HAYAKAWA Kimihide 早川公英

Researcher Number	60467280
Affiliation (based on the past Project Information) *help	2017: 名古屋大学, 医学(系)研究科(研究院), その他 2015 – 2017: 名古屋大学, 医学系研究科, 特任講師 2015: 名古屋大学, 医学(系)研究科(研究院), 講師 2013 – 2014: 名古屋大学, 医学(系)研究科(研究院), 特任講師 2013: 名古屋大学, 大学院医学系研究科, 特任講師 2011 – 2012: 名古屋大学, 工学(系)研究科(研究院), 特任講師 2011: 名古屋大学, 工学研究科, 特任講師
Review Section/Research Field	Principal Investigator Cell biology Except Principal Investigator Biophysics / Rehabilitation science/Welfare engineering / Mechanobiology
Keywords	Principal Investigator 一分子イメージング / 力覚受容 / 力学受容 / 協同性 / ゆらぎ / 張力 / コフィリン / アクチン Except Principal Investigator 近接場光 / コフィリン … More / アクチン線維 / actin / cofilin / イメージング / 切断 / アクチン / 光ピンセット / 張力 / ゆらぎ / 運動負荷強度 / 炎症反応 / 筋損傷 / 筋萎縮 / 一分子 / 細胞運動 / キネティクス / 一分子計測 / AIP1 / 機械刺激受容チャネル / 接着斑 / 細胞骨格 / 機械受容チャネル / 足場 / メカノセンシング / mechanosensor / 分子ねじれ / 一分子操作 / 力受容 / 分子ゆらぎ / 一分子イメージング / 力学刺激 / 張力依存的結合 / 一分子観察 / 回転ゆらぎ / 伸展刺激 / 分子動力学 / 1分子観察 / メカノセンサー Less

Single molecule kinetics analyses of AIP1-enhanced actin filament severing
- Principal Investigator
  
  Tatsumi Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Kanazawa Institute of Technology
The execise intensities causing muscle injury inhibits recovery from muscle atrophy
- Principal Investigator
  
  Itoh Yuta
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Nagoya Gakuin University
Possible roles of actomyosin and mechanosensitive channels in substrate rigidity sensing of cells
- Principal Investigator
  
  SOKABE Masahiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
Single molecule imaging and kinetic analysis of actin filament-cofilin interactions modulated by fluctuations of the actin filament.Principal Investigator
- Principal Investigator
  
  HAYAKAWA Kimihide
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Nagoya University
Structural changes in the actin filament associated with tension sensing
- Principal Investigator
  
  TATSUMI Hitoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Mechanobiology
- Research Institution
  Nagoya University
Actin filaments work as a negative tension sensor: elucidation of itsphysiochemical mechanism
- Principal Investigator
  
  SOKABE Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] The role of actin filaments as a force-transmitter and a force-sensor.2012
- Author(s)
  Tatsumi H, Hayakawa K, Hirata H, Sokabe M.
- Publisher
  Shanghai Sci Tech Liter Pub House
- Data Source
  KAKENHI-PROJECT-21247021
[Book] Nanotechnology in mechanobiology: mechanical manipulation of cells and organelle while monitoring intracellular signaling. In "Mechanosensing Biology" (ed. Noda M)2010
- Author(s)
  Tatsumi H, Hayakawa K, Sokabe M.
- Publisher
  Springer Verlag
- Data Source
  KAKENHI-PROJECT-21247021
[Book] Mechanosensing Biology(Ed.Noda M)2010
- Author(s)
  Tatsumi H, Hayakawa K, Sokabe M
- Total Pages
  219
- Publisher
  Springer verlag pp3-45, Nanotechnology in mechanobiology : mechanical manipulation of cells and organelle while monitoring intracellular signaling
- Data Source
  KAKENHI-PROJECT-21247021
[Journal Article] Training at non-damaging intensities facilitates recovery from muscle atrophy.2017
- Author(s)
  Itoh Y, Murakami T, Mori T, Agata N, Kimura N, Inoue-Miyazu M, Hayakawa K, Hirano T, Sokabe M, Kawakami K
- Journal Title
  
  Muscle and Nerve
  
  Volume: 55(2) Issue: 2 Pages: 243-253
- DOI
  10.1002/mus.25218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05936, KAKENHI-PROJECT-15H03042, KAKENHI-PROJECT-26350638, KAKENHI-PROJECT-26350647, KAKENHI-PROJECT-26350823, KAKENHI-PROJECT-25560254, KAKENHI-PROJECT-26560288, KAKENHI-PROJECT-26750205, KAKENHI-PROJECT-15K01436, KAKENHI-PROJECT-16K12938
[Journal Article] Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.2016
- Author(s)
  Nomura, K., K. Hayakawa, H. Tatsumi, and S. Ono.
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 291 Issue: 10 Pages: 5146-5156
- DOI
  10.1074/jbc.m115.713495
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07025
[Journal Article] The Actin Filament as a Mechanosensor2015
- Author(s)
  辰巳仁史、早川公英、曽我部正博
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 55 Issue: 4 Pages: 187-191
- DOI
  10.2142/biophys.55.187
- NAID
  130005090035
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07025, KAKENHI-PLANNED-15H05936
[Journal Article] アクチン線維は張力を感じ、コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである2015
- Author(s)
  辰巳仁史、早川公英、曽我部正博
- Journal Title
  
  生物物理
  
  Volume: 55 Pages: 187-191
- NAID
  130005090035
- Data Source
  KAKENHI-PROJECT-24247028
[Journal Article] Non-channel Mechanosensors Working at Focal Adhesion-Stress Fiber Complex2015
- Author(s)
  Hirata H, Tatsumi H, Hayakawa K, Sokabe M
- Journal Title
  
  Pflügers Archiv -Eur J Physiol
  
  Volume: 467 Issue: 1 Pages: 141-155
- DOI
  10.1007/s00424-014-1558-3
- Data Source
  KAKENHI-PROJECT-24247028
[Journal Article] Single-molecule imaging and kinetic analysis of cooperative cofilin-actin filament interactions.2014
- Author(s)
  Kimihide Hayakawa, Shotaro Sakakibara, Masahiro Sokabe, Hitoshi Tatsumi
- Journal Title
  
  Proceedings of the National Academy of Science of the United States of America
  
  Volume: 111 (27) Issue: 27 Pages: 9810-9815
- DOI
  10.1073/pnas.1321451111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24657130
[Journal Article] Mechanosensitive channels are activated by stress in the actin stress fibers, which could be involved in gravity sensing in plants2014
- Author(s)
  Hitoshi Tatsumi, Takuya Furuichi, Masataka Nakano, Masatsugu Toyota, Kimihide Hayakawa, Masahiro Sokabe, and Hidetoshi Iida
- Journal Title
  
  Plant Biology
  
  Volume: 16(Suppl. 1) Issue: s1 Pages: 18-22
- DOI
  10.1111/plb.12095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23612003, KAKENHI-PROJECT-24247028, KAKENHI-PUBLICLY-25120708
[Journal Article] Mechanosensing by actin filaments and focal proteins2012
- Author(s)
  Hayakawa K, Tatsumi H, Sokabe M
- Journal Title
  
  Commun Integr Biol
  
  Volume: 5(6) Issue: 6 Pages: 572-576
- DOI
  10.4161/cib.21891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247021, KAKENHI-PROJECT-23612003, KAKENHI-PROJECT-24247028
[Journal Article] Mechanosensing by actin filaments and focal proteins.2012
- Author(s)
  Hayakawa K, Tatsumi H, Sokabe M
- Journal Title
  
  Commun Integr Biol
  
  Volume: 5(6) Pages: 572-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247021
[Journal Article] Mechano-sensing by actin filaments and focal adhesion proteins2012
- Author(s)
  Hayakawa K.,.Tatsumi H., Sokabe M
- Journal Title
  
  Communicative & Integrative Biology
  
  Volume: vol 5 Pages: 572-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23612003
[Journal Article] Force- and Ca2+-dependent internalization of integrin in cultured endothelial cells2011
- Author(s)
  Kiyoshima D, Kawakami K, Hayakawa K, Tatsumi H and Sokabe M.
- Journal Title
  
  J. Cell Science
  
  Volume: 124 Pages: 3859-3870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23612003
[Journal Article] Actin filaments function as a tension sensor via tension-dependent binding of cofilin to the filament.2011
- Author(s)
  Hayakawa K, Tatsumi H, Sokabe M.
- Journal Title
  
  J Cell Biol
  
  Volume: 195(5) Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247021
[Journal Article] Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament2011
- Author(s)
  Hayakawa K, Tatsumi H and Sokabe M.
- Journal Title
  
  J Cell Biol
  
  Volume: 195 Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23612003
[Journal Article] Force- and Ca^-dependent internalization of integrin in cultured endothelial cells.2011
- Author(s)
  Kiyoshima D, Kawakami K, Hayakawa K,Tatsumi H, Sokabe M.
- Journal Title
  
  J Cell Sci
  
  Volume: 124(Pt 22) Pages: 3859-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247021
[Journal Article] Force- and Ca^<2+>-dependent internalization of integrin in cultured endothelial cells2011
- Author(s)
  Kiyoshima D, Kawakami K, Hayakawa K, Tatsumi H and Sokabe M
- Journal Title
  
  Cell Sci 124
  
  Volume: 124 Issue: 22 Pages: 3859-3870
- DOI
  10.1242/jcs.088559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23612003
[Journal Article] Actin filaments function as a tension sensor via tension-dependent binding of cofilin to the filament2011
- Author(s)
  Hayakawa K, Tatsumi H, Sokabe M
- Journal Title
  
  J Cell Biol
  
  Volume: 195(5) Issue: 5 Pages: 721-727
- DOI
  10.1083/jcb.201102039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247021, KAKENHI-PROJECT-23612003
[Journal Article] Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy in primary cultured skeletal myotubes2010
- Author(s)
  Sasai N, Agata N, Inoue-Miyazu M, Kawakami K, Kobayashi K, Sokabe M, Hayakawa K
- Journal Title
  
  Nerve Muscle
  
  Volume: 41(1) Pages: 100-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21247021
[Journal Article] The role of actin filaments as a force-transmitter and a force-sensor
- Author(s)
  Tatsumi, H., K.Hayakawa, H.Hirata, and M.Sokabe
- Journal Title
  
  In Recent Advances in Mechanobiology
  
  Pages: 153-156
- Data Source
  KAKENHI-PROJECT-23612003
[Presentation] The effective intensity of exercise load for facilitating recovery from muscle atrophy in mice2015
- Author(s)
  Y Itoh, N Agata, N Kimura, M Inoue-Miyazu, T Hirano, K Hayakawa, T Murakami, K Kawakami
- Organizer
  World Confederation for Physical Therapy Congress 2015 (WCPT)
- Place of Presentation
  Suntec (Singapore)
- Year and Date
  2015-05-02
- Data Source
  KAKENHI-PROJECT-15K01436
[Presentation] Mechano-sensing by actin filaments2015
- Author(s)
  Hayakawa K, Sokabe M , Tatsumi H
- Organizer
  8th ICCPB
- Place of Presentation
  Kraków, Poland
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24247028
[Presentation] Direct measurement of thermodynamic parameters of cofilin; actin filament interactions at the single molecule level.2014
- Author(s)
  K. Hayakawa, S. Sakakibara, H. Tatsumi, M. Sokabe
- Organizer
  Biophysical Society
- Place of Presentation
  San Fransisco (USA)
- Data Source
  KAKENHI-PROJECT-23612003
[Presentation] Direct measurement of thermodynamic parameters of cofilin-actin filament interactions at the single molecule level.2014
- Author(s)
  早川公英、榊原正太郎、曽我部正博、辰巳仁志
- Organizer
  Biophysical Society
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-24657130
[Presentation] アクチン繊維による力覚受容　“Mechano-sensing” by actin filaments.2014
- Author(s)
  早川公英、辰巳仁史、曽我部正博
- Organizer
  第53回日本生体医工学会大会
- Place of Presentation
  仙台コンベンションセンター（仙台市）
- Year and Date
  2014-06-26
- Invited
- Data Source
  KAKENHI-PROJECT-24657130
[Presentation] DIRECT MEASUREMENT OF THERMODYNAMIC PARAMETERS OF COFILIN-ACTIN FILAMENT INTERACTIONS AT THE SINGLE MOLECULE LEVEL2014
- Author(s)
  Kimihide Hayakawa1, Shotaro Sakakibara2, Hitoshi Tatsumi2, Masahiro Sokabe1
- Place of Presentation
  Biophysical Society Meeting 2014 San Fransisco US
- Year and Date
  2014-02-18
- Data Source
  KAKENHI-PROJECT-23612003
[Presentation] “Mechano-sensing” by actin filaments.2014
- Author(s)
  Kimihide Hayakawa, Masahiro Sokabe, Hitoshi Tatsumi
- Organizer
  INTERNATIONAL SYNPOSIOUM ON MECHANOBIOLOGY 2014
- Place of Presentation
  岡山大学(岡山市）
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24657130
[Presentation] Real time imaging of enhanced cofilin dependent actin filament severing by actin interacting protein 1 (AIP1)2013
- Author(s)
  Carina Sekiguchi, Kimihide Hayakawa, Shoichiro Ono, Masahiro Sokabe, and Hitoshi Tatsumi
- Organizer
  International Symposium on Super-Resolution Imaging
- Place of Presentation
  Okura Actcity Hotel Hamamatsu (浜松市）
- Data Source
  KAKENHI-PROJECT-23612003
[Presentation] Analysis of Cooperative Cofilin-Actin Filament Interactions examined at the single molecule level2013
- Author(s)
  Kimihide Hayakawa, Hitoshi Tatsumi, Shyotaro Sakakibara, Masahiro Sokabe
- Organizer
  日本生物物理学会年会
- Place of Presentation
  京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-23612003
[Presentation] Analysis of Cooperative Cofilin-Actin Filament Interactions examined at the single molecule level.2013
- Author(s)
  早川公英、榊原正太郎、曽我部正博、辰巳仁志
- Organizer
  日本生物物理学会
- Place of Presentation
  京都国際会議場、京都
- Data Source
  KAKENHI-PROJECT-24657130
[Presentation] Mechanosensitive channels are activated via actin stress fibers, which may be involved in gravity sensing in plants2012
- Author(s)
  Hitoshi Tatsumi, Takuya Furuichi, Masataka Nakano, Masatsugu Toyota, Kimihide Hayakawa, Masahiro Sokabe, and Hidetoshi Iida
- Organizer
  ISLSWG Workshop „Plant Biology in Space“
- Place of Presentation
  Freiburg, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-23612003
[Presentation] A theoretical model of cooperative binding of cofilin to actin filaments2012
- Author(s)
  Shota Sakakibara, Kimihide Hayakawa, Hitoshi Tatsumi, Masahiro Sokabe
- Organizer
  日本生物物理学会第50回年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24657130
[Presentation] Direct observation of cooperative binding of cofilin to actin filaments2012
- Author(s)
  Kimihide Hayakawa, Hitoshi Tatsumi, Takahumi Goto, Masahiro Sokabe
- Organizer
  日本生物物理学会第50回年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24657130
[Presentation] Multiple roles of actin cytoskeleton in cell mechanosensing.2010
- Author(s)
  Sokabe M.Hayakawa K, Tatsumi H, Kobayashi T
- Organizer
  6th World Congress on Biomechanics
- Place of Presentation
  Singapore
- Year and Date
  2010-08-04
- Data Source
  KAKENHI-PROJECT-21247021
[Presentation] ATPおよびADP結合アクチンフィラメントに対するコフィリン結合の一分子観察
- Author(s)
  早川公英、曽我部正博、辰巳仁史
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24657130

1. TATSUMI Hitoshi (20171720)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
2. SOKABE Masahiro (10093428)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
3. KOBAYASHI Takeshi (40402565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Itoh Yuta (30454383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 飯田秀利 (70124435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYAKAWA Kimihide 早川 公英

Research Projects

Research Products

Co-Researchers

Single molecule kinetics analyses of AIP1-enhanced actin filament severing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The execise intensities causing muscle injury inhibits recovery from muscle atrophy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Possible roles of actomyosin and mechanosensitive channels in substrate rigidity sensing of cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Single molecule imaging and kinetic analysis of actin filament-cofilin interactions modulated by fluctuations of the actin filament.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural changes in the actin filament associated with tension sensing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Actin filaments work as a negative tension sensor: elucidation of itsphysiochemical mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] The role of actin filaments as a force-transmitter and a force-sensor.2012

Author(s)

Publisher

Data Source

[Book] Nanotechnology in mechanobiology: mechanical manipulation of cells and organelle while monitoring intracellular signaling. In "Mechanosensing Biology" (ed. Noda M)2010

Author(s)

Publisher

Data Source

[Book] Mechanosensing Biology(Ed.Noda M)2010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Training at non-damaging intensities facilitates recovery from muscle atrophy.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.2016

Author(s)

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DOI

Data Source

[Journal Article] The Actin Filament as a Mechanosensor2015

Author(s)

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NAID

ISSN

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Data Source

[Journal Article] アクチン線維は張力を感じ、コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Non-channel Mechanosensors Working at Focal Adhesion-Stress Fiber Complex2015

Author(s)

Journal Title

DOI

HAYAKAWA Kimihide 早川公英