Koga Daisuke 古賀大介

… Alternative Names

古賀大介コガダイスケ

Daisuke Koga 古賀大介

KOGA Daisuke 古賀大介

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Researcher Number	60422482
Other IDs
Affiliation (Current)	2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2017 – 2019: 東京医科歯科大学, 医学部附属病院, 非常勤講師 2015: 東京医科歯科大学, 医学部附属病院, 非常勤講師 2013: 東京医科歯科大学, 医学部附属病院, 助教 2009 – 2011: Tokyo Medical and Dental University, 医学部附属病院, 助教 2007: Tokyo Medical and Dental University, 医学部附属病院, Assistant 2006 – 2007: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 骨代謝 / 薬理学 / 骨吸収 / 骨形成 / PAI-1 / 骨粗鬆症 / 閉経 / laser microdissection / animal model / degeneration of intervertebral disc … More / 分子生物学 / 網羅的検索 / マイクロダイゼクション / マイクロダイゼクション法 / 動物モデル / 椎間板変性 / 軟骨代謝 / 脂質代謝 / ポリフェノール / 変形性膝関節症 / 腸内細菌 / 腸内フローラ / アントシアニジン / TNF / 関節軟骨 / 老化 / RANKL / RANK / OPG Less

Prevention of osteoporosis and osteonecrosis by novel PAI-1 inhibitorPrincipal Investigator
- Principal Investigator
  
  Koga Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
The effect of anthocyanidin on skeletal antiagingPrincipal Investigator
- Principal Investigator
  
  Daisuke Koga
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Investigation of the molecular mechanisms through which osteoclast differentiation regulating factors modulates osteoarthritis progression.Principal Investigator
- Principal Investigator
  
  KOGA Daisuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Molecular analysis for the mechanisms of endoplate sclerosis using laser microdissection techniquePrincipal Investigator
- Principal Investigator
  
  KOGA Daisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University

All 2018 2017 2016 2015 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] A small molecule PAI-1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency-induced osteoporosis model2018
- Author(s)
  Jin G, Aobulikasimu A, Piao J, Aibibula Z, Koga D, Sato S, Ochi H, Tsuji K, Nakabayashi T, Miyata T, Okawa A, Asou Y.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8(4) Issue: 4 Pages: 523-532
- DOI
  10.1002/2211-5463.12390
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847, KAKENHI-PROJECT-17K11000, KAKENHI-PROJECT-26293332
[Journal Article] Limited significance of screening computed tomography after cementless total hip arthroplasty with highly cross-linked polyethylene at 7-10 years of follow-up.2016
- Author(s)
  Takada R, Jinno T, Koga D, Yamauchi Y, Asou Y, Muneta T, Okawa A.
- Journal Title
  
  Mod Rheumatol
  
  Volume: Ｆｅｂ１６ Pages: 1-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462361
[Journal Article] Is Drain Tip Culture Prognostic of Surgical Site Infection? Results of 1380 Drain Tip Cultures in Total Hip Arthroplasty.2015
- Author(s)
  Takada R, Jinno T, Koga D, Hirao M, Muneta T, Okawa A
- Journal Title
  
  J Arthroplasty.
  
  Volume: in press Issue: 8 Pages: 1407-1409
- DOI
  10.1016/j.arth.2015.02.038
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462287, KAKENHI-PROJECT-25462361
[Journal Article] Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.2015
- Author(s)
  Ailixiding M, Aibibula Z, Iwata M, Piao J, Hara Y, Koga D, Okawa A, Morita S, Asou Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 466 Issue: 3 Pages: 319-326
- DOI
  10.1016/j.bbrc.2015.09.019
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462361, KAKENHI-PROJECT-26293332
[Journal Article] Comparison of Different Materials and Proximal Coatings Used for Femoral Components in One-Stage Bilateral Total Hip Arthroplasty.2015
- Author(s)
  Miyatake K, Jinno T, Koga D, Yamauchi Y, Muneta T, Okawa A.
- Journal Title
  
  J Arthroplasty
  
  Volume: 30 Issue: 12 Pages: 2237-2241
- DOI
  10.1016/j.arth.2015.06.019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462361, KAKENHI-PROJECT-26293332
[Journal Article] Is closed suction drainage effective in early recovery of hip joint function? Comparative evaluation in one-stage bilateral total hip arthroplasty.2015
- Author(s)
  Koyano G, Jinno T, Koga D, Hoshino C, Muneta T, Okawa A
- Journal Title
  
  J Arthroplasty.
  
  Volume: 30 Issue: 1 Pages: 74-8
- DOI
  10.1016/j.arth.2014.08.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462287, KAKENHI-PROJECT-25462361
[Journal Article] Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain.2013
- Author(s)
  Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 4 Pages: e60706-e60706
- DOI
  10.1371/journal.pone.0060706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791565, KAKENHI-PROJECT-25462361, KAKENHI-PROJECT-25670637
[Journal Article] Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model2012
- Author(s)
  Hailati Aini, Hiroki Ochi, Munetaka Iwata, Atsushi Okawa, Daisuke Koga, Mutsumi Okazaki, Atsushi Sano, Yoshinori Asou.
- Journal Title
  
  PLoS ONE
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21591935
[Journal Article] Runx2 expression correlates with the degree of disc aging : a comparison between Magnetic Resonance Imaging and Runx2 expression2012
- Author(s)
  Itoh H., Hara Y., Yagawa M., Kato T., Ochi H., Koga D., Okawa A., Shinomiya K., Asou Y.
- Journal Title
  
  J Vet Med Sci
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21591935
[Journal Article] TNFR1 deficiency facilitates articular cartilage ossification and osteophyte formation2011
- Author(s)
  Hailati A., Yamauchi Y., Ochi H., Koga D., Okawa A., Ogishima S., Okazaki M., Asou Y.
- Journal Title
  
  Osteoarthritis and Cartilage suppl
- Data Source
  KAKENHI-PROJECT-21591935
[Journal Article] Runx2 expression correlates with the degree of disc degeneration : a comparison between Magnetic Resonance Imaging and Runx2 expression.
- Author(s)
  古賀大介、麻生義則、四宮謙一, ほか
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591623
[Journal Article] Runx2 expression in the canine disc : cooperative expression with Matrix Metalloproteinase-13 in herniated discs
- Author(s)
  Koga D, Shinomiya K., Asou Y, et. al.
- Journal Title
  
  (in submit)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591623
[Presentation] PAI-1 inhibitor treatment attenuates bone loss by stimulating bone formation in a mouse model of postmenopausal osteporosis2017
- Author(s)
  Guangwen Jin、Jinying Piao、Zulipiya Aibibula、Daisuke Koga、Hiroki Ochi、Kunikazu Tsuji、Toshio Miyata、Atsushi Okawa、Yoshinori Asou
- Organizer
  Annual meeting for American Society for Bone and Mineral Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11000
[Presentation] 人工股関節全置換術後患者に対する静脈血栓塞栓症予防　術前リスクスコアリングによる抗凝固薬の用量調節の有用性2016
- Author(s)
  吉原有俊, 古賀大介, 高田亮平, 平尾昌之, 宗田大, 大川淳, 神野哲也
- Organizer
  第46回日本人工関節学会
- Place of Presentation
  グランフロント大阪(大阪府大阪市）
- Year and Date
  2016-02-26
- Data Source
  KAKENHI-PROJECT-25462361
[Presentation] Xanthine oxidase inhibitor febuxostat attenuate high fat diet-induced osteoarthritis.2016
- Author(s)
  Zulipiya Aibibula*2, Maierhaba Ailixiding*1, Jinying Piao2 , Daisuke Koga2, Atsushi Okawa2, Yoshinori Asou2
- Organizer
  Ａｎｎｕａｌ　ｍｅｅｔｉｎｇ　ｆｏｒ　Ｏｒｔｈｏｐａｅｄｉｃｓ　Ｒｅｓｅａｒｃｈ　Ｓｏｃｉｅｔｙ
- Place of Presentation
  フロリダ州オーランド（米国）
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462361
[Presentation] 高脂肪食誘導性変形性膝関節症におけるキサンチンオキシダーゼ(XOR)の機能解析2015
- Author(s)
  麻生義則, Zulipiya Aibibula, Maierhaba Ailixiding, 朴金瑛, 金光文, 古賀大介, 大川淳
- Organizer
  第30回日本整形外科基礎学術集会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462361
[Presentation] 人工股関節全置換術におけるトラネキサム酸静脈内投与の効果と凝固線溶系に与える影響2015
- Author(s)
  平尾昌之, 神野哲也, 古賀大介, 高田亮平, 瀬川裕子, 星野ちさと, 麻生義則, 森田定雄, 宗田大, 大川淳
- Organizer
  第42回日本股関節学会
- Place of Presentation
  グランフロント大阪（大阪府大阪市）
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25462361
[Presentation] メタボリックシンドロームと変形性膝関節症のクロストークにおけるサーチュイン遺伝子Sirt6の機能解析2015
- Author(s)
  麻生義則, Maierhaba Ailixiding, Zulipiya Aibibula, 朴金瑛, 古賀大介, 大川淳, 森田定雄
- Organizer
  第30回日本整形外科基礎学術集会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25462361
[Presentation] セメント使用/非使用の人工関節再置換術の選択セメントレスカップによる人工股関節再置換術2015
- Author(s)
  神野哲也, 古賀大介, 木村晶理, 高田亮平, 平尾昌之, 星野ちさと, 森田定雄, 大川淳, 宗田大
- Organizer
  第64回東日本整形災害外科学会
- Place of Presentation
  コラッセ福島（福島県福島市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25462361
[Presentation] TNFR1 deficiency facilitates articular cartilage ossification and osteophyte formation2011
- Author(s)
  Hailati A., Yamauchi Y., Ochi H., Koga D., Okawa A., Ogishima S., Okazaki M., Asou Y.
- Organizer
  OARSI world congress on osteoarthritis
- Data Source
  KAKENHI-PROJECT-21591935
[Presentation] 短期高脂肪食負荷によるマウス変形性膝関節症モデルの樹立2011
- Author(s)
  岩田宗峻,越智広樹,原康,多川政弘,古賀大介,大川淳,麻生義則
- Organizer
  東京骨関節フォーラム
- Data Source
  KAKENHI-PROJECT-21591935
[Presentation] SHORT TERM HIGH-FAT DIET INDUCES OSTEOPHYTE FORMATION, APOPTOSIS AND DEGENERATION OF ARTICULAR CHONDROCYTE IN MURINE KNEE JOINT2011
- Author(s)
  古賀大介、麻生義則, ら
- Organizer
  OsteoArthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21591935
[Presentation] サーチュイン遺伝子Sirt6による軟骨代謝制御2011
- Author(s)
  朴金瑛,辻邦和,古賀大介,森田定雄,大川淳,竹田秀,麻生義則
- Organizer
  東京骨関節フォーラム
- Data Source
  KAKENHI-PROJECT-21591935
[Presentation] TNFR1 DEFICIENCY FACILITATES ARTICULAR CARTILAGE OSSIFICATION AND OSTEOPHYTE FORMATION2011
- Author(s)
  古賀大介、麻生義則, ら
- Organizer
  OsteoArthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21591935
[Presentation] Chondroprotective effects of procyanidin in murine articular chondrocytes2010
- Author(s)
  Aini Hailati,麻生義則,越智弘樹,古賀大介,加藤剛,大川淳,佐野淳,岡崎睦
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21591935
[Presentation] Leptin regulation of articular chondrocyte is independent of mechanical stress or sympathetic nerve stimuraltion.2009
- Author(s)
  古賀、麻生、竹田、四宮, ほか
- Organizer
  米国骨代謝学会
- Place of Presentation
  米国
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591623
[Presentation] The distinct role of the infrapatellar fat pad in a murine high-fat diet-induced osteoarthritis model.
- Author(s)
  Munetaka Iwata1, Hiroki Ochi2, Yasushi Hara1, Masahiro Tagawa1, Daisuke Koga3, Atsushi Okawa3, Yoshinori Asou3
- Organizer
  Annual meeting of American Society for Bone and Mineral Research
- Place of Presentation
  Ｂａｌｔｉｍｏｒｅ　ＵＳＡ
- Data Source
  KAKENHI-PROJECT-25462361

1. ASO Yoshinori (50345279)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. SHINOMIYA Kenichi (20111594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. TAKEDA Shu (30376727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 辻邦和 (20323694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. SHIMOJI Takashi (40370150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 立川哲彦 (10085772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. JINNO Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 宗田大

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 越智広樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 佐藤信吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koga Daisuke 古賀 大介

古賀 大介 コガ ダイスケ

Daisuke Koga 古賀 大介

KOGA Daisuke 古賀 大介

Research Projects

Research Products

Co-Researchers

Prevention of osteoporosis and osteonecrosis by novel PAI-1 inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of anthocyanidin on skeletal antiagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the molecular mechanisms through which osteoclast differentiation regulating factors modulates osteoarthritis progression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis for the mechanisms of endoplate sclerosis using laser microdissection techniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A small molecule PAI-1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency-induced osteoporosis model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Limited significance of screening computed tomography after cementless total hip arthroplasty with highly cross-linked polyethylene at 7-10 years of follow-up.2016

Author(s)

Journal Title

Data Source

[Journal Article] Is Drain Tip Culture Prognostic of Surgical Site Infection? Results of 1380 Drain Tip Cultures in Total Hip Arthroplasty.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of Different Materials and Proximal Coatings Used for Femoral Components in One-Stage Bilateral Total Hip Arthroplasty.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Is closed suction drainage effective in early recovery of hip joint function? Comparative evaluation in one-stage bilateral total hip arthroplasty.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model2012

Author(s)

Journal Title

Data Source

[Journal Article] Runx2 expression correlates with the degree of disc aging : a comparison between Magnetic Resonance Imaging and Runx2 expression2012

Author(s)

Journal Title

Data Source

[Journal Article] TNFR1 deficiency facilitates articular cartilage ossification and osteophyte formation2011

Author(s)

Journal Title

Data Source

[Journal Article] Runx2 expression correlates with the degree of disc degeneration : a comparison between Magnetic Resonance Imaging and Runx2 expression.

Author(s)

Description

Koga Daisuke 古賀大介

古賀大介コガダイスケ

Daisuke Koga 古賀大介

KOGA Daisuke 古賀大介

[Presentation] 人工股関節全置換術後患者に対する静脈血栓塞栓症予防　術前リスクスコアリングによる抗凝固薬の用量調節の有用性2016

[Presentation] セメント使用/非使用の人工関節再置換術の選択セメントレスカップによる人工股関節再置換術2015