TERAWAKI Seigo 寺脇正剛

Researcher Number	60437217
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 川崎医科大学, 医学部, 講師 2017 – 2020: 大阪市立大学, 大学院医学研究科, 助教 2016: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 48040:Medical biochemistry-related / General medical chemistry
Keywords	Principal Investigator ユビキチン / 炎症応答 / 炎症 / 免疫応答制御 / オートファジー / プロテイノパチー / 神経炎症 / 神経変性疾患 / メンブレントラフィック / シグナル伝達 … More / 分子免疫制御 / 炎症性疾患 / NETosis / メンブレントラフィッキング / 免疫学 / 細胞生物学 / 炎症疾患 / 免疫制御 Less

Characterization of linear ubiquitin chain for the elucidation of the molecular pathogenesis of ALS and the development of therapeutic strategies.Principal Investigator
- Principal Investigator
  
  Terawaki Seigo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kawasaki Medical School
Inflammatory response regulation by immune system specific autophagy regulator Rufy4Principal Investigator
- Principal Investigator
  
  TERAWAKI Seigo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka City University
Elucidation of the functions and physiological relevance of novel autophagy regulator Rufy4 in immune regulation systemsPrincipal Investigator
- Principal Investigator
  
  TERAWAKI Seigo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University
  Osaka University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis2023
- Author(s)
  Sato Yusuke、Terawaki Seigo、Oikawa Daisuke、Shimizu Kouhei、Okina Yoshinori、Ito Hidefumi、Tokunaga Fuminori
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 10 Pages: 1089213-1089213
- DOI
  10.3389/fmolb.2023.1089213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K07174, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-21H02418, KAKENHI-PROJECT-21H02688, KAKENHI-PUBLICLY-21H00283, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-22H04922
[Journal Article] PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy2022
- Author(s)
  Oe Yukako、Kakuda Keita、Yoshimura Shin-ichiro、Hara Naohiro、Hasegawa Junya、Terawaki Seigo、Kimura Yasuyoshi、Ikenaka Kensuke、Suetsugu Shiro、Mochizuki Hideki、Yoshimori Tamotsu、Nakamura Shuhei
- Journal Title
  
  PLOS Genetics
  
  Volume: 18 Issue: 6 Pages: e1010264-e1010264
- DOI
  10.1371/journal.pgen.1010264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-20KK0341, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-20H03252, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-19H03181, KAKENHI-PROJECT-21H05047
[Journal Article] Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-432022
- Author(s)
  Zhang Qiang、Terawaki Seigo、Oikawa Daisuke、Okina Yoshinori、Usuki Yoshinosuke、Ito Hidefumi、Tokunaga Fuminori
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 15 Pages: 2398-2398
- DOI
  10.3390/cells11152398
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02688, KAKENHI-PUBLICLY-21H00291
[Journal Article] A novel nonsense variant in ARID1B causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome2022
- Author(s)
  Sofronova Viktoriia、Fukushima Yu、Masuno Mitsuo、Naka Mami、Nagata Miho、Ishihara Yasuki、Miyashita Yohei、Asano Yoshihiro、Moriwaki Takahito、Iwata Rina、Terawaki Seigo、Yamanouchi Yasuko、Otomo Takanobu
- Journal Title
  
  Human Genome Variation
  
  Volume: 9 Issue: 1 Pages: 1-6
- DOI
  10.1038/s41439-022-00203-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-20K17055, KAKENHI-PROJECT-23K24328
[Journal Article] Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome2022
- Author(s)
  Sofronova Viktoriia、Iwata Rina、Moriya Takuya、Loskutova Kiunniai、Gurinova Elizaveta、Chernova Mairanush、Timofeeva Anastasia、Shvedova Anna、Vasilev Filipp、Novgorodova Saina、Terawaki Seigo、Moriwaki Takahito、Sukhomyasova Aitalina、Maksimova Nadezhda、Otomo Takanobu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 10 Pages: 5851-5851
- DOI
  10.3390/ijms23105851
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-20K17055
[Journal Article] Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice2021
- Author(s)
  Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
- Journal Title
  
  Inflammation Research
  
  Volume: In press Issue: 5 Pages: 539-541
- DOI
  10.1007/s00011-021-01458-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K17912, KAKENHI-PROJECT-20K16146, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-20H05337, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
[Journal Article] RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages2021
- Author(s)
  Vale?ka Jan、Camosseto Voahirana、McEwan David G.、Terawaki Seigo、Liu Zhuangzhuang、Strock Eva、Almeida Catarina R.、Su Bing、Dikic Ivan、Liang Yinming、Gatti Evelina、Pierre Philippe
- Journal Title
  
  Royal Society Open Science
  
  Volume: 8 Issue: 7 Pages: 202333-202333
- DOI
  10.1098/rsos.202333
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06857
[Journal Article] Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.2021
- Author(s)
  Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 635475-635475
- DOI
  10.3389/fimmu.2021.635475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-20H05337, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
[Journal Article] Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling2021
- Author(s)
  Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
- Journal Title
  
  Plos One
  
  Volume: - Issue: 3 Pages: e0248158-e0248158
- DOI
  10.1371/journal.pone.0248158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17912, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-20H05337, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-20K16146, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
[Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020
- Author(s)
  Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
- Journal Title
  
  Commun. Biol.
  
  Volume: 3 Issue: 1 Pages: 163-163
- DOI
  10.1038/s42003-020-0882-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-19K22968, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H04837, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06937, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-18H05497
[Journal Article] LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury2020
- Author(s)
  Shuhei Nakamura et al.,
- Journal Title
  
  Nature Cell Biology
  
  Volume: 22 Issue: 10 Pages: 1252-1263
- DOI
  10.1038/s41556-020-00583-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22429, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K08208
[Presentation] The inhibition of LUBAC mitigates amyotrophic lateral sclerosis-associated TDP-43 aggregation2022
- Author(s)
  張強, 寺脇正剛, 及川大輔, 翁良徳, 臼杵克之助, 徳永文稔
- Organizer
  第95回生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06857
[Presentation] 直鎖状ユビキチン鎖生成酵素を標的とした阻害剤開発と疾患治療薬としての基礎検討2022
- Author(s)
  及川大輔, 張強, 寺脇正剛, 翁良徳, 臼杵克之助, 徳永文稔
- Organizer
  第74回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-21K06857
[Presentation] LUBAC ubiquitin ligase complex and linear ubiquitination facilitate cytoplasmic aggregation of amyotrophic lateral sclerosis (ALS)-associated TDP-432021
- Author(s)
  Seigo Terawaki, Qiang Zhang, Daisuke Oikawa, Bangzhong Lin, Kazuto Nunomura, Shinsuke Komagawa, Yoshinosuke Usuki, Fuminori Tokunaga
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06857
[Presentation] HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells2021
- Author(s)
  Qiang Zhang, Seigo Terawaki, and Fuminori Tokunaga
- Organizer
  第15回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-21K06857
[Presentation] NDP52のユビキチン結合性を介した炎症応答・細胞死制御とLUBAC阻害剤の影響2020
- Author(s)
  宮下裕久, 及川大輔, 寺脇正剛, 徳永文稔
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06937
[Presentation] Macrophages produce histamine through the interaction with antigen specific Th2 cells2020
- Author(s)
  Naruhito Iwasaki, Seigo Terawaki, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunaga
- Organizer
  第69回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06937
[Presentation] HOIPIN-1, a novel LUBAC inhibitor, suppresses the imiquimod-induced psoriasis-like skin inflammation in mice2019
- Author(s)
  Komakura K., Oikawa D., Terawaki S., Sakamoto S., Mizukami Y., Sugawara K., Tsuruta D., Tokunaga F.
- Organizer
  Society for Investigative Dermatology 77th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06937

1. HIROI Takachika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. PIERRE Philippe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 及川大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 中村修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 岩崎成仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TERAWAKI Seigo 寺脇 正剛

Research Projects

Research Products

Co-Researchers

Characterization of linear ubiquitin chain for the elucidation of the molecular pathogenesis of ALS and the development of therapeutic strategies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inflammatory response regulation by immune system specific autophagy regulator Rufy4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the functions and physiological relevance of novel autophagy regulator Rufy4 in immune regulation systemsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-432022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel nonsense variant in ARID1B causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] The inhibition of LUBAC mitigates amyotrophic lateral sclerosis-associated TDP-43 aggregation2022

Author(s)

Organizer

TERAWAKI Seigo 寺脇正剛