KOYAMA Susumu 小山進

… Alternative Names

小山進コヤマススム

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Researcher Number	60461505
Other IDs
Affiliation (Current)	2025: 第一薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 第一薬科大学, 薬学部, 教授 2015 – 2018: 第一薬科大学, 薬学部, 教授 2010 – 2014: 福岡大学, 薬学部, 准教授
Review Section/Research Field	Principal Investigator Eating habits / Basic Section 59040:Nutrition science and health science-related / Applied health science Except Principal Investigator Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator ドパミン / レプチン / 電気生理学 / 食行動 / 肥満 / ドパミン受容体 / 腹側被蓋野 / 食報酬 / 中脳腹側被蓋野 / 脳内報酬系 … More / 高脂肪食 / 脳内食報酬系 / 過食 / 食行動変容 / 脳スライス標本 / 嗜好性 / ドパミン自己受容体 / GABA … More Except Principal Investigator うつ病 / 精神疾患 / 炎症 / 肥満 / ミクログリア / レプチン / ストレス脆弱性 / 神経炎症 / 拘束ストレス / 肥満病態 / グリア Less

Research for elucidating mechanism of stress vulnerability mediated by adipokine-evoked microglial activation in the obesity
- Principal Investigator
  
  山脇洋輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
脳内報酬系レプチン－ドパミン連関を介した肥満における過食形成機序Principal Investigator
- Principal Investigator
  
  小山進
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Development of novel anti-obesity therapy based on dopamine-leptin interaction in the midbrain for food rewardPrincipal Investigator
- Principal Investigator
  
  Koyama Susumu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
Effect of adipokine on feeding behavior of obese adolescents through dopaminergic reward circuits in the brainPrincipal Investigator
- Principal Investigator
  
  Koyama Susumu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Daiichi University, College of Pharmaceutical Sciences
  Fukuoka University
Functional change in brain reward system is associated with fat preference and hyperphagia in diet-induced obesityPrincipal Investigator
- Principal Investigator
  
  KOYAMA Susumu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Fukuoka University

All 2023 2022 2019 2018 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] 高脂肪食負荷肥満誘発における脳内食報酬系ドパミン神経のレプチンとドパミンの相互作用2023
- Author(s)
  小山　進, 山脇　洋輔, 安川　圭司.
- Journal Title
  
  心身医学
  
  Volume: 64巻1号 Pages: 53-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11595
[Journal Article] Leptin attenuates D2 receptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons2018
- Author(s)
  Murakami T, Enjoji M, Koyama S.
- Journal Title
  
  Physiological Reports
  
  Volume: 6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00933
[Journal Article] Leptin attenuates D(2) receptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons.2018
- Author(s)
  Murakami T, Enjoji M, Koyama S.
- Journal Title
  
  Physiol Rep.
  
  Volume: 6 Issue: 7 Pages: e13631-e13631
- DOI
  10.14814/phy2.13631
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00933
[Journal Article] A persistent Na+ curent and its contribution to burst firing in ventral tegmental area dopamine neurons.2015
- Author(s)
  Koyama S, Enjoji M, Brodie MS, Appel SB.
- Journal Title
  
  Journal of Biomedical Science and Engineering
  
  Volume: 8 Pages: 1-11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350166
[Journal Article] A persistent Na+ current and its contribution to burst firing in ventral tegmental area dopamine neurons.2015
- Author(s)
  Koyama S, Enjoji M, Brodie MS, Appel SB.
- Journal Title
  
  Journal of Biomedical Science and Engineering
  
  Volume: 8 Pages: 1-11
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350166
[Journal Article] Obesity attenuates D2 autoreceptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons.2014
- Author(s)
  Koyama S, Mori M, Kanamaru S, Sazawa T, Miyazaki A, Terai H, Hirose S.
- Journal Title
  
  Physiol Rep
  
  Volume: 2(5) Issue: 5 Pages: 1-10
- DOI
  10.14814/phy2.12004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249060, KAKENHI-PUBLICLY-25129708, KAKENHI-PROJECT-25350166, KAKENHI-PROJECT-25670481
[Journal Article] The effects of zinc and other divalent cations on M-current in ventral tegmental area dopamine neurons.2014
- Author(s)
  Koyama S, Enjoji M, Brodie MS, Appel SB.
- Journal Title
  
  Journal of Biomedical Science and Engineering
  
  Volume: 7 Pages: 1075-1087
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350166
[Journal Article] Obesity decreases exitability of putative ventral tegmental area GABAergic neurons.2013
- Author(s)
  Koyama S., Kawaharada M., Terai H., Ohkurano M., Mori M., Kanamaru S., Hirose S.
- Journal Title
  
  Physiological Reports
  
  Volume: 1 Issue: 5 Pages: 1-11
- DOI
  10.1002/phy2.126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350166
[Journal Article] ストレス性摂食障害研究2013
- Author(s)
  小山　進.
- Journal Title
  
  福岡大学研究部論集 D: 生命科学編
  
  Volume: 2 Pages: 1-71
- NAID
  120005655354
- Data Source
  KAKENHI-PROJECT-25350166
[Journal Article] Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome.2010
- Author(s)
  Murata Y, Kobayashi D, Imuta N,Haraguchi K, Ieiri I, Nishimura R,Koyama S, Mine K.
- Journal Title
  
  J Clin Psychopharmacol
  
  Volume: 30 Pages: 11-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500685
[Journal Article] Acute p38-mediated inhibition of NMDA-induced outward currents inhippocampal CA1 neurons byinterleukin-1β2010
- Author(s)
  Zhang R, Sun L, Hayashi Y, Liu X, Koyama S, Wu Z, Nakanishi H
- Journal Title
  
  Neurobiol Dis
  
  Volume: 38 Pages: 68-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食投与による易肥満マウスにおいては、脳内食報酬系ドパミン神経の興奮が高まる.2022
- Author(s)
  小山　進, 山脇　洋輔, 安川　圭司.
- Organizer
  第63回日本心身医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K11595
[Presentation] レプチンはD2受容体を介した腹側被蓋野ドパミン神経の抑制を減弱させる2019
- Author(s)
  小山　進、村上　貴美、遠城寺　宗近.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K00933
[Presentation] 高脂肪食負荷時における脳内報酬系ドパミン神経レプチン受容体の体重依存的機能低下2015
- Author(s)
  小山　進、村上貴美、遠城寺宗近.
- Organizer
  第58回　日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] 高脂肪食負荷における脳内報酬系ドパミン神経レプチン受容体の体重依存的機能低下2015
- Author(s)
  小山　進, 村上貴美, 遠城寺宗近.
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関市
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] Leptin directly inhibits the excitability of putative ventral tegmental area dopaminergic neurons through activation of K+ conductance.2014
- Author(s)
  Koyama S, Murakami T, Enjoji M.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] 脳内ドパミン報酬系神経に対するレプチンの効果2014
- Author(s)
  小山　進.
- Organizer
  第57回　日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] 脳内ドパミン報酬系神経に対するレプチンの効果2014
- Author(s)
  小山　進.
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] Obesity increases excitability of ventral tegmental area dopamine neurons by attenuating D2 autoreceptor-mediated inhibition.2014
- Author(s)
  Koyama S., Mori M., Kanamaru S., Terai H., Sazawa T., Miyazaki A., Hirose S.
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] Action potential trains enhance spontaneous miniature hyperpolarizations in neonatal ventral tegmental area dopamine neurons2013
- Author(s)
  Koyama S., Brodie M.S., Appel S.B.
- Organizer
  第86回　日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Action potential trains enhance spontaneous miniature hyperpolarizations in neonatal ventral tegmental area dopamine neurons.2013
- Author(s)
  Koyama S, Brodie MS, Appel SB.
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡.
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 青年期肥満者におけるインスリン感受性とインスリン分泌の双曲関係：経口糖負荷試験（OGTT）から得た指標を用いた解析.2013
- Author(s)
  小山　進, 花井美佐江, 村田雄介, 浅野　喬, 美根和典.
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25350166
[Presentation] KCNQ mutation facilitates spontaneous activity of hippocampal GABAergic neuron in neonate mice2013
- Author(s)
  Uchida T., Deshimaru M., Yanagawa Y., Koyama S., Hirose S.
- Organizer
  第86回　日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] KCNQ mutationfacilitates spontaneous activity ofhippocampal GABAergic neuron inneonate mice.2013
- Author(s)
  Uchida T, Deshimaru M, Yanagawa Y,Koyama S, Hirose S.
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Decreased activity of GABA neurons in the central reward system of high-fat diet-induced obese mice.2012
- Author(s)
  Koyama S
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 正常耐糖能を示す青年期肥満者における潜在的糖代謝リスクとその回避2012
- Author(s)
  小山進,花井美佐江,村田雄介,浅野喬,美根和典
- Organizer
  第50回日本糖尿病学会九州地方会
- Place of Presentation
  久留米
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 正常耐糖能を示す青年期肥満者における潜在的糖代謝リスクとその回避2012
- Author(s)
  小山　進, 花井美佐江, 村田雄介, 浅野　喬, 美根和典.
- Organizer
  第50回　日本糖尿病学会九州地方会
- Place of Presentation
  久留米
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Decreased activity of GABA neurons in the central reward system of high-fat diet-induced obese mice2012
- Author(s)
  小山進
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 青年期肥満者の早期耐糖能障害予測におけるアディポネクチンの有用性2012
- Author(s)
  小山進,花井美佐江,荒川秀子,村田雄介,浅野喬,美根和典
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食嗜好を示す肥満マウス脳内報酬系ドパミン神経における選択的D2自己受容体機能低下.2012
- Author(s)
  小山進,大倉野将広,寺井大輝,河原田茉莉,佐澤卓哉,宮崎彩乃,森征慶,金丸尚平,村田雄介,美根和典.
- Organizer
  第14回ブレインサイエンス研究会
- Place of Presentation
  霧島
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食嗜好を示す肥満マウス脳内報酬系ドパミン神経における選択的D2自己受容体機能低下2012
- Author(s)
  小山　進,　大倉野将広,　他.
- Organizer
  第14回ブレインサイエンス研究会
- Place of Presentation
  霧島（鹿児島）
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 青年期肥満者の早期耐糖能障害予測におけるアディポネクチンの有用性2012
- Author(s)
  小山　進, 花井美佐江, 荒川秀子, 村田雄介, 浅野　喬, 美根和典.
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食負荷肥満マウスにおいてはVTAドパミン自己受容体機能が低下する2011
- Author(s)
  森征慶,小山進,寺井大輝,河原田茉莉,大倉野将広,村田雄介,杉本裕子,美根和典
- Organizer
  第39回薬物活性
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食負荷肥満マウスにおける脳内食報酬系ドパミンD2自己受容体機能低下の細胞内機序2011
- Author(s)
  小山進, 寺井大輝, 河原田茉莉, 佐澤卓哉, 宮崎彩乃, 森征慶, 金丸尚平, 村田雄介, 美根和典
- Organizer
  第13回ブレインサイエンス研究会
- Place of Presentation
  熊本
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食負荷肥満マウスにおいてはVTAドパミン自己受容体機能が低下する2011
- Author(s)
  森征慶, 小山進, 寺井大輝, 河原田茉莉, 大倉野将広, 村田雄介, 杉本裕子, 美根和典
- Organizer
  第39回薬物活性シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] 高脂肪食負荷肥満マウスにおける脳内食報酬系ドパミンD2自己受容体機能低下の細胞内機序.2011
- Author(s)
  小山進,寺井大輝,河原田茉莉,佐澤卓哉,宮崎彩乃,森征慶,金丸尚平,村田雄介,美根和典.
- Organizer
  第13回ブレインサイエンス研究会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] The effect of psychological stress on grooming behavior in mice.2010
- Author(s)
  Hashiguchi S, Murata Y, Hara C, Abe E, Tanaka S, Maiguma C, Sugimoto H, Koyama S, Mine K.
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Mine K. Modulation of dopaminergic-rewarding neuronal activity through a dopamine receptor in high-fat diet-induced obese mice.2010
- Author(s)
  Mori M, Koyama S, Kanamaru S, Miyazaki A, Sazawa T, Murata Y
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  鹿児島.
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Long-term intake of inherentry preferable high-fat diet inducesobesity with enhancement of fat preference in mice2010
- Author(s)
  金丸尚平, 小山進, 森征慶, 佐澤卓哉, 宮崎彩乃, 村田雄介, 美根和典
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  鹿児島
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Long-term intake of inherently preferable high-fat dietinduces obesity with enhancement of fat preference in mice.2010
- Author(s)
  Kanamaru S, Koyama S, Mori M, Sazawa T, Miyazaki A, Murata Y, Sugimoto H, Mine K.
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22500685
[Presentation] Modulation of dopaminergic-rewarding neuronal activity through adopamine receptor in high-fat diet'induced obese mice2010
- Author(s)
  森征慶, 小山進, 金丸尚平, 宮崎彩乃, 佐澤卓哉, 村田雄介, 美根和典
- Organizer
  第63回日本薬理学会西南部会
- Place of Presentation
  鹿児島
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22500685

1. 山脇洋輔 (90584061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. MINE Kazunori (60150421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. 廣瀬伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOYAMA Susumu 小山 進

小山 進 コヤマ ススム

Research Projects

Research Products

Co-Researchers

Research for elucidating mechanism of stress vulnerability mediated by adipokine-evoked microglial activation in the obesity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳内報酬系レプチン－ドパミン連関を介した肥満における過食形成機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel anti-obesity therapy based on dopamine-leptin interaction in the midbrain for food rewardPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of adipokine on feeding behavior of obese adolescents through dopaminergic reward circuits in the brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional change in brain reward system is associated with fat preference and hyperphagia in diet-induced obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 高脂肪食負荷肥満誘発における脳内食報酬系ドパミン神経のレプチンとドパミンの相互作用2023

Author(s)

Journal Title

Data Source

[Journal Article] Leptin attenuates D2 receptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons2018

Author(s)

Journal Title

Data Source

[Journal Article] Leptin attenuates D(2) receptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A persistent Na+ curent and its contribution to burst firing in ventral tegmental area dopamine neurons.2015

Author(s)

Journal Title

Data Source

[Journal Article] A persistent Na+ current and its contribution to burst firing in ventral tegmental area dopamine neurons.2015

Author(s)

Journal Title

Data Source

[Journal Article] Obesity attenuates D2 autoreceptor-mediated inhibition of putative ventral tegmental area dopaminergic neurons.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effects of zinc and other divalent cations on M-current in ventral tegmental area dopamine neurons.2014

Author(s)

Journal Title

Data Source

[Journal Article] Obesity decreases exitability of putative ventral tegmental area GABAergic neurons.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ストレス性摂食障害研究2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome.2010

Author(s)

Journal Title

Data Source

[Journal Article] Acute p38-mediated inhibition of NMDA-induced outward currents inhippocampal CA1 neurons byinterleukin-1β2010

KOYAMA Susumu 小山進

小山進コヤマススム