MIZUKAMI Takuo 水上拓郎

… Alternative Names

水上拓郎ミズカミタクオ

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Researcher Number	60415487
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所次世代生物学的製剤研究センター, センター長
Affiliation (based on the past Project Information) *help	2025: 国立健康危機管理研究機構, 次世代生物学的製剤研究センター, センター長 2023: 国立感染症研究所, 次世代生物学的製剤研究センター, センター長 2022: 国立感染症研究所, 次世代生物学的製剤研究センター, 室長 2016 – 2021: 国立感染症研究所, 血液・安全性研究部, 室長 2013 – 2015: 国立感染症研究所, その他部局等, 室長 … More 2013: 国立感染症研究所, その他部局等, その他 2011 – 2012: 国立感染症研究所, 血液・安全性研究部, 室長 2009: National Institute of Infectious Diseases, 血液・安全性研究部 2009: 感染研, 研究員 2006 – 2008: 国立感染症研究所, 血液・安全性研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 90140:Medical technology assessment-related
Keywords	Principal Investigator ニッチ / バイオマーカー / 微小環境 / ATL / 造血幹細胞 / MicroRNA / LNP / mRNAワクチン / 安全性評価 / ATL癌幹細胞 … More / ATL stem cells / HTLV-1 / 癌幹細胞 / 成人T細胞白血病 / Spp1 / 髄外造血 / 体内動態 / 品質管理 / 評価法 / 代替試験法 / 評価方 / 毒性 / 有効性 / インフルエンザ / 肺 / 安全性 / アジュバント / ワクチン / システムズバイオロジー / 感染症 / ウイルス / 免疫学 / がん / 血液学 / stem cell niche / Cancer stem cell / ATL stem cell / transgenic mouse / c-kit/SCFシグナリング / 微小環境 (ニッチ ) / 成人T細胞白血病 (ATL) / 微小環境 (ニッチ) / c-kit/SCF / モデルマウス / HBZ / Tax / カルシウム血症 / HTLV / Niche / Tax Transgenic mouse / Zoledronic acid / 骨浸潤抑制 / 破骨細胞 / osteopontin / ニッチ細胞 / Osteopontin / SDF-1 / 巨核球 / 造血ニッチ / 血液内科学 / LCM / N-Cadherin / 巨核球様細胞 / N-cadherin / 随外造血 / X線照射 / CFU-S / Tie2 / 造血微小環境 / 造血幹細胞ニッチ Less

Development of an efficacy and safety evaluation method based on clarification of the post-vaccination kinetics and biological significance of mRNA vaccines.Principal Investigator
- Principal Investigator
  
  水上拓郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Japan Institute for Health Security
次世代mRNAワクチンの有効性・安全性評価法の開発Principal Investigator
- Principal Investigator
  
  水上拓郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  National Institute of Infectious Diseases
Application of Systems Biology for the evaluation of vaccine safety and qualityPrincipal Investigator
- Principal Investigator
  
  Mizukami Takuo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  National Institute of Infectious Diseases
Characiterization of ATL stem cell candidates in HBZ transgenic mouse modelPrincipal Investigator
- Principal Investigator
  
  Mizukami Takuo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
The Role Of Osteoclasts In the developing Leukemic Stem Cell Niche in a Mouse Model of Adult T-Cell LeukemiaPrincipal Investigator
- Principal Investigator
  
  Mizukami Takuo
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Identification and Characterization of a Hematopoietic Stem Cell Niche in SpleenPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Takuo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
Identification and Characterization of a Hematopoietic Stem Cell Niche in SpleenPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Takuo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases
髄外造血機構を用いた幹細胞ニッチシステムの解明Principal Investigator
- Principal Investigator
  
  水上拓郎
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases

[Book] 医薬品の品質管理とウイルス安全性：ウイルス輸血・血液製剤と感染症2011
- Author(s)
  山口一成、水上拓郎、野島清子
- Total Pages
  301
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] Report for the Eighth Asian National Control Laboratory Network meeting in 2023: Self-sufficiency strategy of plasma-derived medicinal products and regulatory harmonisation2024
- Author(s)
  Choi CW, Choi Y, Maryuningsih YS, Wibisono B, Kim JW, Ramondrana D, Mizukami T, Ochiai M, Samat AA, Mangorangca C, Thi DL, Van HP, Shim SB, Seong SK, Shin IS.
- Journal Title
  
  Biologicals
  
  Volume: 85 Pages: 101754-101754
- DOI
  10.1016/j.biologicals.2024.101754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12901
[Journal Article] Systemically inoculated adjuvants stimulate pDC-dependent IgA response in local site2023
- Author(s)
  Sasaki Eita、Asanuma Hideki、Momose Haruka、Furuhata Keiko、Mizukami Takuo、Matsumura Takayuki、Takahashi Yoshimasa、Hamaguchi Isao
- Journal Title
  
  Mucosal Immunology
  
  Volume: - Issue: 3 Pages: 275-286
- DOI
  10.1016/j.mucimm.2023.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-22K12901, KAKENHI-PROJECT-20K16269
[Journal Article] Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2: Implications for vaccine dose interval2023
- Author(s)
  Miyamoto Sho、Shiwa-Sudo Nozomi、Iwata-Yoshikawa Naoko、Sakai Yusuke、Nagata Noriyo、Arashiro Takeshi、Ainai Akira、Moriyama Saya、Kishida Noriko、Watanabe Shinji、Nojima Kiyoko、Seki Yohei、Mizukami Takuo、Hasegawa Hideki、Ebihara Hideki、Fukushi Shuetsu、Suzuki Tadaki
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 5 Pages: 106694-106694
- DOI
  10.1016/j.isci.2023.106694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08945, KAKENHI-PROJECT-22K12901, KAKENHI-PROJECT-22K12902, KAKENHI-PROJECT-20K21666
[Journal Article] mRNAワクチン等の次世代生物学的製剤の新規安全性評価法の開発2023
- Author(s)
  平賀孔, 関洋平, 野島清子, 吉原愛雄, 水上拓郎.
- Journal Title
  
  細胞
  
  Volume: 55(11) Pages: 930-934
- Data Source
  KAKENHI-PROJECT-22K12901
[Journal Article] Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile2023
- Author(s)
  cite Zhuo SH, Noda N, Hioki K, Jin S, Hayashi T, Hiraga K, Momose H, Li WH, Zhao L, Mizukami T, Ishii KJ, Li YM, Uesugi M.
- Journal Title
  
  J Med Chem
  
  Volume: 66 Issue: 18 Pages: 13266-13279
- DOI
  10.1021/acs.jmedchem.3c01252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12901
[Journal Article] An investigation and assessment of the muscle damage and inflammation at injection site of aluminum-adjuvanted vaccines in guinea pigs2022
- Author(s)
  Sasaki E, Furuhata K, Mizukami T, Hamaguchi I.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 11 Pages: 439-451
- DOI
  10.2131/jts.47.439
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12901
[Journal Article] Safety and immunogenicity of the Pfizer/BioNTech SARS-CoV-2 mRNA third booster vaccine dose against the BA.1 and BA.2 Omicron variants.2022
- Author(s)
  Seki Y, Yoshihara Y, Nojima K, Momose H, Fukushi S, Moriyama S, Wagatsuma A, Numata N, Sasaki K, Kuzuoka T, Yato Y, Takahashi Y, Maeda K, Suzuki T, Mizukami T*, Hamaguchi I.
- Journal Title
  
  Med
  
  Volume: 3: Issue: 6 Pages: 406-421
- DOI
  10.1016/j.medj.2022.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12901
[Journal Article] Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants2022
- Author(s)
  Miyamoto S, Arashiro T, Adachi Y, Moriyama S, Kinoshita H, Fukushi S, Takahashi Y, Suzuki T et al.
- Journal Title
  
  Med
  
  Volume: 3 Issue: 4 Pages: 249-261
- DOI
  10.1016/j.medj.2022.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03500, KAKENHI-PROJECT-21K07060, KAKENHI-PROJECT-21K20767, KAKENHI-PROJECT-21K20768, KAKENHI-PROJECT-22K12901
[Journal Article] 【ワクチン設計のサイエンス】安全性研究からのワクチン・アジュバント設計2021
- Author(s)
  佐々木永太, 水上拓郎, 浜口功.
- Journal Title
  
  医学のあゆみ
  
  Volume: 279 Pages: 971-975
- Data Source
  KAKENHI-PROJECT-19K12873
[Journal Article] Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion2021
- Author(s)
  Sasaki E, Momose H, Furuhata K, Mizukami T, Hamaguchi I.
- Journal Title
  
  J Immunotoxicol.
  
  Volume: 1 Issue: 1 Pages: 163-172
- DOI
  10.1080/1547691x.2021.1979699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K12873
[Journal Article] Nasal alum-adjuvanted vaccine promotes IL-33 release from alveolar epithelial cells that elicits IgA production via type 2 immune responses2021
- Author(s)
  Sasaki E, Asanuma H, Momose H, Furuhata K, Mizukami T, Hamaguchi I.
- Journal Title
  
  PLoS Pathog
  
  Volume: 17 Issue: 8 Pages: e1009890-e1009890
- DOI
  10.1371/journal.ppat.1009890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12873, KAKENHI-PROJECT-20K16269
[Journal Article] Immunogenicity and Toxicity of Different Adjuvants Can Be Characterized by Profiling Lung Biomarker Genes After Nasal Immunization2020
- Author(s)
  Eita Sasaki, Hideki Asanuma, Haruka Momose, Keiko Furuhata, Takuo Mizukami, Isao Hamaguchi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1-19
- DOI
  10.3389/fimmu.2020.02171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12873, KAKENHI-PROJECT-20K16269
[Journal Article] Pharmacodynamic and safety considerations for influenza vaccine and adjuvant design2020
- Author(s)
  Eita Sasaki, Isao Hamaguchi, Takuo Mizukami
- Journal Title
  
  Expert Opinion on Drug Metabolism & Toxicology.
  
  Volume: 16(11) Issue: 11 Pages: 1051-1061
- DOI
  10.1080/17425255.2020.1807936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K12873, KAKENHI-PROJECT-20K16269
[Journal Article] ワクチンの過去と未来 (第2回)　システムズバイオロジーがワクチンにもたらすもの2019
- Author(s)
  佐々木永太, 濱口功, 水上拓郎*
- Journal Title
  
  炎症と免疫
  
  Volume: 27 Pages: 422-427
- Data Source
  KAKENHI-PROJECT-19K12873
[Journal Article] Development and evaluation of human T-cell leukemia virus-1 and -2 multiplex quantitative PCR2019
- Author(s)
  Kuramitsu M, Okuma K, Tezuka K, Nakamura H, Sagara Y, Kurane I, Hamaguchi I
- Journal Title
  
  Microbiol. Immunol.
  
  Volume: 63 Issue: 1 Pages: 458-464
- DOI
  10.1038/s41598-019-52686-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-19K12873, KAKENHI-PROJECT-16H06277
[Journal Article] HTLV-1感染予防法の開発2017
- Author(s)
  水上拓郎、野島清子、浜口功
- Journal Title
  
  血液内科
  
  Volume: 74(3) Pages: 356-362
- Data Source
  KAKENHI-PROJECT-16K09833
[Journal Article] Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.2016
- Author(s)
  Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Hiradate Y, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T*, Hamaguchi I*.
- Journal Title
  
  Oncotarget
  
  Volume: 7(32) Issue: 32 Pages: 51027-51043
- DOI
  10.18632/oncotarget.10210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461440, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-16K09833, KAKENHI-PROJECT-16K10377
[Journal Article] Identification of TL-Om1, an ATL Cell Line, as a Reference Material for Human T-Lymphotropic Virus 1 Quantitative PCR.2015
- Author(s)
  Kuramitsu M, Okuma K, Yamagishi M, Yamochi T, Firouzi S, Momose H, Mizukami T, Takizawa K, Araki K, Sugamura K, Yamaguchi K, Watanabe T, Hamaguchi I.
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: 53 Issue: 2 Pages: 587-596
- DOI
  10.1128/jcm.02254-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J06916, KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-24591383, KAKENHI-PROJECT-24591414, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25860798, KAKENHI-PROJECT-26293226, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-25461440
[Journal Article] Establishment of a new quality control and vaccine safety test for influenza vaccines and adjuvants using gene expression profiling.2015
- Author(s)
  Momose H, Mizukami T, Kuramitsu M, Takizawa K, Masumi A, Araki K, Furuhata K, Yamaguchi K, Hamaguchi I.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 4 Pages: e0124392-e0124392
- DOI
  10.1371/journal.pone.0124392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461440
[Journal Article] Standardization of quantitative PCR for human T-cell leukemia virus type 1 in Japan: A collaborative study2015
- Author(s)
  Kuramitsu M, Okuma K, Yamochi T. et al
- Journal Title
  
  J. Clin. Microbien.
  
  Volume: 53 Issue: 11 Pages: 3485-3491
- DOI
  10.1128/jcm.01628-15
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-25461440, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294
[Journal Article] System vaccinology for the evaluation of influenza vaccine safety bymultiplex gene detection of novel biomarkers in a preclinical study and batch release test2014
- Author(s)
  Mizukami T, Momose H, Kuramitsu M, Takizawa K, Araki K, Furuhata K, Ishii KJ, Hamaguchi I, Yamaguchi K
- Journal Title
  
  PLoS One
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling2014
- Author(s)
  Kasama Y, Mizukami T, Kusunoki H, Peveling-Oberhag J, Nishito Y, Ozawa M, Kohara M, Mizuochi T, Tsukiyama-Kohara K
- Journal Title
  
  PLoS One
  
  Volume: 9(3)
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling2014
- Author(s)
  Kasama Y, Mizukami T, Kusunoki H, Peveling-Oberhag J, Nishito Y, Ozawa M, Kohara M, Mizuochi T, Tsukiyama-Kohara K
- Journal Title
  
  PLoS One
  
  Volume: 9(3) Issue: 3 Pages: 91373-91373
- DOI
  10.1371/journal.pone.0091373
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590547, KAKENHI-PROJECT-23791093, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24658245, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25461440
[Journal Article] Degenerate polymerase chain reaction strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening2013
- Author(s)
  Takizawa K, Nakashima T, Mizukami T, Kuramitsu M, Endoh D, Kawauchi S, Sasaki K, Momose H, Kiba Y, Mizutani T, Furuta RA, Yamaguchi K, Hamaguchi I
- Journal Title
  
  Transfusion
  
  Volume: 53 Pages: 2545-55
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] Degenerate polymerase chain reaction strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening2013
- Author(s)
  Takizawa K, Nakashima T, Mizukami T, Kuramitsu M, Endoh D, Kawauchi S, Sasaki K, Momose H, Kiba Y, Mizutani T, Furuta RA, Yamaguchi K, Hamaguchi I
- Journal Title
  
  Transfusion.
  
  Volume: 17 Issue: 10pt2 Pages: 17-17
- DOI
  10.1111/trf.12193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590314, KAKENHI-PROJECT-23791093, KAKENHI-PROJECT-25304043, KAKENHI-PROJECT-25461440, KAKENHI-PROJECT-25860798
[Journal Article] The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.2012
- Author(s)
  Luc S, Luis TC,..., Mizukami T, Mats........, Patient R, de Bruijn M, Enver T, Nerlov C, Blackburn C, Godin I, Jacobsen SE.
- Journal Title
  
  Nature Immunology
  
  Volume: 13(4) Issue: 4 Pages: 412-419
- DOI
  10.1038/ni.2255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential2012
- Author(s)
  Luc S, Luis TC, Boukarabila H, Macaulay IC, Buza-Vidas N, Bouriez-Jones T, Lutteropp M, Woll PS, Loughran SJ, Mead AJ, Hultquist A, Brown J, Mizukami T, Matsuoka S, Ferry H, Anderson K, Duarte S, Atkinson D, Soneji S, Domanski A, Farley A, Sanjuan-Pla A, Carella C, Patient R, de Bruijn M, Enver T, Nerlov C, Blackburn C, Godin I, Jacobsen SE
- Journal Title
  
  Nat Immunol
  
  Volume: 13 Pages: 412-9
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia.2012
- Author(s)
  Kuramitsu M, Sato-Otsubo A, -省略-, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I.
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2376-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia2012
- Author(s)
  Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2376-84
- Data Source
  KAKENHI-PROJECT-23791093
[Journal Article] Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia2011
- Author(s)
  Kuramitsu M, Matsubara A, Morio T, Takagi M, Toki T, Terui K, RuNan W, Kanno H, Ohga S, Ohara A, Kitoh T, Sugita K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I
- Journal Title
  
  Blood
  
  Volume: (in press) Issue: 10 Pages: 2376-84
- DOI
  10.1182/blood-2011-07-368662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591388, KAKENHI-PROJECT-22591071, KAKENHI-PROJECT-22790922, KAKENHI-PROJECT-23390266, KAKENHI-PROJECT-23791093, KAKENHI-PROJECT-23791162, KAKENHI-PUBLICLY-23118501
[Journal Article] Identification of Cancer Stem Cells in a Tax-transgenic (Tax-Tg) Mouse Model of Adult T- Cell Leukemia / lymphoma (ATL).2009
- Author(s)
  Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall W, Tsujimoto H, Hamaguchi I, Yamaguchi K.
- Journal Title
  
  Blood
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] An improved abnormal toxicity test by using reference vaccine-specific body weight curves and histopathological data for monitoring vaccine quality and safety in Japan.2009
- Author(s)
  Mizukami T, Masumi A, Momose H, Kuramitsu M, Takizawa K, Naito S, Maeyama J, Furuhata K, Tsuruhara M, Hamaguchi I, Yamaguchi K
- Journal Title
  
  Biologicals 37
  
  Pages: 8-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] An improved abnormal toxicity test by using reference vaccine-specific body weight curves and histopathological data for monitoring vaccine quality and safety in Japan.2009
- Author(s)
  Mizukami T, Masumi A, Momose H, Kuramitsu M, Takizawa K, Naito S, Maeyama J, Furuhata K, Tsuruhara M, Hamaguchi I, Yamaguchi K.
- Journal Title
  
  Biologicals. 37
  
  Pages: 8-17
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Deficient RPS19 Protein Production Induces Cell Cycle Arrestin Erythroid Progenitor Cells2008
- Author(s)
  Kuramitsu M, Hamaguchi I Mizukami T, Masumi A, Momose H, Takizawa K, Mochizuki M, Naito S, Yamaguchi K
- Journal Title
  
  British Journal of Hematology 140
  
  Pages: 348-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790669
[Journal Article] Application of DNA microarray technology to influenza A/Vietnam/1194/2004 (H5N1) vaccine safety evaluation.2008
- Author(s)
  Mizukami T, Imai J, Hamaguchi I, Kawamura M, Momose H, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Nomura N, Watanabe S, Yamaguchi K.
- Journal Title
  
  Vaccine. 26
  
  Pages: 227022-227083
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Identification of transcripts commonly expressed in both hematopoietic and germ-line stem cells.2008
- Author(s)
  Mizukami T, Kuramitsu M, Takizawa K, Momose H, Masumi A, Naito S, Iwama A, Ogawa T, Noce T, Hamaguchi I, Yamaguchi K.
- Journal Title
  
  Stem Cells Dev. 17
  
  Pages: 67-80
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Five azacytidine, a DNA methyl trans-ferase inhibitor, specifically inhibits testicular cord formation and Sertoli cell differentiation in vitro.2008
- Author(s)
  Mizukami T, Kanai Y, Fujisawa M, Kanai-Azuma M, Kurohmaru M, Hayashi Y.
- Journal Title
  
  Molecular Reproduction and Development 75
  
  Pages: 1002-1010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Application of DNA microarray technology to influenzaA/Vietnam/1194/2004 (H5N1) vaccine safety evaluation.2008
- Author(s)
  Mizukami T, Imai J, Hamaguchi I, Kawamura M, Momose H, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Nomura N, Watanabe S, Yamaguchi K.
- Journal Title
  
  Vaccine 26
  
  Pages: 2270-2283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Deficient RPS19 protein production induces cell cycle arrest in erythroid progenitor cells.2008
- Author(s)
  Kuramitsu M, Hamaguchi I, Mizukami T, Masumi A, Momose H, Takizawa K, Mochizuki M, Naito S, Yamaguchi K.
- Journal Title
  
  Br J Haematol. 140
  
  Pages: 348-59
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Identification of Transcripts Commonly Expressed in Both Hematopoietic and Germline Stem Cells2008
- Author(s)
  Mizukami T, Kuramitsu M, Takizawa K, Momose H, Masumi A, Naito S, Iwama A, Ogawa T, Noce T, Hamaguchi I, and Yamaguchi K
- Journal Title
  
  Stem cells & Development 17
  
  Pages: 67-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790669
[Journal Article] Five azacytidine, a DNA methyltransferase inhibitor, specifically inhibits testicular cord formation and Sertoli cell differentiation in vitro.2008
- Author(s)
  Mizukami T, Kanai Y, Fujisawa M, Kanai-Azuma M, Kurohmaru M, Hayashi Y.
- Journal Title
  
  Mol Reprod Dev. 75
  
  Pages: 1002-1010
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Application of quantitative gene expression analysis for pertussis vaccine safety control.2008
- Author(s)
  Hamaguchi I, Imai J, Momose H, Kawamura M, Mizukami T, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Kato H, Mizutani T, Horiuchi Y, Nomura N, Watanabe S, Yamaguchi K.
- Journal Title
  
  Vaccine. 26
  
  Pages: 4686-4696
- Data Source
  KAKENHI-PROJECT-20790684
[Journal Article] Two vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control.2007
- Author(s)
  Hamaguchi I, Imai J, Momose H, Kawamura M, Mizukami T, Kato H, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Mochizuki M, Ochiai M, Yamamoto A, Horiuchi Y, Nomura N, Watanabe S, Yamaguchi K
- Journal Title
  
  Vaccine 25
  
  Pages: 3355-3364
- Data Source
  KAKENHI-PROJECT-18790669
[Journal Article] A CTX family cell adhesion molecule, JAM4, is expressed in stem cell and progenitor cell populations of both male germ cell and hematopoietic cell lineages.2006
- Author(s)
  Nagamatsu G, Ohmura M, Mizukami T, Hamaguchi I, Hirabayashi S, Yoshida S, Hata Y, Suda T, Ohbo K
- Journal Title
  
  Molcular and Cellular Biology 26
  
  Pages: 8498-8506
- Data Source
  KAKENHI-PROJECT-18790669
[Journal Article] Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.2006
- Author(s)
  Hamaguchi I, Morisada T, Azuma M, Murakami K, Kuramitsu M, Mizukami T, Ohbo K, Yamaguchi K, Oike Y, Dumont DJ, Suda T
- Journal Title
  
  Blood 107
  
  Pages: 1207-1213
- Data Source
  KAKENHI-PROJECT-18790669
[Journal Article] Expression pattern of alphavbeta3 and alphavbeta5 integrin mRNA in mouse fetal gonads.2006
- Author(s)
  Ishii M, Tay TW, Matsui T, Kidokoro T, Mizukami T, Kanai Y, Hayashi Y, Kurohmaru M
- Journal Title
  
  Journal of Reproduction and Development 52
  
  Pages: 461-468
- Data Source
  KAKENHI-PROJECT-18790669
[Presentation] ワクチン・アジュバントの次世代安全性評価法の開発2023
- Author(s)
  水上拓郎
- Organizer
  第1回近未来ワクチンフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-22K12901
[Presentation] 武漢型、BA.1及びBA.4-5対応型SARS-CoV-2 mRNAワクチンブースター接種によるオミクロン変異株に対する有効性及び安全性に関する研究.2023
- Author(s)
  4.水上拓郎, 野島清子, 関洋平, 百瀬暖佳, 福士秀悦, 森山彩野, 石井美枝, 今井恵子, 高橋宜聖, 前田健, 鈴木忠樹, 吉原愛雄, 濱口功.
- Organizer
  日本ワクチン学会, 2023年10月21日-22日静岡
- Data Source
  KAKENHI-PROJECT-22K12901
[Presentation] 武漢型及びオミクロン対応型2価ワクチンブースター接種(4回目)によるSARS-CoV-2オミクロン変異株に対する中和能及び安全性の評価2023
- Author(s)
  5.関洋平, 野島清子, 百瀬暖佳, 福士秀悦, 森山彩野, 石井美枝子, 今井恵子, 高橋宜聖, 前田健, 鈴木忠樹, 水上拓郎, 吉原愛雄, 濵口功
- Organizer
  第70回日本ウイルス学会、2023年9月26日ー28日、宮城県仙台市
- Data Source
  KAKENHI-PROJECT-22K12901
[Presentation] SARS-CoV-2 mRNAワクチン(コミナティ筋注)ブースター接種による SARS-CoV-2オミクロン変異株に対する中和能及び安全性の評価2022
- Author(s)
  関洋平、野島清子、百瀬暖佳、福士秀悦、森山彩野、高橋宜聖、前田健、鈴木忠樹、水上拓郎、吉原愛雄、濵口功.
- Organizer
  第69回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-22K12901
[Presentation] SARS-CoV-2 mRNAワクチン(コミナティ筋注)ブースター接種によるSARS-CoV-2オミクロン変異株に対する中和能及び安全性に関する研究.2022
- Author(s)
  水上拓郎, 野島清子,関洋平, 百瀬暖佳, 福士秀悦, 森山彩野, 石井美枝子, 今井恵子, 高橋宜聖, 前田健, 鈴木忠樹, 吉原愛雄, 濵口功.
- Organizer
  第29回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-22K12901
[Presentation] Systems vaccinology enable us to evaluate vaccine safety and quality in vitro.2021
- Author(s)
  Mizukami T, Sasaki E, Momose H, Furuhata K, Hamaguchi I
- Organizer
  WC11, 11th World Congress on Alternatives and Animal Use in the Life Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] システム・ワクチノロジーを応用したin vitro次世代アジュバント・ワクチン安全性評価法の開発2021
- Author(s)
  水上拓郎，佐々木永太，百瀬暖佳，古畑啓子，濵口功.
- Organizer
  日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] Reverse toxicologyによる新規アジュバント・スクリーニング系の開発2020
- Author(s)
  水上拓郎, 百瀬暖佳, 佐々木永太, 古畑啓子, 楠英樹, 浅沼秀樹, 濱口功
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] An approach to establish an in vitro evaluation assay for the safety control of influenza vaccines for batch release in Japan.2019
- Author(s)
  Momose H, Sasaki E, Hiradate Y, Hamaguchi I, Mizukami T.
- Organizer
  International Society of Vaccine meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] システムバイオロジーによるワクチン・アジュバントの次世代評価法の開発2019
- Author(s)
  水上拓郎.
- Organizer
  熊本大学平成29年度「文部科学省地域イノベーション・エコシステム形成プログラム」有用植物×創薬システムインテグレーション拠点推進事業特別講義
- Invited
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] 水上拓郎, 百瀬暖佳, 佐々木永太, 平舘裕希, 古畑啓子, 佐藤結子, 楠英樹, 浅沼秀樹, 濵口功. ワクチン及びアジュバントの安全性に関するin vitro代替試験法の開発2019
- Author(s)
  水上拓郎, 百瀬暖佳, 佐々木永太, 平舘裕希, 古畑啓子, 佐藤結子, 楠英樹, 浅沼秀樹, 濵口功.
- Organizer
  第46回日本毒性学会
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] 遺伝子発現プロファイルを応用したワクチン・アジュバントの安全性・有効性予測システムの構築.2019
- Author(s)
  佐々木永太、浅沼秀樹、百瀬暖佳、古畑啓子、水上拓郎、浜口功.
- Organizer
  第26回日本免疫毒性学会
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] Application of Systems Vaccinology for Evaluating the Safety of Vaccines and Adjuvants in Preclinical and Lot Release Tests.2019
- Author(s)
  Mizukami T.
- Organizer
  4th Symposium on Research and Quality Control of Vaccines
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] アジュバント開発を目指したゲノミクス技術によるワクチン・アジュバントの有効性・安全性プロファイル予測評価システムの開発2019
- Author(s)
  佐々木永太、浅沼秀樹、百瀬暖佳、古畑啓子、水上拓郎、浜口功.
- Organizer
  第11回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-19K12873
[Presentation] Characterization of the ATL stem cell (ATLSC) niche and cytokine environment in an ATL mouse model.2018
- Author(s)
  Takuo Mizukami, Wakako Kuribayashi, Kiyoko Nojima, Yuki Hiradate, Eita Sasaki, Madoka Kuramitsu, Haruka Momose, Kenji Sugata, Atsushi Iwama, Masao Matsuoka, Isao Hamaguchi.
- Organizer
  第79回日本血液学会
- Data Source
  KAKENHI-PROJECT-16K09833
[Presentation] Characterization of the ATL stem cell (ATLSC) niche and cytokine environment in an ATL mouse model.2017
- Author(s)
  Takuo Mizukami, Wakako Kuribayashi, Kiyoko Nojima, Yuki Hiradate, Eita Sasaki, Madoka Kuramitsu, Haruka Momose, Kenji Sugata, Atsushi Iwama, Masao Matsuoka, Isao Hamaguchi.
- Organizer
  第79回日本血液学会
- Data Source
  KAKENHI-PROJECT-16K09833
[Presentation] ※ ○ The essential role of c-kit-SCF signaling in the leukemic stem cells mediated ATL cell propagation and drug resistance.2016
- Author(s)
  Kuribayashi W, Mizukami T, Takizawa K, Sugata K, Kuramitsu M, Nojima K, Momose H, Iwama A, Matsuoka M, Hamaguchi I.
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel
- Year and Date
  2016-07-13
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] The essential role of c-kit-SCF signaling in the leukemic stem cells mediated ATL cell propagation and drug resistance.2016
- Author(s)
  uribayashi W, Mizukami T, Takizawa K, Sugata K, Kuramitsu M, Nojima K, Momose H, Iwama A, Matsuoka M, Hamaguchi I.
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club Resort
- Year and Date
  2016-07-13
- Data Source
  KAKENHI-PROJECT-16K09833
[Presentation] 成人T細胞白血病 (ATL) モデルマウスにおけるATL癌幹細胞の発生維持機構におけるc-kit-SCFシグナルの重要性の解明.2016
- Author(s)
  水上拓郎, 栗林和華子, 滝澤和也, 倉光球, 佐々木永太, 平舘裕希, 浅田善久, 岩間厚志, 松岡雄雅, 濵口功.
- Organizer
  第159回日本獣医学会
- Place of Presentation
  日本大学生物資源科学部
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] HBZ-TgマウスモデルにおけるATL癌幹細胞の発生機序解明を目指した分子基盤の解明とその機能解析2016
- Author(s)
  栗林和華子, 水上拓郎, 滝澤和也, 倉光球, 浅田善久, 岩間厚志, 松岡雄雅, 濵口功.
- Organizer
  第３回日本HTLV-1学会
- Place of Presentation
  鹿児島県市町村自治会館
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16K09833
[Presentation] 成人T細胞白血病 (ATL) モデルマウスにおけるATL癌幹細胞の発生維持機構におけるc-kit-SCFシグナルの重要性の解明2016
- Author(s)
  水上拓郎, 栗林和華子, 滝澤和也, 倉光球, 佐々木永太, 平舘裕希, 浅田善久, 岩間厚志, 松岡雄雅, 濵口功.
- Organizer
  第159回日本獣医学会
- Place of Presentation
  日本大学生物資源科学部
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K09833
[Presentation] The c-kit-SCF signaling in the leukemic stem cells development and differentiation in ATL model mice.2016
- Author(s)
  Kuribayashi W, Mizukami T, Takizawa K, Sugata K, Kuramitsu M, Nojima K, Momose H, Iwama A, Matsuoka M, Hamaguchi I
- Organizer
  RIKEN IMS Summer Program (RISP) 2016
- Place of Presentation
  理化学研究所　統合生命医科学研究センター
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-16K09833
[Presentation] The c-kit-SCF signaling in the leukemic stem cells development and differentiation in ATL model mice.2016
- Author(s)
  Kuribayashi W, Mizukami T, Takizawa K, Sugata K, Kuramitsu M, Nojima K, Momose H, Iwama A, Matsuoka M, Hamaguchi I
- Organizer
  RIKEN IMS Summer Program (RISP) 2016
- Place of Presentation
  理化学研究所
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] IDENTIFICATION OF LEUKEMIC STEM CELL CANDIDATES IN AN ATL MOUSE MODEL OF HBZ TRANSGENIC MICE2015
- Author(s)
  Wakako Kuribayashi, Takuo Mizukami, Kazuya Takizawa, Kenji Sugata, Madoka Kuramitsu, Kiyoko Nozima, Haruka Momose, Yoshihisa Asada, Astushi Iwama, Masao Matsuoka, Isao Hamaguchi,
- Organizer
  European hematology association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] The c-kit-SCF signaling in the leukemic stem cells development in ATL model mice2015
- Author(s)
  Wakako Kuribayashi, Takuo Mizukami, Masao Matsuoka, Isao Hamaguchi
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] HBZ-Tgマウスモデルにおける癌幹細胞の機能解析2015
- Author(s)
  栗林和華子, 水上拓郎
- Organizer
  第２回 HTLV-1学会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] Identification of ATL stem cells in an ATL model HBZ transgenic mouse2015
- Author(s)
  Wakako Kuribayashi, Takuo Mizukami, Kazuya Takizawa, Kenji Sugata, Madoka Kuramitsu, Kiyoko Nojima, Haruka Momose, Yoshihisa Asada, Atsushi Iwama, Masao Matsuoka, Isao Hamaguchi
- Organizer
  International Society for Experimental Hematology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] ATLモデルマウスにおけるがん幹細胞のc-kit-SCFの機能解析2015
- Author(s)
  栗林和華子, 水上拓郎
- Organizer
  Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] The c-kit-SCF signaling in the leukemic stem cells development and differentiation in ATL model mice.2015
- Author(s)
  Wakako Kuribayashi, Takuo Mizukami, Kazuya Takizawa, Kenji Sugata, Madoka Kuramitsu, Kiyoko Nozima, Haruka Momose, Yoshihisa Asada, Atsushi Iwama, Masao Matsuoka, Isao Hamaguchi.
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] The Osteoclast Targeting Therapy In Bone Metastasis For a Mouse Model Of Adult T Cell Leukemia2013
- Author(s)
  Takuo Mizukami, PhD1*, Kazuya Takizawa, PhD1*, Jumpei Yamazaki, PhD2*, Wakako Kuribayashi3*, Madoka Kuramitsu, PhD1*, Ryuji Hiramatsu, PhD1*, William W Hall, MD, PhD4*, Hideki Hasegawa, MD, PhD5*, Kazunari Yamaguchi, MD, PhD1* and Isao Hamaguchi, MD, PhD1
- Organizer
  55th Annual Meeting of American Society of Hematology
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] The Role Of Osteoclasts In the developing Leukemic Stem Cell Niche in a Mouse Model of Adult T-Cell Leukemia2013
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Madoka Kuramitsu, Haruka Momose, **Jumpei Yamazaki, ***William Hall, *Hideki Hasegawa, Kazunari Yamaguchi, Isao Hamaguchi
- Organizer
  18回欧州血液学会
- Place of Presentation
  Sweden, Stockholm
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] The role of osteoclast in the leukemic stem cell niche using a mouse model of adult T cell leukemia2013
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Wakako Kuribayashi, Ryuji Hiramatsu, Madoka Kuramitsu, Haruka Momose, Jumpei Yamazaki, William W Hall, Hideki Hasegawa, Kazunari Yamaguchi, Isao Hamaguchi
- Organizer
  日本血液学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] ATLマウスモデルであるHBZ-TgマウスにおけるATLがん幹細胞の同定2013
- Author(s)
  栗林和華子1),2)、水上拓郎2)、滝澤和也2)、倉光球2)、百瀬暖佳2)、菅田謙治3)、浅田善久1)、松岡雅雄3)、濵口功2)
- Organizer
  HTLV-1研究会
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] トランスジェニックマウスを用いた「感染症と癌」のクロストーク2013
- Author(s)
  水上拓郎、滝澤和也、狭間俊介、倉光球、百瀬暖佳、益見厚子、長谷川秀樹、浜口功
- Organizer
  日本獣医学会　サテライトフォーラム
- Place of Presentation
  岐阜大学
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] 成人T細胞白血病マウスモデルを用いた癌幹細胞ニッチ形成における破骨細胞の機能解析と破骨細胞を標的とした治療法の開発2013
- Author(s)
  水上拓郎 1,滝澤和也 1,栗林和華子 2,平松竜司 1,倉光球 1, 山崎淳平 3,William Hall4,長谷川秀樹 5,山口一成 1,浜口功 1
- Organizer
  日本獣医学会
- Place of Presentation
  岐阜大学
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] Identification of Leukemic stem cell and their niche in adult T cell leukemia (ATL) in the Tax-transgenic mouse model.2012
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Madoka Kuramitsu, Haruka Momose, **Jumpei Yamazaki, ***William Hall, *Hideki Hasegawa, Kazunari Yamaguchi, Isao Hamaguchi
- Organizer
  54th American Society of hematology
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-23791093
[Presentation] ATL癌幹細胞のニッチ形成過程における破骨細胞の役割2012
- Author(s)
  水上拓郎、滝澤和也、狭間俊介、倉光球、百瀬暖佳、益見厚子、長谷川秀樹、浜口功
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791093
[Presentation] マウスモデルを用いたATL癌幹細胞及びそのニッチの解析2012
- Author(s)
  水上拓郎、滝澤和也、山崎淳平、倉光球、百瀬暖佳、益見厚子、長谷川秀樹、山口一成、浜口功
- Organizer
  第154回日本獣医学会
- Place of Presentation
  岩手
- Data Source
  KAKENHI-PROJECT-23791093
[Presentation] Identification and Characterization of Bone Marrow-derived Leukemic Stem Cells in a Tax-transgenic Mouse Model of Adult T-Cell Leukemia / Lymphoma.2011
- Author(s)
  Mizukami T, Takizawa K, Kuramitsu M, Momose H, Mausmi A, Yamazaki J, Hasegawa H, Hall W, Yamaguchi K, Hamaguchi I
- Organizer
  XXV IACRLRD Symposium
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-23791093
[Presentation] HTLV-1 Taxトランスジェニックマウスを用いたATL癌幹細胞及びそのニッチの同定2011
- Author(s)
  水上拓郎、滝澤和也、山崎淳平、倉光球、百瀬暖佳、益見厚子、長谷川秀樹、浜口功、山口一成
- Organizer
  日本獣医学会
- Place of Presentation
  大阪府立大学
- Data Source
  KAKENHI-PROJECT-23791093
[Presentation] Identification of cancer stem cell niche in Adult T-Cell Leukemia / lymphoma (ATL) model mouse Tax-transgenic (Tax-Tg) mouse2011
- Author(s)
  Takuo Mizukami, Kazuya Takizawa, Madoka Kuramitsu, Haruka Momose, **Jumpei Yamazaki, Atsuko Masumi, *Hideki Hasegawa, Kazunari Yamaguchi, Isao Hamaguchi
- Organizer
  日本血液学会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23791093
[Presentation] The role for IRF2 on megakaryo-poiesis mediated by IFN-γinduction.2008
- Author(s)
  Atsuko Masumi, Isao Hamaguchi, Madoka Kuramitsu, Takuo Mizukami, Kazuya Takizawa, Haruka Momose, Seishirou Naito, Kazunari Yamaguchi.
- Organizer
  International Society for ICR.
- Place of Presentation
  (ポスター)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] 髄外造血機構を用いた造血幹細胞ニッチの解析2008
- Author(s)
  水上拓郎・浜口功・滝沢和也・倉光球・百瀬暖佳・内藤誠之郎・益見厚子・岡田誠治・山ロ一成
- Organizer
  第145回日本獣医学会
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-18790669
[Presentation] 網羅的迅速検出法(Luminex法)によるインフルエンザワクチンの新しい安全性評価法の開発の試み2008
- Author(s)
  水上拓郎、今井順一、浜口功、河村未佳、百瀬暖佳、内藤誠之郎、前山順一、益見厚子、倉光球、滝沢和也、野村信夫、渡辺慎哉、山口一成.
- Organizer
  日本ワクチン学会
- Place of Presentation
  (口頭)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] 脾臓における造血幹細胞ニッチ細胞の解析2008
- Author(s)
  水上拓郎, 浜口功, 滝沢和也, 倉光球, 百瀬暖佳, 内藤誠之郎, 益見厚子, 岡田誠治, 山口一成.
- Organizer
  日本血液学会
- Place of Presentation
  (ポスター)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] 脾臓における造血幹細胞ニッチ細胞の解析2008
- Author(s)
  水上拓郎,浜口功,滝沢和也,倉光球,百瀬暖佳,内藤誠之郎,益見厚子,岡田誠治,山口一成
- Organizer
  日本血液学会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] HTLV-1 Taxトランスジェニックマウスを用いた腫瘍幹細胞の同定2008
- Author(s)
  水上拓郎、山崎淳平、滝澤和也、倉光球、百瀬暖佳、益見厚子、長谷川秀樹、浜口功、山口一成.
- Organizer
  HTLV-1研究会
- Place of Presentation
  (口頭)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] 網羅的迅速検出法(Luminex法)によるインフルエンザワクチンの新しい安全性評価法の開発の試み2008
- Author(s)
  水上拓郎, 今井順一, 浜口功, 河村未佳, 百瀬暖佳, 内藤誠之郎, 前山順一, 益見厚子, 倉光球, 滝沢和也, 野村信夫, 渡辺慎哉, 山口一成
- Organizer
  日本ワクチン学会
- Place of Presentation
  熊本
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] Identification of Cancer Stem Cells in Adult T-Cell Leukemia/lymphoma (ATL) model mouse Tax-transgenic (Tax-Tg) mouse.2008
- Author(s)
  Mizukami T, Yamazaki J, Hasegawa H, Hamaguchi I, Yamaguchi K
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] Identification and Characterization of a Hematopoietic Stem Cell Niche in Spleen2008
- Author(s)
  Mizukami T, Hamaguchi I, Takizawa T, Kuramitsu M, Momose H, Naito S, Masumi A, Okada S, Yamaguchi Y
- Organizer
  Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] Identification and Characterization of a Hematopoietic Stem Cell Niche in Spleen.2008
- Author(s)
  Mizukami T, Hamaguchi I, Takizawa T, Kuramitsu M, Momose H, Naito S, Masumi A, Okada S, Yamaguchi Y.
- Organizer
  Annual meeting of American Society of Hematology.
- Place of Presentation
  (ポスター)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] Identification of Cancer Stem Cells in Adult T-Cell Leukemia / lymphoma (ATL) model mouse Tax-transgenic (Tax-Tg) mouse.2008
- Author(s)
  Mizukami T, Yamazaki J, Hasegawa H, Hamaguchi I, Yamaguchi K.
- Organizer
  日本癌学会
- Place of Presentation
  (口頭)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] HTLV-1 Taxトランスジェニックマウスを用いた腫瘍幹細胞の同定2008
- Author(s)
  水上拓郎, 山崎淳平, 滝澤和也, 倉光球, 百瀬暖佳, 益見厚子, 長谷川秀樹, 浜口功, 山口一成
- Organizer
  HTLV-1研究会
- Place of Presentation
  東京
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] Tie2 / Angiopoietin-1シグナルを介した造血幹細胞の増殖制御2008
- Author(s)
  百瀬暖佳, 浜口功, 滝澤和也, 水上拓郎, 倉光球, 益見厚子, 山口一成.
- Organizer
  日本分子生物学会
- Place of Presentation
  (口頭)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] 新型インフルエンザ, ウエストナイルウイルス等に対する対策の現状2008
- Author(s)
  水上拓郎, 浜口功, 山口一成.
- Organizer
  日本輸血・細胞治療学会
- Place of Presentation
  (シンポジウム)
- Data Source
  KAKENHI-PROJECT-20790684
[Presentation] Identification of transcripts commonly expressed in both hematopoietic and germline stem cells-Sppl(Secreted phosphoprotein l)is essential for the early niche formation in the bone marrow.2007
- Author(s)
  Mizukami T, Kuramitsu M, Takizawa K, Momose H, Mochizuki M, Masumi A, Naito S, Iwama A, Ogawa T, Noce T, Hamaguchi I, and Yamaguchi K
- Organizer
  第5回国際幹細胞学会
- Place of Presentation
  Cairns Australia
- Data Source
  KAKENHI-PROJECT-18790669
[Presentation] 髄外造血機構を用いた造血幹細胞ニッチの解析2007
- Author(s)
  水上拓郎・浜口功・滝沢和也・倉光球・百瀬暖佳・内藤誠之郎・益見厚子・岡田誠治・山ロ一成
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18790669
[Presentation] 成人T細胞白血病 (ATL)モデルマウスであるHBZトランスジェニックマウスにおける癌幹細胞の同定の試み
- Author(s)
  栗林和華子, 水上拓郎, 滝澤和也, 倉光球, 浅田善久, 岩間厚志, 松岡雅雄, 濵口功
- Organizer
  京都T細胞会議
- Place of Presentation
  京都平安ホテル
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] 造血組織における新たな一過性ニッチ細胞 (TNCs)の同定とその多様な機能
- Author(s)
  水上拓郎、滝澤和也、平松竜司、倉光球、百瀬暖佳、山口一成、浜口功
- Organizer
  日本獣医学会
- Place of Presentation
  北海道大学高等教育推進機構
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] Identification and characterization of cancer stem cells in an HBZ transgeni c mouse model of ATL
- Author(s)
  Wakako Kuribayashi, Takuo Mizukami, Kazuya Takizawa, Madoka Kuramitsu, Iwama Atsushi, Yoshihisa Asada, Masao Matsuoka, Isao Hamaguchi
- Organizer
  日本血液学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25461440
[Presentation] HTLV-1モデルマウスであるHBZ-Tgマウスにおける癌幹細胞の同定と機能解析
- Author(s)
  栗林和華子, 水上拓郎, 滝澤和也, 倉光球, 浅田善久, 岩間厚志, 松岡雅雄, 濵口功
- Organizer
  HTLV-1学会
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2014-08-16 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461440

1. SUZUKI Tadaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KAWAUCHI Shigeto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. FIROUZI Sanaz

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 大賀正一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 高橋宜聖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 岩田奈織子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 浜口功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小原恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 佐々木功典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUKAMI Takuo 水上 拓郎

水上 拓郎 ミズカミ タクオ

Research Projects

Research Products

Co-Researchers

Development of an efficacy and safety evaluation method based on clarification of the post-vaccination kinetics and biological significance of mRNA vaccines.Principal Investigator

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次世代mRNAワクチンの有効性・安全性評価法の開発Principal Investigator

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Application of Systems Biology for the evaluation of vaccine safety and qualityPrincipal Investigator

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Characiterization of ATL stem cell candidates in HBZ transgenic mouse modelPrincipal Investigator

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The Role Of Osteoclasts In the developing Leukemic Stem Cell Niche in a Mouse Model of Adult T-Cell LeukemiaPrincipal Investigator

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Identification and Characterization of a Hematopoietic Stem Cell Niche in SpleenPrincipal Investigator

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Identification and Characterization of a Hematopoietic Stem Cell Niche in SpleenPrincipal Investigator

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髄外造血機構を用いた幹細胞ニッチシステムの解明Principal Investigator

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[Book] 医薬品の品質管理とウイルス安全性：ウイルス輸血・血液製剤と感染症2011

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[Journal Article] Report for the Eighth Asian National Control Laboratory Network meeting in 2023: Self-sufficiency strategy of plasma-derived medicinal products and regulatory harmonisation2024

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[Journal Article] Systemically inoculated adjuvants stimulate pDC-dependent IgA response in local site2023

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[Journal Article] Saturation time of exposure interval for cross-neutralization response to SARS-CoV-2: Implications for vaccine dose interval2023

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[Journal Article] mRNAワクチン等の次世代生物学的製剤の新規安全性評価法の開発2023

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[Journal Article] Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile2023

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MIZUKAMI Takuo 水上拓郎

水上拓郎ミズカミタクオ

[Journal Article] ワクチンの過去と未来 (第2回)　システムズバイオロジーがワクチンにもたらすもの2019