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Shimomura Manabu  下村 学

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SHIMOMURA Manabu  下村 学

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Researcher Number 60457249
Affiliation (Current) 2025: 広島大学, 医系科学研究科(医), 助教
Affiliation (based on the past Project Information) *help 2022 – 2024: 広島大学, 医系科学研究科(医), 助教
2016: 独立行政法人国立病院機構東広島医療センター(臨床研究部), 診療部, 外科医師
2015: 独立行政法人国立病院機構東広島医療センター(臨床研究部), その他部局等, その他
2013 – 2014: 広島大学, 大学病院, 医科診療医
Review Section/Research Field
Principal Investigator
Digestive surgery
Except Principal Investigator
Basic Section 55020:Digestive surgery-related
Keywords
Principal Investigator
遺伝子変異 / 大腸癌 / 遺伝子改変マウス / マイクロサテライト / microsatellite / colorectal cancer / マウスモデル
Except Principal Investigator
マウスモデル / 遺伝子改変マウス / 新規分子標的 / 発癌の分子病態 / 治療抵抗性大腸癌
  • Research Projects

    (3 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (7 People)
  •  Identification of novel driver genes in treatment-resistant colorectal cancer subtypes and development of therapeutic strategies

    • Principal Investigator
      檜井 孝夫
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Hiroshima University
  •  Development of target therapy for microsatelite instability colorectal cancerPrincipal Investigator

    • Principal Investigator
      Shimomura Manabu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Higashihiroshima Medical Center
  •  Investigation of metastasis related genes based on conditinoal knock out mouse modelPrincipal Investigator

    • Principal Investigator
      SHIMOMURA Manabu
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Hiroshima University

All 2016 2015

All Journal Article Presentation

  • [Journal Article] Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation2016

    • Author(s)
      Miguchi M, Hinoi T, Shimomura M et al
    • Journal Title

      PloS One

      Volume: 11 Issue: 11 Pages: 0166422-0166422

    • DOI

      10.1371/journal.pone.0166422

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19892, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-15H02567
  • [Presentation] The generation of colorectal cancer mouse model based on microsatellite instability and the identification of transforming2015

    • Author(s)
      Miguchi M, Hinoi T, Shimomura M, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Yusuke Sotomaru, Hideaki Ijichi, Tsuneo Ikenoue, Kunitoshi Shigeyasu,Kohji Tanakaya, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hideki Ohdan
    • Organizer
      AACR annual meeting 2015
    • Place of Presentation
      フィラデルフィア (USA)
    • Year and Date
      2015-04-18
    • Data Source
      KAKENHI-PROJECT-25861190
  • [Presentation] 大腸癌マウスモデルを用いた新たなTGF-βシグナルターゲット癌関連遺伝子の同定2015

    • Author(s)
      三口真司, 檜井孝夫, 下村学, 安達智洋, 斎藤保文, 新津宏明, 河内雅年, 伊地知秀明, 田中屋宏爾, 大段秀樹
    • Organizer
      第26回消化器癌発生学会
    • Place of Presentation
      米子
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15K19892
  • [Presentation] マイクロサテライト不安定大腸癌マウスモデルの作製とTGF-βシグナルの同定2015

    • Author(s)
      三口真司、檜井孝夫、下村 学、安達智洋、斎藤保文、新津宏明、河内雅年、伊地知秀明、田中屋宏爾、大段秀樹
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-25861190
  • [Presentation] マイクロサテライト不安定大腸癌マウスモデルの作製とTGF-βシグナルターゲットの同定2015

    • Author(s)
      三口真司, 檜井孝夫, 下村学, 安達智洋, 斎藤保文, 新津宏明, 河内雅年, 伊地知秀明, 田中屋宏爾, 大段秀樹
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-15K19892
  • 1.  HINOI Takao (10444689)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  坂本 直也 (20571798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  外丸 祐介 (90309352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  仙谷 和弘 (30508164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  池上 恒雄 (80396712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  高倉 有二 (20581698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HINO Takao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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