TAKANO Jiro 高野二郎

Researcher Number	60415213
Affiliation (based on the past Project Information) *help	2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2010 – 2012: 独立行政法人理化学研究所, 神経蛋白制御研究チーム, 研究員 2008: The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, 研究員 2006: RIKEN, Laboratory for Proteolytic Neuroscience, Research Scientist, 神経蛋白制御研究チーム, 研究員
Review Section/Research Field	Principal Investigator Applied biochemistry / Nerve anatomy/Neuropathology Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator カルパイン / 神経変性疾患 / 遺伝子改変マウス / プロテアーゼ / 学習記憶 / アルツハイマー病 / カルシウムシグナル / プロテオーム解析 / カスパー / 細胞内タンパク質分解 … More / ノックアウトマウス / カスパーゼ / 細胞死 / カルシウム / 個体発生 / カルシウムシグナリング … More Except Principal Investigator tau / 2D-electronhoresis / metabolic labeling / calpastatin / Ca^<2+>-dependent protease / calpain / proteomics / neuronal cell death / 海馬 / タウ / 二次元電気泳動 / メタボリックラベリング / カルパスタチン / カルシウム依存性プロテアーゼ / カルパイン / プロテオミクス / 神経細胞死 Less

細胞内プロテアーゼ・カルパインによる筋組織恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  高野二郎
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of the neuropathological mechanism by using calpain mutant micePrincipal Investigator
- Principal Investigator
  
  TAKANO Jiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of calpain-calpastatin system using genetically modified micePrincipal Investigator
- Principal Investigator
  
  TAKANO Jiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of functional roles of Ca^<2+>-dependent protease calpain in neuronal cell death
- Principal Investigator
  
  IWATA Nobuhisa
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  RIKEN

All 2014 2013 2012 2011 2010 2008 2007 2005

All Journal Article Presentation Book Patent

[Book] 実験医学増刊タンパク質の分解機構ページ196-201「カルパスタチン遺伝子改変マウスを用いた神経変性および生理機能の解析」2008
- Author(s)
  高野二郎
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19780080
[Book] カルパスタチン遺伝子改変マウスを用いた神経変性および生理機構の解析(実験医学Vol.26 No.2)2008
- Author(s)
  高野二郎, 西道隆臣
- Data Source
  KAKENHI-PROJECT-19780080
[Journal Article] Post-myocardial Infarction Remodeling Is Involved in the Progression of Calpain-dependent Cleavage of N-cadherin2014
- Author(s)
  Yoko Kudo-Sakamoto, Hiroshi Akazawa, Kaoru Ito, Jiro Takano, Masamichi Yano, Chizuru Yabumoto, Atsuhiko T. Naito, Toru Oka, Jong-Kook Lee, Yasushi Sakata, Jun-ichi Suzuki, Takaomi C. Saido and Issei Komuro
- Journal Title
  
  The journal of biological chemistry
  
  Volume: 289 Issue: 28 Pages: 19408-19419
- DOI
  10.1074/jbc.m114.567206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J40014, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26450134, KAKENHI-PROJECT-26670395, KAKENHI-PROJECT-26713028
[Journal Article] Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).2013
- Author(s)
  Hubener J, Weber JJ, Richter C, Honold L, Weiss A, Murad F, Breuer P, Wullner U, Bellstedt P, Paquet-Durand F, Takano J, Saido TC, Riess O, Nguyen HP.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 22(3) Pages: 508-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.2012
- Author(s)
  Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S.
- Journal Title
  
  Nat Commun.
  
  Volume: 3 Pages: 130-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor.2012
- Author(s)
  Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Saido T, Minegishi N, Miyata T, Abe T, Yamamoto M.
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 48(3) Pages: 556-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Critical role of calpain in axonal damage-induced retinal ganglion cell death.2012
- Author(s)
  Ryu M, Yasuda M, Shi D, Shanab AY, Watanabe R, Himori N, Omodaka K, Yokoyama Y, Takano J, Saido T, Nakazawa T.
- Journal Title
  
  J Neurosci Res.
  
  Volume: 90(4) Pages: 802-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury.2012
- Author(s)
  Schoch KM, Evans HN, Brelsfoard JM, Madathil SK, Takano J, Saido TC, Saatman KE.
- Journal Title
  
  Exp Neurol.
  
  Volume: 236(2) Pages: 371-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Critical role of calpain in axonal damage-induced retinal ganglion cell death2012
- Author(s)
  Molin Ryu, Toru Nakazawa, et al
- Journal Title
  
  J Neuroci Res
  
  Volume: 90 Issue: 4 Pages: 802-815
- DOI
  10.1002/jnr.22800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689045, KAKENHI-PROJECT-22700379, KAKENHI-PROJECT-24659756
[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology2012
- Author(s)
  Makoto Higuchi, Nobuhisa Iwata, Yukio Matsuba, Jiro Takano, Takahiro Suemoto, Jun Maeda, Bin Ji, Maiko Ono, Matthias Staufenbiel, Tetsuya Suhara, Takaomi C.Saido
- Journal Title
  
  The FASEB Journal
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.2012
- Author(s)
  Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC.
- Journal Title
  
  FASEB J.
  
  Volume: 26(3) Pages: 1204-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.2011
- Author(s)
  Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S.
- Journal Title
  
  J Neurochem.
  
  Volume: 117(3) Pages: 504-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.2011
- Author(s)
  Gomes JR, Lobo AC, Melo CV, Inacio AR, Takano J, Iwata N, Saido TC, de Almeida LP, Wieloch T, Duarte CB.
- Journal Title
  
  J Neurosci.
  
  Volume: 31(12) Pages: 4622-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Potent amyloidogenicity and pathogenicity of Aβ43.2011
- Author(s)
  Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC.
- Journal Title
  
  Nat Neurosci.
  
  Volume: 14(8) Pages: 1023-32
- NAID
  120006985066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p252011
- Author(s)
  Sato, et al
- Journal Title
  
  J.Neurochem.
  
  Volume: 117 Issue: 3 Pages: 504-515
- DOI
  10.1111/j.1471-4159.2011.07222.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057007, KAKENHI-PROJECT-22700379, KAKENHI-PROJECT-23370063
[Journal Article] Potent amyloidogenicity and pathogenicity of Aβ432011
- Author(s)
  Takashi Saito, Takahiro Suemoto, Nathalie Brouwers, Kristel Sleegers, Satoru Funamoto, Naomi Mihira, Yukio Matsuba, Kazuyuki Yamada, Per Nilsson, Jiro Takano, Masaki Nishimura, Nobuhisa Iwata, Christine Van Broeckhoven, Yasuo Ihara, Takaomi C Saido
- Journal Title
  
  Nature Neuroscience
  
  Volume: 14 Issue: 8 Pages: 1023-1032
- DOI
  10.1038/nn.2858
- NAID
  120006985066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379, KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-23500445, KAKENHI-PROJECT-23680039
[Journal Article] Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites2011
- Author(s)
  Joao R.Gomes, Andrea C.Lobo, Carlos V.Melo, Ana R.Inacio, Jiro Takano, Nobuhisa Iwata, Takaomi C.Saido, Luis P.de Almeida, Tadeusz Wieloch, Carlos B.Duarte
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 31 Issue: 12 Pages: 4622-4635
- DOI
  10.1523/jneurosci.3541-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.2011
- Author(s)
  Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 31(19) Pages: 4097-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.2011
- Author(s)
  Zhang G, Thomas AL, Marshall AL, Kernan KA, Su Y, Zheng Y, Takano J, Saido TC, Eddy AA.
- Journal Title
  
  Lab Invest.
  
  Volume: 91(1) Pages: 106-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Vital role of the calpain-calpastatin system for placental-integrity-depen dent embryonic survival2011
- Author(s)
  Jiro Takano, Naomi Mihira, Ryo Fujioka, Emi Hosoki, Athar H.Chishti, Takaomi C.Saido
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 31 Issue: 19 Pages: 4097-4106
- DOI
  10.1128/mcb.05189-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700379
[Journal Article] Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains : Evidence from calpastatin-mutant mice.2005
- Author(s)
  Takano J., et al.
- Journal Title
  
  Journal of Biological Chemistry 280(16)
  
  Pages: 16175-16184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390026
[Patent] アルツハイマー病モデル動物およびその用途2010
- Inventor(s)
  西道隆臣、岩田修永、斎藤貴志、末元隆寛、高野二郎
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2006-170776
- Acquisition Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-22700379
[Presentation] 成体における細胞内プロテアーゼ・カルパインの機能2012
- Author(s)
  高野二郎
- Organizer
  第2回東北眼科疾患病態研究会
- Place of Presentation
  宮城
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-22700379
[Presentation] 胎盤発生における細胞内プロテアーゼ・カルパインの生理機能2012
- Author(s)
  高野二郎
- Organizer
  名古屋市立大学産科婦人科学生殖・遺伝セミナー
- Place of Presentation
  愛知
- Year and Date
  2012-07-07
- Data Source
  KAKENHI-PROJECT-22700379
[Presentation] 遺伝子改変マウスから分かったカルパイン-1 とカルパイン-2 の機能2011
- Author(s)
  高野二郎
- Organizer
  Conference for Biosignal and Medcine
- Place of Presentation
  三重
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-22700379
[Presentation] Analysis of calpain-like protease in brain2011
- Author(s)
  Jiro Takano, Takaomi C.Saido
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22700379
[Presentation] 脳内カルパイン様プロテアーゼの解析2011
- Author(s)
  高野二郎
- Organizer
  日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22700379
[Presentation] Roles of calpain in survival signaling2008
- Author(s)
  高野二郎
- Organizer
  第11回国際生化学・分子生物学会議
- Place of Presentation
  アテネ
- Year and Date
  2008-07-01
- Data Source
  KAKENHI-PROJECT-19780080
[Presentation] The roles of calpain in surviving siganling2007
- Author(s)
  高野二郎
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19780080

1. IWATA Nobuhisa (70246213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 中澤徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKANO Jiro 高野 二郎

Research Projects

Research Products

Co-Researchers

細胞内プロテアーゼ・カルパインによる筋組織恒常性維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the neuropathological mechanism by using calpain mutant micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of calpain-calpastatin system using genetically modified micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of functional roles of Ca^<2+>-dependent protease calpain in neuronal cell death

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学増刊 タンパク質の分解機構 ページ196-201「カルパスタチン遺伝子改変マウスを用いた神経変性および生理機能の解析」2008

Author(s)

Total Pages

Publisher

Data Source

[Book] カルパスタチン遺伝子改変マウスを用いた神経変性および生理機構の解析(実験医学Vol.26 No.2)2008

Author(s)

Data Source

[Journal Article] Post-myocardial Infarction Remodeling Is Involved in the Progression of Calpain-dependent Cleavage of N-cadherin2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).2013

Author(s)

Journal Title

Data Source

[Journal Article] A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.2012

Author(s)

Journal Title

Data Source

[Journal Article] Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor.2012

Author(s)

Journal Title

Data Source

[Journal Article] Critical role of calpain in axonal damage-induced retinal ganglion cell death.2012

Author(s)

Journal Title

Data Source

[Journal Article] Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury.2012

Author(s)

Journal Title

Data Source

[Journal Article] Critical role of calpain in axonal damage-induced retinal ganglion cell death2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology2012

Author(s)

Journal Title

Data Source

[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.2012

Author(s)

Journal Title

Data Source

[Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.2011

Author(s)

Journal Title

Data Source

[Journal Article] Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.2011

Author(s)

TAKANO Jiro 高野二郎

[Book] 実験医学増刊タンパク質の分解機構ページ196-201「カルパスタチン遺伝子改変マウスを用いた神経変性および生理機能の解析」2008