomarkers of Gastric Cancer : A Review2014

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[Journal Article] HIF-1a is a crucial factor in the development of peritoneal dissemination via natural metastatic rouites in scirrhous gastric cancer2013

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NAKAMURA Jun 中村淳

[Presentation] マイトファジー機構の破綻により，ROS HIF 1α 経路が活性化され，胃癌浸潤能が増強される2015