Takeda Norifumi 武田憲文

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TAKEDA NORIFUMI 武田憲文

TAKEDA Norifumi 武田憲文

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Researcher Number	60436483
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 講師 2025: 東京大学, 医学部附属病院, 届出診療員
Affiliation (based on the past Project Information) *help	2019 – 2025: 東京大学, 医学部附属病院, 助教 2013 – 2017: 東京大学, 医学部附属病院, 助教 2009 – 2010: The University of Tokyo, 医学部附属病院, 助教 2008: The University of Tokyo, 医学部・附属病院, 特任助教 2008: The University of Tokyo, 医学部附属病院, 特任教員 2007: The University of Tokyo, 医学部附属病院, 医員 2007: 東京大学, 医学部附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Circulatory organs internal medicine / Medium-sized Section 52:General internal medicine and related fields / Cardiovascular medicine
Keywords	Principal Investigator 創薬 / 心筋再生 / 心不全 / 心線維化 / KLF5 / 心肥大 / 内皮機能障害 / 特発性肺高血圧症 / BMPR2遺伝子 / 血管新生 … More / 血管内皮障害 / 肺動脈性肺高血圧症 / 大動脈瘤 / ロイスディーツ症候群 / TGFβシグナル / マクロファージ / 動脈瘤 / マルファン症候群 / 心筋梗塞 / Hippo-YAP経路 / 心筋細胞分裂 / 分裂能 / 心筋細胞 / YAP / Hippo経路 / 細胞周期 / Fucciシステム / 成体心筋細胞 / IGF-1 / 線維芽細胞 / 心リモデリング / 心筋リモデリング / 心線維芽細胞 / 転写因子 … More Except Principal Investigator FBN1 / マルファン症候群 / メタボリックシンドローム / 動脈硬化 / 機械学習 / 表現型 / 自然言語処理 / 大動脈疾患 / 遺伝子解析 / 細胞機能解析 / 遺伝性大動脈疾患 / 遺伝子改変マウス / MYH11 / TGFベータ受容体 / 家族性大動脈疾患 / 遺伝子改変動物 / 機能解析 / 大動脈瘤 / 大動脈解離 / 家族性疾患 / 脂肪細胞 / 肥満 / 炎症 / マクロファージ / 癌 / ナノ材料 / トランスレーショナルリサーチ / 循環器・高血圧 / KLF5 / 糖尿病 / 転写因子 / 組織リモデリング / 線維化 / 慢性腎疾患 / 慢性炎症 / 上皮-間葉移行 Less

肺細動脈内皮細胞の機能変容に焦点を当てた新規肺高血圧モデルの病態解明と治療法開発Principal Investigator
- Principal Investigator
  
  武田憲文
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
自然言語処理の応用によるマルファン症候群の遺伝子型と表現型の対応に関する研究
- Principal Investigator
  
  野木森宜嗣
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
Role of pulmonary endothelial dysfunction in idiopathic pulmonary hypertensionPrincipal Investigator
- Principal Investigator
  
  武田憲文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  The University of Tokyo
Pathophysiological role of inflammatory and metabolic signals during aortic aneurysm formation in Marfan syndromePrincipal Investigator
- Principal Investigator
  
  TAKEDA NORIFUMI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Enhancement of the endogeneous cardiac regeneration via activation of Hippo-YAP signaling pathwayPrincipal Investigator
- Principal Investigator
  
  TAKEDA NORIFUMI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
Elucidating the pathophysiology of inherited aortic diseases by combinational approach of genetic diagnosis and biotechnologies
- Principal Investigator
  
  Yasushi Imai
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Analysis of cell cycle regulators in adult cardiomyocytesPrincipal Investigator
- Principal Investigator
  
  TAKEDA NORIFUMI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
心肥大や心不全における非心筋細胞の役割Principal Investigator
- Principal Investigator
  
  武田憲文
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
マクロファージニッチによる心血管代謝疾患発症機構の解明と治療法開発
- Principal Investigator
  
  永井良三
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
上皮間葉移行(EMT)による心血管リモデリングの分子機構解明
- Principal Investigator
  
  永井良三
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
病態診断機能を持つ高機能化ナノ粒子による心血管疾患診断・治療法の開発
- Principal Investigator
  
  眞鍋一郎
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Elucidation of cell type-specific KLF5 function and identification of novel mediators of KLF5 activity.Principal Investigator
- Principal Investigator
  
  TAKEDA Norifumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo

[Book] 血管医学：血管再生のメカニズム2016
- Author(s)
  藤原隆行, 武田憲文, 小室一成.
- Total Pages
  7
- Publisher
  メディカルビュー社
- Data Source
  KAKENHI-PROJECT-15K09132
[Book] 医学書院：マルファン症候群と類縁疾患2015
- Author(s)
  武田憲文, 藤田大司, 犬塚亮, 谷口優樹, 縄田寛, 山内治雄, 加藤昌義, 西村敬史, 永原幸, 中島淳, 小野稔, 小室一成.
- Publisher
  呼吸と循環
- Data Source
  KAKENHI-PROJECT-15K09132
[Book] Annual Review 循環器 2015：生体心筋細胞は分裂するのか？2015
- Author(s)
  武田憲文, 原弘典, 小室一成.
- Total Pages
  7
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15K09132
[Book] Annual Review 2015.2015
- Author(s)
  武田憲文, 原弘典, 小室一成.
- Total Pages
  317
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25893043
[Book] 治療2014
- Author(s)
  武田憲文
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-25893043
[Journal Article] PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice2023
- Author(s)
  Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Katoh M, Maemura S, Suzuki T, Takiguchi H, Yanase T, Kubota Y, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Nishimura S, Komuro I.
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 17 Pages: 162632-162632
- DOI
  10.1172/jci.insight.162632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16064, KAKENHI-PROJECT-22K16066, KAKENHI-PROJECT-22K08276, KAKENHI-PROJECT-23K07473, KAKENHI-PROJECT-21K08023, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-21H02908, KAKENHI-PROJECT-23K27352
[Journal Article] Prognostic value of follow-up vasoreactivity test in pulmonary arterial hypertension2023
- Author(s)
  Ishii, S. Hatano, M. Maki, H. Minatsuki, S. Saito, A. Yagi, H. Shimbo, M. Soma, K. Numata, G. Fujiwara, T. Takeda, N. Komuro, I.
- Journal Title
  
  Journal of Cardiology
  
  Volume: - Issue: 1 Pages: 69-75
- DOI
  10.1016/j.jjcc.2023.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08276, KAKENHI-PROJECT-22K16130, KAKENHI-PROJECT-21K16110, KAKENHI-PROJECT-20K08398
[Journal Article] The ratio of TAPSE to PASP predicts prognosis in lung transplant candidates with pulmonary arterial hypertension2023
- Author(s)
  Ishii, S. Minatsuki, S. Hatano, M. Saito, A. Yagi, H. Shimbo, M. Soma, K. Fujiwara, T. Itoh, H. Konoeda, C. Sato, M. Takeda, N. Daimon, M. Nakajima, J. Komuro, I.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3758-3758
- DOI
  10.1038/s41598-023-30924-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08276, KAKENHI-PROJECT-21K16110, KAKENHI-PROJECT-20K08398
[Journal Article] The Genetic Background of Peripheral Pulmonary Artery Stenosis2022
- Author(s)
  後藤耕策, 武田憲文, 沼田玄理, 藤田寛奈, 皆月隼, 波多野将, 小室一成
- Journal Title
  
  The Journal of Japanese College of Angiology
  
  Volume: 62 Issue: 10 Pages: 89-95
- DOI
  10.7133/jca.22-00021
- ISSN
  0387-1126, 1880-8840
- Year and Date
  2022-10-10
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08276
[Journal Article] Proposed Management Policy for Pregnant Women with Loeys-Dietz Syndrome Following Prophylactic Aortic Root Replacement Based on Experience from a Tertiary Care Center2022
- Author(s)
  Sayama Seisuke、Iriyama Takayuki、Takeda Norifumi、Yamauchi Haruo、Toshimitsu Masatake、Seyama Takahiro、Sone Kenbun、Kumasawa Keiichi、Nagamatsu Takeshi、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Int. Heart J.
  
  Volume: 63 Issue: 1 Pages: 176-179
- DOI
  10.1536/ihj.21-341
- NAID
  130008145710
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2022-01-29
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-20K18158
[Journal Article] Two Siblings With Peripheral Pulmonary Arterial Stenosis: Pulmonary Angiography of Advanced and Early Stages2022
- Author(s)
  Goto, K. Minatsuki, S. Fujita, K. Takeda, N. Hatano, M. Komuro, I.
- Journal Title
  
  Chest
  
  Volume: 161 Issue: 2 Pages: e75-e80
- DOI
  10.1016/j.chest.2021.08.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08276
[Journal Article] Family with congenital contractural arachnodactyly due to a novel multiexon deletion of the FBN2 gene2022
- Author(s)
  Yagi Hiroki、Takiguchi Hiroshi、Takeda Norifumi、Inuzuka Ryo、Taniguchi Yuki、Porto Kristine Joyce、Ishiura Hiroyuki、Mitsui Jun、Morita Hiroyuki、Komuro Issei
- Journal Title
  
  Clinical Case Reports
  
  Volume: 10 Issue: 2 Pages: 1-5
- DOI
  10.1002/ccr3.5335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-22K16129
[Journal Article] 大動脈疾患と妊娠出産2022
- Author(s)
  八木宏樹, 佐山晴亮, 入山高行, 武田憲文
- Journal Title
  
  Heart View
  
  Volume: 26 Pages: 270-274
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Predictive Physical Manifestations for Progression of Scoliosis in Marfan Syndrome2021
- Author(s)
  Taniguchi Yuki、Matsubayashi Yoshitaka、Kato So、Doi Toru、Takeda Norifumi、Yagi Hiroki、Inuzuka Ryo、Oshima Yasushi、Tanaka Sakae
- Journal Title
  
  Spine
  
  Volume: 46 Issue: 15 Pages: 1020-1025
- DOI
  10.1097/brs.0000000000003939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-20K09451, KAKENHI-PROJECT-20K18021
[Journal Article] Clinical Impact of Copy Number Variation on the Genetic Diagnosis of Syndromic Aortopathies2021
- Author(s)
  Takeda Norifumi、Inuzuka Ryo、Yagi Hiroki、Morita Hiroyuki、Ando Masahiko、Yamauchi Haruo、Taniguchi Yuki、Porto Kristine Joyce、Kanaya Tsubasa、Ishiura Hiroyuki、Mitsui Jun、Tsuji Shoji、Toda Tatsushi、Ono Minoru、Komuro Issei
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 14 Issue: 4
- DOI
  10.1161/circgen.121.003458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Postpartum Stanford type B aortic dissection in a woman with Loeys-Dietz syndrome who underwent a prophylactic aortic root replacement before conception: A case report2021
- Author(s)
  Shitara Rieko、Iriyama Takayuki、Sayama Seisuke、Takeda Norifumi、Nagamatsu Takeshi、Osuga Yutaka、Fujii Tomoyuki
- Journal Title
  
  Taiwanese Journal of Obstetrics and Gynecology
  
  Volume: 60 Issue: 1 Pages: 145-147
- DOI
  10.1016/j.tjog.2020.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-20K18158
[Journal Article] 大動脈弁輪拡張症2021
- Author(s)
  武田憲文
- Journal Title
  
  今日の治療指針2021年版
  
  Volume: 63 Pages: 445-446
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Impact of pathogenic FBN1 variant types on the development of severe scoliosis in patients with Marfan syndrome2021
- Author(s)
  Taniguchi Yuki、Takeda Norifumi、Inuzuka Ryo、Matsubayashi Yoshitaka、Kato So、Doi Toru、Yagi Hiroki、Yamauchi Haruo、Ando Masahiko、Oshima Yasushi、Tanaka Sakae
- Journal Title
  
  Journal of Medical Genetics
  
  Volume: in press Issue: 1 Pages: 108186-108186
- DOI
  10.1136/jmedgenet-2021-108186
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-20K09405, KAKENHI-PROJECT-20K09451, KAKENHI-PROJECT-20K18021
[Journal Article] Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome2020
- Author(s)
  Hara Hironori、Maemura Sonoko、Fujiwara Takayuki、Takeda Norifumi、Ishii Satoshi、Yagi Hiroki、Suzuki Takaaki、Harada Mutsuo、Toko Haruhiro、Kanaya Tsubasa、Ijichi Hideaki、Moses Harold L.、Takimoto Eiki、Morita Hiroyuki、Akazawa Hiroshi、Komuro Issei
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 11 Pages: e0239908-e0239908
- DOI
  10.1371/journal.pone.0239908
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-18K08097, KAKENHI-PROJECT-19K17667
[Journal Article] 大動脈瘤の発生機序をマルファン症候群から理解する2020
- Author(s)
  武田憲文
- Journal Title
  
  循環器内科
  
  Volume: 87 Pages: 617-623
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] マルファン症候群2020
- Author(s)
  武田憲文
- Journal Title
  
  生体の科学（特集：難病研究の進歩）
  
  Volume: 71 Pages: 486-487
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] マルファン症候群の病態生理と精密医療2020
- Author(s)
  八木宏樹、武田憲文、赤澤宏
- Journal Title
  
  実験医学別冊：循環器学と精密医療
  
  Volume: － Pages: 100-109
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] 遺伝性大動脈瘤の分子メカニズム2020
- Author(s)
  八木宏樹、武田憲文、赤澤宏
- Journal Title
  
  脈管学
  
  Volume: 60 Pages: 25-34
- NAID
  130007807083
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] 大動脈疾患 up-to-date 近年急増する大動脈疾患の最新知見2020
- Author(s)
  八木宏樹、武田憲文
- Journal Title
  
  医学と薬学
  
  Volume: 77 Pages: 1623-1634
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement for Aortic Stenosis in Japan　― Analysis of a Nationwide Inpatient Database ―2020
- Author(s)
  Kamon T、Kaneko H、Kiriyama H、Itoh H、Fujiu K、Kumazawa R、Morita K、Michihata N、Jo T、Miura M、Kodera S、Uehara M、Ando J、Inoue T、Kinoshita O、Yamauchi H、Mori Y、Nakao T、Daimon M、Takeda N、Morita H、Ono M、Yasunaga H、Komuro I
- Journal Title
  
  Circulation Reports
  
  Volume: 2 Issue: 12 Pages: 753-758
- DOI
  10.1253/circrep.CR-20-0116
- NAID
  130007953501
- ISSN
  2434-0790
- Year and Date
  2020-12-10
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] 遺伝性胸部大動脈瘤・解離症2020
- Author(s)
  武田憲文
- Journal Title
  
  別冊・医学のあゆみ：遺伝性心血管疾患のすべて
  
  Volume: － Pages: 105-110
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Pathophysiology of Hereditary Thoracic Aneurysms2020
- Author(s)
  Yagi Hiroki、Takeda Norifumi、Akazawa Hiroshi
- Journal Title
  
  The Journal of Japanese College of Angiology
  
  Volume: 60 Issue: 3 Pages: 25-34
- DOI
  10.7133/jca.19-00030
- NAID
  130007807083
- ISSN
  0387-1126, 1880-8840
- Year and Date
  2020-03-10
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] 遺伝性胸部大動脈瘤・解離症2019
- Author(s)
  武田憲文
- Journal Title
  
  医学のあゆみ
  
  Volume: 268 Pages: 789-794
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Marfan症候群における大動脈瘤形成機序2019
- Author(s)
  八木宏樹、武田憲文
- Journal Title
  
  新しい臨床を開拓するための分子循環器病学
  
  Volume: － Pages: 190-195
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Genetic basis of hereditary thoracic aortic aneurysms and dissections2019
- Author(s)
  Takeda Norifumi、Komuro Issei
- Journal Title
  
  Journal of Cardiology
  
  Volume: 74 Issue: 2 Pages: 136-143
- DOI
  10.1016/j.jjcc.2019.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-17H01560
[Journal Article] Unique Mechanism by Which TGFBR1 Variants Cause 2 Distinct System Diseases　― Loeys-Dietz Syndrome and Multiple Self-Healing Squamous Epithelioma ―2019
- Author(s)
 Fujiwara Takayuki、Takeda Norifumi、Ishii Satoshi、Morita Hiroyuki、Komuro Issei
- Journal Title
 
 Circulation Reports
 
 Volume: 1 Issue: 11 Pages: 487-492
- DOI
 10.1253/circrep.CR-19-0098
- NAID
 130007742756
- ISSN
 2434-0790
- Year and Date
 2019-11-08
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-19K17667
[Journal Article] Vascular Ehlers-Danlos syndrome diagnosed in a patient initiating hemodialysis2019
- Author(s)
  Haruki Ouchi, Hiroshi Nishi, Motonobu Nakamura, Yosuke Hirakawa, Tetsuhiro Tanaka, Norifumi Takeda, Takafumi Akai, Yuichi Ohashi, Katsuyuki Hoshina, Toshio Takayama, Masaomi Nangaku
- Journal Title
  
  Kidney International Reports
  
  Volume: 4 Issue: 11 Pages: 1646-1648
- DOI
  10.1016/j.ekir.2019.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08232, KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-19K08671
[Journal Article] マルファン症候群などの遺伝性大動脈疾患のゲノム診療2019
- Author(s)
  武田憲文
- Journal Title
  
  Mecdical Practice
  
  Volume: 36 Pages: 441-443
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Marfan症候群2019
- Author(s)
  八木宏樹、赤澤宏、武田憲文
- Journal Title
  
  別冊日本臨床領域別症候群シリーズ No.6. 循環器症候群（第3版）
  
  Volume: 6(3) Pages: 346-351
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] 血管型エーラス・ダンロス症候群2019
- Author(s)
  武田憲文
- Journal Title
  
  別冊日本臨床領域別症候群シリーズ No.6. 循環器症候群（第3版）
  
  Volume: 6(3) Pages: 358-363
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] 疾患Review：マルファン症候群2019
- Author(s)
  武田憲文
- Journal Title
  
  SRL宝函
  
  Volume: 40 Pages: 21-30
- Data Source
  KAKENHI-PROJECT-19K08484
[Journal Article] Prostaglandin E2 Signaling as a Target of Anti-Cardiac Fibrosis in Heart Failure Treatment2017
- Author(s)
  Harada M, Takeda N, Toko H.
- Journal Title
  
  Int. Heart J.
  
  Volume: 58 Issue: 1 Pages: 3-4
- DOI
  10.1536/ihj.16-614
- NAID
  130005330498
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-16K09492
[Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure.2017
- Author(s)
  Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 3 Pages: 0174099-0174099
- DOI
  10.1371/journal.pone.0174099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15989, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-17H01560
[Journal Article] Pathophysiology and therapeutic potential of cardiac fibrosis2017
- Author(s)
  Hara Hironori、Takeda Norifumi、Komuro Issei
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 37 Issue: 1 Pages: 13-13
- DOI
  10.1186/s41232-017-0046-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15987, KAKENHI-PROJECT-15K09132
[Journal Article] Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients2016
- Author(s)
  Suzuki J, Imai Y, Aoki M, Fujita D, Takeda N, Aoyama N, Wakayama K, Ikeda Y, Kumagai H, Akazawa H, Izumi Y, Isobe M, Komuro I, Hirata Y
- Journal Title
  
  Int. Heart J.
  
  Volume: 57 Issue: 4 Pages: 456-460
- DOI
  10.1536/ihj.15-395
- NAID
  130006895913
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05824, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-15H04806
[Journal Article] Pathophysiology and management of cardiovascular manifestations in Marfan and Loeys-Dietz syndrome.2016
- Author(s)
  Takeda N, Yagi H, hara H et al.
- Journal Title
  
  International Heart Journal
  
  Volume: 57 Pages: 271-277
- NAID
  130005153709
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461084
[Journal Article] Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys–Dietz Syndromes2016
- Author(s)
  Takeda N, Yagi H, Hara H, Fujiwara T, Fujita D, Nawata K, Inuzuka R, Taniguchi Y, Harada M, Toko H, Akazawa H, Komuro I.
- Journal Title
  
  Int. Heart J.
  
  Volume: 57 Issue: 3 Pages: 271-277
- DOI
  10.1536/ihj.16-094
- NAID
  130005153709
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J00378, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K09132
[Journal Article] A deleterious MYH11 mutation causing familial thoracic aortic dissection2015
- Author(s)
  Takeda N, Morita H, Fujita D, Inuzuka R, Taniguchi Y, Nawata K, Komuro I.
- Journal Title
  
  Human Genome Variation
  
  Volume: 2 Issue: 1 Pages: 15028-15028
- DOI
  10.1038/hgv.2015.28
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09132
[Journal Article] A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees2015
- Author(s)
  Imai Y, Morita H, Takeda N, Miya F, Hyodo H, Fujita D, Tajima T, Tsunoda T, Nagai R, Kubo M, Komuro I
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 195 Pages: 290-292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461084
[Journal Article] Congenital Contractural Arachnodactyly without FBN1 or FBN2 Gene Mutations Complicated by Dilated Cardiomyopathy2015
- Author(s)
 Yagi H, Hatano M, Takeda N#, Harada S, Suzuki Y, Taniguchi Y, Shintani Y, Morita H, Kanamori N, Aoyama T, Watanabe M, Manabe I, Akazawa H, Kinugawa K, Komuro I.
- Journal Title
 
 Intern. Med.
 
 Volume: 54 Issue: 10 Pages: 1237-1241
- DOI
 10.2169/internalmedicine.54.4280
- NAID
 130005069778
- ISSN
 0918-2918, 1349-7235
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-26670395
[Journal Article] Congenital contractural arachnodactyly complicated with aortic dilatation and dissection: Case Report and review of literature2015
- Author(s)
  Takeda N, Morita H, Fujita D, Inuzuka R, Taniguchi Y, Imai Y, Hirata Y, Komuro I.
- Journal Title
  
  Am J Med Genet A
  
  Volume: 167 Issue: 10 Pages: 2382-2387
- DOI
  10.1002/ajmg.a.37162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09132
[Journal Article] Hopx distinguishes hippocampal from lateral ventricle neural stem cells2015
- Author(s)
  Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA, Epstein JA.
- Journal Title
  
  Stem Cell Res
  
  Volume: 15 Issue: 3 Pages: 522-529
- DOI
  10.1016/j.scr.2015.09.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09132
[Journal Article] Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.2015
- Author(s)
  Jain R, Barkauskas C.E, Takeda N, Bowie E.J, Aghajanian H, Wang Q, Padmanabhan A, Manderfield L.J, Gupta M, Li D, Li L, Trivedi C.M, Hoan L.M, Epstein J.A.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 6722-6722
- DOI
  10.1038/ncomms7727
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09132
[Journal Article] A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees2015
- Author(s)
  Takeda N, Imai Y, Morita H, Miya F, Hyodo H, Fujita D, Tajima T, Tsunoda T, Nagai R, Kubo M, Komuor I.
- Journal Title
  
  Int J Cardiol
  
  Volume: 195 Pages: 290-292
- DOI
  10.1016/j.ijcard.2015.05.178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09132
[Journal Article] A novel mutation of TGFBR2 causing Loeys-Dietz syndrome complicated with pregnancy-related fatal cervical arterial dissections2015
- Author(s)
  Takeda N, Fujita N, Morita H, Kato M, Nishimura H, Inuzuka R, Taniguchi Y, Nawata K, Hyodo H, Imai Y, Hirata Y, Komuro I.
- Journal Title
  
  Int J Cardiol
  
  Volume: 201 Pages: 288-290
- DOI
  10.1016/j.ijcard.2015.07.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09132
[Journal Article] Pathophysiology and Japanese clinical characteristics in Marfan syndrome2014
- Author(s)
  Fujita D, Takeda N, Imai Y, Inuduka R, Komuro I, Hirata Y
- Journal Title
  
  Ｐｅｄｉａｔｒｉｃｓ　Ｉｎｔｅｒｎａｔｉｏｎａｌ
  
  Volume: 56 Issue: 4 Pages: 484-491
- DOI
  10.1111/ped.12423
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461084, KAKENHI-PROJECT-25893043
[Journal Article] マルファン症候群の現状と展望2014
- Author(s)
  藤田大司, 武田憲文, 今井靖, 平田恭信.
- Journal Title
  
  日本臨床
  
  Volume: 72 Pages: 1163-1171
- Data Source
  KAKENHI-PROJECT-25893043
[Journal Article] Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.2013
- Author(s)
  Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA.
- Journal Title
  
  Development
  
  Volume: 140 Issue: 8 Pages: 1655-64
- DOI
  10.1242/dev.093005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893043
[Journal Article] Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.2013
- Author(s)
  Takeda N, Jain R, Li D, Li L, Lu MM, Epstein JA.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893043
[Journal Article] Circulating transforming growth factor beta-1 level in Japanese patients with Marfan syndrome.2013
- Author(s)
  Ogawa N, Imai Y, Nishimura H, Kato M, Takeda N, Nawata K, Taketani T, Morota T, Takamoto S, Nagai R, Hirata Y
- Journal Title
  
  International Heart Journal
  
  Volume: 54 Pages: 23-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461084
[Journal Article] Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload2010
- Author(s)
  Norifumi Takeda, et al.
- Journal Title
  
  J Clin Invest. 120
  
  Pages: 254-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790708
[Journal Article] Gamma-delta T-cell-mediated dilated cardiomyopathy.2008
- Author(s)
  Takeda N, Seko Y, Oriuchi Y, Nagai R.
- Journal Title
  
  Int J Cardiol 125
  
  Pages: 130-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells.2008
- Author(s)
  Kato H, Ishida J, Nagano K, Sugaya T, Takeda N, Sugiyama F, Yagami KI, Fujita T, Nangaku M, Fukamizu A.
- Journal Title
  
  Lab Invest 88
  
  Pages: 731-739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.2008
- Author(s)
  Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
- Journal Title
  
  J Biol Chem 283
  
  Pages: 24682-24689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] 心房性ナトリウム利尿ペプチド:主要薬剤各論-特徴, 作用機序, 薬物動態, 適応・禁忌, 臨床成績, 副作用-心不全(下)最新の基礎・臨床研究の進歩2007
- Author(s)
  武田憲文, 平田恭信
- Journal Title
  
  日本臨床 65増刊(5)
  
  Pages: 110-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis.2007
- Author(s)
  Kada N, Suzuki T, Aizawa K, Matsumura T, Ishibashi N, Suzuki N, Takeda N, Munemasa Y, Sawaki D, Ishikawa T, Nagai R.
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27
  
  Pages: 1535-1541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] Rupture of bronchogenic cyst in the pericardium with high carbohydrate antigen 19-9 production.2007
- Author(s)
  Takeda N, Nakajima J, Yamada N, Hiroi Y, Hirata Y, Nagai R.
- Journal Title
  
  Respiratory Medicine Extra 3
  
  Pages: 76-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] 心房性ナトリウム利尿ペプチド2007
- Author(s)
  武田憲文
- Journal Title
  
  日本臨床(増刊:心不全) 65増刊(5)
  
  Pages: 110-114
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] 後腹膜線維症の心血管病変の見方2007
- Author(s)
  武田憲文
- Journal Title
  
  呼吸と循環 55
  
  Pages: 441-447
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] Thrombomodulin Is a Clock-controlled Gene in Vascular Endothelial Cells2007
- Author(s)
  Takeda N
- Journal Title
  
  J Biol Chem 282
  
  Pages: 32561-32567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659198
[Journal Article] 後腹膜線維症の心血管病変の見方2007
- Author(s)
  武田憲文, 平田恭信, 永井良三
- Journal Title
  
  呼吸と循環 55
  
  Pages: 441-447
- Data Source
  KAKENHI-PROJECT-19790518
[Journal Article] Rupture of bronchogenic cyst in the pericardium with high carbohydrate antigen 19-9 production2007
- Author(s)
  Norifumi Takeda (武田憲文)
- Journal Title
  
  Respiratory Medicine 3
  
  Pages: 76-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790518
[Patent] 新規化合物、並びにそれを有効成分とする心筋細胞増殖誘導剤及び心筋の機能障害を伴う疾患の治療剤2016
- Inventor(s)
  小室一成、武田憲文、原弘典、内山真伸、斉藤竜男、畑裕
- Industrial Property Rights Holder
  小室一成、武田憲文、原弘典、内山真伸、斉藤竜男、畑裕
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-244870
- Filing Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Clinical Characteristics and Prognostic Impacts of Parenteral Treprostinil on Severe Pulmonary Hypertension Patients2023
- Author(s)
  新保麻衣, 波多野将, 中村旭, ムンフトールプレブスレン, 石井聡, 齊藤暁人, 八木宏樹, 皆月隼, 相馬桂, 牧尚孝, 網谷英介, 武田憲文, 小室一成
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08276
[Presentation] Investigation of the mechanism of microvessel remodeling in pulmonary hypertension using spatiotemporal multi-scale imaging system2023
- Author(s)
  藤原隆行, 武田憲文, 小室一成
- Organizer
  第7回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-22K08276
[Presentation] マルファン症候群など遺伝性大動脈疾患の外来診療2021
- Author(s)
  武田憲文
- Organizer
  大動脈疾患Web Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] マルファン症候群の側弯重症症例におけるFBN1遺伝子変異パターンの検討2021
- Author(s)
  谷口優樹, 武田憲文, 犬塚亮、松村嘉孝、加藤壯、大島寧、田中栄
- Organizer
  第55回日本側彎症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] 遺伝性大動脈瘤解離症の遺伝子パネル検査によって診断に至った非典型的な臨床像を呈する血管型エーラス・ダンロス症候群の報告2021
- Author(s)
  八木宏樹,武田憲文、秋山奈々、帳香理、網谷英介、赤澤宏、小室一成
- Organizer
  第66回日本人類遺伝学会・第28回日本遺伝子診療学会大会合同開催
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] Xanthine oxidoreductase in adventitial macrophages exacerbates aortic aneurysm progression by amplifying ROS generation in a mouse model of Marfan syndrome2020
- Author(s)
  17.Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Akiko Saga-Kamo, Chizuru Yabumoto, Masahiko Umei, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Norifumi Takeda, Issei Komuro
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] 循環器診療におけるゲノム診療：遺伝性大動脈疾患の遺伝子解析とその有用性2020
- Author(s)
  武田憲文
- Organizer
  第256回日本循環器学会関東甲信越地方会.教育セッションII
- Invited
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] MYH11遺伝子に病的バリアントをもつ親の子どもに対する発症前診断の経験2020
- Author(s)
  張香理、犬塚亮、武田憲文、石浦浩之、戸田達史、織田克利
- Organizer
  第44回日本遺伝カウンセリング学会
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] マルファン症候群症候群症例の身体的特徴および側弯度重症化に関連する因子の検討2019
- Author(s)
  口優樹、松林嘉孝、加藤壮、大島寧、武田憲文、犬塚亮、安藤政彦、田中栄
- Organizer
  第53回日本側彎症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] マルファン症候群の妊娠リスク管理2019
- Author(s)
  武田憲文
- Organizer
  第30回日本心エコー図学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] マルファン症候群をもつ子どもや親への支援：認定遺伝カウンセラーが見るマルファン外来の現状と課題2019
- Author(s)
  帳香里、朝海廣子、犬塚亮、武田憲文
- Organizer
  第55回日本小児循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08484
[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart after ischemic injury2018
- Author(s)
  Hironori Hara, Norifumi Takeda, Tatsuo Saito, Takyuki Fujiwara, Sonoko Maemura, Yutaka Hara, Masanobu Uchiyama, Issei Komuro
- Organizer
  1st Basic CardioVascular Research (BCVR)
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart after ischemic injury2018
- Author(s)
  Hironori Hara, Norifumi Takeda, Tatsuo Saito, Takyuki Fujiwara, Sonoko Maemura, Yutaka Hara, Masanobu Uchiyama, Issei Komuro
- Organizer
  第82回日本循環器病学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] 組織幹細胞の分化・増殖機構の解明と内因性心筋再生の増殖法開発への応用2017
- Author(s)
  武田憲文
- Organizer
  第21心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] マルファン症候群における最新の知見-RA系抑制を含めて2017
- Author(s)
  武田憲文
- Organizer
  循環器疾患研究会
- Place of Presentation
  興和創薬（株）本社会議室（東京都中央区）
- Invited
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Discovery of a small molecule to increase cardiomyocytes and protect the heart afer ischemic injury2017
- Author(s)
  Hara Hironori, Takeda N, Saito T, Fujiwara T, Maemura S, Hata Y, Uchiyama M, Komuro I
- Organizer
  American Heart Association Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Hippo経路を標的として心筋細胞増殖と心筋再生を増幅する薬剤の開発2017
- Author(s)
  原　弘典, 武田憲文, 小室一成
- Organizer
  第54回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] 心筋細胞増殖・心筋保護作用を有し、心筋再生を促進する薬剤開発の試み2017
- Author(s)
  原弘典, 武田憲文, 小室一成
- Organizer
  第8回東京循環器専門医交流会
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都文京区）
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] 心筋細胞の分裂機構の解明・制御と医療への応用2017
- Author(s)
  原弘典, 武田憲文, 小室一成
- Organizer
  第4回東京未来医療フォーラム
- Place of Presentation
  東京ガーデンパレスホテル（東京都文京区）
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Hippo経路を標的とした心筋再生・保護効果を有する新規薬剤の開発2017
- Author(s)
  原弘典、武田憲文、斉藤竜男、藤原隆行、前村園子、畑裕、内山真伸、小室一成
- Organizer
  Molecular Cardiovascular Metabolic Conference 2017
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] 心臓線維化の病態と制御2016
- Author(s)
  武田憲文
- Organizer
  第37回日本炎症・再生医学会
- Place of Presentation
  京都勧業館みやこめっせ（京都府京都市）
- Year and Date
  2016-06-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Hippo-YAP/TAZ-TEADs経路を標的とした、心筋細胞増殖と心筋再生を促進する薬剤開発の試み2016
- Author(s)
  原弘典, 武田憲文, 小室一成
- Organizer
  第4回Heart Science Club
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都文京区）
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] 当院マルファン外来における各種遺伝子異常の頻度2015
- Author(s)
  大森紹玄, 犬塚亮, 田中優, 中釜悠, 進藤考洋, 平田陽一郎, 清水信隆, 藤田大司, 武田憲文, 岡明.
- Organizer
  第51回日本小児循環器学会総会
- Place of Presentation
  ホテル日航東京（東京都港区）
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] マルファン症候群におけるFBN1遺伝子変異パターンとの関連性の解析2015
- Author(s)
  谷口優樹, 筑田博隆, 大島寧, 松林嘉考, 武田憲文, 藤田大司, 犬塚亮, 縄田寛, 小野貴司, 田中栄.
- Organizer
  第49回日本側弯症学会
- Place of Presentation
  りゅーとぴあ新潟市民芸術文化会館（新潟県新潟市）
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] マルファン症候群における包括的診療体制の重要性2015
- Author(s)
  今井靖, 藤田大司, 武田憲文, 西村敬史, 加藤昌義, 鈴木淳一, 小室一成, 平田恭信.
- Organizer
  第56回日本脈管学会学術集会
- Place of Presentation
  虎ノ門ヒルズフォーラム（東京都港区）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15K09132
[Presentation] Cardiac fibroblasts are essential for the adaptive response of the heart to pressure overload2010
- Author(s)
  武田憲文
- Organizer
  第74回日本循環器学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] Cardiac fibroblasts are essential for the adaptive response of the heart to pressure overload2010
- Author(s)
  武田憲文
- Organizer
  厚生労働省難治性疾患克服研究事業特発性心筋症に関する調査研究
- Place of Presentation
  大阪
- Year and Date
  2010-02-04
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] Significance of the transcription factor KLF5 in myocardial hypertrophy in response to pressure overload2009
- Author(s)
  武田憲文
- Organizer
  日本循環器学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] Cardiac fibroblasts are essential for the adaptive response of the heart to pressure overload2009
- Author(s)
  武田憲文
- Organizer
  第26回国際心臓研究学会(ISHR)日本部会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] 心筋リモデリングにおける転写因子KLF5の役割2009
- Author(s)
  武田憲文
- Organizer
  厚生労働省難治性疾患克服研究事業特発性心筋症に関する調査研究(第2回北風班)
- Place of Presentation
  大阪
- Year and Date
  2009-03-03
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] 心筋リモデリングにおける転写因子KLF5の役割2009
- Author(s)
  武田憲文
- Organizer
  第2回臨床研究フォーラム
- Place of Presentation
  御殿場
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] 圧負荷心筋リモデリングにおける線維芽細胞の役割2009
- Author(s)
  武田憲文
- Organizer
  第13回日本心血管内分泌代謝学会学術集会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] 心筋リモデリングにおける転写因子KLF5 の役割2009
- Author(s)
  武田憲文, 真鍋一郎, 永井良三
- Organizer
  厚生労働省難治性疾患克服研究事業特発性心筋症に関する調査研究(第2回北風班)
- Place of Presentation
  大阪
- Year and Date
  2009-03-03
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] 心筋リモデリングにおける転写因子KLF5の役割2009
- Author(s)
  武田憲文
- Organizer
  第15回成人病の病因・病態の解明に関する研究会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] Significance of the transcription factor KLF5 in myocardial hypertrophy in response to pressure overload.2009
- Author(s)
  武田憲文, 真鍋一郎, 永井良三
- Organizer
  日本循環器学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] Cardiac fibroblasts are essential for the adaptive response of the heart to pressure overload2009
- Author(s)
  武田憲文
- Organizer
  米国心臓病学会(AHA2009)
- Place of Presentation
  オーランド, USA
- Data Source
  KAKENHI-PROJECT-21790708
[Presentation] Significance of the transcription factor KLF5 in myocardial hypertrophy in response to pressure overload2008
- Author(s)
  武田憲文
- Organizer
  第72回日本循環器学会総会・学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] Significance of the transcription factor KLF5 in myocardial hypertrophy in response to pressure overload2008
- Author(s)
  武田憲文
- Organizer
  米国心臓病学会(AHA)学術集会
- Place of Presentation
  米国ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] Significance of the transcription factor KLF5 in myocardial hypertrophy in response to pressure overload.2008
- Author(s)
  Norifumi Takeda, Ichiro Manabe, Ryozo Nagai
- Place of Presentation
  米国ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] Significance of the transcription factor KLF5 in myocardial hypertrophy in response to pressure overload2008
- Author(s)
  武田憲文, 真鍋一郎, 永井良三
- Organizer
  日本循環器学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] 心筋リモデリングにおける転写因子KLF5の役割2008
- Author(s)
  武田憲文, 真鍋一郎, 永井良三
- Organizer
  厚生労働省難治性疾患克服研究事業特発性心筋症に関する調査研究(第1回北風班)
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] 圧負荷肥大心モデルにおける転写因子KLF5の役割2008
- Author(s)
  武田憲文, 真鍋一郎, 永井良三
- Organizer
  日本心臓病学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] 心筋リモデリングにおける転写因子KLF5の役割2008
- Author(s)
  武田憲文
- Organizer
  厚生労働省難治性疾患克服研究事業特発性心筋症に関する調査研究(第1回北風班)
- Place of Presentation
  東京
- Year and Date
  2008-10-15
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] 圧負荷肥大心モデルにおける転写因子KLF5の役割2008
- Author(s)
  武田憲文
- Organizer
  日本心臓病学会学術集会・総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790518
[Presentation] Marfan syndrome – Fibrillin I mutation and clinical phenotypes
- Author(s)
  Fujita D, Takeda N, Kato M, Nishimura H, Inuzuka R, Imai Y, Hirata Y, Komuro I.
- Organizer
  第17回日本成人先天性心疾患学会
- Place of Presentation
  東京
- Year and Date
  2015-01-16 – 2015-01-18
- Data Source
  KAKENHI-PROJECT-25893043
[Presentation] Comparison between the original and revised Ghent criteria in Japanese Marfan syndrome
- Author(s)
  Fujita D, Takeda N, Imai Y, Hirata Y, Hirata Y.
- Organizer
  9th International symposium on Marfan syndrome and related disorders
- Place of Presentation
  フランス・パリ
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25893043
[Presentation] Comparison between the original and revised Ghent criteria in Japanese Marfan Population
- Author(s)
  Fujita D, Takeda N, Imai Y, Hirata Y
- Organizer
  9th International Research Symposium on Marfan Syndrome and Related Disorders
- Place of Presentation
  Paris
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25461084
[]

1. 藤生克仁 (30422306)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 永井良三 (60207975)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 眞鍋一郎 (70359628)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Yasushi Imai (20359631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 野木森宜嗣 (50991139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 犬塚亮 (00597560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HARA Hironori

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 西裕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 常盤洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 内藤篤彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 野村征太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeda Norifumi 武田 憲文

TAKEDA NORIFUMI 武田 憲文

TAKEDA Norifumi 武田 憲文

Research Projects

Research Products

Co-Researchers

肺細動脈内皮細胞の機能変容に焦点を当てた新規肺高血圧モデルの病態解明と治療法開発Principal Investigator

Principal Investigator

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自然言語処理の応用によるマルファン症候群の遺伝子型と表現型の対応に関する研究

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Role of pulmonary endothelial dysfunction in idiopathic pulmonary hypertensionPrincipal Investigator

Principal Investigator

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Pathophysiological role of inflammatory and metabolic signals during aortic aneurysm formation in Marfan syndromePrincipal Investigator

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Enhancement of the endogeneous cardiac regeneration via activation of Hippo-YAP signaling pathwayPrincipal Investigator

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Elucidating the pathophysiology of inherited aortic diseases by combinational approach of genetic diagnosis and biotechnologies

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Analysis of cell cycle regulators in adult cardiomyocytesPrincipal Investigator

Principal Investigator

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心肥大や心不全における非心筋細胞の役割Principal Investigator

Principal Investigator

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マクロファージニッチによる心血管代謝疾患発症機構の解明と治療法開発

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上皮間葉移行(EMT)による心血管リモデリングの分子機構解明

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病態診断機能を持つ高機能化ナノ粒子による心血管疾患診断・治療法の開発

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Elucidation of cell type-specific KLF5 function and identification of novel mediators of KLF5 activity.Principal Investigator

Principal Investigator

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[Book] 血管医学：血管再生のメカニズム2016

Author(s)

Takeda Norifumi 武田憲文

TAKEDA NORIFUMI 武田憲文

TAKEDA Norifumi 武田憲文