Yanagi Shigehisa 柳重久

… Alternative Names

YANAGI Shigehisa 柳重久

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Researcher Number	60404422
Other IDs
Affiliation (Current)	2025: 宮崎大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 宮崎大学, 医学部, 講師 2016 – 2022: 宮崎大学, 医学部, 助教 2008 – 2013: University of Miyazaki, 医学部, 助教 2006: 宮崎大学, 医学部, 助手 2005 – 2006: 宮崎大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Basic Section 52010:General internal medicine-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Endocrinology / Biological Sciences
Keywords	Principal Investigator 発癌 / 2型肺胞上皮 / シングルセル解析 / Pten / 分子標的治療 / 肺線維症 / 自然発癌モデル / 腫瘍微小環境 / 癌関連線維芽細胞 / 間葉系細胞 … More / 1細胞解析 / 肺間葉細胞 / 間葉細胞 / シングルセルRNA解析 / 肺腺癌自然発癌モデル / RhoA / 肺癌 / 癌微小環境 / 発がん / 細胞移動調節機構 / 組織幹細胞ニッチ / 特発性肺線維症 / 慢性閉塞性肺疾患 / 内因性幹細胞ニッチ機構 / 肺胞微小環境 / 細胞老化 / 肺微小環境 / 急性肺損傷 / マイクロRNA … More Except Principal Investigator グレリン / 肺癌 / カヘキシア / 細胞骨格 / 細胞老化 / Pten / 骨格筋 / 肺炎 / サルコペニア / 細胞ダイナミクス / 幹細胞 / 肺胞形成 / 肺発生 / 細胞運命決定 / 肺線維症　肺リモデリング / Ror2 / RhoA / 肺リモデリング / 肺線維症 / 内分泌学 / ペプチドホルモン / 糖脂質代謝 / 肥満 / 摂食中枢 / 生理活性ペプチド / defensin / epithelial lining fluid / antimicrobial peptide / respiratory infection / 緑膿菌 / マイクロサンプリング / 気管支肺胞洗浄液 / インターロイキン-8 / 気道上皮 / デフェンシン / 気道被覆液 / 抗菌ペプチド / 呼吸器感染症 / ALI / 六君子湯 / トレンスレーショナルリサーチ / 急性肺損傷 / エネルギー代謝 / QOL / 肺傷害 / 慢性呼吸不全 / 漢方薬 / 化学療法 / 進行肺癌 / 抗癌剤副作用 / 悪液質 / 橋渡し研究 / オクタン酸 / 慢性呼吸器疾患 / 分子標的治療 / 生体内分子イメージング / 癌幹細胞 / 展開医療 / PTENノックアウトモデルマウス / グレリン受容体欠損マウス / 抗炎症効果 / 下肢リハビリテーション / COPD Less

Essentiality of mesenchymal subpopulations for carcinogenesis discovered by one-cell analysis of a mouse model of spontaneous lung adenocarcinoma.Principal Investigator
- Principal Investigator
  
  柳重久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
グレリンシグナルの活性化による高齢者肺炎サルコペニアへの新規治療法の開発
- Principal Investigator
  
  坪内拡伸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Miyazaki
Determination of the mesenchymal subcluster responsible for carcinogenesis of lung cancer and origin of CAF based on the results of single-cell analysisPrincipal Investigator
- Principal Investigator
  
  Yanagi Shigehisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
Investigetion of the pathomechanisims of smoking-related lung disease focusing on tissue stem cell nichePrincipal Investigator
- Principal Investigator
  
  Yanagi Shigehisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Miyazaki
Clarification of the regulation system of cellular dynamics and senescence during lung development
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  University of Miyazaki
Identify the novel bioactive peptides and their role in feeding regulation
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  University of Miyazaki
Elucidation of the pathomechanism of lung fibrosis from the viewpoint of cellular senescence and cytoskeletal organization
- Principal Investigator
  
  Nakazato Masamitsu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
上皮間葉転換早期相を焦点とする急性肺損傷発症機構の解明と新規治療法の探索Principal Investigator
- Principal Investigator
  
  柳重久
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Investigation of the protective effects of ghrelin on the disease progression of acute lung injury and its clinical application
- Principal Investigator
  
  NAKAZATO Masamitsu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Evaluation of effects of ghrelin on patients with advanced lung cancer
- Principal Investigator
  
  MATSUMOTO Nobuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Development research of ghrelin treatment against intractable respiratory diseases
- Principal Investigator
  
  NAKAZATO Masamitsu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Exploration of micro RNA regulating lung fibrosis and epithelial mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  YANAGI Shigehisa
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
幹細胞識別技術による生体内肺癌発症監視機構とAkt/HIF1標的新規治療の研究
- Principal Investigator
  
  中里雅光
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Miyazaki
慢性呼吸器疾患におけるグレリンの病態意義の解明と臨床応用を目指した橋渡し研究
- Principal Investigator
  
  中里雅光
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Investigation of the pathomechanisms of lung fibrosis by using bronchioalveolar epithelium-specific Pten deficient micePrincipal Investigator
- Principal Investigator
  
  YANAGI Shigehisa
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
COPDにおける新規生理活性ペプチドグレリンの病態生理学的意義と臨床応用の試み
- Principal Investigator
  
  NAKAZATO Masamitsu
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki
Molecular analysis of-defensin on expression and host defense in bronchial cells
- Principal Investigator
  
  ASHITANI Jun-ichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  University of Miyazaki

[Book] 分子呼吸器病2014
- Author(s)
  柳重久
- Total Pages
  176
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-24659406
[Book] 内科救急のファーストタッチ2014
- Author(s)
  柳重久
- Total Pages
  455
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24659406
[Book] Annual Review呼吸器20122012
- Author(s)
  柳重久、三好かほり、坪内拡伸、中里雅光
- Total Pages
  269
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22790763
[Book] 肺癌とHIFs. Annual Review呼吸器20122011
- Author(s)
  柳重久、三好かほり、坪内拡伸、中里雅光
- Data Source
  KAKENHI-PROJECT-22790763
[Journal Article] GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity2022
- Author(s)
  Tanida Ryota、Tsubouchi Hironobu、Yanagi Shigehisa、Saito Yusuke、Toshinai Koji、Miyazaki Taiga、Takamura Toshinari、Nakazato Masamitsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 589 Pages: 260-266
- DOI
  10.1016/j.bbrc.2021.12.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-20K11499, KAKENHI-PROJECT-21K08159
[Journal Article] Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome2021
- Author(s)
  Matsuo Ayako、Tanida Ryota、Yanagi Shigehisa、Tsubouchi Hironobu、Miura Ayako、Shigekusa Takafumi、Matsumoto Nobuhiro、Nakazato Masamitsu
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 892 Pages: 173754-173754
- DOI
  10.1016/j.ejphar.2020.173754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08179, KAKENHI-PROJECT-17K16051
[Journal Article] Transition From Distinct Types of KRAS Mutation-Harboring Multifocal Lung Adenocarcinoma to Rhabdoid Tumor2021
- Author(s)
  Setoguchi K, Yanagi S, Gi T, Tsubouchi H, Uto K, Shigekusa T, Matsumoto N, Sato Y, Nakazato M.
- Journal Title
  
  Am J Case Rep.
  
  Volume: 22
- DOI
  10.12659/ajcr.932452
- Data Source
  KAKENHI-PROJECT-21K08159
[Journal Article] The Homeostatic Force of Ghrelin2018
- Author(s)
  Shigehisa Yanagi, Takahiro Sato, Kenji Kangawa, Masamitsu Nakazato
- Journal Title
  
  Cell Metabolism
  
  Volume: 27 Issue: 4 Pages: 786-804
- DOI
  10.1016/j.cmet.2018.02.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08179, KAKENHI-PROJECT-18K19551, KAKENHI-PROJECT-16H05333
[Journal Article] MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation2017
- Author(s)
  Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, et al
- Journal Title
  
  Oncogene
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15460
[Journal Article] Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice.2017
- Author(s)
  Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 819 Pages: 35-42
- DOI
  10.1016/j.ejphar.2017.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-15K19424
[Journal Article] The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections2017
- Author(s)
  Shigehisa Yanagi, Hironobu Tsubouchi, Ayako Miura, Ayako Matsuo, Nobuhiro Matsumoto and Masamitsu Nakazato
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 3 Pages: 503-503
- DOI
  10.3390/ijms18030503
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860610, KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-16K15460
[Journal Article] Clinical application of ghrelin for chronic respiratory failure2017
- Author(s)
  Matsumoto N, Tsubouchi H, Imazu Y, Arimura Y, Yanagi S, Iiboshi H, Nakazato M.
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: Suppl. Pages: S1-S3
- DOI
  10.1507/endocrj.64.S1
- NAID
  130007307950
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15460, KAKENHI-PROJECT-15K19424
[Journal Article] Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line2017
- Author(s)
  Tsubouchi H, Onomura H, Saito Y, Yanagi S, Miura A, Matsuo A, Matsumoto N, Nakazato M.
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: Suppl. Pages: S41-S46
- DOI
  10.1507/endocrj.64.S41
- NAID
  130007307940
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-16K15460, KAKENHI-PROJECT-15K19424
[Journal Article] Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner.2014
- Author(s)
  Tsubouchi H, Yanagi S, Miura A, Iizuka S, Mogami S, Yamada C, Hattori T, Nakazato M
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 306 Issue: 3 Pages: 233-245
- DOI
  10.1152/ajplung.00096.2013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126009, KAKENHI-PROJECT-24659406, KAKENHI-PROJECT-25293216, KAKENHI-PROJECT-26670419
[Journal Article] Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity2013
- Author(s)
  Miyoshi K, Yanagi S, Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita S, Suzuki A, Nakazato M
- Journal Title
  
  Am J Respir Crit Care Med
  
  Volume: 187 Issue: 3 Pages: 262-275
- DOI
  10.1164/rccm.201205-0851oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592132, KAKENHI-PUBLICLY-24111536, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-24591171, KAKENHI-PROJECT-24650201, KAKENHI-PROJECT-24659406, KAKENHI-PUBLICLY-24112515
[Journal Article] Clinical usefulness of the two-question assessment tool for depressive symptoms in Japanese patients with chronic obstructive pulmonary disease.2013
- Author(s)
  Arimura Y, Yamazaki S, Yanagi S, Matsumoto N, Takegami M, Hayashino Y, Fukuhara S, Nakazato M.
- Journal Title
  
  Lung
  
  Volume: 191 Issue: 1 Pages: 101-107
- DOI
  10.1007/s00408-012-9437-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591171, KAKENHI-PROJECT-24659406
[Journal Article] A possible role of galectin-9 in the pulmonary fibrosis of patients with interstitial pneumonia.2013
- Author(s)
  Matsumoto N, Katoh S, Yanagi S, Arimura Y, Tokojima M, Ueno M, Hirashima M, Nakazato M.
- Journal Title
  
  Lung
  
  Volume: 191 Issue: 2 Pages: 191-198
- DOI
  10.1007/s00408-012-9446-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591171, KAKENHI-PROJECT-24659406
[Journal Article] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation2011
- Author(s)
  Yoshifumi Imazu, Shigehisa Yanagi, Kahori Miyoshi, Hironobu Tsubouchi, Shu-ichi Yamashita, Nobuhiro Matsumoto, Jun-ichi Ashitani, Kenji Kangawa, Masamitsu Nakazato
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 15 Issue: 1-3 Pages: 153-158
- DOI
  10.1016/j.ejphar.2011.09.183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790763
[Journal Article] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation2011
- Author(s)
  Imazu Y, Yanagi S, Miyoshi K, Tsubouchi H, Yamashita S, Matsumoto N, Ashitani J, Kangawa K, Nakazato M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 15 Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790763
[Journal Article] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation2010
- Author(s)
  Imazu Y, Yanagi S, Miyoshi K, Tsubouchi H, Yamashita S, Matsumoto N, Ashitani J, Kangawa K, Nakazato M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 672 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659161
[Journal Article] Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections.2007
- Author(s)
  Yanagi S
- Journal Title
  
  Clin Microbiol Infect 13
  
  Pages: 63-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590799
[Journal Article] Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections.2007
- Author(s)
  Yanagi S
- Journal Title
  
  Clin Microbiol Infect 13・1
  
  Pages: 63-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590799
[Journal Article] Elevated BALF concentrations of alpha- and beta-defensins in patients with pulmonary alveolar proteinosis.2007
- Author(s)
  Mukae H, Ishimoto H, Yanagi S, Ishii H, Nakayama S, Ashitani JI, Nakazato M, Kohno S
- Journal Title
  
  Respir Med 101
  
  Pages: 715-721
- Data Source
  KAKENHI-PROJECT-18659240
[Journal Article] Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections.2007
- Author(s)
  Yanagi S, Ashitani J, Imai K, Kyoraku Y, Sano A, Matsumoto N, Nakazato M
- Journal Title
  
  Clin Microbiol Infect 13
  
  Pages: 63-69
- Data Source
  KAKENHI-PROJECT-18659240
[Journal Article] Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection.2006
- Author(s)
  Yanagi S, Ashitani J, Ishimoto H, Date Y, Mukae H, Chino N, Nakazato M
- Journal Title
  
  Respir Res 6
  
  Pages: 130-130
- Data Source
  KAKENHI-PROJECT-18659240
[Journal Article] Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection.2005
- Author(s)
  Yanagi S
- Journal Title
  
  Respir Res 4(6)(in press)
- Data Source
  KAKENHI-PROJECT-17590799
[Journal Article] Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection.2005
- Author(s)
  Yanagi S
- Journal Title
  
  Respir Res 6
  
  Pages: 130-130
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590799
[Presentation] 2型肺胞上皮細胞内因子による肺間葉細胞の摂動で出現する発癌責任間葉サブクラスター.2023
- Author(s)
  柳重久
- Organizer
  日本肺サーファクタント・界面医学会第58回学術研究会
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] Identification of Mesenchymal Subpopulation Responsible for Lung Tumorigenesis by Using Single-Cell RNA-seq.2023
- Author(s)
  柳重久
- Organizer
  European Respiratory Society International Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] シングルセルRNA-seq解析に基づく肺胞前駆細胞-肺間葉細胞サブクラスター間クロストークを焦点としたCOPDの気腫化加速化因子の同定2023
- Author(s)
  柳重久
- Organizer
  第63回日本呼吸器学会学術講演会特別報告5
- Invited
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] 2型肺胞上皮細胞内因子による肺間葉細胞の摂動で出現する発癌責任間葉サブクラスター2022
- Author(s)
  柳重久、坪内拡伸、宮崎泰可
- Organizer
  日本肺サーファクタント・界面医学会第58回学術研究会
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] 加齢性呼吸器疾患における内因性幹細胞ニッチ機構2021
- Author(s)
  柳　重久
- Organizer
  公益財団法人アステラス病態代謝研究会第51回研究報告会
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] 2型肺胞上皮でのPten欠損は細胞老化を加速し、ミトコンドリア恒常性とニッチ恒常性を破綻させ、加齢性の肺気腫を誘導する.2021
- Author(s)
  堀口崇典、柳　重久、坪内拡伸、松尾彩子、重草貴文、松元信弘、中里雅光.
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08159
[Presentation] 現在とこれからの肺線維症治療を俯瞰する2020
- Author(s)
  柳重久
- Organizer
  第85回日本呼吸器学会九州支部秋季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08179
[Presentation] 喫煙関連肺疾患における組織幹細胞ニッチ機構2019
- Author(s)
  柳重久
- Organizer
  第59回日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08179
[Presentation] PTEN Deficiency in Alveolar Type 2 Cells Accelerates Cellular Senescence, Disrupts Epithelial-Mesenchymal and Mitochondrial Homeostasis, and Induces Age-Related Emphysema2019
- Author(s)
  柳重久
- Organizer
  European Respiratory Society International Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08179
[Presentation] 上皮内因子が制御する細胞老化プログラムからみた喫煙関連肺疾患の病態解明2019
- Author(s)
  柳　重久
- Organizer
  第4回肺トランスレーショナルメディシン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08179
[Presentation] 喫煙関連肺疾患における組織幹細胞ニッチ機構2019
- Author(s)
  柳　重久
- Organizer
  日本呼吸器学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08179
[Presentation] The role of Pten in the cell-fate determination of epithelial cells in lung development.2016
- Author(s)
  Ayako Miura, Hironobu Tsubouch Shigehisa Yanagi, Nobuhiro Matsumoto, and Masamitsu Nakazato
- Organizer
  European Respiratory Society International Congress 2016
- Place of Presentation
  United Kingdom, London EXCEL
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K15460
[Presentation] 肺胞上皮細胞Ptenの上皮バリア―統合性に対する役割の解析2013
- Author(s)
  柳重久
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2013-04-21
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] Lung Epithelial Pten Controls Epithelial Barrier Integrity in vitro and in vivo2013
- Author(s)
  Shigehisa Yanagi
- Organizer
  European respiratory society annual congress
- Place of Presentation
  バルセロナ
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Lung epithelial Pten controls epithelial barrier integrity in vitro and in vivo2013
- Author(s)
  柳重久
- Organizer
  European Respiratory Society
- Place of Presentation
  バルセロナ
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] 肺胞上皮細胞Ptenの上皮バリアー統合性に対する役割の解析2013
- Author(s)
  柳重久
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Ghrelin ameliorates cachectic status in the mouse model of lung cancer model2013
- Author(s)
  Tsubouchi H, Yanagi S, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society
- Place of Presentation
  バルセロナ　スペイン
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] Lung epithelial Pten controls epithelial barrier integrity in vitro and in vivo2013
- Author(s)
  Yanagi S, Miyoshi K, Tsubouchi H, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society
- Place of Presentation
  バルセロナ　スペイン
- Data Source
  KAKENHI-PROJECT-24659406
[Presentation] Rikkunshito ameliorates bleomycin-induced lung injury in mice.2012
- Author(s)
  Tsubouchi H, Yanagi S, Iizuka S, Mogami S, Miyoshi K, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Epithelial Pten controls acute lung injury and fibrosis by regulatiug intercellular junctional integrity and EMT.2012
- Author(s)
  Yanagi S, Miyoshi K, Tsubouchi H, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation.2012
- Author(s)
  Yanagi S, Imazu Y, Miyoshi K, Tsubouchi H, Matsumoto N, Nakazato M
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] 肺癌化学療法中の血清グレリン値の臨床的意義2012
- Author(s)
  坂元昭裕、松元信弘、郡山晴喜、坪内拡伸、三好かほり、有村保次、柳重久、佐野ありさ、床島眞紀、中里雅光
- Organizer
  第109回日本内科学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590867
[Presentation] Epithelial Pten controls acute lung injury and fibrosis by regulating intercellular junctional integrity and EMT.2012
- Author(s)
  Yanagi S, Miyoshi K,　Kawahara K, Tsubouchi H, Matsumoto N, Yamashita S, Suzuki A, Nakazato M
- Organizer
  17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine
- Place of Presentation
  Hersonissos, Crete , Greece
- Invited
- Data Source
  KAKENHI-PROJECT-24591171
[Presentation] 高齢者肺癌化学療法での血漿グレリンの動態とQOLとの関連2012
- Author(s)
  坂元昭裕、有村保次、柳重久、佐野ありさ、床島眞紀、松元信弘、中里雅光
- Organizer
  第22回日本老年病学会九州地方会
- Place of Presentation
  佐賀
- Data Source
  KAKENHI-PROJECT-22590867
[Presentation] Lung cancer, Lung tissue stem cell, and Lung cancer stem cell(Symposium)2011
- Author(s)
  Yanagi S
- Organizer
  The 9th Annual Meeting of Japanese Society of Medicine Oncology
- Place of Presentation
  Yokohama
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-22790763
[Presentation] Epithelial Pten plays an essential role in preventing pulmonary fibrosis by regulating the epithelial-mesenchymal transition2011
- Author(s)
  Yanagi S, Miyoshi K, Tsubouchi H, Imazu Y, Matsuioto N, Nakazato M
- Organizer
  106^<th> American Thoracic Society International Conference
- Place of Presentation
  Denver, Colorado.USA
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22790763
[Presentation] Epithelial Pten plays an essential role in preventing pulmonary fibrosis by regulating the epithelial-mesenchymal transition2011
- Author(s)
  Yanagi S, Miyoshi K, Tsubouchi H, Imazu Y, Matsumoto N, Nakazato M
- Organizer
  106thAmerican Thoracic Society International Conference
- Place of Presentation
  Denver, Colorado. USA
- Year and Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-22790763
[Presentation] Epithelial Pten plays an essential role in preventing pulmonary fibrosis by regulating the epithelial-mesenchymal transition2011
- Author(s)
  Miyoshi K, Yanagi S, Tsubouchi H, Imazu Y, Matsumoto N, Yamashita S, Nakazato M
- Organizer
  The 51st Annual Meeting of The Japanese Respiratory Society
- Place of Presentation
  Tokyo
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22790763
[Presentation] 特発性肺線維症の細気管支肺胞上皮におけるPten/PI3K/Akt経路関連分子発現に関する検討2010
- Author(s)
  坪内拡伸, 柳重久, 三好かほり, 中里雅光
- Organizer
  第50回日本呼吸器学会学術講演
- Place of Presentation
  京都
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-22790763
[Presentation] Function of Pten/PI3K/Akt Pathway in Bronchioalveolar Epithelium in the pathogenesis of Lung Fibrosis2009
- Author(s)
  Shigehisa Yanagi
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Vienna
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20790573
[Presentation] 細気管支肺胞上皮特異的Pten欠損マウスを用いたブレオマイシン肺線維症モデルの解析2009
- Author(s)
  三好かほり、柳重久、今津善史、松元信弘、芦谷淳一、中里雅光
- Organizer
  第49回日本呼吸器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790573
[Presentation] Function of PTEN/P13K/AKT pathway in bronchioalveolar epithelium in the pathogenesis of lung fibrosis2009
- Author(s)
  Tsubouchi H, Yanagi S, Miyoshi K, Imazu Y, Arimura Y, Matsumoto N, Ashitani J, Kawahara K, Suzuki A, Nakazato M
- Organizer
  European Respiratory Society
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-20790573
[Presentation] Analysis of Pten function in bronchioalveolar epithelium2008
- Author(s)
  Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Nakazato M, Suzuki A
- Organizer
  8th International Conference on Protein Phosphatases
- Place of Presentation
  Maebashi
- Year and Date
  2008-11-12
- Data Source
  KAKENHI-PROJECT-20013038
[Presentation] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas2008
- Author(s)
  Shigehisa Yanagi
- Organizer
  The 13th Japan-Korea Cancer Research Workshop
- Place of Presentation
  Daejeon, Korea
- Data Source
  KAKENHI-PROJECT-20013038
[Presentation] Pten controls lung morphogenesis, bronchioalveolar stem sells, and onset of lung adenocarcinomas2008
- Author(s)
  Yanagi S, Nakazato M, Suzuki A
- Organizer
  The 13th Japan-Korea cancer Research Workshop
- Place of Presentation
  Daejeon, Korea
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20013038

1. NAKAZATO Masamitsu (10180267)

# of Collaborated Projects: 10 results

# of Collaborated Products: 12 results
2. TSUBOUCHI Hironobu (60573988)

# of Collaborated Projects: 10 results

# of Collaborated Products: 13 results
3. MATSUMOTO Nobuhiro (70418838)

# of Collaborated Projects: 9 results

# of Collaborated Products: 13 results
4. KYOURAKU Yuka (90404425)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KODAMA Tsuyoshi (80404424)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. ASHITANI Jun-ichi (50347069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. MIYOSHI Kahori (50573375)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 松尾彩子 (40776332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 小田康晴 (90843235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. ARIMURA Yasuji (70534080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 今井光一 (00404426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 上野浩晶 (00381062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山口秀樹 (10305097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 迫田秀之 (50376464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 清水浩一郎 (90711292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 三浦綾子 (70710903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 重草貴文 (90867730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 北村瑛子 (20985171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. KAWAHARA Kohichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yanagi Shigehisa 柳 重久

YANAGI Shigehisa 柳 重久

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Essentiality of mesenchymal subpopulations for carcinogenesis discovered by one-cell analysis of a mouse model of spontaneous lung adenocarcinoma.Principal Investigator

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Determination of the mesenchymal subcluster responsible for carcinogenesis of lung cancer and origin of CAF based on the results of single-cell analysisPrincipal Investigator

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Investigetion of the pathomechanisims of smoking-related lung disease focusing on tissue stem cell nichePrincipal Investigator

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上皮間葉転換早期相を焦点とする急性肺損傷発症機構の解明と新規治療法の探索Principal Investigator

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Exploration of micro RNA regulating lung fibrosis and epithelial mesenchymal transitionPrincipal Investigator

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Yanagi Shigehisa 柳重久

YANAGI Shigehisa 柳重久