Nurakami Kazuhiro 村上和弘

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Murakami Kazuhiro 村上和弘

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Researcher Number	60455368
Other IDs
Affiliation (Current)	2025: 金沢大学, がん進展制御研究所, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 金沢大学, がん進展制御研究所, 准教授 2016 – 2020: 金沢大学, がん進展制御研究所, 助教 2015: 北海道大学, 先端生命科学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Developmental biology
Keywords	Principal Investigator オルガノイド / 胃がん / がん幹細胞 / LGR5 / 幹細胞 / 転写因子 / Lgr5 / 遺伝子 / 発現制御 / 細胞・組織 … More / 再生医学 / 癌 / マウス / Nanog / エピジェネティクス / 胚性幹細胞 / 始原生殖細胞 Less

胃がんオルガノイドを用いた幹細胞制御因子の同定と検証Principal Investigator
- Principal Investigator
  
  村上和弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kanazawa University
Analysis of mechanisms which regulate stemness in stomach tumor and searching of new treatment.Principal Investigator
- Principal Investigator
  
  Murakami Kazuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kanazawa University
Visualization of cancer-initiating cells and search for an effective treatment using gastric cancer organoidsPrincipal Investigator
- Principal Investigator
  
  Murakami Kazuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
Analysis of the mechanism which regulates germ cell development in cooperation with transcription factorsPrincipal Investigator
- Principal Investigator
  
  Murakami Kazuhiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kanazawa University
  Hokkaido University

All 2023 2022 2021 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Frequent loss of metastatic ability in subclones of Apc , Kras , Tgfbr2 , and Trp53 mutant intestinal tumor organoids2023
- Author(s)
 Morita Atsuya、Nakayama Mizuho、Wang Dong、Murakami Kazuhiro、Oshima Masanobu
- Journal Title
 
 Cancer Science
 
 Volume: 114 Issue: 4 Pages: 1437-1450
- DOI
 10.1111/cas.15709
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-21K15502, KAKENHI-PROJECT-22H00454, KAKENHI-PROJECT-21J10379, KAKENHI-PROJECT-20K07586, KAKENHI-PROJECT-23K18236
[Journal Article] Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer2022
- Author(s)
  Yamamoto Daisuke、Oshima Hiroko、Wang Dong、Takeda Haruna、Kita Kenji、Lei Xuelian、Nakayama Mizuho、Murakami Kazuhiro、Ohama Takashi、Takemura Hirofumi、Toyota Mutsumi、Suzuki Hiromu、Inaki Noriyuki、Oshima Masanobu
- Journal Title
  
  The Journal of Pathology
  
  Volume: 257 Issue: 1 Pages: 39-52
- DOI
  10.1002/path.5868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04030, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-20H03522, KAKENHI-PROJECT-21K19421, KAKENHI-PROJECT-21K15502, KAKENHI-PROJECT-22H00454, KAKENHI-PROJECT-20K07586
[Journal Article] A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells2021
- Author(s)
  Murakami Kazuhiro、Terakado Yumi、Saito Kikue、Jomen Yoshie、Takeda Haruna、Oshima Masanobu、Barker Nick
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 4 Pages: 1-12
- DOI
  10.1073/pnas.2016806118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522, KAKENHI-PROJECT-20K07586
[Journal Article] A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers2021
- Author(s)
  Fatehullah A.、Terakado Y.、Sagiraju S.、Tan T. L.、Sheng T.、Tan S. H.、Murakami K.、Swathi Y.、Ang N.、Rajarethinam R.、Ming T.、Tan P.、Lee B.、Barker N.
- Journal Title
  
  Nature Cell Biology
  
  Volume: 23 Issue: 12 Pages: 1299-1313
- DOI
  10.1038/s41556-021-00793-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16710, KAKENHI-PROJECT-20K07586
[Journal Article] Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.2019
- Author(s)
  Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 12 Issue: 12 Pages: 2955-2955
- DOI
  10.3390/ijms20122955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15306, KAKENHI-PROJECT-17H01399, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-17K07161, KAKENHI-PROJECT-18K19298
[Journal Article] Automated Counting of Cancer Cells by Ensembling Deep Features2019
- Author(s)
  Liu、Junker、Murakami、Hu
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 9 Pages: 1019-1019
- DOI
  10.3390/cells8091019
- Data Source
  KAKENHI-PROJECT-17K07161
[Journal Article] Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development2019
- Author(s)
  Seishima Ryo、Leung Carly、Yada Swathi、Murad Katzrin Bte Ahmed、Tan Liang Thing、Hajamohideen Amin、Tan Si Hui、Itoh Hideki、Murakami Kazuhiro、Ishida Yoshihiro、Nakamizo Satoshi、Yoshikawa Yusuke、Wong Esther、Barker Nick
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-019-13363-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01399, KAKENHI-PROJECT-17K07161
[Journal Article] Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice.2018
- Author(s)
  Han TS, Voon DC, Oshima H, Nakayama M, Echizen K, Sakai E, Yong ZWE, Murakami K, Yu L, Minamoto T, Ock CY, Jenkins BJ, Kim SJ, Yang HK, Oshima M
- Journal Title
  
  Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice
  
  Volume: 156 Issue: 4 Pages: 1140-1155
- DOI
  10.1053/j.gastro.2018.11.059
- NAID
  120006621945
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07161, KAKENHI-PUBLICLY-17H05616, KAKENHI-PROJECT-19K22558, KAKENHI-PROJECT-18H04030, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-18K19577
[Journal Article] Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis.2018
- Author(s)
  Oshima H, Kok SY, Nakayama M, Murakami K, Voon DC, Kimura T, Oshima M
- Journal Title
  
  FASEB J.
  
  Volume: 33 Issue: 2 Pages: 1873-1886
- DOI
  10.1096/fj.201801176r
- NAID
  120006621946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07161, KAKENHI-PUBLICLY-17H05616, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K07111, KAKENHI-PROJECT-19K22558, KAKENHI-PROJECT-18H04030, KAKENHI-PROJECT-19H03498
[Journal Article] NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers2016
- Author(s)
  Murakami K., Ufuk Gunesdogan U., Zylicz J.J., Tang W.W.C., Sengupta R., Kobayashi T., Kim S., Butler R., Dietmann S., Surani M.A.
- Journal Title
  
  Nature
  
  Volume: 529 Issue: 7586 Pages: 403-407
- DOI
  10.1038/nature16480
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18539
[Presentation] A genome-scale CRISPR screening reveals novel factors regulating Wnt-dependent renewal of Mouse Gastric Epithelial Cells2023
- Author(s)
  村上和弘
- Organizer
  BICON 2022-2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07586
[Presentation] Lgr5陽性の胃がん細胞において幹細胞性を導く機構の解析2022
- Author(s)
  村上和弘, バーカニック
- Organizer
  第81回日本癌学術総会
- Data Source
  KAKENHI-PROJECT-20K07586
[Presentation] LGR5陽性の胃がん細胞において幹細胞性を導く機構の解析2021
- Author(s)
  村上和弘
- Organizer
  第80回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07586
[Presentation] Analysis of mechanisms which regulate the tumor malignancy in LGR5 expressing gastric cancer cells.2019
- Author(s)
  Kazuhiro Murakami, Yumi Terakado, Nick Barker
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07161
[Presentation] 胃がん幹細胞の検討とその制御機構2018
- Author(s)
  寺門侑美, 村上和弘, 大島正伸, 大島浩子, Nick Barker
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07161
[Presentation] 炎症を伴った胃がんにおいて幹細胞性を導く機構の解析2018
- Author(s)
  村上和弘, 寺門侑美, Nick Barker
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07161
[Presentation] Analysis of the mechanism which defines gastrointestinal stemness and its relation to the tumorigenic process2017
- Author(s)
  Kazuhiro Murakami, Yumi Terakado, Nick Barker
- Organizer
  the SGCC 10th annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07161
[Presentation] Analysis of an origin of gastric cancer cells in inflammation-driven tumor organoid2017
- Author(s)
  Kazuhiro Murakami, Yumi Terakado, Nick Barker
- Organizer
  The 76th JCA annual meeting
- Data Source
  KAKENHI-PROJECT-17K07161
[Presentation] Nanog alone induces germ cells in primed epiblast in vitro by activation of enhancers2016
- Author(s)
  Kazuhiro Murakami, Ufuk Gunesdogan, Azim Surani
- Organizer
  第14回　幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場 (兵庫県・淡路市)
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K18539
[Presentation] Nanog induces germ cell fate in competent epiblast cells in vitro2015
- Author(s)
  Kazuhiro Murakami, Ufuk Gunesdogan, Azim Surani
- Organizer
  第38回　日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド (兵庫県・神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18539

1. WANG DONG

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 大島正伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 武田はるな

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 佐藤拓輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. NICHOLAS BARKER

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 寺門侑美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nurakami Kazuhiro 村上 和弘

Murakami Kazuhiro 村上 和弘

Research Projects

Research Products

Co-Researchers

胃がんオルガノイドを用いた幹細胞制御因子の同定と検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mechanisms which regulate stemness in stomach tumor and searching of new treatment.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualization of cancer-initiating cells and search for an effective treatment using gastric cancer organoidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanism which regulates germ cell development in cooperation with transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Frequent loss of metastatic ability in subclones of <i>Apc</i> , <i>Kras</i> , <i>Tgfbr2</i> , and <i>Trp53</i> mutant intestinal tumor organoids2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Automated Counting of Cancer Cells by Ensembling Deep Features2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers2016

Author(s)

Journal Title

DOI

Nurakami Kazuhiro 村上和弘

Murakami Kazuhiro 村上和弘