suzuki genjiro 鈴木元治郎

… Alternative Names

SUZUKI Genjiro 鈴木元治郎

鈴木元治郎スズキゲンジロウ

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Researcher Number	60466034
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主席研究員 2016 – 2018: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 2016: 公益財団法人東京都医学総合研究所, 認知症高次脳機能研究分野, 主席研究員 2013 – 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2010: 独立行政法人理化学研究所, 田中研究ユニット, 研究員
Review Section/Research Field	Principal Investigator Cell biology / Basic Section 49010:Pathological biochemistry-related / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Nerve anatomy/Neuropathology / Biological Sciences
Keywords	Principal Investigator プリオン / TDP-43 / 神経細胞 / プリオン様伝播 / αシヌクレイン / 前頭側頭葉変性症 / 筋萎縮性側索硬化症 / 筋委縮性側索硬化症 / 神経変性疾患 / ALS … More / タンパク質 / 酵母 / 老化 / 細胞老化 … More Except Principal Investigator プリオン / 筋萎縮性側索硬化症 / アグリソーム / プロフィリン１ / prion / seeding / LC3 / aggresome / mutation / ALS / TDP-43 / Profilin1 / 酵母 / 凝集体 / アミロイド Less

αシヌクレインの神経細胞への取り込み・リン酸化機序の解明Principal Investigator
- Principal Investigator
  
  鈴木元治郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
TDP-43凝集体を形成する病態モデルの確立と解析Principal Investigator
- Principal Investigator
  
  鈴木元治郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The aggregation mechanism of TDP-43 proteinPrincipal Investigator
- Principal Investigator
  
  SUZUKI Genjiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations
- Principal Investigator
  
  TANAKA Yoshinori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The molecular mechanism of asymmetric inheritance of damaged proteins.Principal Investigator
- Principal Investigator
  
  SUZUKI Genjiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The Institute of Physical and Chemical Research
細胞分裂に伴う蛋白質凝集体の不均等分配機構の解明
- Principal Investigator
  
  田中元雅
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2019 2018 2017 2016 2015 2014 2013 2010 Other

All Journal Article Presentation

[Journal Article] TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy2023
- Author(s)
  Tanaka Yoshinori、Ito Shun-ichi、Suzuki Genjiro
- Journal Title
  
  Autophagy Reports
  
  Volume: 3 Issue: 1 Pages: 3-3
- DOI
  10.1080/27694127.2023.2291250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-23K06837
[Journal Article] Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-432023
- Author(s)
  Tanaka Yoshinori、Ito Shun-ichi、Honma Yuki、Hasegawa Masato、Kametani Fuyuki、Suzuki Genjiro、Kozuma Lina、Takeya Kosuke、Eto Masumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 11 Pages: 105272-105272
- DOI
  10.1016/j.jbc.2023.105272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-23K06339, KAKENHI-PROJECT-23K06837
[Journal Article] Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.2022
- Author(s)
  Awa S, Suzuki G, Masuda-Suzukake M, Nonaka T, Saito M, Hasegawa M.
- Journal Title
  
  Scientific reports
  
  Volume: 12 Issue: 1 Pages: 1163-1163
- DOI
  10.1038/s41598-022-04780-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288
[Journal Article] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms2022
- Author(s)
  Hosokawa M, Masuda-Suzukake M, Shitara H, Shimozawa A, Suzuki G, Kondo H, Nonaka T, Campbell W, Arai T, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 145 Issue: 1 Pages: 349-361
- DOI
  10.1093/brain/awab289
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07618, KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-22K07362
[Journal Article] The effect of truncation on prion-like properties of α-synuclein.2018
- Author(s)
  Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, and Hasegawa M.
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Issue: 36 Pages: 13910-13920
- DOI
  10.1074/jbc.ra118.001862
- NAID
  120007133755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16K21650
[Journal Article] Following the fate of endocytosed fibrils2017
- Author(s)
  Hasegawa Masato、Suzuki Genjiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 32 Pages: 13498-13499
- DOI
  10.1074/jbc.h117.780296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21650
[Journal Article] Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.2017
- Author(s)
  Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 969-988
- DOI
  10.1093/hmg/ddx011
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-16K21650, KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016
- Author(s)
  Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
- Journal Title
  
  The journal of Biological Chemistry
  
  Volume: 291 Issue: 11 Pages: 5473-83
- DOI
  10.1074/jbc.m115.695379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-ORGANIZER-25115001, KAKENHI-PLANNED-25115006, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25250010, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-16K14675
[Journal Article] Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.2016
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 25 Issue: 7 Pages: 1420-33
- DOI
  10.1093/hmg/ddw024
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-16K21650
[Journal Article] The proceeding of drug development based on the propagation of tau protein2016
- Author(s)
  Suzuki G, Hasegawa M.
- Journal Title
  
  Nihon Rinsho
  
  Volume: 74 Pages: 432-7
- NAID
  40020797303
- Data Source
  KAKENHI-PROJECT-16K21650
[Journal Article] Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.2016
- Author(s)
  Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
- Journal Title
  
  J. Biol. Chem., J. Biol. Chem.
  
  Volume: 291 Issue: 36 Pages: 18675-18688
- DOI
  10.1074/jbc.m116.734707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016
- Author(s)
  Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 17 Pages: 8896-907
- DOI
  10.1074/jbc.m115.713552
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02356, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650
[Journal Article] Expanding the yeast prion world: Active prion conversion of non-glutamine/asparagine-rich Mod5 for cell survival.2013
- Author(s)
  Genjiro Suzuki, Motomasa Tanaka
- Journal Title
  
  Prion
  
  Volume: 7 Issue: 2 Pages: 109-113
- DOI
  10.4161/pri.22685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25840080
[Presentation] alpha-synuclein strains that cause distinct pathologies differentially inhibit proteasome.2022
- Author(s)
  Genjiro Suzuki
- Organizer
  23rd TMIMS International Symposium New Frontiers in Ubiquitin Proteasome System
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07288
[Presentation] Different properties of α-synuclein conformational strains2019
- Author(s)
  Genjiro Suzuki, Masato Hasegawa
- Organizer
  The 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21650
[Presentation] Different properties of α-synuclein conformational strains2018
- Author(s)
  Genjiro Suzuki, Masato Hasegawa
- Organizer
  日本神経科学大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21650
[Presentation] ALSの原因となるプロフィリン1変異は機能獲得によりTDP-43の蓄積を誘起する2016
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  H27年度　ALS病態解明班　成果報告会
- Place of Presentation
  都市センターホテル(東京都千代田区)
- Year and Date
  2016-01-26
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2016
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  第14回医学研国際シンポジウム
- Place of Presentation
  東京都医学総合研究所 (東京都世田谷区)
- Year and Date
  2016-06-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] プリオンひろがる　―タンパク質構造変化による機能獲得―2016
- Author(s)
  鈴木元治郎
- Organizer
  明治薬科大学認知症創薬資源研究開発センター　公開セミナー
- Place of Presentation
  明治薬科大学　（東京都清瀬市）
- Year and Date
  2016-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-16K21650
[Presentation] Progranulin overexpression decrease levels of the matured form of cathepsin D due to enhancement of lysosomal acidificaition.2016
- Author(s)
  Tanaka Y, Suzuki G, Hosokawa M, Kametani F, Hasegawa M, Nishihara M.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Gain-of-function Profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause intracellular TDP-43 aggregation.2015
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  Brain Protein Aging and Dementia Control, 1st International Symposium 2015
- Place of Presentation
  野依記念学術交流館(愛知県名古屋市)
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] ALSの原因となるプロフィリン1変異はTDP-43の凝集を誘起する2015
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  第41回日本認知症学会
- Place of Presentation
  リンクステーションホテル青森(青森県青森市)
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] ALSの原因となるプロフィリン１変異は機能獲得によりTDP-43の凝集を誘起する2015
- Author(s)
  田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
- Organizer
  認知症研究を知る若手研究者の集まり 2015
- Place of Presentation
  ニューサンピア高崎(群馬県高崎市)
- Year and Date
  2015-08-02
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2015
- Author(s)
  Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
- Organizer
  Neuroscience 2015, SfN's 45th annual meeting
- Place of Presentation
  シカゴ(米国)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] プリオン現象を利用した酵母の新たな抗ウイルス作用機構2014
- Author(s)
  鈴木元治郎
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府・京都市)
- Year and Date
  2014-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-25840080
[Presentation] 二本鎖RNAウイルスへ変異を導入する酵母プリオン様因子[KIL-d]の解析2010
- Author(s)
  鈴木元治郎
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪・大阪大学
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PUBLICLY-22020036
[Presentation] 二本鎖RNAウイルスへ変異を導入する酵母プリオン様因子[KIL-d]の解析2010
- Author(s)
  鈴木元治郎
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸・ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PUBLICLY-22020036
[Presentation] The mechanism of asymmetric distribution of prion protein in the yeast cell.
- Author(s)
  Genjiro Suzuki, Motomasa Tanaka
- Organizer
  Asian Pacific Prion Symposium 2013(アジア太平洋プリオンシンポジウム2013)
- Place of Presentation
  ハウステンボス　佐世保
- Invited
- Data Source
  KAKENHI-PROJECT-25840080
[Presentation] 酵母における老化タンパク質凝集体の不均等分配のメカニズム
- Author(s)
  鈴木元治郎, 田中元雅
- Organizer
  日本細胞生物学会年会
- Place of Presentation
  ウインクあいち　名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-25840080

1. TANAKA Yoshinori (00747933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. HASEGAWA Masato (10251232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. NONAKA Takashi (30356258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. KAMETANI Fuyuki (70186013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. HOSOKAWA Masato (00435116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 田中元雅 (40321781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鈴掛雅美(増田雅美)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 久永眞市

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

suzuki genjiro 鈴木 元治郎

SUZUKI Genjiro 鈴木 元治郎

鈴木 元治郎 スズキ ゲンジロウ

Research Projects

Research Products

Co-Researchers

αシヌクレインの神経細胞への取り込み・リン酸化機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TDP-43凝集体を形成する病態モデルの確立と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The aggregation mechanism of TDP-43 proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanism of asymmetric inheritance of damaged proteins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞分裂に伴う蛋白質凝集体の不均等分配機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-432023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of truncation on prion-like properties of α-synuclein.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Following the fate of endocytosed fibrils2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016

Author(s)

suzuki genjiro 鈴木元治郎

SUZUKI Genjiro 鈴木元治郎

鈴木元治郎スズキゲンジロウ

[Presentation] プリオンひろがる　―タンパク質構造変化による機能獲得―2016