yahata naoki 八幡直樹

… Alternative Names

Yahata Naoki 八幡直樹

YAHATA Naoki 八幡直樹

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Researcher Number	60450607
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 藤田医科大学, 医学部, 講師 2018 – 2020: 藤田医科大学, 医学部, 助教 2016 – 2017: 藤田保健衛生大学, 医学部, 助教 2013: 藤田保健衛生大学, 医学部, 助教 2012: 京都大学, iPS細胞研究所, 研究員
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 49010:Pathological biochemistry-related / Pediatrics / Basic Section 48040:Medical biochemistry-related / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 56010:Neurosurgery-related / Neurosurgery
Keywords	Principal Investigator iPS細胞 / ミトコンドリア / mtDNA / 創薬 / 発生・分化 / ミトコンドリアDNA / TALEN / 神経細胞 / 分化誘導 / アルツハイマー病 … More Except Principal Investigator … More iPS / ゲノム編集 / iPS細胞 / MELAS / がん代謝 / 神経膠腫 / 網羅的代謝解析 / 網羅的遺伝子解析 / IDH変異 / グリオーマ / 再生療法 / gene editing / ミトコンドリア病 / TALEN / IDH / IDH1 / 代謝 / 腫瘍化 / 変異型IDH / mutant IDH / glioma Less

アストロサイト-ニューロン相互作用からミトコンドリア病神経病態を解き明かすPrincipal Investigator
- Principal Investigator
  
  八幡直樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Fujita Health University
疾患iPS細胞由来ニューロンにおける変異mtDNAの時空間的動態観察ツールの開発Principal Investigator
- Principal Investigator
  
  八幡直樹
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Fujita Health University
Elucidation of molecular mechanism of MELAS using iPS cells derived from MELAS patients with various heteroplasmy.
- Principal Investigator
  
  秦龍二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka Prefectural Hospital Organization, Osaka Psychitriac Medical Center (Osaka Psychiatric Researc
Establishment of iPSC disease models with mitochondrial DNA mutations using genome editing technology.Principal Investigator
- Principal Investigator
  
  Yahata Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Fujita Health University
Development of novel gene therapy for MELAS by editing mitochondorial DNA
- Principal Investigator
  
  Hata Ryuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Fujita Health University
Elucidation of the mechanism of tumorigenesis and development of new treatments using iPS cell-derived mutant IDH glioma model
- Principal Investigator
  
  OHBA SHIGEO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Fujita Health University
Mutant IDH-induced iPS-derived glioma cells
- Principal Investigator
  
  OHBA SHIGEO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Fujita Health University
Elucidation of pathological threshold in mitochondrial disease patient-derived iPSC model.Principal Investigator
- Principal Investigator
  
  Yahata Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Fujita Health University
Analysis of cholinergic neurons derived from Alzheimer's disease patient-specific iPS cellsPrincipal Investigator
- Principal Investigator
  
  YAHATA Naoki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Fujita Health University
  Kyoto University

All 2023 2021 2018 2017 2016 2013 2012 Other

All Journal Article Presentation Book Patent

[Book] iPS細胞作製技術を利用した神経疾患病因機構の解明と創薬開発への取り組み遺伝子医学MOOK 222012
- Author(s)
  八幡直樹、井上治久
- Data Source
  KAKENHI-PROJECT-24700367
[Journal Article] TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.2017
- Author(s)
  Yahata N., Matsumoto Y., Omi M., Yamamoto N., Hata R.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 15557-15557
- DOI
  10.1038/s41598-017-15871-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11495, KAKENHI-PROJECT-16K19675
[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013
- Author(s)
  Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 4 Pages: 487-496
- DOI
  10.1016/j.stem.2013.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
[Journal Article] iPS細胞作製技術を利用した神経疾患病因機構の解明と創薬開発への取り組み2012
- Author(s)
  八幡直樹、井上治久
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 22 Pages: 98-102
- Data Source
  KAKENHI-PROJECT-24700367
[Patent] TALエフェクターヌクレアーゼ対およびその利用2023
- Inventor(s)
  八幡直樹、秦　龍二
- Industrial Property Rights Holder
  八幡直樹、秦　龍二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-217626
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K07782
[Patent] ミトコンドリア病誘発変異型mtDNA率の異なるiPS細胞群2017
- Inventor(s)
  秦龍二、八幡直樹、尾身実
- Industrial Property Rights Holder
  秦龍二、八幡直樹、尾身実
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-034673
- Filing Date
  2017-02-27
- Data Source
  KAKENHI-PROJECT-16K19675
[Patent] ミトコンドリア病誘発変異型ｍｔＤＮＡ率の異なるｉＰＳ細胞群2017
- Inventor(s)
  秦龍二、八幡直樹、尾身実
- Industrial Property Rights Holder
  秦龍二、八幡直樹、尾身実
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-199578
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19675
[Presentation] ミトコンドリア病患者由来iPS細胞の神経細胞への分化誘導2023
- Author(s)
  八幡　直樹、大熊　真人、秦　龍二
- Organizer
  第55回藤田医科大学医学会学術大会　名古屋
- Data Source
  KAKENHI-PROJECT-21K07782
[Presentation] Development of novel gene therapy for MELAS by editing mitochondrial DNA2023
- Author(s)
  Hata R, Yahata N , Omi M, Yoshikawa T
- Organizer
  第64回日本神経学会学術集会　東京
- Data Source
  KAKENHI-PROJECT-21K07782
[Presentation] Development of mutant mtDNA-targeted TALENs and their application to iPSC-based mitochondrial disease model.2023
- Author(s)
  Yahata, N., Boda, H. and Hata, R
- Organizer
  International Meeting on Mitochondrial Pathology (EUROMIT 2023) Bologna Italy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07782
[Presentation] 変異mtDNAを標的としたTALENの開発とミトコンドリア病iPS細胞モデルへの応用2021
- Author(s)
  八幡　直樹
- Organizer
  第20回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07782
[Presentation] ミトコンドリア病患者由来iPS細胞の骨格筋細胞への分化誘導2021
- Author(s)
  八幡　直樹、秦　龍二
- Organizer
  第53回藤田医科大学医学会
- Data Source
  KAKENHI-PROJECT-21K07782
[Presentation] ミトコンドリア病iPS細胞の変異mtDNA比率を改変するPlatinum TALENの改良2021
- Author(s)
  八幡　直樹、帽田　仁子、秦　龍二
- Organizer
  日本ゲノム編集学会　第6回大会
- Data Source
  KAKENHI-PROJECT-21K07782
[Presentation] TALENを用いたMELAS患者由来iPS細胞における変異ミトコンドリアDNA比率の改変2018
- Author(s)
  八幡直樹、松本祐嗣、尾身　実、山本直樹、秦　龍二
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16K19675
[Presentation] MELAS患者由来iPS細胞の樹立2016
- Author(s)
  八幡　直樹、秦　龍二
- Organizer
  日本解剖学会　第76回中部支部学術集会
- Place of Presentation
  信州大学医学部附属病院　(長野)
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K19675
[Presentation] Generation of induced pluripotent stem cells from a MELAS patient with m.13513G>A mutation.2016
- Author(s)
  Naoki Yahata and Ryuji Hata
- Organizer
  The 13th Conference of Asian Society　for　Mitochondrial　Research　and　Medicine　and　The　16th　Conference　of　Japanese　Society　of　Mitochondrial Research and Medicine
- Place of Presentation
  TKP Garden City Shinagawa (Tokyo, Japan)
- Year and Date
  2016-10-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19675
[Presentation] Anti-Amyloidβdrug validation using human iPS cell-derived neurons for the treatment of Alzheimer's disease2013
- Author(s)
  Asai M, Yahata N, Iwata N, and Inoue H.
- Organizer
  The 11^<th> International Conference on Alzheimer's & Parkinson's Disease
- Place of Presentation
  Firenze Fiera (Florence, Italy)
- Year and Date
  2013-03-07
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] 神経分化過程におけるAβ40とAβ42の産生比の変化とその責任遺伝子の解析2013
- Author(s)
  浅井将、中野梨絵、荒木希、渡邊かおり、八幡直樹、関恒慶、小林千浩、戸田達史、城谷圭朗、井上治久、岩田修永
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] 神経分化過程におけるAβ40とAβ42の産生比の変化とその責任遺伝子の解析2013
- Author(s)
  浅井将、中野梨絵、荒木希、渡邊かおり、八幡直樹、関恒慶、小林千浩、戸田達史、城谷圭朗、井上治久、岩田修永
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] 家族性アルツハイマー病患者由来iPS細胞の樹立と解析2013
- Author(s)
  近藤孝之、八幡直樹、舟山美里、月田香代子、浅井将、岩田修永、川勝忍、和泉唯信、梶龍兒、朝田隆、高橋良輔、井上治久
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2013-05-30
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] 家族性アルツハイマー病患者由来iPS細胞の樹立と解析2013
- Author(s)
  近藤孝之、八幡直樹、舟山美里、月田香代子、浅井将、岩田修永、川勝忍、和泉唯信、梶龍兒、朝田隆、高橋良輔、井上治久
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] ヒトiPS細胞を用いたアルツハイマー病治療薬探索基盤の開発2012
- Author(s)
  八幡直樹、浅井将、岩田修永、井上治久
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] Anti-Aβdrug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease2012
- Author(s)
  Yahata N, Asai M, Iwata N, and Inoue H.
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2012-09-18
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] Anti-Amyloidβdrug validation using human iPS cell-derived neurons for the treatment of Alzheimer's disease2012
- Author(s)
  Yahata N, Asai M, Iwata N, and Inoue H.
- Organizer
  The 42th Annual meeting of the Society for Neuroscience
- Place of Presentation
  the Ernest N. Morial Convention Center (New Orleans, LA)
- Year and Date
  2012-10-17
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
- Author(s)
  Yahata N., Asai M., Iwata N., and Inoue H.
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] ヒトiPS細胞を用いたアルツハイマー病治療薬探索基盤の開発
- Author(s)
  八幡直樹、浅井将、岩田修永、井上治久
- Organizer
  第53回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] Anti-Aβ drug validation using human iPS cell-derived neurons for the treatment of Alzheimer’s disease
- Author(s)
  Asai M., Yahata N., Iwata N., and Inoue H.
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24700367
[Presentation] Anti-Amyloid β drug validation using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
- Author(s)
  Yahata N., Asai M., Iwata N., and Inoue H.
- Organizer
  The 42th Annual meeting of the Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24700367

1. Hata Ryuji (90258153)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. OHBA SHIGEO (80338061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 廣瀬雄一 (60218849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 尾身実 (00400416)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 吉川哲史 (80288472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 常陸圭介 (10508469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 平山明由 (00572405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大熊真人 (50329710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中嶋和紀 (10442998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MURAKAMI Kazuma

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山本直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 泰龍二

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
13. 入江一浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yahata naoki 八幡 直樹

Yahata Naoki 八幡 直樹

YAHATA Naoki 八幡 直樹

Research Projects

Research Products

Co-Researchers

アストロサイト-ニューロン相互作用からミトコンドリア病神経病態を解き明かすPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患iPS細胞由来ニューロンにおける変異mtDNAの時空間的動態観察ツールの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism of MELAS using iPS cells derived from MELAS patients with various heteroplasmy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of iPSC disease models with mitochondrial DNA mutations using genome editing technology.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel gene therapy for MELAS by editing mitochondorial DNA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of tumorigenesis and development of new treatments using iPS cell-derived mutant IDH glioma model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mutant IDH-induced iPS-derived glioma cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathological threshold in mitochondrial disease patient-derived iPSC model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cholinergic neurons derived from Alzheimer's disease patient-specific iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] iPS細胞作製技術を利用した神経疾患病因機構の解明と創薬開発への取り組み 遺伝子医学MOOK 222012

Author(s)

Data Source

[Journal Article] TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞作製技術を利用した神経疾患病因機構の解明と創薬開発への取り組み2012

Author(s)

Journal Title

Data Source

[Patent] TALエフェクターヌクレアーゼ対およびその利用2023

Inventor(s)

Industrial Property Rights Holder

yahata naoki 八幡直樹

Yahata Naoki 八幡直樹

YAHATA Naoki 八幡直樹

[Book] iPS細胞作製技術を利用した神経疾患病因機構の解明と創薬開発への取り組み遺伝子医学MOOK 222012