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Shimizu Ippei  清水 逸平

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清水 逸平  シミズ イッペイ

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Researcher Number 60444056
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
2021 – 2023: 順天堂大学, 医学部, 准教授
2016 – 2021: 新潟大学, 医歯学総合研究科, 特任准教授
2015: 新潟大学, 医歯(薬)学総合研究科, 特任准教授
2014 – 2015: 新潟大学, 医歯(薬)学総合研究科, 准教授
2011: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / General internal medicine and related fields / Pathological medical chemistry / Circulatory organs internal medicine / Cardiovascular medicine
Except Principal Investigator
Basic Section 53020:Cardiology-related / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 48030:Pharmacology-related / Basic Section 55030:Cardiovascular surgery-related / Cardiovascular medicine / Cardiovascular surgery
Keywords
Principal Investigator
心不全 / 褐色脂肪 / 心房細動 / NASH / 老化 / 加齢同期 / 老化促進代謝物質 / 老化促進分子 / セノメタボライト関連疾患 / 加齢関連線維性疾患 … More / 慢性腎臓病 / 収縮能が保たれた心不全 / 加齢関連線維化促進分子 / コリン代謝 / サルコペニア / 老化促進代謝物質(セノメタボライト) / 分泌型線維化促進分子 / 選択的老化細胞除去 / 非アルコール生脂肪性肝炎 / 肥満疾患 / 線維化促進分泌型タンパク質 / 非アルコール性脂肪性肝炎 / 褐色脂肪不全 / 心筋代謝リモデリング / 褐色脂肪由来代謝産物 / 褐色アディポカイン / 肥満 / 慢性炎症 / インスリン抵抗性 / コリン / メタボローム / 代謝的リモデリング / ミトコンドリア … More
Except Principal Investigator
細胞老化 / 老化細胞除去 / 食品成分 / 老化 / Senolysis / 大動脈疾患 / 加齢性疾患 / アンチエイジング / 補体 / 肥満 / 代謝 / オートファジー / 白色内臓脂肪 / 糖代謝異常 / 内臓白色脂肪 / 解糖系 / ベージュ細胞 / サルコペニア / 心不全 / 代謝産物 / 血管 / 細胞除去 / 血管内皮 / SIRT1 / 褐色脂肪 / ポリフェノール / Sirt1 / 加齢関連疾患 / senolysis / 老化細胞 / AICAR / Cxcl9 / 活性酸素 / 血管新生 / 大動脈瘤 / 大動脈解離 Less
  • Research Projects

    (15 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (17 People)
  •  Pathogenic role of senocules in synchronization of agingPrincipal Investigator

    • Principal Investigator
      清水 逸平
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  加齢性疾患におけるコリン代謝不全の病的意義の解明

    • Principal Investigator
      吉田 陽子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Juntendo University
  •  補体抑制因子を介した老化制御機構の解明および加齢性疾患治療法の開発

    • Principal Investigator
      古内 亮
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Juntendo University
  •  大動脈疾患における細胞老化の病的意義の解明

    • Principal Investigator
      長澤 綾子
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Niigata University
  •  Senolysis ameliorates pathologies in atrial fibrillationPrincipal Investigator

    • Principal Investigator
      Shimizu Ippei
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Niigata University
  •  Pathological roles of senometabolites in cardiovascular disordersPrincipal Investigator

    • Principal Investigator
      Shimizu Ippei
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Juntendo University
      Niigata University
  •  Identification of novel senolytic drugs to treat age-related diseases

    • Principal Investigator
      Katsuumi Goro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Juntendo University
      Niigata University
  •  A Novel Mechanism of Homeostasis via Regulation of Vascular Aging in Brown Adipose Tissue

    • Principal Investigator
      Furuuchi Ryo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Juntendo University
      Niigata University
  •  Mechanism of white adipose tissue beiging through the modulation of glycolysis

    • Principal Investigator
      Yoshida Yohko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Juntendo University
      Niigata University
  •  The pathological role of secreted protein in promoting fibrosis in non alcoholic steatohepatitis.Principal Investigator

    • Principal Investigator
      Shimizu Ippei
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      Niigata University
  •  Brown adipose tissue dysfunction promotes metabolic disorder in a failing heart.Principal Investigator

    • Principal Investigator
      Shimizu Ippei
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Niigata University
  •  Elucidation of Vascular Remodeling through the Senescence Signal in Aortic Diseases

    • Principal Investigator
      nagasawa ayako
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Niigata University
  •  Elucidation of aging mechanism by novel aging related molecules

    • Principal Investigator
      Suda Masayoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Niigata University
  •  The pathological role of brown adipose tissue dysfunction in age related disorders.Principal Investigator

    • Principal Investigator
      Shimizu Ippei
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Niigata University
  •  心不全発症進展に対するインスリンシグナルの関与についての基盤研究Principal Investigator

    • Principal Investigator
      清水 逸平
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Chiba University

All 2022 2020 2019 2018 2017 2016 2015 2012 2011

All Journal Article Presentation Book Patent

  • [Book] アディポサイエンス2011

    • Author(s)
      清水逸平
    • Total Pages
      8
    • Publisher
      フジメディカル出版
    • Data Source
      KAKENHI-PROJECT-23790833
  • [Journal Article] p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure2012

    • Author(s)
      Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T
    • Journal Title

      Cell Metab

      Volume: 15 Issue: 1 Pages: 51-64

    • DOI

      10.1016/j.cmet.2011.12.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390237, KAKENHI-PROJECT-23790833, KAKENHI-PROJECT-24390195, KAKENHI-PUBLICLY-23126504
  • [Patent] 4.フラビン含有モノオキシゲナーゼ阻害による心不全治療法2019

    • Inventor(s)
      清水逸平、南野徹
    • Industrial Property Rights Holder
      清水逸平、南野徹
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-161902
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Patent] 非アルコール性脂肪性肝炎治療剤2015

    • Inventor(s)
      清水逸平、南野徹
    • Industrial Property Rights Holder
      国立大学法人新潟大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-13
    • Data Source
      KAKENHI-PROJECT-26893080
  • [Presentation] Activation of Endothelial Sirt1 by Polyphenol Inhibits Capillary Rarefaction in Brown Adipose Tissue and Contributes for Maintaining Systemic Metabolic Health.2022

    • Author(s)
      Ryo Furuuchi, Ippei Shimizu, Tohru Minamino
    • Organizer
      第86回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08485
  • [Presentation] ボイセンベリーポリフェノールによる褐色脂肪血管ネットワーク制御機構の解明2022

    • Author(s)
      古内 亮、吉田陽子、清水 逸平、南野 徹
    • Organizer
      第22回日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-19K08485
  • [Presentation] Polyphenol inhibits capillary rarefaction in brown adipose tissue and contributes for maintaining systemic metabolic health in obesity.2020

    • Author(s)
      古内 亮、清水逸平、南野徹
    • Organizer
      日本循環器学会
    • Data Source
      KAKENHI-PROJECT-19K08485
  • [Presentation] ボイセンベリーポリフェノールによる褐色脂肪組織の血管ネットワーク維持機構の解析2020

    • Author(s)
      古内 亮、清水逸平、南野徹
    • Organizer
      抗加齢医学会
    • Data Source
      KAKENHI-PROJECT-19K08485
  • [Presentation] Polyphenol inhibits capillary rarefaction in brown adipose tissue and contributes for maintaining systemic metabolic health in obesity.2020

    • Author(s)
      Ryo Furuuchi, Ippei Shimizu, Tohru Minamino,
    • Organizer
      第84回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08485
  • [Presentation] ボイセンベリーポリフェノールによる褐色脂肪組織の血管ネットワーク維持機構の解析2020

    • Author(s)
      古内 亮、清水 逸平、南野 徹
    • Organizer
      第20回日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-19K08485
  • [Presentation] 褐色脂肪研究を通した肥満関連疾患の新規治療標的分子の探索2019

    • Author(s)
      清水逸平
    • Organizer
      心血管内分泌代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Presentation] Disoriented choline metabolism promotes metabolic disorder in the failing heart2019

    • Author(s)
      清水逸平
    • Organizer
      第83回日本循環器学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] Senometabolite promotes pathologies in cardiovascular disorders.“Think aging” makes “Sync aging”.2019

    • Author(s)
      Shimizu I
    • Organizer
      The 50th NIPS International Symposium, MIRACLES, in Cardiovascular Physiology.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Presentation] 老化促進代謝物質を介した加齢同期メカニズムの解明2019

    • Author(s)
      清水逸平
    • Organizer
      日本体力医学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Presentation] Senolytic drug as a novel candidate for next anti-aging medicine.2019

    • Author(s)
      Shimizu I
    • Organizer
      International Conference and Exhibition on Indonesian Medical Education and Research Institute
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Presentation] Disoriented choline metabolism promotes pathologies in the failing heart2019

    • Author(s)
      清水逸平
    • Organizer
      心不全学会、日本・台湾心不全学会合同シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Presentation] Pathological roles of senometabolites in cardiovascular-metabolic disorders2019

    • Author(s)
      清水逸平
    • Organizer
      ISHR2019
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03650
  • [Presentation] 加齢性疾患における褐色脂肪不全の意義2018

    • Author(s)
      清水逸平
    • Organizer
      糖尿病学会
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] Roles of aging signaling and disoriented choline metabolism in the failing heart2018

    • Author(s)
      清水逸平
    • Organizer
      International Society for Heart Research(ISHR)日本部会総会2018
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] 心不全における、心筋・代謝的リモデリングの意義2018

    • Author(s)
      清水逸平
    • Organizer
      第91回日本内分泌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] 心不全、肥満における褐色脂肪不全の意義2018

    • Author(s)
      清水逸平
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] 心不全、肥満における褐色脂肪不全の意義2018

    • Author(s)
      清水逸平
    • Organizer
      第23回アディポサイエンスシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] 心血管代謝疾患における脂肪不全の意義2017

    • Author(s)
      清水逸平
    • Organizer
      日本心血管内分泌代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] 老化疾患における褐色脂肪不全の意義2017

    • Author(s)
      清水逸平
    • Organizer
      第38回日本肥満学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06244
  • [Presentation] The pathological roles of brown and white adipose tissue dysfunction in heart failure, obesity and diabetes2016

    • Author(s)
      清水逸平
    • Organizer
      第80回日本循環器学会総会・学術集会
    • Place of Presentation
      仙台市民会館(宮城県、仙台市)
    • Year and Date
      2016-03-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-26893080
  • [Presentation] 心不全における老化シグナルの意義2015

    • Author(s)
      清水逸平
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県、松山市)
    • Year and Date
      2015-10-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-26893080
  • [Presentation] 肥満と心血管老化2015

    • Author(s)
      清水逸平
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-26893080
  • [Presentation] A crucial role for senescence-associated glycoprotein(SAGP) in the maintenance of vessel homeostasis2015

    • Author(s)
      清水 逸平
    • Organizer
      脳血管抗加齢医学会
    • Place of Presentation
      梅田スカイビル(大阪府・大阪市)
    • Year and Date
      2015-11-28
    • Data Source
      KAKENHI-PROJECT-15K09154
  • [Presentation] 心不全、肥満における脂肪不全の意2015

    • Author(s)
      清水逸平
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-26893080
  • [Presentation] Adipose p53 is critically involved in the development of in sulin resistance in heart failure2012

    • Author(s)
      Ippei Shimizu
    • Organizer
      Aging, Biology of Gordon research conference
    • Place of Presentation
      Ventura, Los Angeles(米国)
    • Data Source
      KAKENHI-PROJECT-23790833
  • [Presentation] Adipose p53 is critically involved in the development of insulin resistance in heart failure2011

    • Author(s)
      清水逸平
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23790833
  • 1.  南野 徹 (90328063)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 7 results
  • 2.  Yoshida Yohko (00586232)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  Sakimura Kenji
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  Okuda Shujiro
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  Sasaoka Toshikuni
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  nagasawa ayako (20768999)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  Furuuchi Ryo (60750073)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 8.  土田 正則 (60293221)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  Soga Tomoyoshi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  Suda Masayoshi (70714509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Katsuumi Goro (60815356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Minokoshi Yasuhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  Aoki Junken
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Hayano Toshiya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Terai Shuji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Nakagami Hironori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  Walsh Kenneth
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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