Maita Hiroshi 米田宏

… Alternative Names

MAITA Hiroshi 米田宏

米田宏マイタヒロシ

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Researcher Number	60431318
Other IDs
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Affiliation (Current)	2025: 北海道大学, 薬学研究院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 北海道大学, 薬学研究院, 講師 2011 – 2015: 北海道大学, 薬学研究科(研究院), 講師 2009 – 2010: Hokkaido University, 大学院・薬学研究院, 講師 2007: Hokkaido University, 大学院・薬学研究院, 助教 2006: 北海道大学, 大学院薬学研究院, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Science and Engineering
Keywords	Principal Investigator スプライシング / スプライソソーム / snRNP / CDK9 / ケミカルバイオロジー / 低分子化合物 / スプリットルシフェラーゼ / pre-mRNAスプライシング / 分子生物学 / シグナル伝達 … More / snRNA / レポーター / 核内構造体 / SMN / プロリン異性化 / 阻害剤 / pre-mRNA スプライシング / RNA-seq / 転写スプライシング共役機構 / スプライス部位変異 / fidelity / split luciferase / spliceosome / pre-mRNA splicing / シグナル転達 / 遺伝子 / 網膜色素変性症 Less

スプライソソーム構成因子の改変によるスプライシング制御法の開発Principal Investigator
- Principal Investigator
  
  米田宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Investigation of small molecule compounds that target the cellular defect in spliceosome assembly and function.Principal Investigator
- Principal Investigator
  
  Maita Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
相分離構造体とプロリン異性化の連携機構の解析と可視化ツールの開発Principal Investigator
- Principal Investigator
  
  米田宏
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Chemical approach to elucidate the molecular mechanism for the splice site selectionPrincipal Investigator
- Principal Investigator
  
  Maita Hiroshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Suppression of the splicing mutation based on the molecular mechanism of pre-mRNA splicing fidelityPrincipal Investigator
- Principal Investigator
  
  MAITA Hiroshi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Analysis of the assembly and functional defect of the spliceosome associated with Retinitis pigmentosaPrincipal Investigator
- Principal Investigator
  
  MAITA Hiroshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
A study to elucidate how AdRP-associated mutations in splicing factors affect the spliceosome formation pathwayPrincipal Investigator
- Principal Investigator
  
  MAITA Hiroshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
網膜色素変性症原因遺伝子PAP-1を介した新たなPim-1シグナル伝達経路の解析Principal Investigator
- Principal Investigator
  
  米田宏
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

[Book] Winding and Tangling. An Initial Phase of Membrane-Less Organelle Formation. In: Kurokawa, R. (eds) Phase Separation in Living Cells.2023
- Author(s)
  Hiroshi Maita, Shinichi Nakagawa
- Total Pages
  21
- Publisher
  Springer
- ISBN
  9789819948857
- Data Source
  KAKENHI-PROJECT-23K06093
[Journal Article] BAY61-3606 Alters snRNP Composition and Enhances Usage of Suboptimal Splice Acceptor Site2023
- Author(s)
  Kenji Tomita、Shinichi Nakagawa、Hiroyoshi Ariga、Hiroshi Maita
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 147-157
- DOI
  10.1248/bpb.b22-00471
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20K07028
[Journal Article] Development of a Cell-Based Assay Using a Split-Luciferase Reporter for Compound Screening2023
- Author(s)
  Sato Satoshi、Ariga Hiroyoshi、Maita Hiroshi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 7 Pages: 1010-1014
- DOI
  10.1248/bpb.b23-00042
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-07-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06093
[Journal Article] The cell type‐specific ER membrane protein UGS148 is not essential in mice2021
- Author(s)
  Takahashi Osamu、Tanahashi Mayuko、Yokoi Saori、Kaneko Mari、Yanaka Kaori、Nakagawa Shinichi、Maita Hiroshi
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 1 Pages: 43-60
- DOI
  10.1111/gtc.12910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04889, KAKENHI-PUBLICLY-20H04687, KAKENHI-PUBLICLY-21H05708, KAKENHI-PROJECT-17H03604, KAKENHI-PROJECT-20K07028, KAKENHI-PROJECT-21K19246, KAKENHI-PROJECT-19K16247, KAKENHI-PLANNED-21H05274
[Journal Article] What is the switch for coupling transcription and splicing? RNA Polymerase II C-terminal domain phosphorylation, phase separation and beyond. (Review)2020
- Author(s)
  Maita H, Nakagawa S.
- Journal Title
  
  Wiley interdisciplinary reviews. RNA.
  
  Volume: 11 Issue: 1
- DOI
  10.1002/wrna.1574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08225, KAKENHI-PROJECT-16H06279
[Journal Article] A Splicing Reporter Tuned to Non-AG Acceptor Sites Reveals that Luteolin Enhances the Recognition of Non-canonical Acceptor Sites.2016
- Author(s)
  Msanori Chiba, Hiroyoshi Ariga, Hiroshi Maita
- Journal Title
  
  Chemical Biology and Drug Design
  
  Volume: 87 Issue: 2 Pages: 275-282
- DOI
  10.1111/cbdd.12656
- NAID
  120006581491
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460057
[Journal Article] A split luciferase-based reporter for detection of a cellular macromolecular complex.2014
- Author(s)
  Hiroshi Maita, Kenji Tomita, Hiroyoshi Ariga
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 452 Pages: 1-9
- DOI
  10.1016/j.ab.2014.01.015
- NAID
  120005460254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790068, KAKENHI-PROJECT-25460057
[Journal Article] A split luciferase-based reporter for detection of a cellular macromolecular complex2014
- Author(s)
  Maita H., Tomita K. and Ariga H
- Journal Title
  
  Anal. Biochem
  
  Volume: 452 Pages: 1-9
- NAID
  120005460254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790068
[Journal Article] Spliceosome discards intermediates via the DEAH box ATPase Prp43p.2010
- Author(s)
  Mayas R.M., Maita H., Semlow D.R., Staley J.P.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 107
  
  Pages: 10020-10025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790056
[Journal Article] Secretion of DJ-1 into the serum of patients with Parkinson's disease.2008
- Author(s)
  Chinatsu Maita
- Journal Title
  
  Neuroscience Letters 431
  
  Pages: 86-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890001
[Journal Article] Specific cleavage of DJ-1 under an oxidative condition.2006
- Author(s)
  Ooe, H., Maita, C., Maita, H., Iguchi-Ariga, S.M., Ariga, H.
- Journal Title
  
  Neuroscience Letters 406
  
  Pages: 165-168
- Data Source
  KAKENHI-PROJECT-18890001
[Journal Article] Exon ligation is proofread by the DExD/H-box ATPase Prp22p.2006
- Author(s)
  Mayas, R.M., Maita, H., Staley, J.P.
- Journal Title
  
  Nature Structual and Molecular Biology 13
  
  Pages: 482-490
- Data Source
  KAKENHI-PROJECT-18890001
[Presentation] Elucidation of an assembly mechanism of cytoplasmic U-bodies2023
- Author(s)
  杉栞太朗、嶋田雄大、湯浅博晶、中川真一、米田宏
- Organizer
  日本RNA学会
- Data Source
  KAKENHI-PROJECT-23K06093
[Presentation] Rapid separation of SMN from Coilin induce○d by small molecules2023
- Author(s)
  Saki Ohazama, Shinichi Nakagawa, Hiroshi Maita
- Organizer
  RNA 2023 (The 28th Annual Meeting of the RNA Society)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06093
[Presentation] SMNタンパク質のプロリン異性化によるCajal bodyとGem形成の制御機構2021
- Author(s)
  大峽咲希、中川真一、米田宏
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-20H04687
[Presentation] 天然物を用いたsnRNP形成機構の解明2021
- Author(s)
  米田　宏
- Organizer
  第２３回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07028
[Presentation] SMNタンパク質のプロリン異性化によるCajal bodyとGem形成の制御機構2021
- Author(s)
  大峽咲希、中川真一、米田　宏
- Organizer
  第４４回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07028
[Presentation] 天然物を用いたsnRNP形成機構の解明2021
- Author(s)
  米田宏
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PUBLICLY-20H04687
[Presentation] CDK9阻害剤のスプライシング調節メカニズムの解析2020
- Author(s)
  米田　宏
- Organizer
  第４３回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07028
[Presentation] Chemical approach to elucidate the regulatory mechanisms of snRNP biogenesis2019
- Author(s)
  米田　宏
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08225
[Presentation] 翻訳抑制作用を示す化合物による U-body 誘導機構の解析2018
- Author(s)
  米田　宏
- Organizer
  日本RNA学会
- Data Source
  KAKENHI-PROJECT-16K08225
[Presentation] Chemical approach to study how membrane-less organelles control RNA processing2018
- Author(s)
  米田　宏
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K08225
[Presentation] 高等真核生物がスプライス部位認識の正確性と柔軟性を両立する仕組み2017
- Author(s)
  米田　宏
- Organizer
  日本分子生物学会第40回年会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K08225
[Presentation] スプライス部位認識の正確性を緩める化合物の作用機構2017
- Author(s)
  米田　宏
- Organizer
  日本RNA学会第19回年会
- Data Source
  KAKENHI-PROJECT-16K08225
[Presentation] 変異スプライス部位でのスプライシングを誘導する化合物の発見と解析2017
- Author(s)
  米田　宏
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-16K08225
[Presentation] Identification of small compounds that affect the cellular snRNP levels2016
- Author(s)
  米田　宏
- Organizer
  RNA2016
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2016-06-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460057
[Presentation] スプライシング異常を改善する生薬由来化合物の探索2015
- Author(s)
  千葉政徳、有賀寛芳、米田宏
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市、神戸学院大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25460057
[Presentation] アクセプター部位変異存在下でスプライシングを回復させる化合物の探索2015
- Author(s)
  米田　宏
- Organizer
  日本RNA学会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25460057
[Presentation] Detection of Cellular U5 snRNP Levels Using Split Luciferase2014
- Author(s)
  Maita H. and Ariga H
- Organizer
  The 16^<th> Annual Meeting of the RNA Society
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23790068
[Presentation] Screening of compounds affecting spliceosome formation by a split luciferase-based snRNP reporter2013
- Author(s)
  冨田健司、有賀寛芳、米田宏
- Organizer
  日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市、神戸国際展示場
- Data Source
  KAKENHI-PROJECT-25460057
[Presentation] 細胞内snRNP量を変化させる化合物の探索2013
- Author(s)
  米田　宏
- Organizer
  日本RNA学会年会
- Place of Presentation
  愛媛県松山市、ひめぎんホール
- Data Source
  KAKENHI-PROJECT-23790068
[Presentation] Analysis of the spliceosome formation by a newly developed snRNP reporter2012
- Author(s)
  Tomita K., Ariga H. and Maita H
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23790068
[Presentation] A possible role for Prp3-Sad1/USP39 interaction in the spliceosomal assembly2011
- Author(s)
  Shiida M., Ariga H. and Maita H
- Organizer
  日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23790068
[Presentation] Detection of free U5 snRNP level in living cells2010
- Author(s)
  米田宏
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790056
[Presentation] Detection of free U5 snRNP levels in living cells2010
- Author(s)
  Maita, H., Ariga, H.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790056
[Presentation] split Luciferaseを応用した新規U5 snRNP検出法の確立2009
- Author(s)
  米田宏
- Organizer
  日本RNA学会
- Place of Presentation
  新潟・朱鷺メッセ
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-21790056
[Presentation] Split Luciferaseを応用した新規U5 snRNP検出法の確立2009
- Author(s)
  Maita, H., Ariga, H.
- Organizer
  第11回日本RNA学会年会
- Place of Presentation
  新潟県
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-21790056
[Presentation] 網膜色素変性症(RP9)の原因遺伝子PAP-1/RP9hの結合因子の探索2007
- Author(s)
  米田宏
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18890001
[Presentation] Detection of Free U5 snRNP Levels Using Split Luciferase
- Author(s)
  米田　宏
- Organizer
  RNA society meeting 2011
- Place of Presentation
  京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23790068

1. 横井佐織

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maita Hiroshi 米田 宏

MAITA Hiroshi 米田 宏

米田 宏 マイタ ヒロシ

Research Projects

Research Products

Co-Researchers

スプライソソーム構成因子の改変によるスプライシング制御法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of small molecule compounds that target the cellular defect in spliceosome assembly and function.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

相分離構造体とプロリン異性化の連携機構の解析と可視化ツールの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chemical approach to elucidate the molecular mechanism for the splice site selectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of the splicing mutation based on the molecular mechanism of pre-mRNA splicing fidelityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the assembly and functional defect of the spliceosome associated with Retinitis pigmentosaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study to elucidate how AdRP-associated mutations in splicing factors affect the spliceosome formation pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

網膜色素変性症原因遺伝子PAP-1を介した新たなPim-1シグナル伝達経路の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Winding and Tangling. An Initial Phase of Membrane-Less Organelle Formation. In: Kurokawa, R. (eds) Phase Separation in Living Cells.2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] BAY61-3606 Alters snRNP Composition and Enhances Usage of Suboptimal Splice Acceptor Site2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Development of a Cell-Based Assay Using a Split-Luciferase Reporter for Compound Screening2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The cell type‐specific ER membrane protein UGS148 is not essential in mice2021

Author(s)

Journal Title

DOI

Maita Hiroshi 米田宏

MAITA Hiroshi 米田宏

米田宏マイタヒロシ