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suzuki genjiro  鈴木 元治郎

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… Alternative Names

SUZUKI Genjiro  鈴木 元治郎

鈴木 元治郎  スズキ ゲンジロウ

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Researcher Number 60466034
Other IDs
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主席研究員
2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help 2021 – 2024: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主席研究員
2016 – 2018: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員
2016: 公益財団法人東京都医学総合研究所, 認知症高次脳機能研究分野, 主席研究員
2013 – 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員
2010: 独立行政法人理化学研究所, 田中研究ユニット, 研究員
Review Section/Research Field
Principal Investigator
Cell biology / Basic Section 49010:Pathological biochemistry-related / Basic Section 51030:Pathophysiologic neuroscience-related
Except Principal Investigator
Nerve anatomy/Neuropathology / Biological Sciences
Keywords
Principal Investigator
プリオン / TDP-43 / 神経細胞 / プリオン様伝播 / αシヌクレイン / 前頭側頭葉変性症 / 筋萎縮性側索硬化症 / 筋委縮性側索硬化症 / 神経変性疾患 / ALS … More / タンパク質 / 酵母 / 老化 / 細胞老化 … More
Except Principal Investigator
プリオン / 筋萎縮性側索硬化症 / アグリソーム / プロフィリン1 / prion / seeding / LC3 / aggresome / mutation / ALS / TDP-43 / Profilin1 / 酵母 / 凝集体 / アミロイド Less
  • Research Projects

    (6 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (8 People)
  •  αシヌクレインの神経細胞への取り込み・リン酸化機序の解明Principal Investigator

    • Principal Investigator
      鈴木 元治郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  TDP-43凝集体を形成する病態モデルの確立と解析Principal Investigator

    • Principal Investigator
      鈴木 元治郎
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  The aggregation mechanism of TDP-43 proteinPrincipal Investigator

    • Principal Investigator
      SUZUKI Genjiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations

    • Principal Investigator
      TANAKA Yoshinori
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  The molecular mechanism of asymmetric inheritance of damaged proteins.Principal Investigator

    • Principal Investigator
      SUZUKI Genjiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  細胞分裂に伴う蛋白質凝集体の不均等分配機構の解明

    • Principal Investigator
      田中 元雅
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research

All 2023 2022 2019 2018 2017 2016 2015 2014 2013 2010 Other

All Journal Article Presentation

  • [Journal Article] TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy2023

    • Author(s)
      Tanaka Yoshinori、Ito Shun-ichi、Suzuki Genjiro
    • Journal Title

      Autophagy Reports

      Volume: 3 Issue: 1 Pages: 3-3

    • DOI

      10.1080/27694127.2023.2291250

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-23K06837
  • [Journal Article] Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-432023

    • Author(s)
      Tanaka Yoshinori、Ito Shun-ichi、Honma Yuki、Hasegawa Masato、Kametani Fuyuki、Suzuki Genjiro、Kozuma Lina、Takeya Kosuke、Eto Masumi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 299 Issue: 11 Pages: 105272-105272

    • DOI

      10.1016/j.jbc.2023.105272

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-23K06339, KAKENHI-PROJECT-23K06837
  • [Journal Article] Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.2022

    • Author(s)
      Awa S, Suzuki G, Masuda-Suzukake M, Nonaka T, Saito M, Hasegawa M.
    • Journal Title

      Scientific reports

      Volume: 12 Issue: 1 Pages: 1163-1163

    • DOI

      10.1038/s41598-022-04780-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288
  • [Journal Article] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms2022

    • Author(s)
      Hosokawa M, Masuda-Suzukake M, Shitara H, Shimozawa A, Suzuki G, Kondo H, Nonaka T, Campbell W, Arai T, Hasegawa M
    • Journal Title

      Brain

      Volume: 145 Issue: 1 Pages: 349-361

    • DOI

      10.1093/brain/awab289

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07618, KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-22K07362
  • [Journal Article] The effect of truncation on prion-like properties of α-synuclein.2018

    • Author(s)
      Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, and Hasegawa M.
    • Journal Title

      J Biol Chem

      Volume: 293 Issue: 36 Pages: 13910-13920

    • DOI

      10.1074/jbc.ra118.001862

    • NAID

      120007133755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16K21650
  • [Journal Article] Following the fate of endocytosed fibrils2017

    • Author(s)
      Hasegawa Masato、Suzuki Genjiro
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 32 Pages: 13498-13499

    • DOI

      10.1074/jbc.h117.780296

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21650
  • [Journal Article] Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.2017

    • Author(s)
      Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
    • Journal Title

      Human Molecular Genetics

      Volume: 26 Pages: 969-988

    • DOI

      10.1093/hmg/ddx011

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-16K21650, KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
  • [Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016

    • Author(s)
      Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
    • Journal Title

      The journal of Biological Chemistry

      Volume: 291 Issue: 11 Pages: 5473-83

    • DOI

      10.1074/jbc.m115.695379

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-ORGANIZER-25115001, KAKENHI-PLANNED-25115006, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25250010, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25650014, KAKENHI-PROJECT-26251004, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-16K14675
  • [Journal Article] Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.2016

    • Author(s)
      Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
    • Journal Title

      Human Molecular Genetics

      Volume: 25 Issue: 7 Pages: 1420-33

    • DOI

      10.1093/hmg/ddw024

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-16K21650
  • [Journal Article] The proceeding of drug development based on the propagation of tau protein2016

    • Author(s)
      Suzuki G, Hasegawa M.
    • Journal Title

      Nihon Rinsho

      Volume: 74 Pages: 432-7

    • NAID

      40020797303

    • Data Source
      KAKENHI-PROJECT-16K21650
  • [Journal Article] Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.2016

    • Author(s)
      Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
    • Journal Title

      J. Biol. Chem., J. Biol. Chem.

      Volume: 291 Issue: 36 Pages: 18675-18688

    • DOI

      10.1074/jbc.m116.734707

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
  • [Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.2016

    • Author(s)
      Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 17 Pages: 8896-907

    • DOI

      10.1074/jbc.m115.713552

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02356, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K21650
  • [Journal Article] Expanding the yeast prion world: Active prion conversion of non-glutamine/asparagine-rich Mod5 for cell survival.2013

    • Author(s)
      Genjiro Suzuki, Motomasa Tanaka
    • Journal Title

      Prion

      Volume: 7 Issue: 2 Pages: 109-113

    • DOI

      10.4161/pri.22685

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25840080
  • [Presentation] alpha-synuclein strains that cause distinct pathologies differentially inhibit proteasome.2022

    • Author(s)
      Genjiro Suzuki
    • Organizer
      23rd TMIMS International Symposium New Frontiers in Ubiquitin Proteasome System
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07288
  • [Presentation] Different properties of α-synuclein conformational strains2019

    • Author(s)
      Genjiro Suzuki, Masato Hasegawa
    • Organizer
      The 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21650
  • [Presentation] Different properties of α-synuclein conformational strains2018

    • Author(s)
      Genjiro Suzuki, Masato Hasegawa
    • Organizer
      日本神経科学大会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21650
  • [Presentation] ALSの原因となるプロフィリン1変異は機能獲得によりTDP-43の蓄積を誘起する2016

    • Author(s)
      田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
    • Organizer
      H27年度 ALS病態解明班 成果報告会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2016-01-26
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2016

    • Author(s)
      Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
    • Organizer
      第14回医学研国際シンポジウム
    • Place of Presentation
      東京都医学総合研究所 (東京都世田谷区)
    • Year and Date
      2016-06-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] プリオンひろがる ―タンパク質構造変化による機能獲得―2016

    • Author(s)
      鈴木元治郎
    • Organizer
      明治薬科大学認知症創薬資源研究開発センター 公開セミナー
    • Place of Presentation
      明治薬科大学 (東京都清瀬市)
    • Year and Date
      2016-05-31
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K21650
  • [Presentation] Progranulin overexpression decrease levels of the matured form of cathepsin D due to enhancement of lysosomal acidificaition.2016

    • Author(s)
      Tanaka Y, Suzuki G, Hosokawa M, Kametani F, Hasegawa M, Nishihara M.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] Gain-of-function Profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause intracellular TDP-43 aggregation.2015

    • Author(s)
      Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
    • Organizer
      Brain Protein Aging and Dementia Control, 1st International Symposium 2015
    • Place of Presentation
      野依記念学術交流館(愛知県名古屋市)
    • Year and Date
      2015-10-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] ALSの原因となるプロフィリン1変異はTDP-43の凝集を誘起する2015

    • Author(s)
      田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
    • Organizer
      第41回日本認知症学会
    • Place of Presentation
      リンクステーションホテル青森(青森県青森市)
    • Year and Date
      2015-10-03
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] ALSの原因となるプロフィリン1変異は機能獲得によりTDP-43の凝集を誘起する2015

    • Author(s)
      田中良法、野中隆、鈴木元治郎、亀谷富由樹、長谷川成人
    • Organizer
      認知症研究を知る若手研究者の集まり 2015
    • Place of Presentation
      ニューサンピア高崎(群馬県高崎市)
    • Year and Date
      2015-08-02
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] Mutations in the PFN1 gene induce degenerative changes through aggregation of both mutant PFN1 and TDP-43.2015

    • Author(s)
      Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M.
    • Organizer
      Neuroscience 2015, SfN's 45th annual meeting
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2015-10-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18370
  • [Presentation] プリオン現象を利用した酵母の新たな抗ウイルス作用機構2014

    • Author(s)
      鈴木元治郎
    • Organizer
      日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2014-10-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-25840080
  • [Presentation] 二本鎖RNAウイルスへ変異を導入する酵母プリオン様因子[KIL-d]の解析2010

    • Author(s)
      鈴木元治郎
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪・大阪大学
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PUBLICLY-22020036
  • [Presentation] 二本鎖RNAウイルスへ変異を導入する酵母プリオン様因子[KIL-d]の解析2010

    • Author(s)
      鈴木元治郎
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸・ポートアイランド
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PUBLICLY-22020036
  • [Presentation] The mechanism of asymmetric distribution of prion protein in the yeast cell.

    • Author(s)
      Genjiro Suzuki, Motomasa Tanaka
    • Organizer
      Asian Pacific Prion Symposium 2013(アジア太平洋プリオンシンポジウム2013)
    • Place of Presentation
      ハウステンボス 佐世保
    • Invited
    • Data Source
      KAKENHI-PROJECT-25840080
  • [Presentation] 酵母における老化タンパク質凝集体の不均等分配のメカニズム

    • Author(s)
      鈴木元治郎, 田中元雅
    • Organizer
      日本細胞生物学会年会
    • Place of Presentation
      ウインクあいち 名古屋
    • Invited
    • Data Source
      KAKENHI-PROJECT-25840080
  • 1.  TANAKA Yoshinori (00747933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 2.  HASEGAWA Masato (10251232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 3.  NONAKA Takashi (30356258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 4.  KAMETANI Fuyuki (70186013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 5.  HOSOKAWA Masato (00435116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  田中 元雅 (40321781)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  鈴掛 雅美(増田雅美)
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  久永 眞市
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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