Ishiguro Kazuhiro 石黒和博

… Alternative Names

ISHIGURO Kazuhiro 石黒和博

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Researcher Number	60432275
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2018: 名古屋大学, 医学部, 招へい教員 2016: 名古屋大学, 医学系研究科, 招へい教員 2014: 名古屋大学, 医学(系)研究科(研究院), 准教授 2013 – 2014: 名古屋大学, 医学(系)研究科(研究院), 特任准教授 2013: 名古屋大学, 医学系研究科, 特任准教授 … More 2012: 名古屋大学, 医学(系)研究科(研究院), 准教授 2011: 名古屋大学, 医学(系)研究科(研究院), 寄附講座准教授 2011: 名古屋大学, 大学院・医学系研究科, 講座准教授 2009 – 2011: Nagoya University, 大学院・医学系研究科, 寄附講座准教授 2008: 名古屋大学, 医学部, 准教授 2008: Nagoya University, 医学部・寄附講座, 准教授 2007: Nagoya University, 医学部, 寄附講座准教授 Less
Review Section/Research Field	Principal Investigator General pharmacology / Gastroenterology / General internal medicine (including Psychosomatic medicine) Except Principal Investigator Gastroenterology
Keywords	Principal Investigator サイトカイン / 炎症 / 腸炎 / 生薬 / ケモカイン / マクロファージ / 炎症性腸疾患 / primary fibroblasts / 腸内細菌 / lipopolysaccharide … More / T細胞 / 天然化合物 / ミトコンドリア / lipopolyscharide / 伝統薬物 … More Except Principal Investigator 化学療法 / DNAメチル化 / マイクロアレイ / ＤＮＡメチル化 / 遺伝子発現 / 薬剤耐性 / 消化器癌 Less

Regulation of Cytokine/Chemokine Production and Anti-inflammatory therapy by Natural ProductsPrincipal Investigator
- Principal Investigator
  
  Ishiguro Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya University
Specific reduction in cytokine production with natural compoundsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
Gene analysis of gastrointestinal (esophagus, stomach and colorectum) cancer related with pathogenesis and treatment
- Principal Investigator
  
  MAEDA Osamu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya University
Development of novel strategy for the treatment of inflammatory diseases with natural products such as herbal ingredientsPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
Development of anti-inflammatory therapy targeting macrophagesPrincipal Investigator
- Principal Investigator
  
  ISHIGURO Kazuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Nagoya University

All 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

[Journal Article] Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction2017
- Author(s)
  Kazuhiro Ishiguro, Osamu Watanabe, Masanao Watanabe, Takeshi Yamarua, Masanobu Matsushita, Hidemi Goto, Yoshiki Hirooka
- Journal Title
  
  Clinical Immunology
  
  Volume: 180 Pages: 120-127
- DOI
  10.1016/j.clim.2017.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09306
[Journal Article] Combinational use of lipid-based reagents for efficient transfection of primary fibroblasts and hepatoblasts2017
- Author(s)
  Kazuhiro Ishiguro, Osamu Watanabe, Masanao Watanabe, Takeshi Yamarua, Masanobu Matsushita, Hidemi Goto, Yoshiki Hirooka
- Journal Title
  
  Biotechniques
  
  Volume: 63 Issue: 1 Pages: 37-39
- DOI
  10.2144/000114569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09306
[Journal Article] S100G expression and function in fibroblasts on colitis induction2016
- Author(s)
  Kazuhiro Ishiguro, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Takafumi Ando, Hidemi Goto, Yoshiki Hirooka
- Journal Title
  
  International Immunopharmacology
  
  Volume: 39 Pages: 92-96
- DOI
  10.1016/j.intimp.2016.07.017
- NAID
  120005893264
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K09306
[Journal Article] Alteration of gene expression and DNA methylation in drug-resistant gastric cancer2014
- Author(s)
  Osamu Maeda, Takafumi Ando, Naoki Ohmiya, Kazuhiro Ishiguro, Osamu Watanabe, Ryoji Miyahara, Yoko Hibi, Taku Nagai, Kiyofumi Yamada, Hidemi Goto
- Journal Title
  
  Oncology Reports
  
  Volume: 31 Pages: 1883-1890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590914
[Journal Article] Suppressive action of acetate on interleukin-8 production via tubulin alpha acetylation.2014
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
- Journal Title
  
  Immunology and Cell Biology
  
  Volume: 92 Issue: 7 Pages: 624-630
- DOI
  10.1038/icb.2014.31
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590317
[Journal Article] ＤＮＡメチル化と正常大腸 ―特に field cancerization について―2012
- Author(s)
  前田修、安藤貴文、石黒和博、渡辺修、日比陽子、永井拓、山田清文、舩坂好平、宮原良二、大宮直木、後藤秀実、Jean-Pierre J.Issa
- Journal Title
  
  生物物理化学
  
  Volume: 56
- NAID
  130004456515
- Data Source
  KAKENHI-PROJECT-23590914
[Journal Article] Tubulin alpha functions as an adaptor for NFAT-importin beta interaction2011
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
- Journal Title
  
  J. Immunol
  
  Volume: 186 Pages: 2710-2713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] De hydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages2011
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
- Journal Title
  
  Int. Immunopharmacol
  
  Volume: 11 Pages: 1362-1367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] Tubulin α functions as an adaptor for NFAT-importin β interaction2011
- Author(s)
  石黒和博, ら
- Journal Title
  
  Journal of Immunology
  
  Volume: 186 Issue: 5 Pages: 2710-3
- DOI
  10.4049/jimmunol.1003322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages2011
- Author(s)
  石黒和博, ら
- Journal Title
  
  International Immunopharmacology
  
  Volume: 11 Issue: 9 Pages: 1362-7
- DOI
  10.1016/j.intimp.2011.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] Novel application of low pH-dependent fluorescent dyes to examine colitis2010
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando, Osamu Watanabe, Hidemi Goto
- Journal Title
  
  BMC Gastroenterol
  
  Volume: 10 Pages: 4-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] Novel mouse model of colitis characterized by hapten-protein visualization2010
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Osamu Watanabe, Hidemi Goto
- Journal Title
  
  Biotechniques
  
  Volume: 49 Pages: 641-648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] Novel application of low pH-dependent fluorescent dyes to examine colitis2010
- Author(s)
  石黒和博, ら
- Journal Title
  
  BMC Gastroenterology 10
  
  Pages: 4-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590278
[Journal Article] Specific reaction of α, β-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage.2008
- Author(s)
  Kazuhiro Ishiguro, et al
- Journal Title
  
  FEBS Letters
  
  Volume: 582 Pages: 3531-3536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Journal Article] Novel application of 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole to visualize lysosomes in live cells2008
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando and Hidemi Goto
- Journal Title
  
  BioTechniques 45
  
  Pages: 465-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Journal Article] Novel application of 4-nitro-7-(1-piperazinyl)-2, 1, 3-benzoxadiazole to visualize lysosomes in live cells.2008
- Author(s)
  Kazuhiro Ishiguro, et al
- Journal Title
  
  Biotechniques
  
  Volume: 45 Pages: 465-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Journal Article] Specific reaction of α, β-unsaturated carbonyl compounds such as 6 shogaol with sulfhydryl groups in tubulin leading to microtubule damage2008
- Author(s)
  Kazuhiro Ishiguro, Takafumi Ando, Osamu Watanabe and Hidemi Goto
- Journal Title
  
  FEBS Letters 582
  
  Pages: 3531-3536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Journal Article] Bc110 is phosphorylated on Serl38 by Ca^<2+>/calmodulin-dependent protein kinase II2007
- Author(s)
  Kazuhiro Ishiguro, et. al.
- Journal Title
  
  Molecular Immunology 44
  
  Pages: 2105-2110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Journal Article] Acetate inhibits NFAT activation in T cells via importin betal interference2007
- Author(s)
  Kazuhiro Ishiguro, et. al.
- Journal Title
  
  European Journal of Immunology 37
  
  Pages: 2309-2316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Journal Article] Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms2007
- Author(s)
  Kazuhiro Ishiguro, et. al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 362
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590691
[Patent] 腸管粘膜蛍光観察用検査試薬2010
- Inventor(s)
  石黒和博
- Industrial Property Rights Holder
  名古屋大学
- Filing Date
  2010-08-02
- Overseas
- Data Source
  KAKENHI-PROJECT-21590278
[Patent] 活性化マクロファージ特異的細胞死誘導薬2009
- Inventor(s)
  石黒和博, ら
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2009-284267
- Filing Date
  2009-12-22
- Data Source
  KAKENHI-PROJECT-21590278
[Patent] 微小管破壊剤及びそれを含有する癌細胞増殖抑制剤2008
- Inventor(s)
  石黒和博, ら
- Industrial Property Rights Holder
  名古屋大学
- Filing Date
  2008-05-01
- Overseas
- Data Source
  KAKENHI-PROJECT-19590691
[Patent] 活性化マクロファージ特異的細胞死誘導薬2008
- Inventor(s)
  石黒和博
- Industrial Property Rights Holder
  名古屋大学
- Filing Date
  2008-12-22
- Data Source
  KAKENHI-PROJECT-21590278
[Patent] 微小管破壊剤及びそれを含有する癌細胞増殖抑制剤2008
- Inventor(s)
  石黒和博、安藤貴文、後藤秀実
- Industrial Property Rights Holder
  国立大学法人名古屋大学
- Filing Date
  2008-05-01
- Overseas
- Data Source
  KAKENHI-PROJECT-19590691
[Presentation] シスプラチンおよびフッ化ピリミジンへの耐性胃癌のマイクロアレイを用いた遺伝子発現およびDNAメチル化解析2013
- Author(s)
  前田修、安藤貴文、石黒和博、渡辺修、宮原良二、中村正直、舩坂好平、後藤秀実
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜(パシフィコ横浜)(一般演題, 口演)
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-23590914
[Presentation] 腸内細菌代謝産物による大腸上皮のケモカイン産生制御2013
- Author(s)
  石黒和博、安藤貴文、後藤秀実
- Organizer
  第５０回日本消化器免疫学会総会　シンポジウム
- Place of Presentation
  ホテルグランドヒル市ヶ谷、東京都新宿区
- Data Source
  KAKENHI-PROJECT-24590317
[Presentation] ハプテンータンパク複合体を蛍光観察できる新しい腸炎モデルの開発2011
- Author(s)
  石黒和博, ら
- Organizer
  第48回日本消化器免疫学会総会
- Place of Presentation
  石川県金沢市
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21590278
[Presentation] ハプテン-タンパク複合体を蛍光観察できる新しい腸炎モデルの開発2011
- Author(s)
  石黒和博
- Organizer
  第48回日本消化器免疫学会総会
- Place of Presentation
  石川県金沢市
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21590278
[Presentation] 大腸粘膜蛍光観察検査試薬の開発2010
- Author(s)
  石黒和博, ら
- Organizer
  第47回日本消化器免疫学会総会
- Place of Presentation
  滋賀県大津市大津プリンスホテル
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21590278
[Presentation] 大腸粘膜蛍光観察検査試薬の開発2010
- Author(s)
  石黒和博
- Organizer
  第47回日本消化器免疫学会総会
- Place of Presentation
  滋賀県大津市
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21590278
[Presentation] 大腸粘膜の腺管および炎症細胞の新しい蛍光観察法2009
- Author(s)
  石黒和博, ら
- Organizer
  JDDW 2009 シンポジウム
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590278
[Presentation] 大腸粘膜の腺管および炎症細胞の新しい蛍光観察法2009
- Author(s)
  石黒和博
- Organizer
  JDDW 2009シンポジウム
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21590278
[Presentation] T細胞においてCaMKIIはCarma1のリン酸化を介してNF-kappaBの活性化を制御している2007
- Author(s)
  石黒和博, ら
- Organizer
  第44回日本消化器免疫学会総会口演
- Place of Presentation
  東京
- Year and Date
  2007-07-08
- Data Source
  KAKENHI-PROJECT-19590691
[Presentation] Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation2007
- Author(s)
  Kazuhiro Ishiguro, et. al.
- Organizer
  13th International Congress of Mucosal Immunology, oral
- Place of Presentation
  Tokyo
- Year and Date
  2007-07-09
- Data Source
  KAKENHI-PROJECT-19590691
[Presentation] 腸内細菌の主要代謝産物である酢酸の作用機序とバイオマーカー
- Author(s)
  石黒和博
- Organizer
  第４９回日本消化器免疫学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24590317
[Presentation] シスプラチンおよびフッ化ピリミジンへの耐性胃癌のマイクロアレイを用いた遺伝子発現およびＤＮＡメチル化解析
- Author(s)
  前田修、安藤貴文、石黒和博、渡辺修、宮原良二、中村正直、舩坂好平、後藤秀実
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-23590914
[Presentation] ハプテン－タンパク複合体を蛍光観察できる新しい腸炎モデル
- Author(s)
  石黒和博
- Organizer
  第９８回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590317
[Presentation] 腸内細菌主要代謝産物である酢酸が発揮するT細胞活性化制御の分子機序
- Author(s)
  石黒和博
- Organizer
  第９回日本消化管学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590317
[Presentation] Novel mouse model of colitis to visualize hapten-protein formation
- Author(s)
  石黒和博
- Organizer
  International Ulcer Week 2012, 14th International Conference of Ulcer Research Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24590317

1. GOTO Hidemi (10215501)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. ANDO Takafumi (80378041)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. MAEDA Osamu (20378053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. WATANABE Osamu (80378059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. OHMIYA Naoki (00335035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. MIYAHARA Ryoji (50378056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Ishiguro Kazuhiro 石黒 和博

ISHIGURO Kazuhiro 石黒 和博

Research Projects

Research Products

Co-Researchers

Regulation of Cytokine/Chemokine Production and Anti-inflammatory therapy by Natural ProductsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Specific reduction in cytokine production with natural compoundsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene analysis of gastrointestinal (esophagus, stomach and colorectum) cancer related with pathogenesis and treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel strategy for the treatment of inflammatory diseases with natural products such as herbal ingredientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of anti-inflammatory therapy targeting macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combinational use of lipid-based reagents for efficient transfection of primary fibroblasts and hepatoblasts2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] S100G expression and function in fibroblasts on colitis induction2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Alteration of gene expression and DNA methylation in drug-resistant gastric cancer2014

Author(s)

Journal Title

Data Source

[Journal Article] Suppressive action of acetate on interleukin-8 production via tubulin alpha acetylation.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ＤＮＡメチル化と正常大腸 ―特に field cancerization について―2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Tubulin alpha functions as an adaptor for NFAT-importin beta interaction2011

Author(s)

Journal Title

Data Source

[Journal Article] De hydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages2011

Author(s)

Journal Title

Data Source

[Journal Article] Tubulin α functions as an adaptor for NFAT-importin β interaction2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages2011

Author(s)

Ishiguro Kazuhiro 石黒和博

ISHIGURO Kazuhiro 石黒和博