Kakizawa Taeko 柿澤多惠子

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KAKIZAWA Taeko 柿澤多惠子

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Researcher Number	60445963
Affiliation (Current)	2025: 関東学院大学, 理工学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2017: 早稲田大学, 理工学術院, 講師(任期付) 2013 – 2015: 早稲田大学, 理工学術院, 講師 2011 – 2012: 工学院大学, 工学部, 講師 2010: 京都府立医科大学, 医学研究科, 研究員
Review Section/Research Field	Principal Investigator Drug development chemistry
Keywords	Principal Investigator 創薬科学 / アルツハイマー病 / ペプチド / 創薬化学 / 酵素阻害剤 / BACE1阻害剤

Preparation of histone demethylase inhibitors based on substrate specificityPrincipal Investigator
- Principal Investigator
  
  Kakizawa Taeko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Waseda University
Design and synthesis of long-acting BACE1 inhibitors incorporating unnatural amino acidsPrincipal Investigator
- Principal Investigator
  
  KAKIZAWA Taeko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Waseda University
  Kogakuin University
Development of new BACE1 inhibitors : an approach for downsizing moleculesPrincipal Investigator
- Principal Investigator
  
  KAKIZAWA Taeko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kogakuin University
  Kyoto Prefectural University of Medicine

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors2018
- Author(s)
  Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 2 Pages: 167-169
- DOI
  10.1016/j.bmcl.2017.11.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460159
[Journal Article] Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide2016
- Author(s)
  Taeko Kakizawa, Tamio Mizukami, Yukihiro Itoh, Makoto Hasegawa, Ryuzo Sasaki, Takayoshi Suzuki
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 26 Issue: 4 Pages: 1193-1195
- DOI
  10.1016/j.bmcl.2016.01.036
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14982, KAKENHI-PROJECT-26460159
[Journal Article] Histone H3 peptide based LSD1-selective inhibitors2015
- Author(s)
  Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Hiroki Tsumoto, Takayoshi Suzuki
- Journal Title
  
  Bioorganic and medicinal chemistry letters
  
  Volume: 25 Issue: 9 Pages: 1925-1928
- DOI
  10.1016/j.bmcl.2015.03.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460159
[Journal Article] Linking of phosphinidene-capped triruthenium carbonyl clusters with diphosphine ligands2015
- Author(s)
  Taeko Kakizawa , Hisako Hashimoto, Hiromi Tobita
- Journal Title
  
  INORGANICA CHIMICA ACTA
  
  Volume: 425 Pages: 7-10
- DOI
  10.1016/j.ica.2014.09.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24109011, KAKENHI-PROJECT-24790117, KAKENHI-PROJECT-26460159
[Journal Article] Lysine-Specific Demethylase 1-Selective Inactivators Based on Protein-Targeted Drug Delivery Mechanism2013
- Author(s)
  Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N, Suzuki T
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 52 Issue: 33 Pages: 8620-8624
- DOI
  10.1002/anie.201303999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24790117, KAKENHI-PROJECT-24890193, KAKENHI-PROJECT-221S0001
[Journal Article] Octacarbonyldi-μ2-hydro-[μ3-[(1,3,5-trimetylphenyl)phosphinidene]] (triphenylphosphane)-triangulo-triruthenium2012
- Author(s)
  Taeko Kakizawa
- Journal Title
  
  Acta Crystallographica Section E
  
  Volume: E68 Issue: 10 Pages: m1293-m1293
- DOI
  10.1107/s1600536812039499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790117
[Journal Article] Evaluation of superior BACE1 cleavage sequences containing unnatural amino acids2011
- Author(s)
  T. Kakizawa, A. Sanjoh, A. Kobayashi, Y. Hattori, K. Teruya, and K. Akaji
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 19 Issue: 9 Pages: 2785-2789
- DOI
  10.1016/j.bmc.2011.03.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790119, KAKENHI-PROJECT-23550195
[Journal Article] Dehydrocoupling reactions of secondary and primary amine-borane adducts catalyzed by half-sandwich carbonyl complexes, [CpMn(CO)_3], [(η^6-C_6H_6) Cr(CO)_3], and [CpV(CO)_4]2011
- Author(s)
  T. Kakizawa, Y. Kawano, K. Naganeyama, and M. Shimoi
- Journal Title
  
  Chemistry Letters
  
  Volume: 40 Issue: 2 Pages: 171-173
- DOI
  10.1246/cl.2011.171
- NAID
  10027814770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790119
[Journal Article] Development of L40I HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate.2011
- Author(s)
  Henri-Obadja Kumada, Jeffrey-Tri Nguyen, Keiji Nishiyama, Taeko Kakizawa, Yasuhiro Arii, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso
- Journal Title
  
  J. Peptide Science
  
  Volume: 17(8) Issue: 8 Pages: 569-575
- DOI
  10.1002/psc.1375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790119, KAKENHI-PROJECT-23790145
[Journal Article] The E22SS-type mutant of amyloid SS peptide (ASS) adopts distinct selfassembly mechanisms from wild- type ASS.2011
- Author(s)
  Youhei Sohma, Hui Wang, Atsuhiko Taniguchi, Yuta Hirayama, Taeko Kakizawa, Hidehito Mukai, Yoshiaki Kiso
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Issue: 12 Pages: 3787-3792
- DOI
  10.1016/j.bmc.2011.04.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-22790119
[Journal Article] Dehydrocoupling reactions of secondary and primary amine-borane adducts catalyzed by half-sandwich carbonyl complexes, [CpMn(CO)_3], [(η^6-C_6H_6)Cr(CO)_3], and [CpV(CO)_4]2011
- Author(s)
  Taeko Kakizawa
- Journal Title
  
  Chemistry letters
  
  Volume: VOL.40 Pages: 171-173
- NAID
  10027814770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790119
[Journal Article] Evaluation of superior BACE1 cleavage sequences containing unnatural amino acids2011
- Author(s)
  Taeko Kakizawa
- Journal Title
  
  Bioorganic and medicinal chemistry
  
  Volume: VOL.19 Pages: 2785-2789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790119
[Journal Article] Tetrapeptides, as small-sized peptidic inhibitors ; synthesis and their inhibitory activity against BACE12010
- Author(s)
  Taeko Kakizawa
- Journal Title
  
  Journal of peptide science
  
  Volume: VOL.16 Pages: 257-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790119
[Journal Article] Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against2010
- Author(s)
  Taeko Kakizawa, Koushi Hidaka, Daisuke Hamada, Ryoji Yamaguchi, Tsuyoshi Uemura, Hitomi Kitamura, Harichandra D. Tagad, Takashi Hamada, Zyta Ziora, Yoshio Hamada, Tooru Kimura, Yoshiaki Kiso
- Journal Title
  
  BACE1. J. Peptide Science
  
  Volume: 16 Issue: 6 Pages: 257-262
- DOI
  10.1002/psc.1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790119
[Presentation] Lysine-Specific Demethylase 1 Inhibitory Activity of Histone H3 Peptides Incorporating Modified Lysine 42017
- Author(s)
  Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, and Takayoshi Suzuki
- Organizer
  第 54 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-26460159
[Presentation] Modification of the Lysine Residue of Histone H3 Peptides as Lysine-Specific Demethylase 1 inhibitors2016
- Author(s)
  Taeko Kakizawa, Takayoshi Suzuki
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26460159
[Presentation] Evaluation of phenylcyclopropylamine-type inhibitors by an in vitro lysine-specific demethylase 2 assay in the presence of NPAC dodecapeptide2015
- Author(s)
  Taeko Kakizawa, Tamio Mizukami, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  第52回　ペプチド討論会
- Place of Presentation
  平塚中央公民館
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460159
[Presentation] Aβ1-42およびAβ1-43のC末端モチーフを有するアルツハイマー病治療薬の開発2014
- Author(s)
  荒井卓也、大野彰子、柿澤多惠子、栗原正明、宮田直樹、中川秀彦、福原潔
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] 抗酸化作用を有する新規アルツハイマー病治療薬の開発2013
- Author(s)
  荒井卓也、大野彰子、柿澤多惠子、小澤俊彦、宮田直樹、栗原正明、中川秀彦、福原潔
- Organizer
  第66回日本酸化ストレス学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] Peptidic Inactivator for Histone Demethylase LSD12013
- Author(s)
  Taeko Kakizawa, Daisuke Ogasawara, Yukihiko Itoh, Hiroki Tsumoto, Koshiki Mino, Kiyoshi　Fukuhara, Takaki Koide, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata, Takayoshi Suzuki
- Organizer
  APIPS (4th Asia-Pacific International Peptide symposium, 50th Japanese Peptide Symposioum)
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] Evaluation of substrate specificities for BACE1 using synthetic peptide libraries2010
- Author(s)
  Taeko Kakizawa・Yasunao Hattori・Kenta Teruya・Akira Sanjoh・Kenichi Akaji
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] Evaluation of substrate specificities for BALE 1 using synthetic peptide libraries2010
- Author(s)
  Taeko Kakizawa
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors2010
- Author(s)
  Taeko Kakizawa・Koushi Hidaka・Daisuke Hamada・Ryoji Yamaguchi・Tsuyoshi Uemura・Hitomi Kitamura・Harichandra D. Tagad・Takeshi Hamada・Zyta Ziora・Yoshio Hamada・Tooru Kimura・Yoshiaki Kiso
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] Design and preparation of the tetrapeptides as low molecular sized BACE1 inhibitors2010
- Author(s)
  Taeko Kakizawa
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] ペプチドライブラリーを用いたBACE 1基質特異性の検討2010
- Author(s)
  柿澤多惠子・服部恭尚・照屋健太・三城明・赤路健一
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都テルサ
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] LC-MSを用いたペプチドライブラリーからのBACE 1基質特異性のスクリーニング2010
- Author(s)
  柿澤多惠子・服部恭尚・照屋健太・三城明・赤路健一
- Organizer
  第6回3大学連携研究フォーラム
- Place of Presentation
  京都府立大学
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] Click Peptide : Application to E22Δ-type Mutant of Amyloid β Peptide2010
- Author(s)
  Hui Wang・Youhei Sohma・Atsuhiko Taniguchi・Yuta Hirayama・Taeko Kakizawa・Hidehito Mukai・Yoshiaki Kiso
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22790119
[Presentation] A Specific Substrate for BACE1 Determined by Peptide Library Screening
- Author(s)
  Taeko Kakizawa
- Organizer
  The 11th International Symposium on Advanced Technology (ISAT-Special)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] Truncation Studies of Histone H3 Peptide Analogs as Lysine-Specific Demethylase 1 Inactivators
- Author(s)
  Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26460159
[Presentation] Truncation Studies of Histone H3 Peptide Analogs as Lysine-Specific Demethylase 1 Inactivators
- Author(s)
  Kakizawa, Yosuke Ota, Yukihiro Itoh, and Takayoshi Suzuki
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] Structure-Activity Relationship Studies of the Peptidic Inactivators of Histone Demethylase LSD1
- Author(s)
  Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, and Takayoshi Suzuki
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] Phosphinidene-capped ruthenium carbonyl clusters; syntheses, reactivities, and structure expansion reactions
- Author(s)
  Taeko Kakizawa
- Organizer
  The 11th International Symposium on Advanced Technology (ISAT-Special)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-24790117
[Presentation] Structure-Activity Relationship Studies of the Peptidic Inactivators of Histone Demethylase LSD1
- Author(s)
  Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26460159

1. HIDAKA Koushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. HASEGAWA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. SOHMA Youhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SUZUKI Takayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 木曽良明

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 木村徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 向井秀仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 橋本久子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 飛田博実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakizawa Taeko 柿澤 多惠子

KAKIZAWA Taeko 柿澤 多惠子

Research Projects

Research Products

Co-Researchers

Preparation of histone demethylase inhibitors based on substrate specificityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and synthesis of long-acting BACE1 inhibitors incorporating unnatural amino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new BACE1 inhibitors : an approach for downsizing moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone H3 peptide based LSD1-selective inhibitors2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Linking of phosphinidene-capped triruthenium carbonyl clusters with diphosphine ligands2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysine-Specific Demethylase 1-Selective Inactivators Based on Protein-Targeted Drug Delivery Mechanism2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Octacarbonyldi-μ2-hydro-[μ3-[(1,3,5-trimetylphenyl)phosphinidene]] (triphenylphosphane)-triangulo-triruthenium2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of superior BACE1 cleavage sequences containing unnatural amino acids2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dehydrocoupling reactions of secondary and primary amine-borane adducts catalyzed by half-sandwich carbonyl complexes, [CpMn(CO)_3], [(η^6-C_6H_6) Cr(CO)_3], and [CpV(CO)_4]2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Development of L40I HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The E22SS-type mutant of amyloid SS peptide (ASS) adopts distinct selfassembly mechanisms from wild- type ASS.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dehydrocoupling reactions of secondary and primary amine-borane adducts catalyzed by half-sandwich carbonyl complexes, [CpMn(CO)_3], [(η^6-C_6H_6)Cr(CO)_3], and [CpV(CO)_4]2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Evaluation of superior BACE1 cleavage sequences containing unnatural amino acids2011

Kakizawa Taeko 柿澤多惠子

KAKIZAWA Taeko 柿澤多惠子