NAMBA Kazunori 難波一徳

Researcher Number	60425684
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2021: 慶應義塾大学, 医学部(信濃町), 共同研究員 2015 – 2018: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 2015: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 研究員 2014: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 研究員 2013: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚障害研究室, 研究員 … More 2012: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 2011: 独立行政法人国立病院機構東京医療センター(臨床研究センター), 臨床研究センター, 研究員 2010 – 2011: 独立行政法人国立病院機構東京医療センター(臨床研究センター), 聴覚平衡覚研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator OTOF / BDNF / ANSD / Otoferlin / Auditory Neuropathy / ノックアウトマウス / アポトーシス / 遺伝子改変マウス / ラセン神経節細胞 / 遺伝子 … More / SGN / DPOAE / らせん神経節 / オトフェリン / オーディトリーニューロパチー / Otof / 発現系ベクター / 変異 / GFP融合 / 精製 / 結晶化 / pGEX / pET / ベクター / 発現系 / 発現ベクター / STAS / 大腸菌 / 大量発現系 / 構造解析 / p.H723R / STASドメイン / SLC26A4 / ペンドリン / ペンドレッド症候群 / 国際情報交換, 対象国:米国,フランス / TUNEL / 蝸牛 / neurodegeneration / 神経細胞 / Spiral Ganglion / 蝸牛神経節 / 立体構造 / 内耳 / 蝸牛神経 / 蛋白質 / 難聴 / 形態 / 遺伝子変異 / 耳科学 … More Except Principal Investigator 胎生致死 / ゲノム編集 / 神経芽腫細胞 / 難聴遺伝子 / 蝸牛神経 / 内耳奇形 Less

Construction of a mouse model for Auditory Neuropathy Spectrum DisorderPrincipal Investigator
- Principal Investigator
  
  NAMBA Kazunori
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Molecular functional analysis of ZBTB10, the novel candidate deafness gene associated with cochlear nerve hypoplasia
- Principal Investigator
  
  Mutai Hideki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
A study of structural impairments of STAS domain caused by common p.H723R mutation of SLC26A4 in patients with Pendred syndromePrincipal Investigator
- Principal Investigator
  
  Namba Kazunori
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Spiral ganglion degeneration in a mouse model of auditory neuropathy spectrum disorderPrincipal Investigator
- Principal Investigator
  
  NAMBA Kazunori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
The structural study aim to elucidate congenital hearing loss caused by OTOF gene mutationPrincipal Investigator
- Principal Investigator
  
  NAMBA Kazunori
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  独立行政法人国立病院機構東京医療センター(臨床研究センター)
  独立行政法人国立病院機構(東京医療センター臨床研究センター)

All 2019 2018 2017 2016 2015 2013 2012 2011

All Journal Article Presentation Book

[Book] Co-Immunoprecipitation Methods for Brain Tissue2019
- Author(s)
  難波一徳, 金子寛生　他
- Total Pages
  166
- Publisher
  Humana Press
- ISBN
  9781493989850
- Data Source
  KAKENHI-PROJECT-15K10774
[Journal Article] Deterioration in Distortion Product Otoacoustic Emissions in Auditory Neuropathy Patients With Distinct Clinical and Genetic Backgrounds.2018
- Author(s)
  Kyoko Kitao; Hideki Mutai; Kazunori Namba; Noriko Morimoto; Atsuko Nakano; Yukiko Arimoto; Tomoko Sugiuchi; Sawako Masuda; Yasuhide Okamoto; Noriko Morita; Hirokazu Sakamoto; Tomoko Shintani; Satoshi Fukuda; Kimitaka Kaga; Tatsuo Matsunaga
- Journal Title
  
  Ear and Hearing
  
  Volume: Ahead of Print Issue: 1 Pages: 0196-0202
- DOI
  10.1097/aud.0000000000000586
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10774, KAKENHI-PROJECT-18K09336
[Journal Article] Homozygous EDNRB Mutation in a Patient with Waardenburg Syndrome Type 12017
- Author(s)
  Noriko Morimoto, Hideki Mutai, Kazunori Namba, Hiroki Kaneko, Rika Kosaki, Tatsuo Matsunaga
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10773
[Journal Article] Frequency and Specific Characteristics of the Incomplete Partition Type III Inner Ear Anomaly in Children with Hearing Loss2017
- Author(s)
  Ayako Kanno, Hideki Mutai, Kazunori Namba, Noriko Morita, Atsuko Nakano, Noboru Ogahara, Tomoko Sugiuchi, Kaoru Ogawa, Tatsuo Matsunaga
- Journal Title
  
  Laryngoscope
  
  Volume: 印刷中 Issue: 7 Pages: 1663-1669
- DOI
  10.1002/lary.26245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10773
[Journal Article] Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss.2017
- Author(s)
  Yamamoto N, Mutai H, Namba K, Morita N, Masuda S, Nishi Y, Nakano A, Masuda S, Fujioka M, Kaga K, Ogawa K, Matsunaga T.
- Journal Title
  
  Orphanet J Rare Dis
  
  Volume: 25;12(1) Issue: 1 Pages: 157-157
- DOI
  10.1186/s13023-017-0708-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19733, KAKENHI-PROJECT-17H07404, KAKENHI-PROJECT-15K10773, KAKENHI-PROJECT-15K15624, KAKENHI-PROJECT-15H04991
[Journal Article] Clinical characteristics of a Japanese family with hearing loss accompanied by　compound heterozygous mutations in LOXHD12016
- Author(s)
  Minami S, Mutai H, Namba M, Sakamoto H, Matsunaga T
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: S0385-8146 Issue: 6 Pages: 30065-7
- DOI
  10.1016/j.anl.2016.02.010
- NAID
  130005773901
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10773, KAKENHI-PROJECT-25462657
[Journal Article] High prevalence of CDH23 mutation in patients with congenital high-frequency recessive or sporadic hereditary hearing loss2015
- Author(s)
  Mizutari K, Mutai H., Namba K., Miyanaga Y., Nakano A., Arimoto Y., Masuda S., Morimoto N., Sakamoto H., Kaga K., Matsunaga T.
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 10 Issue: 1 Pages: 60-60
- DOI
  10.1186/s13023-015-0276-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592573, KAKENHI-PROJECT-15K10773, KAKENHI-PROJECT-26462572
[Journal Article]2012
- Author(s)
  Matsunaga T, Mutai H, Kunishima S, Namba K, Morimoto N, Shinjo Y, Arimoto Y, Kataoka Y, Shintani T, Morita N, Sugiuchi T, Masuda S, Nakano A, Taiji H, Kaga K.
- Journal Title
  
  Clin Genet
  
  Volume: 82(5) Issue: 5 Pages: 425-32
- DOI
  10.1111/j.1399-0004.2012.01897.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791641, KAKENHI-PROJECT-23591429, KAKENHI-PROJECT-24390391, KAKENHI-PROJECT-24592573
[Presentation] Apoptosis is Associated with Decreased BDNF Signal in the Spiral Ganglion of Otof -deficient Mouse2018
- Author(s)
  Kazunori Namba, Hideki Mutai, Tatsuo Matsunaga
- Organizer
  41th annual midwinter meeting, Association for Research in Otolaryngology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10773
[Presentation] TECTA蛋白の構造解析による新規変異の分子病態予測2017
- Author(s)
  山本修子、難波一徳、務台英樹、森田訓子、松永達雄
- Organizer
  第27回日本耳科学会
- Data Source
  KAKENHI-PROJECT-15K10773
[Presentation] Auditory Neuropathyの特徴を示すOTOF遺伝子欠損マウスを用いた蝸牛神経低形成の新規モデル2013
- Author(s)
  難波一徳、藤井正人、加我君孝、松永達雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24791819
[Presentation] Auditory Neuropathyの特徴を示すOTOF遺伝子欠損マウスを用いた蝸牛神経低形成の新規モデル2013
- Author(s)
  難波一徳、藤井正人、加我君孝、松永達雄
- Organizer
  日本生化学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24791819
[Presentation] 温度感受性Auditory NeuropathyにおけるOTOF遺伝子の新規特異的変異の同定2011
- Author(s)
  松永達雄、新正由紀子、山本聡、難波一徳、務台英樹、加我君孝
- Organizer
  日本耳科学会総会・学術講演会
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22791641

1. Mutai Hideki (60415891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 鈴木喜大 (40712659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 藤岡正人 (70398626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Sawasaki Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OGAWA Kaoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 松永達雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 宮冬樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAMBA Kazunori 難波 一徳

Research Projects

Research Products

Co-Researchers

Construction of a mouse model for Auditory Neuropathy Spectrum DisorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular functional analysis of ZBTB10, the novel candidate deafness gene associated with cochlear nerve hypoplasia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of structural impairments of STAS domain caused by common p.H723R mutation of SLC26A4 in patients with Pendred syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spiral ganglion degeneration in a mouse model of auditory neuropathy spectrum disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The structural study aim to elucidate congenital hearing loss caused by OTOF gene mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Co-Immunoprecipitation Methods for Brain Tissue2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Deterioration in Distortion Product Otoacoustic Emissions in Auditory Neuropathy Patients With Distinct Clinical and Genetic Backgrounds.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homozygous EDNRB Mutation in a Patient with Waardenburg Syndrome Type 12017

Author(s)

Journal Title

Data Source

[Journal Article] Frequency and Specific Characteristics of the Incomplete Partition Type III Inner Ear Anomaly in Children with Hearing Loss2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical characteristics of a Japanese family with hearing loss accompanied by compound heterozygous mutations in LOXHD12016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] High prevalence of CDH23 mutation in patients with congenital high-frequency recessive or sporadic hereditary hearing loss2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article]2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Apoptosis is Associated with Decreased BDNF Signal in the Spiral Ganglion of Otof -deficient Mouse2018

Author(s)

Organizer

Data Source

[Presentation] TECTA蛋白の構造解析による新規変異の分子病態予測2017

NAMBA Kazunori 難波一徳

[Journal Article] Clinical characteristics of a Japanese family with hearing loss accompanied by　compound heterozygous mutations in LOXHD12016