OYAMA Takuji 大山拓次

Researcher Number	60423133
Other IDs	https://orcid.org/0000-0002-3411-7608
Affiliation (Current)	2024: 山梨大学, 大学院総合研究部, 教授
Affiliation (based on the past Project Information) *help	2023: 山梨大学, 大学院総合研究部, 教授 2018 – 2020: 山梨大学, 大学院総合研究部, 准教授 2015 – 2016: 山梨大学, 総合研究部, 准教授 2015: 山梨大学, 准教授 2015: 山梨大学, 医学工学総合研究部, 准教授 … More 2014: 山梨大学, 総合研究部, 助教 2013: 山梨大学, 医学工学総合研究部, 助教 2008 – 2010: 大阪大学, 蛋白質研究所, 特任研究員 2007: 大阪大学, 蛋白質研究所, 寄附研究部門助教 2006: 大阪大学, 蛋白質研究所, 寄附研究部門助手 Less
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry Except Principal Investigator Medium-sized Section 64:Environmental conservation measure and related fields / Life / Health / Medical informatics / Structural biochemistry
Keywords	Principal Investigator 結晶構造解析 / DNA複製 / 古細菌 / Ｘ線結晶構造解析 / DNAポリメラーゼD / X線結晶構造解析 / CMGヘリカーゼ複合体 / 超好熱古細菌 / CMGヘリカーゼ / タンパク質DNA複合体 … More Except Principal Investigator … More 立体構造解析 / 共生微生物 / 糖化酵素 / バイオマス / 高分子構造・物性アルゴリズム / 生体超分子構造 / アルゴリズム / 高分子構造・物性 / 分子機械 / 生体生命情報学 / クランプ / DNA複製 / 単粒子解析 / 立体構造 / 複合体 / 画像解析 / 生物物理 / 可視化 / 生体分子 / ナノバイオ / 電子顕微鏡 / プロテオミクス / 核磁気共鳴 / X線結晶構造解析 / 転写共役因子 / 脂肪酸代謝物 / 転写制御 / 脂肪酸 / 転写調節因子 / 蛋白質立体構造 / 脂質代謝物 / 核内受容体 / ホメオスターシス Less

難培養性微生物の木質分解酵素の機能解明とバイオマス利用技術の基盤創出
- Principal Investigator
  
  野田悟子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 64:Environmental conservation measure and related fields
- Research Institution
  Ibaraki University
Structural biology on the interaction between archaeal CMG helicase and DNA polymerase DPrincipal Investigator
- Principal Investigator
  
  OYAMA Takuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  University of Yamanashi
Structural study on the clamp PCNA-loading mechanism by the clamp loader RFCPrincipal Investigator
- Principal Investigator
  
  OYAMA Takuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Yamanashi
Attempts in unifying biological molecular data via graph methods
- Principal Investigator
  
  Shirai Tsuyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Structural analysis to investigate the coordinating role of DNA clamp in replisome
- Principal Investigator
  
  Mayanagi Kouta
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyushu University
Structural basis of functional coupling between transcription and cellular metabolism
- Principal Investigator
  
  MORIKAWA Kosuke
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Osaka University

[Journal Article] Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome.2022
- Author(s)
  Oki, K., Nagata, M., Yamagami, T., Numata, T., Ishino, S., Oyama, O., and Ishino, Y.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 50 Issue: 7 Pages: 3601-3615
- DOI
  10.1093/nar/gkab799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22289, KAKENHI-PROJECT-20H02916, KAKENHI-PROJECT-20J12260, KAKENHI-PROJECT-20K21281, KAKENHI-PROJECT-18K06081
[Journal Article] Preparation of co-crystals of human PPARα-LBD and ligand for high-resolution X-ray crystallography2021
- Author(s)
  Kamata Shotaro、Oyama Takuji、Ishii Isao
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 1 Pages: 100364-100364
- DOI
  10.1016/j.xpro.2021.100364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16359, KAKENHI-PROJECT-18K06081
[Journal Article] A crystallization and preliminary X-ray diffraction study of the Arabidopsis thaliana proliferating cell nuclear antigen (PCNA2) alone and in a complex with a PIP-box peptide from Flap endonuclease 12020
- Author(s)
  Kowalska Ewa、Strza?ka Wojciech、Oyama Takuji
- Journal Title
  
  Acta Biochimica Polonica
  
  Volume: 67 Pages: 49-52
- DOI
  10.18388/abp.2020_2896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06081
[Journal Article] PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates2020
- Author(s)
  Kamata Shotaro、Oyama Takuji、Saito Kenta、Honda Akihiro、Yamamoto Yume、Suda Keisuke、Ishikawa Ryo、Itoh Toshimasa、Watanabe Yasuo、Shibata Takahiro、Uchida Koji、Suematsu Makoto、Ishii Isao
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 11 Pages: 101727-101727
- DOI
  10.1016/j.isci.2020.101727
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16359, KAKENHI-PROJECT-18K06081, KAKENHI-PROJECT-17H06170
[Journal Article] Direct visualization of DNA baton pass between replication factors bound to PCNA2018
- Author(s)
  Mayanagi Kouta、Ishino Sonoko、Shirai Tsuyoshi、Oyama Takuji、Kiyonari Shinichi、Kohda Daisuke、Morikawa Kosuke、Ishino Yoshizumi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 16209-16209
- DOI
  10.1038/s41598-018-34176-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05442, KAKENHI-PROJECT-18K06081, KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18K06089
[Journal Article] 細胞内の巨大な分子モーター「ダイニン」の構造解析2016
- Author(s)
  大山拓次、栗栖源嗣、昆隆英
- Journal Title
  
  放射光
  
  Volume: 29 Pages: 82-89
- NAID
  40020850525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440023
[Journal Article] Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication.2016
- Author(s)
  Oyama, T., Ishino, S., Shirai, T., Yamagami, T., Nagata, M., Ogino, H., Kusunoki, M., and Ishino, Y.
- Journal Title
  
  Nucleic Acids, Res.
  
  Volume: 44 Issue: 19 Pages: 9509-9517
- DOI
  10.1093/nar/gkw789
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-16J02633, KAKENHI-PROJECT-26440023
[Journal Article] Peroxisome proliferator-activated receptor gamma (PPARgamma) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPARgamma partial agonists bind to PPARgamma LBD in different conformations2015
- Author(s)
  Ohashi M, Gamo K, Oyama T, Miyachi H
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 25 Issue: 14 Pages: 2758-2762
- DOI
  10.1016/j.bmcl.2015.05.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440023, KAKENHI-PROJECT-24370046
[Journal Article] Different structures of the two peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding domains in homodimeric complex with partial agonist, but not full agonist2015
- Author(s)
  M. Ohashi, T. Oyama, H. Miyachi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: - Issue: 13 Pages: 2639-2644
- DOI
  10.1016/j.bmcl.2015.04.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07435, KAKENHI-PROJECT-26440023, KAKENHI-PROJECT-24370046
[Journal Article] Modification of Chimeric (2S, 3S)-butanediol dehydrogenase based on structural information.2015
- Author(s)
  Shimegi T, Mochizuki K, Oyama T, Ohtsuki T, Kusunoki M, Ui S
- Journal Title
  
  Protein Pept Lett
  
  Volume: 22 Pages: 226-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440023
[Journal Article] Integrated molecular mechanism directing nucleosome reorganization by human FACT2015
- Author(s)
  Tsunaka Y, Fujiwara Y, Oyama T, Hirose S, Morikawa K
- Journal Title
  
  Genes Dev
  
  Volume: 30(6) Issue: 6 Pages: 673-686
- DOI
  10.1101/gad.274183.115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-26251008, KAKENHI-PROJECT-26440023
[Journal Article] Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activated receptor γ (PPARγ)-selective antagonists based on the helix12-folding inhibition hypothesis.2015
- Author(s)
  M. Ohashi, K. Gamo, Y. Tanaka, M. Waki, Y. Beniyama, K. Matsuno, J. Wada, M. Tenta, J. Eguchi, M. Makishima, N. Matsuura, T. Oyama, H. Miyachi.
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 90 Pages: 53-67
- DOI
  10.1016/j.ejmech.2014.11.017
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J07435, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-26440023
[Journal Article] Modification of Chimeric (2S, 3S)-butanediol dehydrogenase based on structural information2014
- Author(s)
  Shimegi T, Mochizuki K, Oyama T, Kusunoki M, Ui S
- Journal Title
  
  Protein Pept Lett
  
  Volume: 22 Pages: 226-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] Purification and characterization of a protease from Isaria cicadae2014
- Author(s)
  Takekawa C, Nakamura K, Homma H, Oyama T
- Journal Title
  
  Mushroom Science and Biotechnology
  
  Volume: 22 Pages: 74-78
- NAID
  110009863113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] Crystallization and preliminary X-ray diffraction analysis of domain chimeric L-(2S, 3S)-butanediol dehydrogenase2014
- Author(s)
  Shimegi T, Oyama T, Ohtsuki T, Kurisu G, Kusunoki M, Ui S
- Journal Title
  
  Acta Cryst F
  
  Volume: 70 Issue: 4 Pages: 461-463
- DOI
  10.1107/s2053230x13032755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-26440023
[Journal Article] Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists2014
- Author(s)
  Tanaka Y, Gamo K, Oyama T, Ohashi M, Waki M, Matsuo K, Matsuura N, Tokiwa H, Miyachi H
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 24 Issue: 16 Pages: 4001-4005
- DOI
  10.1016/j.bmcl.2015.06.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] Disordered interdomain region of Gins is important for functional tetramer formation to stimulate MCM helicase in Thermoplasma acidophilum2014
- Author(s)
  Ogino H, Ishino S, Oyama T, Kohda D, Ishino Y
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 79 Issue: 3 Pages: 432-438
- DOI
  10.1080/09168451.2014.982503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-26440023, KAKENHI-PROJECT-12J03099
[Journal Article] Revealing the intracellular ultrastructure of filopodia with cryo-electron tomography.2014
- Author(s)
  Shinji Aramaki, Kouta Mayanagi, Kazuhiro Aoyama and Takuo Yasunaga
- Journal Title
  
  Microscopy (Oxf) Suppl.
  
  Volume: 63 Issue: suppl 1 Pages: 133-134
- DOI
  10.1093/jmicro/dfu071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J06623, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] Purification and characterization of a protease from Isaria cicadae2014
- Author(s)
  Takekawa C, Nakamura K, Homma H, Oyama T
- Journal Title
  
  Mushroom Science and Biotechnology
  
  Volume: 22 Pages: 74-78
- NAID
  110009863113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440023
[Journal Article] Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists.2014
- Author(s)
  Y. Tanaka, K. Gamo, T. Oyama, M. Ohashi, M. Waki, K. Matsuno, N. Matsuura, H. Tokiwa, H. Miyachi.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 24 Issue: 16 Pages: 4001-4005
- DOI
  10.1016/j.bmcl.2014.06.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07435, KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-26440023
[Journal Article] Structure of the entire stalk region of the dynein motor domain2014
- Author(s)
  Yosuke Nishikawa, Takuji Oyama, Narutoshi Kamiya, Takahide Kon, Yoko Y. Toyoshima, Haruki Nakamura, Genji Kurisu
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 426 Issue: 19 Pages: 3232-3245
- DOI
  10.1016/j.jmb.2014.06.023
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-24370046, KAKENHI-PUBLICLY-25113504, KAKENHI-PUBLICLY-25117503, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-25291031, KAKENHI-PROJECT-25440070, KAKENHI-PROJECT-26291014, KAKENHI-PROJECT-26291034, KAKENHI-PROJECT-26440023
[Journal Article] Crystal Structures Of Copper-Depleted And Copper-Bound Fungal Pro-Tyrosinase: Insights Into Endogenous Cysteine-Dependent Copper Incorporation2013
- Author(s)
  Shinobu Itoh, et al.
- Journal Title
  
  J. Biol.Chem.
  
  Volume: 288 Issue: 30 Pages: 22128-22140
- DOI
  10.1074/jbc.m113.477612
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22105007, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24655153, KAKENHI-PROJECT-25620044
[Journal Article] Design and synthesis of a series of a-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved a queous solubility.2013
- Author(s)
  Masao Ohashi, et.al.
- Journal Title
  
  Bioorg. Med Chem.
  
  Volume: 21 Issue: 8 Pages: 2319-2332
- DOI
  10.1016/j.bmc.2013.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07435, KAKENHI-PROJECT-23247016, KAKENHI-PROJECT-23390329, KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-24370046
[Journal Article] Mutational and Structural Analyses of Caldanaerobius polysaccharolyticus Man5B Reveal Novel Active Site Residues for Family 5 Glycoside Hydrolases2013
- Author(s)
  Takuji Oyama, George E Schmitz, Dylan Dodd, Yejun Han, Alanna Burnett, Naoko Nagasawa, Roderick I Mackie, Haruki Nakamura, Kosuke Morikawa, & Isaac Cann
- Journal Title
  
  PLoS ONE.
  
  Volume: 8 Issue: 11 Pages: e80448-e80448
- DOI
  10.1371/journal.pone.0080448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23247016, KAKENHI-PROJECT-23370071, KAKENHI-PROJECT-24370046
[Journal Article] Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist.2012
- Author(s)
  Shintaro Ban　他７名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 11 Pages: 3460-3464
- DOI
  10.1016/j.bmc.2012.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23247016, KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-24370046
[Journal Article] Detecting structural similarity of ligand interactions in the lipid metabolic system including enzymes, lipid-binding proteins and nuclear receptors.2011
- Author(s)
  Shionyu-Mitsuyama, C., Waku, T., Shiraki, T., Oyama, T., Shirai, T., Morikawa, K.
- Journal Title
  
  Protein Eng Des Sel 24
  
  Pages: 397-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Design, Synthesis, and Structural analysis of phenylpropanoic acid-Type PPARy-selective agonists : discovery of reversed stereochemistry-activity relationship.2011
- Author(s)
  Ohashi, M., Oyama, T., Nakagome, I., Satoh, M., Nishino, Y., Nobusada, H., Hirono, S., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  JMed Chem 54
  
  Pages: 331-341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] The nuclear receptor PPARy individually responds to serotonin-and fatty acid-metabolites.2010
- Author(s)
  Waku, T., Shiraki, T., Oyama, T., Maebara, K., Nakamori, R., Morikawa, K.
- Journal Title
  
  EMBO J 29
  
  Pages: 3395-3407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Structural insight into PPARy activation through covalent modification with endogenous fatty acids.2009
- Author(s)
  Waku, T., Shiraki, T., Oyama, T., Fujimoto, Y., Maebara, K., Kamiya, N., Jingami, H., Morikawa, K.
- Journal Title
  
  J Mol Biol 385
  
  Pages: 188-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex2009
- Author(s)
  Nishida, H., Mayanagi, K., Kiyonari, S., Sato, Y., Oyama, T., Ishino, Y., Morikawa, K.
- Journal Title
  
  Proc Natl Acad Sci USA. 106(49)
  
  Pages: 20693-20698
- NAID
  10026599264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 c-terminal segment2009
- Author(s)
  Strzalka, W., Oyama, T., Tori, K., Morikawa, K.
- Journal Title
  
  Protein Science (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids2009
- Author(s)
  Waku, T., Shiraki, T., Oyama, T., Fujimoto, Y., Maebara, K., Kamiya, N., Jingami, H., Morikawa, K.
- Journal Title
  
  J Mol Biol 385
  
  Pages: 188-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Atomic structure of mutant PPARγ LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARy/RXRa function by covalently bound ligands.2009
- Author(s)
  Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 320-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Adaptability and selectivity of the human peroxisome profilerator-activated receptor(PPAR)pan agonists revealed from crystal structures2009
- Author(s)
  Oyama, T., Toyota, K., Waku, T., Hirakawa, Y., Nagasawa, N., Kasuga, J., Hashimoto, Y., Miyachi, H., Morikawa, K.
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr 65
  
  Pages: 786-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm2009
- Author(s)
  Oyama, T., Oka, H., Mayanagi, K., Shirai, T., Matoba, K., Fujikane, R., Ishino, Y., Morikawa, K.
- Journal Title
  
  BMC Struct Biol 9
  
  Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Structural insight into PPARγ activation through covalent modification with endogenous fatty acids2009
- Author(s)
  Waku, T., Shiraki, T., Oyama, T., Fujimoto, Y., Maebara, K., Kamiya, N., Jingami, H. & Morikawa, K.
- Journal Title
  
  J. Mol. Biol. 385
  
  Pages: 188-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands2009
- Author(s)
  Waku, T., Shiraki T., Oyama T., Morikawa. K.
- Journal Title
  
  FEBS Lett 583
  
  Pages: 320-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm.2009
- Author(s)
  Oyama, T., Oka, H., Mayanagi, K., Shirai, T., Matoba, K., Fujikane, R., Ishino, Y., Morikawa, K.
- Journal Title
  
  BMC Struct.Biol. 9
  
  Pages: 2-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.2009
- Author(s)
  Strzalka, W., Oyama, T., Tori, K., Morikawa, K.
- Journal Title
  
  Protein Sci 18
  
  Pages: 1072-1080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Atomic structure of mutant PPARγLBD complexed with 15d-PGJ2 : novel modulation mechanism of PPARγ/RXRαfunction by covalently bound ligands2009
- Author(s)
  Waku, T., Shiraki, T., Oyama, T. & Morikawa, K.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 320-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Design and Synthesis of Peroxisome Proliferator-activated Receptor(PPAR)Delta Agonists and Its Implication to the Driving Force to Elicit PPAR Delta Selectivity2009
- Author(s)
  Kasuga, J., Oyama, T., Nakagome, I., Aoyama, A., Sako, K., Makishima, M., Hirono, S., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  Yakugaku Zasshi 129
  
  Pages: 709-718
- NAID
  130000136176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A2009
- Author(s)
  Takemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y, Hanaoka F, Yanagisawa J, Kimura K.
- Journal Title
  
  Nature Structural & Molecular Biology 16
  
  Pages: 1302-1308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment2009
- Author(s)
  Strzalka, W., Oyama, T., Tori, K., Morikawa, K.
- Journal Title
  
  Protein Sci 18
  
  Pages: 1072-1080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists : effect of introduction of fluorine at the linker part.2008
- Author(s)
  Kasuga, J., Oyama, T., Hirakawa, Y., Makishima, M., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  Bioorg Med Chem Lett 18
  
  Pages: 4525-4528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands2008
- Author(s)
  Araya, Y., Kasuga, J., Toyota, K., Hirakawa, Y., Oyama, T., Makishima, M., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  Chem Pharm Bull (Tokyo) 56
  
  Pages: 1357-1359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Peroxisome proliferator-activated receptor (PPAR) agonists with a 3, 4-dihydro-2H-benzo [e] [1, 3] oxazine and 2, 3, 4, 5-tetrahydrobenzo [f] [1, 4] oxazepine skeleton: effects of cyclization of linker moiety on PPAR-agonistic activity2008
- Author(s)
  Ohgane, K., Kasuga, J., Oyama, T., Hirakawa, Y., Morikawa, K., Makishima, M., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  Heterocycles 75
  
  Pages: 2187-2192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists2008
- Author(s)
  Kasuga, J., Oyama, T., Nakagome, I., Makishima, M., Hirono, S., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  ChemMedChem 3
  
  Pages: 1662-1666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists.2008
- Author(s)
  Kasuga, J., Oyama, T., Nakagome, I., Makishima, M., Hirono, S., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  ChemMedChem 3
  
  Pages: 1662-1666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Improvement of the transactivation activity of phenylpropanoic acid-type per oxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part2008
- Author(s)
  Kasuga, J., Oyama, T., Hirakawa, Y., Makishima, M., Morikawa, K., Hashimoto, Y., Miyachi, H.
- Journal Title
  
  Bioorg Med Chem Lett 18
  
  Pages: 4525-4528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Analysis of the role of Aurora B on the chromosomal targeting of condensin I.2007
- Author(s)
  Takemoto, A., Muravama, A., Katano, M., Urano, T., Furukawa, K., Yokoyama, S., Yanagisawa, J., Hanaoka, F., Kimura, K.
- Journal Title
  
  Nucleic Acids Res 35
  
  Pages: 2403-2412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Journal Article] Crystal structures of autoinhibitory PDZ domain of Tamalin : implications for metabotropic glutamate receptor trafficking regulation.2007
- Author(s)
  Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
- Journal Title
  
  EMBO J 26
  
  Pages: 2192-2205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18GS0316
[Presentation] 結晶構造解析より明らかになったブタンジオール生産に重要なSerratia marcescens ニコチンアミダーゼの多量体構造2019
- Author(s)
  大山拓次、大槻隆司
- Organizer
  日本結晶学会　2019年度年会ポスター
- Data Source
  KAKENHI-PROJECT-18K06081
[Presentation] ブタンジオール生産能に関わるSerratia marcescens由来ニコチンアミダーゼのX 線結晶構造解析2019
- Author(s)
  大山拓次、大槻隆司
- Organizer
  日本微生物生態学会　第33回大会ポスター
- Data Source
  KAKENHI-PROJECT-18K06081
[Presentation] 結晶構造から明らかになった古細菌GANのDNA複製でのCMG因子および修復でのヌクレアーゼとしての2つの役割2016
- Author(s)
  大山拓次、石野園子、白井剛、山上健、永田麻梨子、尾木野弘実、楠木正巳、石野良純
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440023
[Presentation] Activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Hiromi Ogino, Sonoko Ishino, Kouta Mayanagi, Takuji Oyama, Tsuyoshi Shirai, Kosuke Morikawa, Gyri Teien Haugland, Nils-Kare Birkeland, Daisuke Kohda, Yoshizumi Ishino
- Organizer
  Thermophiles 2013
- Place of Presentation
  Regensburg, Germany
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 核内受容体PPARδリガンド結合ドメインとパーシャルアゴニストJK122の複合体結晶構造2013
- Author(s)
  大山拓次、中村仁美、春日淳一、宮地弘幸、楠木正巳
- Organizer
  平成25年度日本生化学会関東支部例会
- Place of Presentation
  山梨
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] ダイニンモータードメインのX線構造解析2013
- Author(s)
  昆隆英、大山拓次、下-昆理恵子、須藤和夫、栗栖源嗣
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 組み替えhuman poly(ADP-ribose) polymerase 1の精製とその立体構造解析2013
- Author(s)
  Kenichi Koyama, Takayuki Eguchi, Hiroyuki Morita, Kazuo Kamemura, Yoshisuke Nishi, Masanao Miwa Tsuyoshi Shirai
- Organizer
  生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Ogino H, Ishino S, Mayanagi K, Oyama T, Shirai T, Morikawa K, Haugland GT, Birkeland NK, Kohda D, Ishino Y
- Organizer
  Thermophiles 2013
- Place of Presentation
  Regensburg, Germany
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Divergently evolved activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Hiromi Ogino, Sonoko Ishino, Kouta Mayanagi, Takuji Oyama, Tsuyoshi Shirai, Kosuke Morikawa, Gyri Teien Haugland, Nils-Kare Birkeland, Daisuke Kohda, Yoshizumi Ishino
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 核内受容体PPARγリガンド結合ドメインとスルホン酸含有新規パーシャルアゴニストの複合体結晶構造2013
- Author(s)
  大山拓次、大橋雅生、宮地弘幸、楠木正巳
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 好熱性アーキアThermoplasma acidophilumにおける複製ヘリカーゼ活性化機構の分岐進化2013
- Author(s)
  尾木野弘実, 石野園子, 真柳浩太, 大山拓次, 白井剛, 森川耿右, Haugland Gyri Teien, Birkeland Nils-Kare, 神田大輔, 石野良純
- Organizer
  第１４回極限環境生物学会
- Place of Presentation
  川崎
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Divergently evolved activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Ogino H, Ishino S, Mayanagi K, Oyama T, Shirai T, Morikawa K, Haugland GT, Birkeland NK, Kohda D, Ishino Y
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸, 兵庫県
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] 組み替えhuman poly(ADP-ribose) polymerase 1の精製と予備的構造解析2013
- Author(s)
  Kenichi Koyama, Kouta Mayanagi, Takayuki Eguchi, Hiroyuki Morita, Kazuo Kamemura, Yoshisuke Nishi, Masanao Miwa Tsuyoshi Shirai
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 好熱性アーキアThermoplasma acidophilumにおける複製ヘリカーゼ活性化機構の分岐進化2013
- Author(s)
  尾木野弘実, 石野園子, 真柳浩太, 大山拓次, 白井剛, 森川耿右, Haugland Gyri Teien, Birkeland Nils-Kare, 神田大輔, 石野良純
- Organizer
  第１４回極限環境生物学会
- Place of Presentation
  川崎, 神奈川県
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] 線菌Saccharopolyspora rectivirgula由来の耐熱性β-ガラクトシダーゼ酵素の結晶構造生物2012
- Author(s)
  渡辺慎太郎、大山拓次、竹内耕平、中山亨、楠木正巳
- Organizer
  第85回日本生化学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Thermoplasma acidophilum由来Cdc6/Orclとホモ4量体のGINSによるMCMとの相乗的な活性化2012
- Author(s)
  尾木野弘実、石野園子、真柳浩太、大山拓次、白井剛、森川耿右、Gyri Teien Haugland、Nils-Kare Birkeland、石野良純
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 新規セントロメア特異的ヒストン様複合体CENP-TWSXの構造機能解析2012
- Author(s)
  西野達哉、竹内康造、Karen Gascoigne、鈴木應志、堀哲也、大山拓次、森川耿右、Iain Cheeseman、深川竜郎
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-21
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 放線菌Saccharopolyspora rectivirgula由来の耐熱性β-ガラクトシダーゼ野生型酵素の結晶構造解析2012
- Author(s)
  渡辺慎太郎、大山拓次、竹内耕平、中山亨、楠木正巳
- Organizer
  平成24年度日本結晶学会年会
- Place of Presentation
  東北大学片平キャンパス
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Structural basis for the activation of the nuclear receptor, PPARgamma, by fatty acid-and serotonin metabolites2012
- Author(s)
  Tsuyoshi Waku, Takuma Shiraki, Takuji Oyama, Clara Shinyu, Kosuke Morikawa
- Organizer
  第85回日本生化学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] ダイニンモータードメインの2.8-Å結晶構造2012
- Author(s)
  昆隆英、大山拓次、下一昆理恵子、須藤和夫、栗栖源嗣
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] モータータンパク質ダイニンに特徴的なストーク領域の構造研究2012
- Author(s)
  西河洋祐、大山拓次、枝松正樹、豊嶋陽子、昆隆英、栗栖源嗣
- Organizer
  平成24年度日本結晶学会年会
- Place of Presentation
  東北大学片平キャンパス
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Structural basis for the activation of the nuclear receptor, PPARgamma, by fatty acid-and serotonin metabolites2010
- Author(s)
  和久剛、白木琢磨、大山拓次、森川耿右
- Organizer
  Korea-Japan Chromatin & Epigenetics Joint Symposium 2010
- Place of Presentation
  Hyundai sungwoo resort, Hoengseong Gun(韓国)
- Year and Date
  2010-01-21
- Data Source
  KAKENHI-PROJECT-18GS0316
[Presentation] ヒト由来PPARαと蛍光性アゴニストとの複合体の構造2009
- Author(s)
  大山拓次、長沢奈央子、宮地弘幸、森川耿右
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-18GS0316
[Presentation] RecQに関連する古細菌由来Hjmヘリカーゼの結晶構造とその機能2009
- Author(s)
  大山拓次、真柳浩太、白井剛、藤兼亮輔、石野良純、森川耿右
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ(熊本)
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-18GS0316
[Presentation] リガンドの共通部分構造を認識する脂質シグナル系タンパク質部位の探索2008
- Author(s)
  塩生くらら、和久剛、大山拓次、白木琢磨、白井剛、森川耿右
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-18GS0316
[Presentation] リガンドの共通部分構造を認識する脂質シグナル系タンパク質部位の探索2008
- Author(s)
  塩生くらら、和久剛、大山拓次、白木琢磨、白井剛、森川耿右
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-18GS0316
[Presentation] 大豆イソフラボングルコシルトランスフェラーゼGmIF7GTの結晶構造解析
- Author(s)
  桑名美貴子、楠木正巳、大山拓次、中山亨
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京大学農学部（東京都文京区）
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-26440023
[Presentation] 大豆イソフラボングルコシルトランスフェラーゼGmIF7GTの結晶構造解析
- Author(s)
  桑名美貴子、楠木正巳、大山拓次、中山亨
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京大学、東京
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 大豆イソフラボングルコシルトランスフェラーゼGmIF7GTの構造生物学
- Author(s)
  桑名美貴子、楠木正巳、大山拓次、中山亨
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26440023
[Presentation] 大豆イソフラボングルコシルトランスフェラーゼGmIF7GTの構造生物学
- Author(s)
  桑名美貴子、楠木正巳、大山拓次、中山亨
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Revealing the intracellular ultrastructure of filopodia with cryo-electron tomography
- Author(s)
  Aramaki S, Mayanagi K, Aoyama K, Yasunaga T
- Organizer
  日本顕微鏡学会第５８回シンポジウム
- Place of Presentation
  九州大学、福岡
- Year and Date
  2014-11-16 – 2014-11-17
- Data Source
  KAKENHI-PROJECT-24370046

1. Mayanagi Kouta (50418571)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. SHIRAI Tsuyoshi (00262890)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. ISHINO Yoshizumi (30346837)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
4. MORIKAWA Kosuke (80012665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 30 results
5. MURAYAMA Akiko (50431656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. TATE Shinーichi (20216998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIMURA Keiji (50332268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. SHIRAKI Takuma (10311747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. TAKAO Toshifumi (10197048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 野田悟子 (80342830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISHI Shunsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊東忍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 石野園子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鎌田祥太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 中村春木

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OYAMA Takuji 大山 拓次

Research Projects

Research Products

Co-Researchers

難培養性微生物の木質分解酵素の機能解明とバイオマス利用技術の基盤創出

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Review Section

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Structural biology on the interaction between archaeal CMG helicase and DNA polymerase DPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Structural study on the clamp PCNA-loading mechanism by the clamp loader RFCPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Attempts in unifying biological molecular data via graph methods

Principal Investigator

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Research Institution

Structural analysis to investigate the coordinating role of DNA clamp in replisome

Principal Investigator

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Structural basis of functional coupling between transcription and cellular metabolism

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of co-crystals of human PPARα-LBD and ligand for high-resolution X-ray crystallography2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A crystallization and preliminary X-ray diffraction study of the Arabidopsis thaliana proliferating cell nuclear antigen (PCNA2) alone and in a complex with a PIP-box peptide from Flap endonuclease 12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct visualization of DNA baton pass between replication factors bound to PCNA2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 細胞内の巨大な分子モーター「ダイニン」の構造解析2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peroxisome proliferator-activated receptor gamma (PPARgamma) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPARgamma partial agonists bind to PPARgamma LBD in different conformations2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different structures of the two peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding domains in homodimeric complex with partial agonist, but not full agonist2015

OYAMA Takuji 大山拓次