dejima katsufumi 出嶋克史

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Dejima Katsufumi 出嶋克史

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Researcher Number	60457439
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2014 – 2024: 東京女子医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Functional biochemistry
Keywords	Principal Investigator RNAi / 亜鉛 / C. elegans / 全身性RNAi / 亜鉛輸送体 / dsRNA / 小胞輸送 / 細胞・組織 / Systemic RNAi / zinc transporter / systemic RNAi / RNA干渉 / 細胞外RNA

Regulation of systemic RNAi by zinc metabolism and zinc binding proteinsPrincipal Investigator
- Principal Investigator
  
  出嶋克史
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Women's Medical University
Cellular and molecular mechanisms of systemic dsRNA spreadingPrincipal Investigator
- Principal Investigator
  
  出嶋克史
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Women's Medical University
Molecular and cellular mechanisms underlying intercellular transfer of double stranded RNAPrincipal Investigator
- Principal Investigator
  
  Dejima Katsufumi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Women's Medical University
Analysis of the mechanisms by which the extracellular dsRNA systemically spreads.Principal Investigator
- Principal Investigator
  
  Dejima Katsufumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Women's Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 Other

All Journal Article Presentation Other

[Journal Article] An Endomembrane Zinc Transporter Negatively Regulates Systemic RNAi in C. elegans2023
- Author(s)
  Dejima Katsufumi、Imae Rieko、Suehiro Yuji、Yoshida Keita、Mitani Shohei
- Journal Title
  
  Sneak Peak
  
  Volume: NA
- DOI
  10.2139/ssrn.4366150
- Data Source
  KAKENHI-PROJECT-20K06561
[Journal Article] An endomembrane zinc transporter negatively regulates systemic RNAi in Caenorhabditis elegans2023
- Author(s)
  Dejima Katsufumi、Imae Rieko、Suehiro Yuji、Yoshida Keita、Mitani Shohei
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 6 Pages: 106930-106930
- DOI
  10.1016/j.isci.2023.106930
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06561, KAKENHI-PROJECT-23K06110, KAKENHI-PROJECT-20H03422
[Journal Article] Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi2023
- Author(s)
  Yoshida Keita、Suehiro Yuji、Dejima Katsufumi、Yoshina Sawako、Mitani Shohei
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 10 Pages: 108067-108067
- DOI
  10.1016/j.isci.2023.108067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06561, KAKENHI-PROJECT-17K18135, KAKENHI-PROJECT-20H03422
[Journal Article] Balancer-assisted outcrossing to remove unwanted background mutations2022
- Author(s)
  Katsufumi Dejima, Shohei Mitani
- Journal Title
  
  MicroPubl Biology
  
  Volume: v.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06561
[Journal Article] Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals2021
- Author(s)
  Suehiro Yuji、Yoshina Sawako、Motohashi Tomoko、Iwata Satoru、Dejima Katsufumi、Mitani Shohei
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-021-87226-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06561, KAKENHI-PROJECT-20H03422, KAKENHI-PROJECT-18K14616, KAKENHI-PROJECT-17K18135
[Journal Article] Analysis of GPI-anchored proteins involved in germline stem cell proliferation in theCaenorhabditis elegansgermline stem cell niche2020
- Author(s)
  Rikitake Marika、Matsuda Ayako、Murata Daisuke、Dejima Katsufumi、Nomura Kazuko H、Abbott Karen L、Mitani Shohei、Nomura Kazuya
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 168 Issue: 6 Pages: 589-602
- DOI
  10.1093/jb/mvaa075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06561, KAKENHI-PROJECT-20H03422
[Journal Article] An Aneuploidy-Free and Structurally Defined Balancer Chromosome Toolkit for Caenorhabditis elegans2018
- Author(s)
  Dejima Katsufumi、Hori Sayaka、Iwata Satoru、Suehiro Yuji、Yoshina Sawako、Motohashi Tomoko、Mitani Shohei
- Journal Title
  
  Cell Reports
  
  Volume: 22 Issue: 1 Pages: 232-241
- DOI
  10.1016/j.celrep.2017.12.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18517, KAKENHI-PROJECT-17K18135, KAKENHI-PROJECT-16H05123
[Journal Article] Chondroitin 4-O-sulfotransferase is indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes.2016
- Author(s)
  Izumikawa, T., Dejima, K., Watamoto, Y., Nomura, K. H., Kanai, N., Rikitake, M., Tou, M., Murata, D., Yanagita, E., Kano, A., Mitani, S., Nomura, K., and Kitagawa, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 44 Pages: 23294-23304
- DOI
  10.1074/jbc.m116.757328
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293014, KAKENHI-PROJECT-26670033, KAKENHI-PROJECT-16K07298, KAKENHI-PROJECT-16K18517, KAKENHI-PROJECT-16H05088
[Journal Article] RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database.2014
- Author(s)
  Akiyoshi S, Nomura KH, Dejima K, Murata D, Matsuda A, Kanaki N, Takaki T, Mihara H, Nagaishi T, Furukawa S, Ando KG, Yoshina S, Mitani S, Togayachi A, Suzuki Y, Shikanai T, Narimatsu H, Nomura K.
- Journal Title
  
  Glycobiology
  
  Volume: 25(1) Issue: 1 Pages: 8-20
- DOI
  10.1093/glycob/cwu080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24241073, KAKENHI-PROJECT-24390053, KAKENHI-PROJECT-24570165, KAKENHI-PROJECT-24770138, KAKENHI-PROJECT-25640004, KAKENHI-PROJECT-25870759, KAKENHI-PROJECT-26891023
[Journal Article] Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.2014
- Author(s)
  Dejima K, Kang S, Mitani S, Cosman PC, Chisholm AD.
- Journal Title
  
  Development
  
  Volume: 141 Issue: 22 Pages: 4354-65
- DOI
  10.1242/dev.113266
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390053, KAKENHI-PROJECT-26891023
[Presentation] Genetic analysis of the RNAi defective mutants for zinc-binding molecules2023
- Author(s)
  Katsufumi Dejima and Shohei Mitani
- Organizer
  24th International C. elegans Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06561
[Presentation] Genetic balancer chromosomes created by CRISPR-mediated genome editing in C. elegans.2022
- Author(s)
  Katsufumi Dejima
- Organizer
  Asian Network of Research Resource Centers
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06561
[Presentation] Analysis of endomembrane-related zinc transporter mutants that suppress the systemic RNAi defect of rsd-3 mutant2021
- Author(s)
  Katsufumi Dejima, Rieko Imae, Yuji Suehiro and Shohei Mitani
- Organizer
  23rd international C. elegans conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06561
[Presentation] Negative regulation of systemic RNAi by an endosome-resident zinc transporter in C. elegans2019
- Author(s)
  Katsufumi Dejima, Rieko Imae, Yuji Suehiro and Shohei Mitani
- Organizer
  2019 RNA Therapeutics: From Mechanisms to Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] An endosome-resident zinc transporter negatively regulates systemic dsRNA spreading in C. elegans2019
- Author(s)
  Katsufumi Dejima, Rieko Imae, Yuji Suehiro and Shohei Mitani
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] An endosome-resident zinc transporter is involved in negative regulation of systemic dsRNA spreading in C. elegans2019
- Author(s)
  Katsufumi Dejima, Rieko Imae, Yuji Suehiro and Shohei Mitani
- Organizer
  22nd International C. elegans Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] An endomembrane-resident zinc transporter negatively regulates systemic RNAi in C. elegans.2018
- Author(s)
  Katsufumi Dejima, Rieko Imae, Yuji Suehiro and Shohei Mitani
- Organizer
  C. elegans Development, Cell Biology & Gene Expression Meeting EMBO workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] Balancer chromosome toolkit for C. elegans2017
- Author(s)
  K. Dejima, S. Hori, S. Iwata, S. Yoshina, Y. Suehiro, T. Motohashi, S. Mitani
- Organizer
  21st International C. elegans Conference University of California, Los Angeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] Genetic engineering of chromosomal balancer toolkit for gene-clusters mediated by CRISPR/Cas9 in Caenorhabditis elegans.2016
- Author(s)
  Iwata, S., Dejima, K., Hori, S., Yoshina, S., Suehiro, Y., Mitani, S
- Organizer
  The 7th Asia-Pacific Worm meeting
- Place of Presentation
  中国、北京
- Year and Date
  2016-06-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] Analysis of suppressor mutants that allow systemic RNAi in the absence of RSD-32016
- Author(s)
  Katsufumi Dejima, Rieko Imae Yuji Suehiro and Shohei Mitani
- Organizer
  The 7th Asia-Pacific Worm meeting
- Place of Presentation
  中国、北京
- Year and Date
  2016-06-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18517
[Presentation] 線虫C. elegans における全身性RNAiを負に制御する因子の探索
- Author(s)
  出嶋　克史、今江　理恵子、三谷　昌平
- Organizer
  第37回日本分子生物学会年会会期
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26891023
[]

1. TOGAYACHI Akira

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2. 成松久

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3. 北川裕之

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4. 三谷昌平

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dejima katsufumi 出嶋 克史

Dejima Katsufumi 出嶋 克史

Research Projects

Research Products

Co-Researchers

Regulation of systemic RNAi by zinc metabolism and zinc binding proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cellular and molecular mechanisms of systemic dsRNA spreadingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular and cellular mechanisms underlying intercellular transfer of double stranded RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanisms by which the extracellular dsRNA systemically spreads.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Endomembrane Zinc Transporter Negatively Regulates Systemic RNAi in C. elegans2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An endomembrane zinc transporter negatively regulates systemic RNAi in Caenorhabditis elegans2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Balancer-assisted outcrossing to remove unwanted background mutations2022

Author(s)

Journal Title

Data Source

[Journal Article] Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of GPI-anchored proteins involved in germline stem cell proliferation in theCaenorhabditis elegansgermline stem cell niche2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Aneuploidy-Free and Structurally Defined Balancer Chromosome Toolkit for Caenorhabditis elegans2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chondroitin 4-O-sulfotransferase is indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Genetic analysis of the RNAi defective mutants for zinc-binding molecules2023

Author(s)

dejima katsufumi 出嶋克史

Dejima Katsufumi 出嶋克史