Harano Yuichi 原野雄一

… Alternative Names

HARANO Yuichi 原野雄一

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Researcher Number	60456259
Other IDs
Affiliation (Current)	2025: 姫路獨協大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2014 – 2019: 姫路獨協大学, 薬学部, 准教授 2011 – 2013: 大阪大学, たんぱく質研究所, 准教授 2012: 大阪大学, たんぱく質研究所, 特任准教授 2008 – 2012: 大阪大学, 蛋白質研究所, 特任准教授 2008: Tokyo Institute of Technology, グローバルエッジ研究院, テニュア・トラック助教
Review Section/Research Field	Principal Investigator Bioinformatics/Life informatics / Biological physics/Chemical physics/Soft matter physics Except Principal Investigator Complex systems
Keywords	Principal Investigator 蛋白質 / 水和熱力学 / 溶液化学 / 水和自由エネルギー / 構造活性相関 / in silico 創薬 / in silico創薬 / 結合自由エネルギー / 溶媒和熱力学 / 理論創薬 … More / 生物物理学 / 熱力学 / 生体分子 / 国際研究者交流（ドイツ） / 国際情報交換（ドイツ） / 積分幾何学 / 計算化学 / Hadwiger定理 / 液体論 / エントロピー / 構造予測 / 立体構造 / 溶媒和エントロピー / 立体構造予測 / タンパク質 … More Except Principal Investigator 量子化学計算 / 分子動力学シミュレーション / ABCトランスポータ / ホモロジーモデリング / 水和 / MMPBSA法 / CFTR / MDシミュレーション / 自由エネルギー / ABCトランスポーター / ATP加水分解自由エネルギー / 蛋白質-リガンド結合自由エネルギー / 水和エンタルピー / 水和エントロピー / 水和自由エネルギー / 水 / ATP / ABC トランスポータ Less

Thermodynamic analysis of bimolecular assembly driven by solvent waterPrincipal Investigator
- Principal Investigator
  
  Harano Yuichi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological physics/Chemical physics/Soft matter physics
- Research Institution
  Himeji Dokkyo University
Hydration thermodynamics of a protein developed by using Hadwiger theoremPrincipal Investigator
- Principal Investigator
  
  HARANO Yuichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Himeji Dokkyo University
  Osaka University
Elucidation of the functional mechanism of ABC transporters using computer simulations
- Principal Investigator
  
  SAKURAI Minoru
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Institute of Technology
Developing a method for predicting protein structure based on physical chemistry of liquidPrincipal Investigator
- Principal Investigator
  
  HARANO Yuichi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  Osaka University
  Tokyo Institute of Technology

All 2017 2016 2015 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Glycosaminoglycan Binding and Non-endocytic Membrane Translocation of Cell-permeable Octaarginine Monitored by Real Time In-cell NMR Spectroscopy2017
- Author(s)
  Y. Takechi-Haraya, K. Aki, Y. Tohyama, Y. Harano, T. Kawakami, H. Saito, E. Okamura
- Journal Title
  
  Pharmaceuticals
  
  Volume: 10 Issue: 2 Pages: 42-60
- DOI
  10.3390/ph10020042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K05254, KAKENHI-PROJECT-15K05401, KAKENHI-PROJECT-17H03979
[Journal Article] Water based on a molecular model behaves like a hard-sphere solvent for a nonpolar solute when the reference interaction site model and related theories are employed2016
- Author(s)
  T. Hayashi, H. Oshima, Y. Harano, M. Kinoshita
- Journal Title
  
  J. Phys.: Condens. Matter
  
  Volume: 28 Issue: 34 Pages: 344003-344003
- DOI
  10.1088/0953-8984/28/34/344003
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05254
[Journal Article] An Accurate and Efficient Computation Method of the Hydration Free Energy of a Large, Complex Molecule2015
- Author(s)
  T. Yoshidome, T. Ekimoto, N. Matubayasi, Y. Harano, M. Kinoshita, M. Ikeguchi
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 142 Pages: 175101-175101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05254
[Journal Article] A morphometric approach for the accurate solvation thermodynamics of proteins and ligands2013
- Author(s)
  Y. Harano, R. Roth, S. Chiba
- Journal Title
  
  J. Comput. Chem.
  
  Volume: 34 Issue: 23 Pages: 1969-1974
- DOI
  10.1002/jcc.23348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650158
[Journal Article] Does water drive protein folding?2013
- Author(s)
  Y. Maruyama, Y. Harano
- Journal Title
  
  Chem. Phys. Lett.
  
  Volume: 581 Pages: 85-90
- DOI
  10.1016/j.cplett.2013.07.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650158
[Journal Article] A scoring function based on solvation thermodynamics for protein structure prediction2012
- Author(s)
  S. Du
- Journal Title
  
  BIOPHYSICS
  
  Volume: 8 Issue: 0 Pages: 127-138
- DOI
  10.2142/biophysics.8.127
- NAID
  130002104520
- ISSN
  1349-2942
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PROJECT-22300100, KAKENHI-PROJECT-24650158, KAKENHI-PLANNED-20118004, KAKENHI-PLANNED-20118006
[Journal Article] Application of Hydration Thermodynanlics to the Evaluation of Protein Structures and Protein-Ligand Binding2012
- Author(s)
  Y. Harano
- Journal Title
  
  Entropy
  
  Volume: 14 Issue: 8 Pages: 1443-1468
- DOI
  10.3390/e14081443
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-24650158
[Journal Article] Evaluation of Protein-Ligand Binding Free Energy Focused on its Entropic Components2012
- Author(s)
  S.Chiba, Y.Harano, R.Roth, M.Kinoshita, M.Sakurai
- Journal Title
  
  J.Comput.Chem.
  
  Volume: 33 Issue: 5 Pages: 550-560
- DOI
  10.1002/jcc.22891
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118004, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-22300100, KAKENHI-PROJECT-24650158
[Journal Article] Free-energy function for discriminating the native fold of a protein from misfolded decoys2011
- Author(s)
  Yasuda S, Yoshidome T, Harano Y, Roth R, Oshima H, Oda K, Sugita Y, Ikeguchi M, Kinoshita M
- Journal Title
  
  Proteins
  
  Volume: 79 Pages: 2161-2171
- NAID
  120005593601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Free-Energy Function for Discriminating the Native Fold of a Protein from Misfolded Decoys2011
- Author(s)
  S.Yasuda, T.Yoshidome, Y.Harano, E.Roth, H.Oshima, K.Oda, Y.Sugita, M.Ikeguchi, M.Kinoshita
- Journal Title
  
  Proteins-Structure Function and Bioinformatics
  
  Volume: 79 Issue: 7 Pages: 2161-2171
- DOI
  10.1002/prot.23036
- NAID
  120005593601
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118004, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-20700267, KAKENHI-PROJECT-22300100
[Journal Article] Morphometric Approach to Thermodynamic Quantities of Solvation of Complex Molecules : Extension to Multicomponent Solvent2011
- Author(s)
  R.Kodama, R.Roth, Y.Harano, M.Kinoshita
- Journal Title
  
  Journal of Chemical Physics
  
  Volume: 135 Issue: 4
- DOI
  10.1063/1.3617247
- NAID
  120003338824
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118004, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-20700267, KAKENHI-PROJECT-22300100
[Journal Article] Effects of side-chain packing on the formation of secondary structures in protein folding2010
- Author(s)
  Yasuda, S ; Yoshidome, T ; Oshima, H ; Kodama, R ; Harano, Y ; Kinoshita, M
- Journal Title
  
  JOURNAL OF CHEMICAL PHYSICS
  
  Volume: 132 Pages: 65105-65105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Effects of side-chain packing on the formation of secondary structures in protein folding2010
- Author(s)
  Yasuda S, Yoshidome T, Oshima H, Kodama R, Harano Y, Kinoshita M
- Journal Title
  
  J.Chem.Phys. 132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Effects of side-chain packingon the formation of secondary structures in proteinfolding2010
- Author(s)
  S. Yasuda, T. Yoshidome, H. Oshima, R. Kodama, Y.Harano, M. Kinoshita M
- Journal Title
  
  J. Chem. Phys. 132
  
  Pages: 65105-65105
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20118006
[Journal Article] Effects of side-chain packing on the formation of secondary structures in protein folding2010
- Author(s)
  S.Yasuda, T.Yoshidome, H.Oshima, R.Kodama, Y.Harano, M.Kinoshita
- Journal Title
  
  J.Chem.Phys.
  
  Volume: 132
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20118006
[Journal Article] Effects of side-chain packing on the formation of secondary structures in protein folding2010
- Author(s)
  Yasuda S, Yoshidome T, Oshima H, Kodama R, Harano Y, Kinoshita M
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Theoretical analysis on thermal stability of a protein focused on the water entropy2009
- Author(s)
  Amano K, Yoshidome T, Harano Y, Oda K, Kinoshita M
- Journal Title
  
  Chem. Phys. Lett.
  
  Volume: 474 Pages: 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Theoretical analysis on thermal stability of a protein focused on the water entropy2009
- Author(s)
  Amano K, Yoshidome T, Harano Y, Oda K, Kinoshita M
- Journal Title
  
  Chem.Phys.Lett. 474
  
  Pages: 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Pressure effects on structures formed by entropically driven self-assembly : Illustration for denaturation of proteins2009
- Author(s)
  Yoshidome T, Harano Y, Kinoshita M
- Journal Title
  
  Phys. Rev. E.
  
  Volume: 79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Free-energy function based on an all-atom model for proteins2009
- Author(s)
  Yoshidome, T, Oda, K ; Harano, Y, et al.
- Journal Title
  
  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 77
  
  Pages: 950-961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Pressure effects on structures formed by entropically driven self-assembly : Illustration for denaturation of proteins2009
- Author(s)
  Yoshidome T, Harano Y, Kinoshita M
- Journal Title
  
  Phys.Rev.E. 79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Pressure effects on structures formed by entropically driven self-assembly : Illustration for denaturation of proteins2009
- Author(s)
  Yoshidome, T, Harano, Y ; Kinoshita, M
- Journal Title
  
  PHYSICAL REVIEW E 79
  
  Pages: 11912-11912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Theoretical analysis on thermal stability of a protein focused on the water entropy2009
- Author(s)
  Amano, K ; Yoshidome, T, Harano, Y, et al.
- Journal Title
  
  CHEMICAL PHYSICS LETTERS 474
  
  Pages: 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Free-energy function based on an all-atom model for proteins2009
- Author(s)
  Yoshidome T, Oda K, Harano Y, Roth R, Sugita Y, Ikeguhci M, Kinoshita M
- Journal Title
  
  Proteins
  
  Volume: 77 Pages: 950-961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Free-energy function based on an all-atom model for proteins2009
- Author(s)
  Yoshidome T, Oda K, Harano Y, Roth R, Sugita Y, Ikeguhci M, Kinoshita M
- Journal Title
  
  Proteins 77
  
  Pages: 950-961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Molecular mechanism of pressure denaturation of proteins2008
- Author(s)
  Y. Harano, T. Yoshidome, & M. Kinoshita
- Journal Title
  
  Journal of Chemical Physics 129
  
  Pages: 145103-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Journal Article] Pressure effects on structures formed by entropically drivenself-assembly : Illustration for denaturation of proteins2008
- Author(s)
  T. Yoshidome, Y. Harano, & M. Kinoshita
- Journal Title
  
  Physical Review E 79
  
  Pages: 11912-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] Does water drive a protein to fold?2013
- Author(s)
  Yutaka Maruyama, Yuichi Harano
- Organizer
  第 51 回日本生物物理学会年会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-24650158
[Presentation] A Morphometric Approach for the Accurate Solvation Thermodynamics of Proteins and Ligands2013
- Author(s)
  Yuichi Harano, Roland Roth, Shuntaro Chiba
- Organizer
  第 51 回日本生物物理学会年会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-24650158
[Presentation] 巨大分子の自己組織化を考える為のエネルギー論2013
- Author(s)
  原野雄一
- Organizer
  「次世代の物質科学・ナノサイエンスを探る」研究会
- Place of Presentation
  北海道大学
- Invited
- Data Source
  KAKENHI-PROJECT-24650158
[Presentation] ペプチドおよび蛋白質の溶解度計算を目指した形態熱力学2012
- Author(s)
  原野雄一
- Organizer
  蛋白研セミナー
- Place of Presentation
  大阪大学
- Invited
- Data Source
  KAKENHI-PROJECT-24650158
[Presentation] Theoretical studies for biomolecular behavior in a liquid state from the viewpoint of molecular crowding2010
- Author(s)
  原野雄一
- Organizer
  第48回生物物理学会
- Place of Presentation
  東北大学
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] Theoretical studies for biomolecular behavior in a liquid state from the viewpoint of molecular crowding.2010
- Author(s)
  原野雄一
- Organizer
  第48回日本生物物理学会
- Place of Presentation
  東北大学(招待講演)
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] Development of predicting the native structure of a protein focusing on water entropy2010
- Author(s)
  原野雄一
- Organizer
  The 4th Mini-Symposium on Liquid
- Place of Presentation
  九州大学
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] Refinement of Modeled Protein Structure by Replica Exchange Molecular Dynamics and Hydration Entropy based Scoring Function2010
- Author(s)
  S.Du, Y.Harano, M.Sakurai, M.Kinoshita
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  東北大
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] Theoretical studies for biomolecular behavior in a liquid state from the view point of molecular crowding2010
- Author(s)
  Y.Harano
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  東北大
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] Application of the Scoring Function Based on Solvation Free Energy to Protein Structure Prediction2010
- Author(s)
  S.Du, Y.Harano, M.Sakurai, M.Kinoshita
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] A novel method for evaluating protein-ligand binding affinity based on thermodynamics: focusing on entropy2010
- Author(s)
  S. Chiba, Y. Harano, M. Kinoshita and M. Sakurai
- Organizer
  Pacifichem 2010 Congress
- Place of Presentation
  ホノルル(アメリカ)
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] Development of predicting the native structure of a protein focusing on py2010
- Author(s)
  原野雄一
- Organizer
  The 4th Mini-Symposium onwater entro Liquid
- Place of Presentation
  九州大学
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] A novel method for evaluating protein-ligand binding affinity based on thermodynamics : focusing on entropy2010
- Author(s)
  S.Chiba, Y.Harano, M.Kinoshita, M.Sakurai
- Organizer
  Pacifichem 2010 Congress
- Place of Presentation
  ホノルル
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] 水のエントロピーに焦点をおいたタンパク質-リガンド間結合能の評価2009
- Author(s)
  原野雄一, 他3名
- Organizer
  生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] 水のエントロピーに焦点を置いたタンパク質-リガンド間結合能の新規計算手法2009
- Author(s)
  千葉峻太朗、野村淳磨、原野雄一、木下政弘、櫻井実
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  アスティ徳島(徳島)
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] リガンド-タンパク質間の結合自由エネルギーに対するマルチフィジクス的計算手法の比較および評価2009
- Author(s)
  千葉峻太朗、野村淳磨、原野雄一、木下政弘、櫻井実
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテル
- Data Source
  KAKENHI-PLANNED-20118006
[Presentation] タンパク質の立体構造予測に向けた新規スコア関数2008
- Author(s)
  原野雄三、他5名
- Organizer
  生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20700267
[Presentation] Hydration thermodynamics for biomolecular dynamics
- Author(s)
  原野雄一
- Organizer
  第５２回日本生物物理学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24650158

1. SAKURAI Minoru (50162342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 桜井実

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
3. 木下正弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Harano Yuichi 原野 雄一

HARANO Yuichi 原野 雄一

Research Projects

Research Products

Co-Researchers

Thermodynamic analysis of bimolecular assembly driven by solvent waterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hydration thermodynamics of a protein developed by using Hadwiger theoremPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the functional mechanism of ABC transporters using computer simulations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing a method for predicting protein structure based on physical chemistry of liquidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glycosaminoglycan Binding and Non-endocytic Membrane Translocation of Cell-permeable Octaarginine Monitored by Real Time In-cell NMR Spectroscopy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Water based on a molecular model behaves like a hard-sphere solvent for a nonpolar solute when the reference interaction site model and related theories are employed2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Accurate and Efficient Computation Method of the Hydration Free Energy of a Large, Complex Molecule2015

Author(s)

Journal Title

Data Source

[Journal Article] A morphometric approach for the accurate solvation thermodynamics of proteins and ligands2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Does water drive protein folding?2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A scoring function based on solvation thermodynamics for protein structure prediction2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Application of Hydration Thermodynanlics to the Evaluation of Protein Structures and Protein-Ligand Binding2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Protein-Ligand Binding Free Energy Focused on its Entropic Components2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Free-energy function for discriminating the native fold of a protein from misfolded decoys2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Free-Energy Function for Discriminating the Native Fold of a Protein from Misfolded Decoys2011

Author(s)

Journal Title

DOI

Harano Yuichi 原野雄一

HARANO Yuichi 原野雄一