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Shindo Akihiro  新堂 晃大

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新堂 晃大  シンドウ アキヒロ

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Researcher Number 60422820
Other IDs
Affiliation (Current) 2025: 三重大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 三重大学, 医学系研究科, 教授
2020 – 2021: 三重大学, 医学部附属病院, 准教授
2016 – 2019: 三重大学, 医学部附属病院, 助教
2006 – 2007: 三重大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / Basic Section 56010:Neurosurgery-related / Neurosurgery
Except Principal Investigator
Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 52010:General internal medicine-related / Basic Section 52020:Neurology-related / Neurology
Keywords
Principal Investigator
血液脳関門 / アルツハイマー病 / 脳アミロイド血管症 / ペントラキシン3 / 白質 / ペントラキシン3 / 血管新生 / 炎症 / 脳梗塞 / 脳卒中 … More / 補体 / アミロイドβ / アミロイド関連画像異常 / アストロサイト / oligodendrocyte / glia / endothelial cell / neural stem cell / astrocyte / pentraxin 3 / White matter / Stroke / Astrocyte / Pentraxin 3 / グリア / 神経再生 / オリゴデンドロサイト … More
Except Principal Investigator
認知症 / プロテオミクス / 酸化ストレス / 血液バイオマーカー / 若年性アルツハイマー病 / バイオマーカー / 抗Aβ抗体 / アミロイドβ前駆体タンパク質 / ARIA / 血管周囲腔 / グリンパティック / アミロイドβ / アミロイド血管症 / アルツハイマー病 / タッチパネル式スクリーニングシステム / 軽度認知機能障害 / 高次脳機能検査 / 高学歴 / 軽度認知障害 / 高次脳機能障害 Less
  • Research Projects

    (8 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (17 People)
  •  Elucidation of the Molecular mechanism and development of predictive markers for ARIA using animal models

    • Principal Investigator
      北爪 しのぶ
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Fukushima Medical University
  •  Overcoming amyloid-related imaging abnormalities associated with anti-amyloid-beta monoclonal antibodiesPrincipal Investigator

    • Principal Investigator
      新堂 晃大
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Mie University
  •  若年性アルツハイマー病の原因解明と早期血液バイオマーカーの探索

    • Principal Investigator
      及川 伸二
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Mie University
  •  脳アミロイド血管症:ペントラキシン3を標的とした新規治療法の開発Principal Investigator

    • Principal Investigator
      新堂 晃大
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Mie University
  •  A strategic research to establish blood biomarker for cerebral amyloid angiopathy and disease modifying therapy in dementia.

    • Principal Investigator
      Tomimoto Hidekazu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Mie University
  •  Development of novel treatment of ischemic stroke via pentraxin 3Principal Investigator

    • Principal Investigator
      Shindo Akihiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Mie University
  •  Effect of pentraxin 3 in subacute phase of ischemic strokePrincipal Investigator

    • Principal Investigator
      Shindo Akihiro
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurosurgery
    • Research Institution
      Mie University
  •  タッチパネル式コンピュータによる高学歴専門職集団の痴呆の早期スクリーニング

    • Principal Investigator
      葛原 茂樹
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Mie University

All 2023 2022 2021 2020 2019 2017 2016 2007

All Journal Article Presentation Book

  • [Book] Non-neuronal mechanisms of brain damage and repair after stroke2016

    • Author(s)
      A Shindo, T Maki, K Itoh, N Miyamoto, N Egawa, AC Liang, T Noro, J Lok, EH Lo, K Arai
    • Total Pages
      408
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Journal Article] Association between behavioral and psychological symptoms and cerebral small vessel disease MRI findings in memory clinic patients2023

    • Author(s)
      Shinohara Masaki、Matsuda Kana、Ii Yuichiro、Tabei Ken-ichi、Nakamura Naoko、Hirata Yoshinori、Ishikawa Hidehiro、Matsuyama Hirofumi、Matsuura Keita、Maeda Masayuki、Tomimoto Hidekazu、Shindo Akihiro
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 15 Pages: 01-08

    • DOI

      10.3389/fnagi.2023.1143834

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07433, KAKENHI-PROJECT-20K08104, KAKENHI-PROJECT-19K17031
  • [Journal Article] Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy2022

    • Author(s)
      Hirata Yoshinori、Kato Natsuko、Muraga Kanako、Shindo Akihiro、Nakamura Naoko、Matsuura Keita、Ii Yuichiro、Shiga Mariko、Tabei Ken-ichi、Satoh Masayuki、Fukuma Tomoyuki、Kagawa Yoshihiko、Fujita Satoshi、Kogue Ryota、Umino Maki、Maeda Masayuki、Sakuma Hajime、Dohi Kaoru、Tomimoto Hidekazu
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 16 Pages: 818288-818288

    • DOI

      10.3389/fncel.2022.818288

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10314, KAKENHI-PROJECT-19H03572, KAKENHI-PROJECT-20K08104, KAKENHI-PROJECT-21K07433, KAKENHI-PROJECT-21K12194, KAKENHI-PROJECT-17K17811, KAKENHI-PROJECT-19K07865, KAKENHI-PROJECT-19K17031
  • [Journal Article] Relationship between Neurological Deterioration and Blood Pressure/Heart Rate Variability in Patients with Acute Cerebral Infarction2022

    • Author(s)
      Shimada Takaaki、Shindo Akihiro、Imai Hiroshi、Momosaki Ryo、Suzuki Hidenori、Tomimoto Hidekazu
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 31 Issue: 7 Pages: 106504-106504

    • DOI

      10.1016/j.jstrokecerebrovasdis.2022.106504

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07433, KAKENHI-PROJECT-22K19669, KAKENHI-PROJECT-20K09346
  • [Journal Article] Imaging Characteristics for Predicting Cognitive Impairment in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy2022

    • Author(s)
      Taniguchi Akira、Shindo Akihiro、Tabei Ken-ichi、Onodera Osamu、Ando Yukio、Urabe Takao、Kimura Kazumi、Kitagawa Kazuo、Miyamoto Yoshihiro、Takegami Misa、Ihara Masafumi、Mizuta Ikuko、Mizuno Toshiki、Tomimoto Hidekazu
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 14 Pages: 01-08

    • DOI

      10.3389/fnagi.2022.876437

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07433, KAKENHI-PROJECT-21K12194, KAKENHI-PROJECT-22K07528, KAKENHI-PROJECT-17K17811
  • [Journal Article] Micro-MRI improves the accuracy of clinical diagnosis in cerebral small vessel disease2021

    • Author(s)
      Ishikawa H, Niwa A, Kato S, Ii Y,Shindo A, Matsuura K, Nishiguchi Y, Tamura A, Taniguchi A, Maeda M, Hashizume Y, Tomimoto H
    • Journal Title

      Brain Communications

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03572
  • [Journal Article] Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation2021

    • Author(s)
      Kato Natsuko、Muraga Kanako、Hirata Yoshinori、Shindo Akihiro、Matsuura Keita、Ii Yuichiro、Shiga Mariko、Tabei Ken-ichi、Satoh Masayuki、Fujita Satoshi、Fukuma Tomoyuki、Kagawa Yoshihiko、Fujii Eitaro、Umino Maki、Maeda Masayuki、Sakuma Hajime、Ito Masaaki、Tomimoto Hidekazu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 18995-18995

    • DOI

      10.1038/s41598-021-98484-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10314, KAKENHI-PROJECT-19H03572, KAKENHI-PROJECT-20K08104, KAKENHI-PROJECT-21K12194, KAKENHI-PROJECT-17K17811
  • [Journal Article] Reversible splenial lesion in a patient with new-onset refractory status epilepticus (NORSE)2020

    • Author(s)
      Mizutani Akane Unno、Shindo Akihiro、Arikawa Shigeo、Shimada Takuya、Matsuura Keita、Ikejiri Kaoru、Suzuki Kei、Imai Hiroshi、Tomimoto Hidekazu
    • Journal Title

      eNeurologicalSci

      Volume: 18 Pages: 100220-100220

    • DOI

      10.1016/j.ensci.2019.100220

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18349, KAKENHI-PROJECT-19K18318, KAKENHI-PROJECT-18K16557
  • [Journal Article] Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome2020

    • Author(s)
      Matsuyama Hirofumi、Shindo Akihiro、Shimada Takuya、Yata Kenichiro、Wakita Hideaki、Takahashi Ryosuke、Tomimoto Hidekazu
    • Journal Title

      Brain Research

      Volume: 1736 Pages: 146779-146779

    • DOI

      10.1016/j.brainres.2020.146779

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03572, KAKENHI-PROJECT-18K16557
  • [Journal Article] Clinical Features and Experimental Models of Cerebral Small Vessel Disease2020

    • Author(s)
      Shindo Akihiro、Ishikawa Hidehiro、Ii Yuichiro、Niwa Atsushi、Tomimoto Hidekazu
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 12 Pages: 109-109

    • DOI

      10.3389/fnagi.2020.00109

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16557
  • [Journal Article] Cortical Microinfarcts Detected by 3-Tesla Magnetic Resonance Imaging2020

    • Author(s)
      Ishikawa Hidehiro、Ii Yuichiro、Shindo Akihiro、Tabei Ken-ichi、Umino Maki、Ito Ai Ogawa、Matsuura Keita、Taniguchi Akira、Matsuyama Hirofumi、Niwa Atsushi、Ogura Toru、Yoshimaru Kimiko、Satoh Masayuki、Maeda Masayuki、Tomimoto Hidekazu
    • Journal Title

      Stroke

      Volume: 51 Issue: 3 Pages: 1010-1013

    • DOI

      10.1161/strokeaha.119.028202

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K17811, KAKENHI-PROJECT-18K15446, KAKENHI-PROJECT-19H03572, KAKENHI-PROJECT-16K10315, KAKENHI-PROJECT-20K08104
  • [Journal Article] Microbleeds after Carotid Artery Stenting: Small Embolism May Induce Cerebral Microbleeds2019

    • Author(s)
      Ogawa Ito Ai、Shindo Akihiro、Ii Yuichiro、Matsuura Keita、Tabei Ken-ichi、Maeda Masayuki、Umino Maki、Suzuki Yume、Shiba Masato、Toma Naoki、Suzuki Hidenori、Tomimoto Hidekazu
    • Journal Title

      Cerebrovascular Diseases Extra

      Volume: 9 Issue: 2 Pages: 57-65

    • DOI

      10.1159/000500112

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10314, KAKENHI-PROJECT-17K17811, KAKENHI-PROJECT-18K16557, KAKENHI-PROJECT-16K10315
  • [Journal Article] Small Cortical Infarcts Transformed to Lobar Cerebral Microbleeds: A Case Series2019

    • Author(s)
      Ito Ai Ogawa、Shindo Akihiro、Ii Yuichiro、Ishikawa Hidehiro、Taniguchi Akira、Shiba Masato、Toma Naoki、Suzuki Hidenori、Tomimoto Hidekazu
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 28 Issue: 4 Pages: e30-e32

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.12.050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K16557
  • [Journal Article] Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice.2019

    • Author(s)
      Shimada T, Shindo A, Matsuyama H, Yata K, Niwa A, Sasaki R, Ayaki T, Maki T, Wakita H, Tomimoto H.
    • Journal Title

      Neuroscience Letters

      Volume: 704 Pages: 133-140

    • DOI

      10.1016/j.neulet.2019.04.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09684, KAKENHI-PROJECT-16K15246, KAKENHI-PROJECT-18K16557, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-19H03572
  • [Journal Article] Magnesium sulfate protects oligodendrocyte lineage cells in a rat cell-culture model of hypoxic-ischemic injury.2016

    • Author(s)
      Itoh K, Maki T, Shindo A, Egawa N, Liang AC, Itoh N, Lo EH, Lok J, Arai K.
    • Journal Title

      Neurosci Res

      Volume: 106 Pages: 66-69

    • DOI

      10.1016/j.neures.2015.12.004

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Journal Article] Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke2016

    • Author(s)
      Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K.
    • Journal Title

      Stroke

      Volume: 47 Issue: 4 Pages: 1094-100

    • DOI

      10.1161/strokeaha.115.012133

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15246, KAKENHI-PROJECT-16K20005
  • [Journal Article] Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats.2016

    • Author(s)
      Liang AC, Mandeville ET, Maki T, Shindo A, Som AT, Egawa N, Itoh K, Chuang TT, McNeish JD, Holder JC, Lok J, Lo EH, Arai K.
    • Journal Title

      Cell Transplant

      Volume: 25 Issue: 4 Pages: 705-714

    • DOI

      10.3727/096368916x690557

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Presentation] 血管性認知症2021

    • Author(s)
      新堂晃大
    • Organizer
      第46回日本脳卒中学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03572
  • [Presentation] Serum protein biomarkers in the diagnosis of cerebral amyloid angiopathy (CAA).2021

    • Author(s)
      Nishiguchi Y, Tachibana K, Mori Y, Matsuyama H, Shindo A, Oikawa S,Tomimoto H.
    • Organizer
      第62回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19H03572
  • [Presentation] Cerebral Venous Thrombosis Caused by Congenital Thrombophilia in Japan2020

    • Author(s)
      Akihiro Shindo
    • Organizer
      International Stroke Conference 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16557
  • [Presentation] 血管性認知症と脳アミロイド血管症2020

    • Author(s)
      新堂晃大
    • Organizer
      第45回日本脳卒中学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03572
  • [Presentation] アルツハイマー病の血管危険因子:脳小血管病変2019

    • Author(s)
      新堂晃大
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03572
  • [Presentation] Critical Care with thiamine treatment in a patient of Marchiafava-Bingami disease2017

    • Author(s)
      A Shindo, R Asada, K Suzuki, H Ishikawa, E Kawamoto, M Fujioka, H Tomimoto, H Imai
    • Organizer
      Society of Critical Care Medicine’s (SCCM) 47th Critical Care Congress
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2017-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Presentation] Pentraxin 3 supports blood-brain barrier integrity after ischemic stroke2017

    • Author(s)
      Akihiro Shindo, Takakuni Maki, Naohiro Egawa, Anna C. Liang, Kanako Itoh, Eng H. Lo, Ken Arai, Hidekazu Tomimoto
    • Organizer
      World congress of Neurology 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Presentation] Astrocytic pentraxin 3 supports blood-brain barrier integrity under acute phase of ischemic stroke2016

    • Author(s)
      A Shindo, T Maki, N Egawa, K Itoh, A Liang, E Lo, K Arai, H Tomimoto
    • Organizer
      日本神経学会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Presentation] Astrocyte-derived Pentraxin 3 Supports Blood-Brain Barrier Integrity after ischemic stroke2016

    • Author(s)
      A Shindo, T Maki, N Egawa, K Itoh, A Liang, E Lo, K Arai, H Tomimoto
    • Organizer
      Asian and Oceanian Congress of Neurology
    • Place of Presentation
      KLCC, Kuala Lumpur, Malaysia
    • Year and Date
      2016-08-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K20005
  • [Presentation] 高学歴専門職高齢者における軽度認知障害の評価法2007

    • Author(s)
      新堂 晃大
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2007-05-16
    • Data Source
      KAKENHI-PROJECT-17659263
  • 1.  Tomimoto Hidekazu (80324648)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 2.  及川 伸二 (10277006)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  北爪 しのぶ (80301753)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  葛原 茂樹 (70111383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  成田 有吾 (50242954)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  佐藤 正之 (70303732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  松山 裕文 (80750025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  石川 英洋 (00793499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  伊井 裕一郎 (40362347)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  村田 真理子 (10171141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小林 果 (70542091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ARAI Ken
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 13.  WAKITA Hideaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  前田 正幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 15.  海野 真記
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 16.  鈴木 圭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  田部井 賢一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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