Araki Kenichirou 新木健一郎

… Alternative Names

新木健一郎アラキケンイチロウ

Araki Kenichiro 新木健一郎

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Researcher Number	60431706
Other IDs
Affiliation (Current)	2025: 群馬大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023: 群馬大学, 医学部附属病院, 講師 2020 – 2021: 群馬大学, 医学部附属病院, 講師 2017 – 2021: 群馬大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator OT-Iマウス / 抗原特異的疲弊化CD8T細胞 / 免疫治療耐性 / 骨格筋減少 / 免疫耐性獲得機構 / BCAA / Hepa1-6 / 肝癌 / 筋萎縮 / PGC-1α過剰発現マウス … More / PGC-1αマウス / 肝筋連関 / 肝再生率 / PGC1αマウス / 肝筋相関 / 分岐鎖アミノ酸 / 肝切除 / 肝再生 / サルコペニア / 膵臓癌 / サイトカイン / 膵癌 / コノフィリン / 癌関連線維芽細胞 … More Except Principal Investigator 肝臓外科 / 肝再生 / 肝細胞 / Galectin 3阻害剤 / マウス皮下腫瘍モデル / 肝胆膵癌 / M2BPGi / 癌関連線維芽細胞 / 肝胆膵がん Less

Impact of sarcopenia and creation of novel therapeutic targets by immunotherapeutic resistance mechanisms in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  新木健一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlationPrincipal Investigator
- Principal Investigator
  
  Araki Kenichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor
- Principal Investigator
  
  Harimoto Norifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Development of novel therapeutic agents targeting cancer-associated fibroblasts (CAFs) via suppression of fibrosis in pancreatic cancer.Principal Investigator
- Principal Investigator
  
  Araki Kenichiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Gunma University

All 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021
- Author(s)
  Gantumur D, Harimoto N, Muranushi R, Hoshino K, Batbayar C, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Yokobori T, Aishima S, Shirabe K.
- Journal Title
  
  Hepatol Res .
  
  Volume: Online ahead of print. Issue: 10 Pages: 1058-1063
- DOI
  10.1111/hepr.13648
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021
- Author(s)
  Yamanaka T, Harimoto N, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Handa T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Umezawa K, Shirabe K.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: Online ahead of print. Issue: 6 Pages: 1019-1028
- DOI
  10.1158/1535-7163.mct-20-0150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16352
[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020
- Author(s)
  Yamanaka Takahiro、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Handa Tadashi、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 7 Pages: 986-994
- DOI
  10.1038/s41416-020-0744-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16199
[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020
- Author(s)
  Dolgormaa Gantumur、Harimoto Norifumi、Ishii Norihiro、Yamanaka Takahiro、Hagiwara Kei、Tsukagoshi Mariko、Igarashi Takamichi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Handa Tadashi、Yokobori Takehiko、Oyama Tetsunari、Kuwano Hiroyuki、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 123 Issue: 7 Pages: 1145-1153
- DOI
  10.1038/s41416-020-0971-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16199, KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-18K07665
[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019
- Author(s)
  Hagiwara Kei、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Gantumur Dorgormaa、Yamanaka Takahiro、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Hosouchi Yasuo、Shirabe Ken
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 27 Issue: 3 Pages: 924-930
- DOI
  10.1245/s10434-019-07708-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019
- Author(s)
  Ishii Norihiro、Harimoto Norifumi、Araki Kenichiro、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Yamanaka Takahiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Shirabe Ken
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 12 Pages: 1398-1405
- DOI
  10.1111/hepr.13412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.2019
- Author(s)
  Ishii N, Araki K (Corresponding Author), Yokobori T, Hagiwara K, Dorgormaa G, Yamanaka T, Handa T, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Harimoto N, Masamune A, Umezawa K, Kuwano H, Shirabe K.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 1 Pages: 334-344
- DOI
  10.1111/cas.13847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16529
[Journal Article] Response to the letter by Dr. Naoya Yamada, and Dr. Koichi Mizuta regarding our manuscript: "Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis".2019
- Author(s)
  Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M.
- Journal Title
  
  J Gastroenterol
  
  Volume: 54 Issue: 2 Pages: 206-7
- DOI
  10.1007/s00535-018-1524-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-16K15606
[Journal Article] Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis.2018
- Author(s)
  Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 53 Issue: 7 Pages: 819-826
- DOI
  10.1007/s00535-017-1425-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-16K15606
[Patent] コノフィリンまたはその薬理学的に許容される塩を有効成分とする癌関連線維芽細胞抑制剤および癌治療用医薬2018
- Inventor(s)
  調憲、新木健一郎、石井範洋、梅澤一夫
- Industrial Property Rights Holder
  調憲、新木健一郎、石井範洋、梅澤一夫
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2019-038751
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K16529
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020
- Author(s)
  山中崇弘、播本憲史、村主遼、星野弘毅、萩原慶、石井範洋、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、新木健一郎、梅澤一夫、調憲
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-18H02877
[Presentation] Conophyllineは癌関連線維芽細胞の抑制を介して膵癌の進展を抑制する2019
- Author(s)
  石井範洋、新木健一郎、萩原慶、山中崇弘、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、梅澤一夫、桑野博行、調　憲
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16529
[Presentation] Conophyllineを用いた癌関連線維芽細胞を標的とした膵癌の新規治療法の開発2018
- Author(s)
  石井範洋、新木健一郎、萩原慶、山中崇弘、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、播本憲史、梅澤一夫、桑野博行、調　憲
- Organizer
  第49日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K16529
[Presentation] Conophylline inhibits pancreatic cancer progression via suppression of cancer promoting cytokines produced by cancer-associated fibroblast.2018
- Author(s)
  Norihiro Ishii, Kenichiro Araki, Kei Hagiwara, Dorgormaa Gantumur, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Norihumi Harimoto, Kazuo Umezawa, Hiroyuki Kuwano, Ken Shirabe
- Organizer
  13th IHPBA World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16529
[Presentation] Conophyllineは癌関連線維芽細胞の抑制を介して膵癌の進展を抑制する2018
- Author(s)
  石井範洋、新木健一郎、萩原　慶、山中崇弘、塚越真梨子、五十嵐隆通、渡辺　亮、久保憲生、梅澤一夫、桑野博行、調　憲
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16529
[Presentation] 癌関連線維芽細胞を標的とした膵癌の新規治療に関する基礎的研究2017
- Author(s)
  石井範洋、新木健一郎、山中崇弘、塚越真梨子、五十嵐隆通、渡辺　亮、久保憲生、梅澤一夫、桑野博行、調　憲
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K16529
[Presentation] Novel therapeutic strategy for pancreatic cancer by targeting cancer-associated fibroblast.2017
- Author(s)
  Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Hiroyuki Kuwano, Ken Shirabe
- Organizer
  JDDW2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16529

1. Shirabe Ken (70264025)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. Harimoto Norifumi (00419582)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
3. 塚越真梨子 (60781317)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. 久保憲生 (10464744)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
5. 五十嵐隆通 (20648472)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
6. 渡辺亮 (60738847)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
7. 石井範洋 (00711508)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
8. 横堀武彦 (60420098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Umezawa Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 半田正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Araki Kenichirou 新木 健一郎

新木 健一郎 アラキ ケンイチロウ

Araki Kenichiro 新木 健一郎

Research Projects

Research Products

Co-Researchers

Impact of sarcopenia and creation of novel therapeutic targets by immunotherapeutic resistance mechanisms in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic agents targeting cancer-associated fibroblasts (CAFs) via suppression of fibrosis in pancreatic cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Response to the letter by Dr. Naoya Yamada, and Dr. Koichi Mizuta regarding our manuscript: "Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis".2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis.2018

Author(s)

Journal Title

DOI

Araki Kenichirou 新木健一郎

新木健一郎アラキケンイチロウ

Araki Kenichiro 新木健一郎

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020