Koizume Shirou 小井詰史朗

… Alternative Names

KOIZUME Shiro 小井詰史朗

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Researcher Number	60416063
Other IDs
Affiliation (Current)	2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん分子病態学部, 副技官・主任研究員 2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技官・主任研究員
Affiliation (based on the past Project Information) *help	2024: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん分子病態学部, 副技官・主任研究員 2022 – 2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技官・主任研究員 2021: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技管・主任研究員 2020: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 副技幹・主任研究員 2011 – 2019: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, その他 … More 2014: 神奈川県立がんセンター臨床研究所, 主任研究員 2013: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態学部, 主任研究員 2011: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 研究員 2011: 神奈川県立がんセンター臨床研究所, 主任研究員 2010: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態研究部門, 研究員 2009: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態研究部門, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 54010:Hematology and medical oncology-related / Tumor biology / Tumor biology Except Principal Investigator Experimental pathology / Urology
Keywords	Principal Investigator 卵巣癌 / ハイポキシア / 淡明細胞腎細胞癌 / 低酸素 / ICAM-1 / 卵巣明細胞腺がん / 卵巣明細胞癌 / アポトーシス / 癌 / がん関連血栓塞栓症 … More / 静脈血栓塞栓症 / がん / 血栓塞栓症 / ICAM1 / 卵巣がん / 遺伝子発現 … More Except Principal Investigator 低栄養 / 血液凝固 / 低酸素 / 組織因子 / TF / 脂質 / 進行度予測 / 悪性度 / 診断マーカー / 進行度 / 早期診断マーカー / 低脂質 / GPCR / 前立腺がん / 血液凝固第7因子 / tissue factor / 血栓塞栓 / 肝細胞癌 / fVII / TFPI / 肝がん / 凝固 / 凝固第VII因子 / クルクミン / マイクロパーティクル / 第VII / 遺伝子発現 / 低血清 / 血液凝固第VII因子 / factor VII Less

淡明細胞腎細胞癌にて発現するICAM-1: 治療標的化に向けた発現機構と機能の解明Principal Investigator
- Principal Investigator
  
  小井詰史朗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kanagawa Cancer Center Research Institute
ICAM-1 expressed in ovarian clear cell carcinoma: Elucidation of full aspects including apoptosis resistance mechanismPrincipal Investigator
- Principal Investigator
  
  Koizume Shiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Effect of ectopically synthesized coagulation factor VII on venous thromboembolism and malignancyPrincipal Investigator
- Principal Investigator
  
  Koizume Shiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Investigation of pathophysiology and biomarker discovery for prostate cancer in the lipid-deficient hypoxia microenvironment
- Principal Investigator
  
  Miyagi Yohei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanagawa Cancer Center Research Institute
Development of therapeutic strategy of poor prognostic ovarian cancer targeting ischemia-driven expression of ICAM-1Principal Investigator
- Principal Investigator
  
  Koizume Shiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanagawa Cancer Center Research Institute
Investigation of mechanisms to keep blood vessels patent in hepatocellular carcinoma.
- Principal Investigator
  
  MIYAGI Yohei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kanagawa Cancer Center Research Institute
Analysis of Sp1-dependent adaptation mechanism of cancer cells to hypoxia for tumor microenvironment-targeted therapyPrincipal Investigator
- Principal Investigator
  
  KOIZUME Shiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanagawa Cancer Center Research Institute
Coagulation factor VII producing tumors and their release of microparticles with coagulation initiating capacity
- Principal Investigator
  
  MIYAGI Yohei
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  地方独立行政法人神奈川県立病院機構
   Kanagawa Cancer Center Research Institute

[Book] 腫瘍循環器学の現況と展望クリニカルトピック・組織因子の機能調節メカニズム in BIO Clinica, 2019, vol 34, No. 102019
- Author(s)
  小井詰史朗、宮城洋平
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-18K08346
[Book] Encyclopedia of Signaling Molecules2017
- Author(s)
  Koizume S, Miyagi Y.
- Total Pages
  4700
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26430135
[Book] Breast Cancer: Current and Alternative Therapeutic Modalities2011
- Author(s)
  Koizume S
- Total Pages
  16
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-23501280
[Book] Functional Correlates, and Potential for a New Therapeutic Target. Breast Cancer. Current and Alternative Therapeutic Modalities2011
- Author(s)
  Shiro Koizume and Yohei Miyagi
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-21590455
[Book] Ectopic synthesis of coagulation factor VII in breast cancer cells: Mechanisms, functional correlates, and potential for a new therapeutic target. Breast Cancer : Current and Alternative Therapeutic Modalities2011
- Author(s)
  Koizume S, Miyagi Y
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-23501280
[Journal Article] Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin2023
- Author(s)
  Koizume S, Kanayama T, Kimura Y, Hirano H, Takahashi T, Ota Y, Miyazaki K, Yoshihara M, Nakamura Y, Yokose T, Kato H, Takenaka K, Sato S, Tadokoro H, Miyagi E, Miyagi Y.
- Journal Title
  
  Cancer Sci
  
  Volume: 00 Issue: 6 Pages: 1-14
- DOI
  10.1111/cas.15774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09484, KAKENHI-PROJECT-20K09422
[Journal Article] Authors' reply to the Letter to the Editor: Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer2022
- Author(s)
  Koizume S, Kobayashi S, Ruf W, Miyagi Y
- Journal Title
  
  Cancer Sci
  
  Volume: ー Issue: 5 Pages: 1888-1890
- DOI
  10.1111/cas.15324
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09484
[Journal Article] Tissue factor in cancer-associated thromboembolism: possible mechanisms and clinical applications2022
- Author(s)
  Koizume S, Miyagi Y
- Journal Title
  
  Br J Cancer
  
  Volume: 127 Issue: 12 Pages: 2099-2107
- DOI
  10.1038/s41416-022-01968-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09484
[Journal Article] Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma2022
- Author(s)
  Koizume S, Takahashi T, Nakamura Y, Yoshihara M, Ota Y, Sato S, Tadokoro H, Yokose T, Kato H, Miyagi E, Miyagi Y
- Journal Title
  
  Br J Cancer
  
  Volume: ー Issue: 3 Pages: 462-473
- DOI
  10.1038/s41416-022-01808-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09484, KAKENHI-PROJECT-20K09422
[Journal Article] Tissue factor pathway inhibitor 2 is specifically expressed in ovarian clear cell carcinoma tissues in the nucleus, cytoplasm and extracellular matrix2021
- Author(s)
  Yukihide Ota, Shiro Koizume, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Tomoko Takahashi, Shinya Sato, Shohei Myoba, Norihisa Ohtake, Hisamori Kato, Tomoyuki Yokose, Etsuko Miyagi, Yohei Miyagi
- Journal Title
  
  Oncology Reports
  
  Volume: 45 Issue: 3 Pages: 1023-1032
- DOI
  10.3892/or.2021.7944
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-18K08346
[Journal Article] Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer2021
- Author(s)
  Kobayashi S, Koizume S, Takahashi T, Ueno M, Oishi R, Nagashima S, Sano Y, Fukushima T, Tezuka S, Morimoto M, Nakamura S, Narimatsu H, Ruf W, Miyagi Y
- Journal Title
  
  Cancer Sci
  
  Volume: 112 Issue: 11 Pages: 4679-4691
- DOI
  10.1111/cas.15106
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09484, KAKENHI-PROJECT-16H06277
[Journal Article] Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles2019
- Author(s)
  Koizume S, Takahashi T, Yoshihara M, Nakamura Y, Ruf W, Takenaka K, Miyagi E, and Miyagi Y.
- Journal Title
  
  Thromb. Haemost.
  
  Volume: 印刷中 Issue: 07 Pages: 1058-1071
- DOI
  10.1055/s-0039-1687876
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08346, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-15K06833
[Journal Article] Drug screening Pelizaeus-Merzbacher disease by quantifying the total levels and membrane localization of PLP12019
- Author(s)
  Kouga T, Koizume S, Aoki S, Jimbo E, Yamagata T, Inoue K, Osaka H.
- Journal Title
  
  Mol Genet Metab Rep
  
  Volume: 20 Pages: 100474-100474
- DOI
  10.1016/j.ymgmr.2019.100474
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08346
[Journal Article] Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O2 and Plasma Supply2017
- Author(s)
  Koizume S, Miyagi Y.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 18 Issue: 4 Pages: 809-809
- DOI
  10.3390/ijms18040809
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430135
[Journal Article] A splicing mutation of proteolipid protein 1 in Pelizaeus-Merzbacher disease.2016
- Author(s)
  Omata T, Nagai J, Shimbo H, Koizume S, Miyagi Y, Kurosawa K, Yamashita S, Osaka H, Inoue K.
- Journal Title
  
  Brain & Development
  
  Volume: 38 Issue: 6 Pages: 581-584
- DOI
  10.1016/j.braindev.2015.12.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430135, KAKENHI-PROJECT-25670485, KAKENHI-PROJECT-15H04878, KAKENHI-PROJECT-16H05361
[Journal Article] Lipid droplets: A key cellular organelle associated with cancer cell survival under normoxia and hypoxia.2016
- Author(s)
  Koizume S, Miyagi Y.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 17 Issue: 9 Pages: 1430-1430
- DOI
  10.3390/ijms17091430
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430135
[Journal Article] High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors2016
- Author(s)
  Koizume S, Ito S, Yoshioka Y, Kanayama T, Nakamura Y, Yoshihara M, Yamada R, Ochiya T, Ruf W, Miyagi E, Hirahara F, Miyagi Y
- Journal Title
  
  Thromb Haemost
  
  Volume: 115 Issue: 02 Pages: 299-310
- DOI
  10.1160/th15-03-0213
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462602, KAKENHI-PROJECT-26430135
[Journal Article] Diverse mechanisms　of　Sp1-dependent　transcriptional　regulation　potentially　involved　in　the　adaptive　response　of cancer cells to oxygen-deficient conditions.2016
- Author(s)
  Koizume S, Miyagi Y.
- Journal Title
  
  Cancers
  
  Volume: 8 Issue: 1 Pages: 2-2
- DOI
  10.3390/cancers8010002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430135
[Journal Article] Tissue factor-factor VII complex as a key regulator of ovarian cancer phenotypes.2015
- Author(s)
  Koizume S, Miyagi Y.
- Journal Title
  
  Biomarkers in Cancer
  
  Volume: 7(S1) Pages: 1-13
- DOI
  10.4137/bic.s29318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430135
[Journal Article] Suppressing the TF-fVII pathway at the gene expression level: a strategy to inhibit aberrant signaling cascades associated with cancer cells2015
- Author(s)
  Koizume S and Miyagi Y
- Journal Title
  
  Cancer Cell Microenviron
  
  Volume: 2
- DOI
  10.14800/ccm.734
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430135
[Journal Article] Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer2015
- Author(s)
  Koizume S, Ito S, Nakamura Y et al.
- Journal Title
  
  Mol Cancer
  
  Volume: 14 Issue: 1 Pages: 77-77
- DOI
  10.1186/s12943-015-0351-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430135, KAKENHI-PROJECT-25462602
[Journal Article] Anti-apoptotic genes are synergistically activated in OVSAYO cells cultured under conditions of serum starvation and hypoxia.2015
- Author(s)
  Koizume S, Miyagi Y.
- Journal Title
  
  Genomics Data
  
  Volume: 5 Pages: 129-131
- DOI
  10.1016/j.gdata.2015.05.029
- Open Access
- Data Source
  KAKENHI-PROJECT-26430135
[Journal Article] Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets.2014
- Author(s)
  Koizume, S and Miyagi, Y.
- Journal Title
  
  World J Clin Oncology
  
  Volume: 5(5) Issue: 5 Pages: 908-920
- DOI
  10.5306/wjco.v5.i5.908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590499, KAKENHI-PROJECT-26430135
[Journal Article] Annexin A4 is involved in proliferation, chemoresistance and migration and invasion in ovarian clear cell adenocarcinoma cells.2013
- Author(s)
  Mogami T, Yokota N, Asai-sato M, Yamada R, Koizume S, Sakuma Y, Yoshihara M, Nakamura Y, Takano Y, Hirahara F, Miyagi Y, and Miyagi E.
- Journal Title
  
  PLOS ONE
  
  Volume: 8 Issue: 11 Pages: 1-8
- DOI
  10.1371/journal.pone.0080359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-25430165, KAKENHI-PROJECT-25462602
[Journal Article] Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells.2013
- Author(s)
  Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, and Miyagi Y.
- Journal Title
  
  Lab Invest.
  
  Volume: 93 Issue: 10 Pages: 1137-1146
- DOI
  10.1038/labinvest.2013.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-24590440, KAKENHI-PROJECT-25670178
[Journal Article] HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII gene activation under hypoxic conditions in ovarian cancer cells2012
- Author(s)
  Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y.
- Journal Title
  
  Nucleic Acid Res
  
  Volume: 32(4) Pages: 1457-1461
- Data Source
  KAKENHI-PROJECT-21590455
[Journal Article] NF-kB signaling is activated and confers resistance to apoptosis in three-dimentionally cultured EGFR-mutant lung adenocarcinoma cells.2012
- Author(s)
  Sakuma, Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 243 Issue: 4 Pages: 667-671
- DOI
  10.1016/j.bbrc.2012.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-24590440
[Journal Article] HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells2012
- Author(s)
  Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y
- Journal Title
  
  Nucleic Acid Research
  
  Volume: 40(12) Issue: 12 Pages: 5389-5401
- DOI
  10.1093/nar/gks201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590455, KAKENHI-PROJECT-22591860, KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-23790633, KAKENHI-PROJECT-24590499
[Journal Article] WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutunt lung adenocarcinomas more efficiently than Src inhibitors2012
- Author(s)
  Sakuma Y, et al
- Journal Title
  
  Laboratory Investigation
  
  Volume: 92 Issue: 3 Pages: 371-383
- DOI
  10.1038/labinvest.2011.187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790367, KAKENHI-PROJECT-23501280
[Journal Article] The association between RAS gene mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort2012
- Author(s)
  Fukahori M, Yoshida A, Hayashi H, Yoshihara M, Matsukuma S, Sakuma Y, Koizume S, Okamoto N, Kondo T, Masuda M, and Miyagi Y
- Journal Title
  
  Thyroid
  
  Volume: 22 Issue: 7 Pages: 683-689
- DOI
  10.1089/thy.2011.0261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280
[Journal Article] Differential detection of KRAS mutations in codons 12 and 13 with a modified loop-hybrid (LH) mobility shift assay using an insert-type LH-generator2011
- Author(s)
  Matsukuma S, Yoshihara M, Suda T, Shiozawa M, Akaike M, Ishikawa, T, Koizume S, Sakuma Y, and Miyagi Y
- Journal Title
  
  Clin. Chim. Acta.
  
  Volume: 412 Issue: 19-20 Pages: 1874-1878
- DOI
  10.1016/j.cca.2011.06.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-221S0001
[Journal Article] Simple and precise detection of UGT1A1 polymorphisms with a modified loop-hybrid mobility shift assay using Cy5-labeled loop probes2011
- Author(s)
  Matsukuma S, Saito H, Yamada K, Okamoto N, Ishikawa T, Yoshihara M, Koizume S, Sakuma Y, and Miyagi Y
- Journal Title
  
  Clin. Chim. Acta.
  
  Volume: 412 Issue: 17-18 Pages: 1668-1672
- DOI
  10.1016/j.cca.2011.05.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280, KAKENHI-PROJECT-221S0001
[Journal Article] ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis2011
- Author(s)
  Sakuma Y, Tsunezumi J, Nakamura Y, Yoshihara M, Matsukuma S, Koizume S, and Miyagi Y
- Journal Title
  
  Oncol. Rep.
  
  Volume: 25 Issue: 3 Pages: 661-667
- DOI
  10.3892/or.2010.1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280
[Journal Article] Mild phenotype in Pelizaeus-Merzbacher disease caused by a PLP1-specific mutation2010
- Author(s)
  Osaka H, Koizume S, Aoyama H, Iwamoto H, Kimura S, Nagai J, Kurosawa K, and Yamashita S
- Journal Title
  
  Brain Dev.
  
  Volume: 32 Issue: 9 Pages: 703-707
- DOI
  10.1016/j.braindev.2009.11.004
- NAID
  10027492517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280
[Journal Article] Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells2009
- Author(s)
  Yokota N, Koizume S, Miyagi E, Hirahara F, Nakamura Y, Kikuchi K, Ruf W, Sakuma Y, Tsuchiya E, Miyagi Y.
- Journal Title
  
  Br J Cancer
  
  Volume: 101 Pages: 2023-2029
- Data Source
  KAKENHI-PROJECT-21590455
[Journal Article] HNF-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferase2009
- Author(s)
  Koizume, S., Yokota, N., Miyagi, E., Hirahara, F., Nakamura, Y., Sakuma, Y., Yoshida, A., Kameda, Y., Tsuchiya, E. and Miyagi, Y
- Journal Title
  
  Mol. Cancer Res.
  
  Volume: 7 Issue: 12 Pages: 1928-1936
- DOI
  10.1158/1541-7786.mcr-09-0372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280
[Journal Article] Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells2009
- Author(s)
  Yokota, N., Koizume, S., Miyagi, E., Hirahara, F., Nakamura, Y., Kikuchi, K., Ruf, W., Sakuma, Y. Tsuchiya, E., and Miyagi, Y
- Journal Title
  
  Br. J. Cancer
  
  Volume: 101 Issue: 12 Pages: 2023-2029
- DOI
  10.1038/sj.bjc.6605406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280
[Journal Article] HNF-4 independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases2009
- Author(s)
  Koizume S, Yokota N, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Yoshida A, Kameda Y, Tsuchiya E, Ruf W, Miyagi Y.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 7(12) Pages: 1928-1936
- Data Source
  KAKENHI-PROJECT-21590455
[Journal Article] Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells2009
- Author(s)
  Yokota N, Koizume S, Miyagi E, Hirahara F, Nakamura Y, Kikuchi K, Ruf W, Sakuma Y, Tsuchiya E, Miyagi Y.
- Journal Title
  
  British Journal of Cancer 101
  
  Pages: 2023-2029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590455
[Journal Article] HNF-4 independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases2009
- Author(s)
  Koizume S, Yokota N, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Yoshida A, Kameda Y, Tsuchiya E, Ruf W, Miyagi Y.
- Journal Title
  
  Molecular Cancer Research 7(12)
  
  Pages: 1928-1936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590455
[Journal Article] Breast cancer phenotypes regulated by tissue factor-factor VII : possible therapeutic targets
- Author(s)
  Koizume S, Miyagi Y. World. J. Ciln
- Journal Title
  
  Oncol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞癌細胞による組織因子陽性細胞外小胞の産生とその血液凝固活性2022
- Author(s)
  田所弘子、小井詰史朗、吉原光代、太田幸秀、佐藤慎哉、宮城洋平
- Organizer
  第８１回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K09484
[Presentation] 異所性CD69発現は不フィブロネクチン依存的に卵巣明細胞がん細胞の上皮間葉転換を促進させる2022
- Author(s)
  小井詰史朗、太田　幸秀、中村圭靖、吉原光代、佐藤慎哉、田所弘子、宮城悦子、宮城洋平
- Organizer
  第８１回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K09484
[Presentation] 酸素、脂肪酸供給欠乏環境下で誘起されるリポファジー-ICAM-1経路は卵巣明細胞癌の予後不良性と相関する2022
- Author(s)
  小井詰史朗、宮城洋平
- Organizer
  第１８回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-21K09484
[Presentation] リポファジー-ICAM-1経路は卵巣明細胞がんの予後不良性と相関する2021
- Author(s)
  小井詰史朗、中村圭靖、吉原光代、太田幸秀、佐藤慎哉、田所弘子、宮城悦子、宮城洋平
- Organizer
  第８０回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K09484
[Presentation] 卵巣明細胞がん細胞由来組織因子発現細胞外小胞の血液凝固能評価2021
- Author(s)
  田所弘子、小井詰史朗、吉原光代、太田幸秀、佐藤慎哉、宮城洋平
- Organizer
  第８０回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K09484
[Presentation] TFPI-2は接着斑の形成阻害により卵巣明細胞癌における細胞接着を抑制する2021
- Author(s)
  太田幸秀、小井詰史朗、佐藤慎哉、田所弘子、星野大輔、中村圭靖、宮城悦子、宮城洋平
- Organizer
  第８０回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K09484
[Presentation] Tissue factor pathway inhibitor-2 (TFPI-2) is a novel immunohistochemical biomarker in ovarian clear cell carcinoma.2020
- Author(s)
  太田　幸秀、小井詰　史朗、佐藤　慎哉、中村　圭靖、宮城　悦子、宮城　洋平
- Organizer
  第７９回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] Hypoxia-driven CD69 synthesis enhances ovarian clear cell carcinoma cell survival via integrin-fibronectin interaction2020
- Author(s)
  小井詰　史朗、太田　幸秀、中村　圭靖、吉原光代、佐藤　慎哉、横瀬智之、宮城悦子、宮城洋平
- Organizer
  第７９回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] Cancer progression by an enzyme expression under serum starvation and hypoxia2019
- Author(s)
  竹中　克也、小森　由香子、中村　圭靖、小井詰　史朗、宮城　洋平
- Organizer
  第７８回　日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] HIF1 and SREBP1 collaborate to induce GILZ expression to produce procoagulant microvesicles in ovarian cancer cells2019
- Author(s)
  小井詰　史朗、中村　圭靖、吉原光代、宮城　悦子、竹中　克也、宮城　洋平
- Organizer
  第７８回　日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] 膵癌患者の血液中組織因子による血栓塞栓症発症予測2019
- Author(s)
  小林　智、小井詰　史朗、上野　誠、宮城　洋平、森本　学
- Organizer
  第２回　日本腫瘍循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] 胆道癌における血栓塞栓症リスクと血液中の組織因子との関連解析2019
- Author(s)
  小井詰　史朗、小林　智、高橋　朋子、森本　学、上野　誠、宮城　洋平
- Organizer
  第２回　日本腫瘍循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] Ectopic synthesis of CD69 is important for intra-peritoneal survival of ovarian clear cell carcinoma cells2018
- Author(s)
  小井詰史朗、中村圭靖、吉原光代、竹中克也、宮城洋平
- Organizer
  第７７回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] 膵臓癌における血栓塞栓症リスクと血液中の組織因子との関連解析2018
- Author(s)
  小井詰史朗、小林智、高橋朋子、森本学、上野誠、宮城洋平
- Organizer
  第１回　日本腫瘍循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] 低酸素、血清除去環境に暴露された卵巣癌細胞におけるCD69発現依存的タンパク質リン酸化の解析2018
- Author(s)
  小井詰史朗、金山知彦、岡山明子、木村弥生、宮城洋平
- Organizer
  第２７回　日本癌転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] Expression of an ATP-grasp superfamily enzyme under hypoxia2018
- Author(s)
  竹中克也、小森由香子、中村圭靖、小井詰史朗、宮城洋平
- Organizer
  第７７回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08346
[Presentation] 転写因子SREBP-1は虚血性環境における卵巣明細胞癌による抗凝固性細胞外小胞の生成に重要である2016
- Author(s)
  小井詰史朗、中村圭靖、吉原光代、宮城悦子、平原史樹、宮城洋平
- Organizer
  第７５回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430135
[Presentation] Cd69 induced in CCC cells cultured under serum starvation and hypoxia activates cell surface integrin2015
- Author(s)
  金山　知彦、小井詰史朗、宮城悦子、平原史樹、宮崎　香、宮城洋平
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430135
[Presentation] High-level shedding of tissue factor-rich microvesicles from ovarian clear cell carcinoma cells causes hypercoagulation.2015
- Author(s)
  小井詰史朗、中村圭靖、吉原光代、宮城悦子、平原史樹、宮城洋平
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430135
[Presentation] 虚血性環境下相乗的に発現誘導されるICAM-1は卵巣明細胞腫瘍の増殖を促進する2013
- Author(s)
  小井詰　史朗、宮城　洋平
- Organizer
  第１１回　がんとハイポキシア研究会
- Place of Presentation
  仙台（東北大学）
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 前立腺がんにおけるSPOP 遺伝子変異の頻度は本邦例と米国からの報告例の間に差を認めない2013
- Author(s)
  宮城洋平、松隈章一、吉原光代、中村圭靖、小井詰史朗、岸田健、横瀬智之、高野康雄
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 虚血性環境下相乗的に発現誘導されるCD69 は卵巣明細胞癌において細胞運動能、浸潤能を亢進する2013
- Author(s)
  金山知彦、小井詰史朗、宮城洋平
- Organizer
  第11回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 前立腺がんにおけるSPOP遺伝子変異の頻度は本邦例と米国からの報告例の間に差を認めない2013
- Author(s)
  宮城洋平、松隈　章一、吉原　光代、中村　圭靖、小井詰　史朗、岸田　健、横瀬　智之、高野　康雄
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣癌細胞により分泌される組織因子含有マイクロパーティクルの性質2013
- Author(s)
  伊藤　慎、小井詰　史朗、吉原　光代、中村　圭靖、宮城　悦子、平原　史樹、高野　康雄
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 虚血性環境下相乗的に発現誘導されるCD69は卵巣明細胞癌において細胞運動能、浸潤能を亢進する2013
- Author(s)
  金山　知彦、小井詰　史朗、宮城　洋平
- Organizer
  第１１回　がんとハイポキシア研究会
- Place of Presentation
  仙台（東北大学）
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 相乗的ICAM1 発現誘導の阻害は明細胞卵巣腫瘍の増殖を抑制する2013
- Author(s)
  小井詰史朗、伊藤慎、吉原光代、中村圭靖、宮城悦子、平原史樹、高野康雄、宮城洋平
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 虚血性環境下相乗的に発現誘導されるICAM-1 は卵巣明細胞腫瘍の増殖を促進する2013
- Author(s)
  小井詰史朗、宮城洋平
- Organizer
  第11回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 相乗的ICAM1発現誘導の阻害は明細胞卵巣腫瘍の増殖を抑制する2013
- Author(s)
  小井詰　史朗、伊藤　慎、吉原　光代、中村　圭靖、宮城　悦子、平原　史樹、高野　康雄
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣癌細胞により分泌される組織因子含有マイクロパーティクルの性質2013
- Author(s)
  伊藤慎、小井詰史朗、吉原光代、中村圭靖、宮城悦子、平原史樹、高野康雄、宮城洋平
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 肝細胞癌で発現する異所性TFPI1 による癌細胞での接着阻害2012
- Author(s)
  伊藤慎、小井詰史朗、高野康雄、宮城洋平
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞癌において低酸素、低血清環境下HIF, Sp1依存的に相乗的に発現誘導される遺伝子とその機能について2012
- Author(s)
  小井詰　史朗
- Organizer
  第10回　がんとハイポキシア研究会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] Functional analysis of annexin A4 and the implication in ovarian clear cell carcinoma (OCCA) phenotypes2012
- Author(s)
  Tae Mogami, Naho Yokota, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Yuji Sakuma, Shiro Koizume, Mikiko Asai-Sato, Etsuko Miyagi, Fumiki Hirahara, and Yohei Miyagi
- Organizer
  The 103^<th> AACR annual meeting
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞癌において低酸素、低血清環境下HIF, Sp1 依存的に相乗的に発現誘導される遺伝子とその機能について2012
- Author(s)
  小井詰史朗、宮城洋平
- Organizer
  第9回がんとハイポキシア研究会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] HIF2/Sp1/mTOR 相互作用によるICAM1 発現は虚血性環境における卵巣癌細胞生存を促進する2012
- Author(s)
  小井詰史朗、宮城悦子、平原史樹、吉原光代、高野康雄、宮城洋平
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] HIF1/Sp1/mTOR相互作用によるICAM1発現は虚血性環境における卵巣癌細胞生存を促進する2012
- Author(s)
  小井詰　史朗
- Organizer
  第７１回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] HIF2α/Sp1/mTOR interaction mediates a deacetylation-dependent FVII gene activation under serum deprived condition in ovarian cancer cells2012
- Author(s)
  Shiro Koizume, Etsuko Miyagi, Fumiki Hirahara, Yasuo Takano, Wolfram Ruf, and Yohei Miyagi
- Organizer
  The 103^<th> AACR annual meeting
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 甲状腺濾胞性腫瘍におけるRAS 遺伝子変異の頻度と臨床病理学的意義2012
- Author(s)
  宮城洋平、吉田明、松隈章一、佐久間裕司、小井詰史朗、吉原光代、岡本直幸、横瀬智之、近藤哲夫、高野康雄
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] HIF2a/Sp1/mTOR interaction mediates a deacetylation-dependent FVII gene activation under serum deprived condition in ovarian cancer cells.2012
- Author(s)
  小井詰　史朗
- Organizer
  AACR annual meeting 2012
- Place of Presentation
  シカゴ
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 肝細胞癌で見られるTF 及びTFPI1 の特異的な発現2011
- Author(s)
  伊藤慎、小井詰史朗、中村圭靖、高野康雄、宮城洋平
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞腺癌におけるANXA4 発現の解析2011
- Author(s)
  最上多恵、横田奈朋、常住淳、辻祥太郎、小井詰史朗、佐藤美紀子、宮城悦子、宮城洋平、平原史樹
- Organizer
  第10回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  松江
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞腺癌で高発現するannexin A4の機能解析2011
- Author(s)
  最上多恵、横田奈朋、伊藤慎、吉原光代、中村圭靖、佐久間裕司、小井詰史朗、辻祥太郎、宮城悦子、平原史樹、宮城洋平
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] Hypoxic activation of FVII gene in cancer cells mediated by interaction among HIF2α, Sp1, and HDAC42011
- Author(s)
  Koizume S, Miyagi E, Hirahara F, Nakamura Y, Takano Y, Ruf W, Miyagi Y
- Organizer
  The 102^<th> AACR annual meeting
- Place of Presentation
  Orlando, FA
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] Hypoxic activation of FVII gene in cancer cells mediated by interaction among HIF2α, Sp1, and HDAC42011
- Author(s)
  Shiro Koizume, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Eiju Tsuchiya, Wolfram Ruf, Yohei Miyagi
- Organizer
  第102回米国がん学会年会
- Place of Presentation
  オーランド,フロリダ
- Year and Date
  2011-04-04
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Hypoxic activation of FVII gene in cancer cells mediated by interaction among HIF2, Sp1, and HDAC42011
- Author(s)
  Koizume S
- Organizer
  The 102th AACR annual meeting
- Place of Presentation
  Orlando, FA
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞癌においてHIF2α/Sp1/mTOR相互作用は脱アセチル化依存性転写を誘導するあ2011
- Author(s)
  小井詰史朗、宮城悦子、平原史樹、中村圭靖、高野康雄、宮城洋平
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation]2011
- Author(s)
  Shiro Koizume, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Eiju Tsuchiya, Wolfram Ruf, and Yohei Miyagi
- Organizer
  The 102nd AACR Annual Meeting 2011
- Place of Presentation
  Orlando, FL
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] 浮遊状態のEGFR 変異陽性肺腺癌細胞は恒常的EGFR 活性化によりapoptosis を回避する2011
- Author(s)
  佐久間裕司、中村圭靖、吉原光代、小井詰史朗、宮城洋平
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] HIF2α-Sp1 相互作用が関与するFVII 遺伝子低酸素発現誘導2011
- Author(s)
  小井詰史朗、宮城洋平
- Organizer
  第8回がんとハイポキシア研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 低酸素、低血清環境下HIF2α, Sp1 依存的に相乗的に発現誘導される遺伝子について2011
- Author(s)
  小井詰史朗、宮城洋平
- Organizer
  第9回がんとハイポキシア研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞がん細胞においてHIF2α/Sp1/mTOR相互作用は脱アセチル化依存性転写を誘導する2011
- Author(s)
  小井詰史朗、宮城悦子、平原史樹、中村圭靖、高野康雄、宮城洋平
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] 卵巣明細胞がん細胞においてHIF2α/Sp1/mTOR相互作用は脱アセチル化依存性転写を誘導する2011
- Author(s)
  小井詰史朗、宮城悦子、平原史樹、中村圭靖、高野康雄、宮城洋平
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Src阻害薬とBcl-2阻害 ABT-263の併用療法は肺腺癌細胞のanoikis抵抗性を克服する2010
- Author(s)
  佐久間裕司, 中村圭靖, 吉原光代, 小井詰史朗, 宮城洋平
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Activation of FVII gene in ovarian cancer cells associated with HIF2alpha-Sp1 interaction and histone deacetylation2010
- Author(s)
  Shiro Koizume, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Eiju Tsuchiya, Yohei Miyagi
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  リーガロイヤルホテル,大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] 卵巣がん細胞におけるFVII遺伝子発現誘導にはHIF2α-Sp 1相互作用とピストン脱アセチル化が関与する2010
- Author(s)
  小井詰史朗, 宮城悦子, 平原史樹, 中村圭靖, 土屋永寿, 宮城洋平
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Curcumin inhibits ectopic human coagulation factor VII synthesis in breast cancer cells by targeting p300/CBP activity2009
- Author(s)
  Shiro Koizume, Naho Yokota, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Akira Yoshida, Eiju Tsuchiya, Wolfram Ruf, Yohei Miyagi
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Hypoxic induction of coagulation factor VII(FVII) in ovarian cancer cells associated with activation of blood coagulation2009
- Author(s)
  Shiro Koizume and Yohei Miyagi
- Organizer
  The 7^<th> annual Meeting for the Japanese Association for Cancer and Hypoxia Research.第7回がんとハイポキシア研究会
- Place of Presentation
  京都
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Release of TF/fVIIa positive highly-coagulating microparticles from ovarian cancer cells and its increse under hypoxia2009
- Author(s)
  Yokota N, Koizume S, Miyagi E, Hirahara F, Nakamura Y, Yoshida A, Tsuchiya E, Ruf W, Miyagi Y
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Curcumin inhibits ectopic human coagulation factor VII synthesis in breast cancer cells by targeting p300/CBP activity2009
- Author(s)
  Shiro Koizume, Naho Yokota, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Akira Yoshida, Eiju Tsuchiya, Wolfram Ruf, Yohei Miyagi
- Organizer
  米国がん学会年会(AACR2009)
- Place of Presentation
  コロラド州デンバー
- Year and Date
  2009-04-21
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Release of TF/fVIIa Positive Highly-coagulating Microparticles from Ovarian Cancer Cellsand Its Increse Under Hypoxia2009
- Author(s)
  Naho Yokota, Shiro Koizume, Yoshiyasu Nakamura, Yuji Sakuma, Mikiko-Asai Sato, Etsuko Miyagi, Fumiki Hirahara, Eiju Tsuchiya, Yohei Miyagi
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] Curcumin Inhibits Ectopic Human Coagulation Factor VII Synthesis in Breast Cancer Cells by Targeting p300/CBP Activity2009
- Author(s)
  Shiro Koizume, Naho Yokota, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Akira Yoshida, Eiju Tsuchiya, Wolfram Ruf, and Yohei Miyagi
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21590455
[Presentation] 低酸素、低血清環境下HIF2, Sp1依存的に相乗的に発現誘導される遺伝子について
- Author(s)
  小井詰　史朗
- Organizer
  第９回　がんとハイポキシア研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] 卵巣明細胞癌においてHIF2alpha/Sp1/mTOR相互作用は脱アセチル化依存性転写を誘導する。
- Author(s)
  小井詰　史朗
- Organizer
  第７０回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501280
[Presentation] CD69 induced in CCC cells under serum starvation and hypoxia enhances cell motility and invasiveness.
- Author(s)
  Kanayama T, Koizume S, and Miyagi Y
- Organizer
  日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430135
[Presentation] Sp1 and HIFs mediate synergistic activation of ICAM1 gene under serum starved hypoxia and promotes growth of ovarian cancer
- Author(s)
  Koizume S, Ito S, Nakamura Y et al.
- Organizer
  AACR annual meeting 2014
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-26430135
[Presentation] 肝細胞癌で発見する異所性TFPI1による癌細胞での接着阻害
- Author(s)
  伊藤　慎，小井詰史朗、高野康雄、宮城洋平
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590499
[Presentation] Lipid starvation and hypoxia synergistically activates Sp1-dependent genes to promote growth of ovarian cancer
- Author(s)
  Koizume S, Ito S, Nakamura Y et al.
- Organizer
  日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430135
[Presentation] 虚血性環境下卵巣明細胞癌において誘発される相乗的遺伝子発現に関与する血清因子
- Author(s)
  小井詰　史朗、宮城　洋平
- Organizer
  がんとハイポキシア研究会
- Place of Presentation
  佐賀
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26430135

1. MIYAGI Yohei (00254194)

# of Collaborated Projects: 8 results

# of Collaborated Products: 93 results
2. 河内利賢 (10328205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SATO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 宮城悦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山田六平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐久間裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koizume Shirou 小井詰 史朗

KOIZUME Shiro 小井詰 史朗

Research Projects

Research Products

Co-Researchers

淡明細胞腎細胞癌にて発現するICAM-1: 治療標的化に向けた発現機構と機能の解明Principal Investigator

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ICAM-1 expressed in ovarian clear cell carcinoma: Elucidation of full aspects including apoptosis resistance mechanismPrincipal Investigator

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Effect of ectopically synthesized coagulation factor VII on venous thromboembolism and malignancyPrincipal Investigator

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Investigation of pathophysiology and biomarker discovery for prostate cancer in the lipid-deficient hypoxia microenvironment

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Development of therapeutic strategy of poor prognostic ovarian cancer targeting ischemia-driven expression of ICAM-1Principal Investigator

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Investigation of mechanisms to keep blood vessels patent in hepatocellular carcinoma.

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Analysis of Sp1-dependent adaptation mechanism of cancer cells to hypoxia for tumor microenvironment-targeted therapyPrincipal Investigator

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Coagulation factor VII producing tumors and their release of microparticles with coagulation initiating capacity

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[Book] 腫瘍循環器学の現況と展望 クリニカルトピック・組織因子の機能調節メカニズム in BIO Clinica, 2019, vol 34, No. 102019

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[Book] Encyclopedia of Signaling Molecules2017

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[Book] Breast Cancer: Current and Alternative Therapeutic Modalities2011

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[Book] Functional Correlates, and Potential for a New Therapeutic Target. Breast Cancer. Current and Alternative Therapeutic Modalities2011

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[Book] Ectopic synthesis of coagulation factor VII in breast cancer cells: Mechanisms, functional correlates, and potential for a new therapeutic target. Breast Cancer : Current and Alternative Therapeutic Modalities2011

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[Journal Article] Cancer cell-derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin2023

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DOI

Koizume Shirou 小井詰史朗

KOIZUME Shiro 小井詰史朗

[Book] 腫瘍循環器学の現況と展望クリニカルトピック・組織因子の機能調節メカニズム in BIO Clinica, 2019, vol 34, No. 102019

[Journal Article] Diverse mechanisms　of　Sp1-dependent　transcriptional　regulation　potentially　involved　in　the　adaptive　response　of cancer cells to oxygen-deficient conditions.2016