Suzuki Yasuyo 鈴木康予

… Alternative Names

SUZUKI Yasuyo 鈴木康予

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Researcher Number	60416188
Other IDs
Affiliation (Current)	2025: 愛知県医療療育総合センター発達障害研究所, 遺伝子医療研究部, 主任研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 愛知県医療療育総合センター発達障害研究所, 遺伝子医療研究部, 主任研究員 2019: 愛知県医療療育総合センター発達障害研究所, 遺伝子医療研究部, 研究員 2018: 愛知県心身障害者コロニー発達障害研究所, 遺伝子医療研究部, 研究員 2014 – 2017: 愛知県心身障害者コロニー発達障害研究所, 遺伝学部, 研究員 2013: 独立行政法人国立長寿医療研究センター, バイオリソース研究室, 流動研究員 2011: 独立行政法人国立長寿医療研究センター, バイオリソース研究室, 特任研究員 2010: 独立行政法人国立長寿医療研究センター, バイオリソース研究室, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Basic Section 47040:Pharmacology-related / Nerve anatomy/Neuropathology
Keywords	Principal Investigator α-synuclein / Mowat-Wilson症候群 / 発達障害 / ZEB2 / 多系統萎縮症 / 神経変性疾患 / 転写因子 / 知的障害 / Mowat-Wilson症候群（MOWS） / 小頭症 … More / てんかん / トランスクリプトーム / 先天異常症候群 / モワット・ウィルソン症候群 / ＰＲＯＳ / ｍＴＯＲ / ＰＩ３Ｋ / PI3K / 体細胞モザイク変 / 体細胞モザイク変異 / メトホルミン / PIK3CA / PROS / 過成長症候群 / リソソーム病 / β-グルコセレブロシダーゼ / カテプシン / リソソーム / パーキンソン病 / シスタチンC / 多系統委縮症 / 神経科学 / 多系統萎縮症(MSA) / タンパク質精製 / トランスジェニックマウス / オリゴデンドロサイト / 多系統委縮症(MSA) Less

Investigation of Transcriptional Regulation of ZEB2 for the Treatment of Mowat-Wilson SyndromePrincipal Investigator
- Principal Investigator
  
  鈴木康予
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
シナプス可塑性に着目した知的障害を呈するモワット・ウィルソン症候群の病態解明Principal Investigator
- Principal Investigator
  
  鈴木康予
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
Selective effects of metformin on the cells with PIK3CA activating mutationsPrincipal Investigator
- Principal Investigator
  
  Suzuki Yasuyo
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Institute for Developmental Research Aichi Developmental Disability Center
Effect of lysosomal enzymes on alpha-synuclein accumulation causing neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Suzuki Yasuyo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
Oligodendrocytic protein contribute to neuronal accumulation of alpha-synuclein in multiple system atrophyPrincipal Investigator
- Principal Investigator
  
  SUZUKI Yasuyo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
  National Center for Geriatrics and Gerontology
Identification of neurodegeneration-inducing factor released from oligodendrocytesPrincipal Investigator
- Principal Investigator
  
  SUZUKI Yasuyo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Center for Geriatrics and Gerontology

All 2023 2022 2019 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Pathogenicity evaluation of variants of uncertain significance at exon-intron junction by splicing assay in patients with Mowat?Wilson syndrome2023
- Author(s)
  Suzuki Yasuyo、Nomura Noriko、Yamada Kenichiro、Yamada Yasukazu、Fukuda Ayumi、Hoshino Kyoko、Abe Shinpei、Kurosawa Kenji、Inaba Mie、Mizuno Seiji、Wakamatsu Nobuaki、Hayashi Shin
- Journal Title
  
  European Journal of Medical Genetics
  
  Volume: 66 Issue: 12 Pages: 104882-104882
- DOI
  10.1016/j.ejmg.2023.104882
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07289, KAKENHI-PROJECT-21K07880
[Journal Article] The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS).2017
- Author(s)
  Suzuki Y, Enokido Y, Yamada K, Inaba M, Kuwata K, Hanada N, Morishita T, Mizuno S, Wakamatsu N.
- Journal Title
  
  Oncotarget
  
  Volume: 8(28) Issue: 28 Pages: 45470-45483
- DOI
  10.18632/oncotarget.17566
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10070, KAKENHI-PROJECT-16K14586, KAKENHI-PROJECT-15K06764, KAKENHI-PROJECT-15K09610, KAKENHI-PLANNED-25117007
[Journal Article] Clinical and molecular genetic characterization of two siblings with trisomy 2p24.3-pter and monosomy 5p14.3-pter.2017
- Author(s)
  Fukushi D, Kurosawa K, Suzuki Y, Suzuki K, Yamada K, Watanabe S, Yokochi K, Wakamatsu N.
- Journal Title
  
  Am J Med Genet A
  
  Volume: 173(8) Issue: 8 Pages: 2201-2209
- DOI
  10.1002/ajmg.a.38313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10070, KAKENHI-PROJECT-15K06764, KAKENHI-PROJECT-15K09610
[Journal Article] Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.2014
- Author(s)
  Suzuki, Y., Jin, C., and Yazawa, I
- Journal Title
  
  American Journal of Pathology
  
  Volume: 184 Issue: 3 Pages: 790-799
- DOI
  10.1016/j.ajpath.2013.11.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430058, KAKENHI-PROJECT-25830045
[Journal Article] beta-III Tubulin fragments inhibit alpha-synuclein accumulation in models of multiple system atrophy.2014
- Author(s)
  Yasuyo Suzuki, Chenghua Jin, Tamaki Iwase, Ikuru Yazawa
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 35 Pages: 24374-24382
- DOI
  10.1074/jbc.m114.557215
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430058, KAKENHI-PROJECT-25830045
[Journal Article] Increased aggregation of polyleucine compared with that of polyglutamine in dentatorubral-pallidoluysian atrophy protein.2013
- Author(s)
  Suzuki Y, Jin C, Yazawa I.
- Journal Title
  
  Neuroscience Letters
  
  Volume: 552 Pages: 156-161
- DOI
  10.1016/j.neulet.2013.07.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430058, KAKENHI-PROJECT-25830045
[Journal Article] Binding of neuronal α-synuclein to ss-III tubulin and accumulation in a model of multiple system atrophy.2012
- Author(s)
  Nakayama K, Suzuki Y, Yazawa I.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 417 Issue: 4 Pages: 1170-1175
- DOI
  10.1016/j.bbrc.2011.12.092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500326, KAKENHI-PROJECT-22700386
[Journal Article] Pathological accumulation of atrophin-1 in dentatorubral-pallidol uysian atrophy2011
- Author(s)
  Yasuyo Suzuki, Ikuru Yazawa
- Journal Title
  
  International Journal of Clinical and Experimental Pathology
  
  Volume: 4 Pages: 378-384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700386
[Journal Article] Pathological accumulation of atrophin-1 in dentatorubral-pallidoluysian atrophy2011
- Author(s)
  Yasuyo Suzuki, Ikuru Yazawa
- Journal Title
  
  International Journal of Clinical and Experimental Pathology
  
  Volume: 4 Pages: 378-384
- URL
  http://www.ijcep.com/files/IJCEP1103009.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700386
[Journal Article] Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy.2010
- Author(s)
  Suzuki Y, Nakayama K, Hashimoto N, and Yazawa I.
- Journal Title
  
  FEBS Journal
  
  Volume: 277 Issue: 23 Pages: 4873-4887
- DOI
  10.1111/j.1742-4658.2010.07893.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500326, KAKENHI-PROJECT-22700386
[Journal Article] Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy2010
- Author(s)
  Suzuki Y, Nakayama K, Hashimoto N, Yazawa I.
- Journal Title
  
  FEBS Journal
  
  Volume: Vol.277 Pages: 4873-4887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700386
[Presentation] Mowat-Wilson症候群の原因遺伝子ZEB2の発現制御機構の解析2023
- Author(s)
  鈴木康予, 野村紀子, 山田憲一郎, 林深
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07289
[Presentation] Mowat-Wilson症候群の重症度に相関した原因遺伝子ZEB2 のスプライシング領域バリアント2023
- Author(s)
  鈴木康予
- Organizer
  第22回東海小児遺伝カンファレンス
- Data Source
  KAKENHI-PROJECT-21K07289
[Presentation] Mowat-Wilson症候群の原因遺伝子ZEB2のイントロンバリアントが及ぼすRNAスプライシングへの影響.2022
- Author(s)
  鈴木康予、野村紀子、山田憲一郎、福田あゆみ、星野恭子、山田裕一、稲葉美枝、水野誠司、若松延昭、林　深
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-21K07289
[Presentation] PIK3CA-related overgrowth spectrum (PROS)：症例の解析とPI3K/AKT/ mTORシグナル阻害剤の治療効果2019
- Author(s)
  鈴木康予
- Organizer
  第1回藤田医大疾患モデル科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06696
[Presentation] Clinical and molecular genetic characterization of two siblings with trisomy 2p24.3-pter and monosomy 5p14.3-pter2017
- Author(s)
  Fukushi D、Kurosawa K、Suzuki Y、Suzuki K、Yamada K、Watanabe S、Yokochi K、Wakamatsu N
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] Two female patients with Xq27.3q28 deletion and skewed X-inactivation display similar phenotypes as Hunter syndrome2017
- Author(s)
  Katoh K、Aiba K、Fukushi D、Suzuki Y、Yamada K、Wakamatsu N
- Organizer
  XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] メトホルミンがPIK3CA-related overgrowth spectrum（PROS）患者由来細胞におよぼす治療効果2017
- Author(s)
  鈴木康予、榎戸　靖、山田憲一郎、稲葉美枝、花田直樹、森下　剛、水野誠司、若松延昭
- Organizer
  2017年度生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] Clinical characterization of a patient with PIK3CA-related overgrowth spectrum (PROS)2016
- Author(s)
  Yasuyo Suzuki
- Organizer
  第8回NAGOYAグローバルリトリート
- Place of Presentation
  あいち健康プラザ（愛知）
- Year and Date
  2016-02-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] オリゴデンドロサイト由来液性因子の神経細胞α-synuclein蓄積における機序2016
- Author(s)
  佐々木飛翔、鈴木康予、金成花、矢澤生
- Organizer
  第89回　日本生化学会大会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] PIK3CA-related overgrowth spectrum (PROS)の1症例2016
- Author(s)
  鈴木康予, 水野誠司, 榎戸靖, 山田憲一郎, 稲葉美枝, 村松友佳子, 花田直樹, 森下剛, 若松延昭
- Organizer
  第27回日本整形外科学会骨系統疾患研究会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2016-02-12
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] Deficiency of lysosomal enzymes leads to an increase in insoluble alpha-synuclein2016
- Author(s)
  鈴木康予、若松延昭
- Organizer
  第57回　日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] 病気を知る研究～治療法を見つけるために～2015
- Author(s)
  鈴木康予
- Organizer
  静岡サイエンススクール「サイエンス・オータムプログラム2015」キャリアデザインワークショップ
- Place of Presentation
  静岡大学（静岡）
- Year and Date
  2015-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] PIK3CA-related overgrowth spectrum（PROS）の1症例2015
- Author(s)
  鈴木康予，榎戸靖，山田憲一郎，若松延昭，水野誠司，花田直樹，森下剛
- Organizer
  第103回東海臨床遺伝・代謝懇話会
- Place of Presentation
  安保ホール（愛知）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] PIK3CA-related overgrowth spectrum (PROS)の病態解明2015
- Author(s)
  鈴木康予, 榎戸靖, 山田憲一郎, 花田直樹, 森下剛, 水野誠司, 若松延昭
- Organizer
  BMB2015（第88回日本生化学会大会・第38回日本分子生物学会年会合同大会）
- Place of Presentation
  神戸国際会議場（兵庫）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] SF3B4の欠失が見られるNager症候群の1症例2015
- Author(s)
  福士大輔, 水野誠司, 稲葉美枝, 鈴木香, 野村紀子, 鈴木康予, 山田憲一郎, 若松延昭
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K06764
[Presentation] 多系統萎縮症におけるオリゴデンドロサイト由来シスタチンCが神経細胞のα-synuclein蓄積を誘導する2014
- Author(s)
  鈴木康予，金成花，矢澤生
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25830045
[Presentation] 多系統萎縮症におけるオリゴデンドロサイト封入体形成の神経細胞への影響2013
- Author(s)
  鈴木康予，都竹佳子，矢澤生
- Organizer
  Neuro2013（第36回日本神経科学大会，第56回日本神経化学会大会，第23回日本神経回路学会大会　合同大会）
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-25830045
[Presentation] Neuronal α-synuclein binds to β-III tubulin to accumulate in an MSA model2012
- Author(s)
  Yasuyo Suzuki, Kimiko Nakayama, Ikuru Yazawa
- Organizer
  4th International Congress on Multiple System Atrophy
- Place of Presentation
  Toulouse (France)
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-22700386
[Presentation] Neuronalα-synuclein binds toβ-III tubulin to accumulate in an MSA model2012
- Author(s)
  Yasuyo Suzuki, Kimiko Nakayama, Ikuru Yazawa
- Organizer
  4th International Congress on Multiple System Atrophy
- Place of Presentation
  Toulouse(France)
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-22700386
[Presentation] 多系統萎縮症モデルマウスではオリゴデンドロサイトα-synucleinの蓄積によりシナプス機能の低下が起こる2011
- Author(s)
  伊藤浩志,金成花,鈴木康予,矢澤生
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22700386
[Presentation] 多系統萎縮症におけるα-synucleinとβ-III tubulinの相互作用の分子機構2011
- Author(s)
  鈴木康予,中山貴美子,矢澤生
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22700386
[Presentation] 細胞質におけるDRPLA蛋白C末ペプチドの凝集2010
- Author(s)
  鈴木康予,矢澤生
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22700386
[Presentation] 多系統萎縮症の神経細胞α-synuclein蓄積におけるβIII-tubulinの役割2010
- Author(s)
  中山貴美子,鈴木康予,矢澤生
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22700386

1. 若松延昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 山田憲一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 矢澤生

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Suzuki Yasuyo 鈴木 康予

SUZUKI Yasuyo 鈴木 康予

Research Projects

Research Products

Co-Researchers

Investigation of Transcriptional Regulation of ZEB2 for the Treatment of Mowat-Wilson SyndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シナプス可塑性に着目した知的障害を呈するモワット・ウィルソン症候群の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Selective effects of metformin on the cells with PIK3CA activating mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of lysosomal enzymes on alpha-synuclein accumulation causing neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oligodendrocytic protein contribute to neuronal accumulation of alpha-synuclein in multiple system atrophyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of neurodegeneration-inducing factor released from oligodendrocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pathogenicity evaluation of variants of uncertain significance at exon-intron junction by splicing assay in patients with Mowat?Wilson syndrome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS).2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and molecular genetic characterization of two siblings with trisomy 2p24.3-pter and monosomy 5p14.3-pter.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] beta-III Tubulin fragments inhibit alpha-synuclein accumulation in models of multiple system atrophy.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased aggregation of polyleucine compared with that of polyglutamine in dentatorubral-pallidoluysian atrophy protein.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Binding of neuronal α-synuclein to ss-III tubulin and accumulation in a model of multiple system atrophy.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathological accumulation of atrophin-1 in dentatorubral-pallidol uysian atrophy2011

Author(s)

Journal Title

Data Source

Suzuki Yasuyo 鈴木康予

SUZUKI Yasuyo 鈴木康予