YONASHIRO Ryo 與那城亮

Researcher Number	60453809
Other IDs
Affiliation (based on the past Project Information) *help	2018: 東京医科歯科大学, 難治疾患研究所, 助教 2008 – 2011: Tokyo University of Pharmacy and Life Science, 生命科学部, 助教
Review Section/Research Field	Principal Investigator Functional biochemistry / Pathological medical chemistry / Basic Section 50010:Tumor biology-related Except Principal Investigator Neurochemistry/Neuropharmacology / Medium-sized Section 50:Oncology and related fields
Keywords	Principal Investigator タンパク質分解 / 品質管理 / ミトコンドリア / 神経変性疾患 / ユビキチン / 細胞内タンパク質分解 / ERAD / ユビキチンリガーゼ / 筋萎縮性側索硬化症 / 活性酸素 … More Except Principal Investigator 神経変性疾患 / ポリグルタミン病 / 神経回路形成 / CRAG / 遺伝子治療 / ミトコンドリアユビキチンリガーゼMITOL / MAP1B-LC1 / Mfn2 / 神経ガイダンス / 活性酸素 / ミトコンドリア / 低酸素応答 / 遺伝子発現 / 染色体構造 / 代謝酵素 / 代謝 / がん / クロマチン構造 Less

Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancer
- Principal Investigator
  
  中山恒
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Asahikawa Medical College
  Tokyo Medical and Dental University
低酸素応答性エピジェネティクスの制御機構と低酸素性乳癌の悪性化の分子機構の解明Principal Investigator
- Principal Investigator
  
  與那城亮
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Medical and Dental University
ミトコンドリアユビキチンリガーゼによる酸化タンパク質排除機構と神経変性疾患Principal Investigator
- Principal Investigator
  
  與那城亮
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Neuronal development via redox signaling and mitochondrial dynamics
- Principal Investigator
  
  YANAGI Shigeru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
A role of mitochondrial ubiquitin ligase MITOL in mitochondrial quality control.Principal Investigator
- Principal Investigator
  
  YONASHIRO Ryo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2018 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Pyruvate dehydrogenase PDH-E1beta is downregulated under prolonged hypoxic condition, and controls the progression of tumor growth by altering the metabolic status in cancer cells2018
- Author(s)
  Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K.
- Journal Title
  
  Cancer Res
  
  Volume: 78 Pages: 1592-1603
- DOI
  10.1158/0008-5472.can-17-1751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05523, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K08260, KAKENHI-PROJECT-18K07225
[Journal Article] Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death2012
- Author(s)
  Yonashiro, R., Kimijima, Y., Shimura, T., Kawaguchi, K., Fukuda, T., Inatome, R., and Yanagi, S.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A.
  
  Volume: 109(7) Pages: 2382-2387
- DOI
  10.1073/pnas.1114985109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650195, KAKENHI-PROJECT-23790380
[Journal Article] A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.2011
- Author(s)
  Sugiura A., Yonashiro R., Fukuda T., Matsushita N., Nagashima S., Inatome R., Yanagi S.
- Journal Title
  
  Mitochondrion 11
  
  Pages: 139-146
- Data Source
  KAKENHI-PROJECT-20300133
[Journal Article] Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms.2011
- Author(s)
  Matsushita N., Yonashiro R., Ogata Y., Sugiura A., Nagashima S., Fukuda T., Inatome R., Yanagi S.
- Journal Title
  
  Genes Cells 16
  
  Pages: 190-202
- Data Source
  KAKENHI-PROJECT-20300133
[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009
- Author(s)
  Yonashiro R., Sugiura A., Miyachi M., Fukuda T., Matsushita N., Inatome R., Ogata Y., Suzuki T., Dohmae N., Yanagi S.
- Journal Title
  
  Mol.Biol.Cell 20
  
  Pages: 4524-4530
- Data Source
  KAKENHI-PROJECT-20300133
[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009
- Author(s)
  Yonashiro, R.
- Journal Title
  
  Mol.Biol.Cell 20
  
  Pages: 4524-4530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300133
[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009
- Author(s)
  Yonashiro, R.
- Journal Title
  
  Mol.Biol.Cell 20
  
  Pages: 4524-4530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770109
[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009
- Author(s)
  Yonashiro, R., Sugiura, A., Miyachi, M., Fukuda, T., Matsushita, N., Inatome, R., Ogata, Y., Suzuki, T., Dohmae, N., Yanagi, S.
- Journal Title
  
  Mol. Biol. Cell 20(21)
  
  Pages: 4524-4530
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるS-ニトロシル化LC1のユビキチン化2010
- Author(s)
  與那城亮、川口浩平、志村卓哉、長谷川江里香、稲留涼子、柳茂
- Organizer
  BMB 2010第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20300133
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクス2009
- Author(s)
  與那城亮、君嶋悠矢、杉浦歩、柳茂
- Organizer
  第9回日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクス2009
- Author(s)
  與那城亮、君嶋悠矢、杉浦歩、柳茂
- Organizer
  第9回日本ミトコンドリア学会年会
- Place of Presentation
  東
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-20300133
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクス2009
- Author(s)
  與那城亮
- Organizer
  第9回日本ミトコンドリア学会年会
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2009-12-18
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクスの制御2009
- Author(s)
  君嶋悠矢、杉浦歩、長谷川江里香、渡辺香林、遠藤雄二郎、松下暢子、與那城亮、柳茂
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクスの制御2009
- Author(s)
  君嶋悠矢、杉浦歩、長谷川江里香、渡辺香林、遠藤雄二郎、松下暢子、與那城亮、柳茂
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20300133
[Presentation] Degradation of expanded polyglutamine protein by mitochodirial ubiquitn ligase MITOL2008
- Author(s)
  杉浦歩、與那城亮、宮地美沙子、尾形佳靖、柳茂
- Organizer
  The 7th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLは筋萎縮性側索硬化症原因蛋白質変異SOD1をユビキチン化する2008
- Author(s)
  與那城亮、宮地美沙子、杉浦歩、柳茂
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2008-07-01
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] Mitochondrial Ubiquitin Ligase, MITOLの機能解析2008
- Author(s)
  杉浦歩、與那城亮、秋元拓也、君嶋悠矢、宮沢良太、柳茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクスの制御2008
- Author(s)
  君嶋悠矢、中川隆司、與那城亮、杉浦歩、東ヶ崎健、加藤薫、柳茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] a novel mitochondrial ubiquitin ligase, ubiquitinates mutant SOD1 which causes amyotrophic lateral sclerosis2008
- Author(s)
  與那城亮、杉浦歩、秋元拓也、福田敏史、松下暢子、柳茂
- Organizer
  The 7th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクスの制御2008
- Author(s)
  君嶋悠矢、中川隆司、與那城亮、杉浦歩、東ヶ崎健、加藤薫、柳茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20300133
[Presentation] Mitochondrial Ubiquitin Ligase,MITOLの機能解析2008
- Author(s)
  杉浦歩、與那城亮、秋元拓也、君嶋悠矢、宮沢良太、柳茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20300133
[Presentation] DT40欠損細胞を用いたMITOLの機能解析2008
- Author(s)
  秋元拓也、杉浦歩、中川隆司、君嶋悠矢、與那城亮、柳茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-20770109
[Presentation] ミトコンドリアユビキチンリガーゼMITOLは筋萎縮性側索硬化症原因蛋白質変異SOD1をユビキチン化する2008
- Author(s)
  與那城亮、宮地美沙子、杉浦歩、柳茂
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2008-07-01
- Data Source
  KAKENHI-PROJECT-20300133
[Presentation] DT40欠損細胞を用いたMITOLの機能解析2008
- Author(s)
  秋元拓也、杉浦歩、中川隆司、君嶋悠矢、與那城亮、柳茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20300133

1. YANAGI Shigeru (60252003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. MATSUSHITA Nobuko (30333222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. FUKUDA Toshifumi (50372313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 中山恒 (10451923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 谷本幸介 (60611613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 谷水直樹 (00333386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 武田憲彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YONASHIRO Ryo 與那城 亮

Research Projects

Research Products

Co-Researchers

Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

低酸素応答性エピジェネティクスの制御機構と低酸素性乳癌の悪性化の分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミトコンドリアユビキチンリガーゼによる酸化タンパク質排除機構と神経変性疾患Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuronal development via redox signaling and mitochondrial dynamics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of mitochondrial ubiquitin ligase MITOL in mitochondrial quality control.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pyruvate dehydrogenase PDH-E1beta is downregulated under prolonged hypoxic condition, and controls the progression of tumor growth by altering the metabolic status in cancer cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.2011

Author(s)

Journal Title

Data Source

[Journal Article] Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms.2011

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009

Author(s)

Journal Title

Data Source

[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるS-ニトロシル化LC1のユビキチン化2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ミトコンドリアユビキチンリガーゼMITOLによるミトコンドリアダイナミクス2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

YONASHIRO Ryo 與那城亮