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TERAWAKI Seigo  寺脇 正剛

ORCIDConnect your ORCID iD *help
Researcher Number 60437217
Other IDs
Affiliation (Current) 2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2021 – 2023: 川崎医科大学, 医学部, 講師
2017 – 2020: 大阪市立大学, 大学院医学研究科, 助教
2016: 大阪大学, 医学系研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 49010:Pathological biochemistry-related / Basic Section 48040:Medical biochemistry-related / General medical chemistry
Keywords
Principal Investigator
ユビキチン / 炎症応答 / 炎症 / 免疫応答制御 / オートファジー / プロテイノパチー / 神経炎症 / 神経変性疾患 / メンブレントラフィック / シグナル伝達 … More / 分子免疫制御 / 炎症性疾患 / NETosis / メンブレントラフィッキング / 免疫学 / 細胞生物学 / 炎症疾患 / 免疫制御 Less
  • Research Projects

    (3 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (6 People)
  •  Characterization of linear ubiquitin chain for the elucidation of the molecular pathogenesis of ALS and the development of therapeutic strategies.Principal Investigator

    • Principal Investigator
      Terawaki Seigo
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Kawasaki Medical School
  •  Inflammatory response regulation by immune system specific autophagy regulator Rufy4Principal Investigator

    • Principal Investigator
      TERAWAKI Seigo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Osaka City University
  •  Elucidation of the functions and physiological relevance of novel autophagy regulator Rufy4 in immune regulation systemsPrincipal Investigator

    • Principal Investigator
      TERAWAKI Seigo
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka City University
      Osaka University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer’s disease and amyotrophic lateral sclerosis2023

    • Author(s)
      Sato Yusuke、Terawaki Seigo、Oikawa Daisuke、Shimizu Kouhei、Okina Yoshinori、Ito Hidefumi、Tokunaga Fuminori
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 10 Pages: 1089213-1089213

    • DOI

      10.3389/fmolb.2023.1089213

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K07174, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-21H02418, KAKENHI-PROJECT-21H02688, KAKENHI-PUBLICLY-21H00283, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-22H04922
  • [Journal Article] PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy2022

    • Author(s)
      Oe Yukako、Kakuda Keita、Yoshimura Shin-ichiro、Hara Naohiro、Hasegawa Junya、Terawaki Seigo、Kimura Yasuyoshi、Ikenaka Kensuke、Suetsugu Shiro、Mochizuki Hideki、Yoshimori Tamotsu、Nakamura Shuhei
    • Journal Title

      PLOS Genetics

      Volume: 18 Issue: 6 Pages: e1010264-e1010264

    • DOI

      10.1371/journal.pgen.1010264

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-20KK0341, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-20H03252, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-19H03181, KAKENHI-PROJECT-21H05047
  • [Journal Article] Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-432022

    • Author(s)
      Zhang Qiang、Terawaki Seigo、Oikawa Daisuke、Okina Yoshinori、Usuki Yoshinosuke、Ito Hidefumi、Tokunaga Fuminori
    • Journal Title

      Cells

      Volume: 11 Issue: 15 Pages: 2398-2398

    • DOI

      10.3390/cells11152398

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02688, KAKENHI-PUBLICLY-21H00291
  • [Journal Article] A novel nonsense variant in ARID1B causing simultaneous RNA decay and exon skipping is associated with Coffin-Siris syndrome2022

    • Author(s)
      Sofronova Viktoriia、Fukushima Yu、Masuno Mitsuo、Naka Mami、Nagata Miho、Ishihara Yasuki、Miyashita Yohei、Asano Yoshihiro、Moriwaki Takahito、Iwata Rina、Terawaki Seigo、Yamanouchi Yasuko、Otomo Takanobu
    • Journal Title

      Human Genome Variation

      Volume: 9 Issue: 1 Pages: 1-6

    • DOI

      10.1038/s41439-022-00203-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-20K17055, KAKENHI-PROJECT-23K24328
  • [Journal Article] Hematopoietic Disorders, Renal Impairment and Growth in Mucopolysaccharidosis-Plus Syndrome2022

    • Author(s)
      Sofronova Viktoriia、Iwata Rina、Moriya Takuya、Loskutova Kiunniai、Gurinova Elizaveta、Chernova Mairanush、Timofeeva Anastasia、Shvedova Anna、Vasilev Filipp、Novgorodova Saina、Terawaki Seigo、Moriwaki Takahito、Sukhomyasova Aitalina、Maksimova Nadezhda、Otomo Takanobu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 10 Pages: 5851-5851

    • DOI

      10.3390/ijms23105851

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-20K17055
  • [Journal Article] Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice2021

    • Author(s)
      Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    • Journal Title

      Inflammation Research

      Volume: In press Issue: 5 Pages: 539-541

    • DOI

      10.1007/s00011-021-01458-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K17912, KAKENHI-PROJECT-20K16146, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-20H05337, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
  • [Journal Article] RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages2021

    • Author(s)
      Vale?ka Jan、Camosseto Voahirana、McEwan David G.、Terawaki Seigo、Liu Zhuangzhuang、Strock Eva、Almeida Catarina R.、Su Bing、Dikic Ivan、Liang Yinming、Gatti Evelina、Pierre Philippe
    • Journal Title

      Royal Society Open Science

      Volume: 8 Issue: 7 Pages: 202333-202333

    • DOI

      10.1098/rsos.202333

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06857
  • [Journal Article] Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.2021

    • Author(s)
      Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F.
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 635475-635475

    • DOI

      10.3389/fimmu.2021.635475

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-20H05337, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
  • [Journal Article] Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling2021

    • Author(s)
      Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    • Journal Title

      Plos One

      Volume: - Issue: 3 Pages: e0248158-e0248158

    • DOI

      10.1371/journal.pone.0248158

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17912, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-20H05337, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-20K16146, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21K06857, KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-16H06276
  • [Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020

    • Author(s)
      Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    • Journal Title

      Commun. Biol.

      Volume: 3 Issue: 1 Pages: 163-163

    • DOI

      10.1038/s42003-020-0882-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22541, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-19K22968, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H04837, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06937, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury2020

    • Author(s)
      Shuhei Nakamura et al.,
    • Journal Title

      Nature Cell Biology

      Volume: 22 Issue: 10 Pages: 1252-1263

    • DOI

      10.1038/s41556-020-00583-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22429, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-18K08208
  • [Presentation] The inhibition of LUBAC mitigates amyotrophic lateral sclerosis-associated TDP-43 aggregation2022

    • Author(s)
      張強, 寺脇正剛, 及川大輔, 翁良徳, 臼杵克之助, 徳永文稔
    • Organizer
      第95回 生化学会大会
    • Data Source
      KAKENHI-PROJECT-21K06857
  • [Presentation] 直鎖状ユビキチン鎖生成酵素を標的とした阻害剤開発と疾患治療薬としての基礎検討2022

    • Author(s)
      及川大輔, 張強, 寺脇正剛, 翁良徳, 臼杵克之助, 徳永文稔
    • Organizer
      第74回 日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-21K06857
  • [Presentation] LUBAC ubiquitin ligase complex and linear ubiquitination facilitate cytoplasmic aggregation of amyotrophic lateral sclerosis (ALS)-associated TDP-432021

    • Author(s)
      Seigo Terawaki, Qiang Zhang, Daisuke Oikawa, Bangzhong Lin, Kazuto Nunomura, Shinsuke Komagawa, Yoshinosuke Usuki, Fuminori Tokunaga
    • Organizer
      第44回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06857
  • [Presentation] HOIPIN-8, a chemical inhibitor for linear ubiquitination, suppresses ALS-related TDP-43 aggregation and inflammatory responses in neuronal cells2021

    • Author(s)
      Qiang Zhang, Seigo Terawaki, and Fuminori Tokunaga
    • Organizer
      第15回 日本臨床ストレス応答学会大会
    • Data Source
      KAKENHI-PROJECT-21K06857
  • [Presentation] NDP52のユビキチン結合性を介した炎症応答・細胞死制御とLUBAC阻害剤の影響2020

    • Author(s)
      宮下 裕久, 及川 大輔, 寺脇 正剛, 徳永 文稔
    • Organizer
      第93回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K06937
  • [Presentation] Macrophages produce histamine through the interaction with antigen specific Th2 cells2020

    • Author(s)
      Naruhito Iwasaki, Seigo Terawaki, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunaga
    • Organizer
      第69回 日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K06937
  • [Presentation] HOIPIN-1, a novel LUBAC inhibitor, suppresses the imiquimod-induced psoriasis-like skin inflammation in mice2019

    • Author(s)
      Komakura K., Oikawa D., Terawaki S., Sakamoto S., Mizukami Y., Sugawara K., Tsuruta D., Tokunaga F.
    • Organizer
      Society for Investigative Dermatology 77th Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06937
  • 1.  HIROI Takachika
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  PIERRE Philippe
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  及川 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  徳永 文稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 5.  中村 修平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  岩崎 成仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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