Mizoguchi Yoshito 溝口義人

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MIZOGUCHI Yoshito 溝口義人

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Researcher Number	60467892
Other IDs
Affiliation (Current)	2025: 佐賀大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 佐賀大学, 医学部, 教授 2017 – 2022: 佐賀大学, 医学部, 准教授 2014 – 2016: 佐賀大学, 医学部, 講師 2010 – 2012: 佐賀大学, 医学部, 講師 2009: Kyushu University, 医学研究院, 特別教員 2008: Kyushu University, 大学院・医学研究院, 特別教員
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science / Basic Section 55060:Emergency medicine-related / Studies on the Super-Aging Society
Keywords	Principal Investigator ミクログリア / 薬理学 / 神経炎症 / うつ病 / 貪食能 / BDNF / カルシウム / 高齢者医療 / 炎症 / iMG cells … More / 認知症 / 医学 / 神経科学 / ＮＯ / 細胞内カルシウムイオン動態 / 脳血管内皮細胞 / アミロイドβ / ドネペジル / 認知症治療薬 / アルツハイマー型認知症 / 神経生理学 / 抗うつ薬 / 精神薬理 / 気分障害 / 脳由来神経栄養因子(BDNF) … More Except Principal Investigator 高齢者 / 認知機能 / 認知症 / ミクログリア様細胞 / 神経炎症 / ミクログリア / せん妄 / 脳画像 / 縦断研究 / 認知機能低下 / うつ病 / 認知機能予後 / 外傷 / 睡眠 / オレキシン受容体拮抗薬 / ICU / 重症患者 / 抑うつ症状 / 閉塞性睡眠時無呼吸症候群 / 持続式陽圧呼吸療法 / 睡眠時無呼吸症候群 / 反復性経頭蓋磁気刺激 / 反復経頭蓋磁気刺激 / フローサイトメトリー / Ca 2+ イメージング / Macrophage polarization / DAP12 / TREM2 / 神経炎症仮説 / 貪食能 / FCM / iMG / 関連分子 / default network / 生物学的指標 / 健康 / 不安 / 宗教行動 / 線条体 / 愛着 / 来世信念 / バイオマーカー / 疫学研究 / 健常高齢者 / 抑うつ状態 / サイトカイン / 頭部ＭＲＩ / オキシトシン / 可溶性インターロイキン-2受容体 / 頭部MRI / 抑うつ / cortisol / 長鎖不飽和脂肪酸 / うつ状態 / コホート研究 / FAB / MMSE / ハミルトンうつ病尺度 / MHPG / 唾液 / Beck Depression Inventory / Frontal Assessment Battery / Mini-Mental State Examination / saliva 3-methoxy-4-hydroxuphenylglycol Less

高齢者うつ病および認知症における脳内ミクログリアの機能の共通点と相違点Principal Investigator
- Principal Investigator
  
  溝口義人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saga University
外傷患者のせん妄予測モデル構築と長期認知機能解明
- Principal Investigator
  
  松岡綾華
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Saga University
dynamic analysis in induced-microglial cells from patients with major depression disorder and obstructive sleep apnea syndrome before and after treated with continuous positive airway pressure therapy
- Principal Investigator
  
  野上耕二郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saga University
反復性経頭蓋磁気刺激による治療抵抗性うつ病の治療メカニズムの探索
- Principal Investigator
  
  立石洋
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saga University
dynamic state analysis in induced-microglial cells from delirium population and non-delirium population
- Principal Investigator
  
  村川徹 (平地徹)
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Saga University
Association of afterlife beliefs with mental health and its underlying mechanism of brain in older people
- Principal Investigator
  
  Imamura Yoshiomi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Kurume University
How anti-Alzheimer's drug affect microglia and neurovascular unit ?Principal Investigator
- Principal Investigator
  
  Mizoguchi Yoshito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Saga University
development of biomakers predicting dementia incidence
- Principal Investigator
  
  monji akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Saga University
A prospective study for biomakers that predict incident dementia: the Imari study
- Principal Investigator
  
  Kawashima Toshiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Saga University
A prospective study to detect the factors to cause later cognitive decline or depressive state in Japanese elderly-Three years follow up study-
- Principal Investigator
  
  YAMADA Shigeto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Saga University
Mechanisms underlying effects of BDNF and antidepressants on microglia ; Possible role of TRPC channels(MIZOGUCHI YOSHITO)Principal Investigator
- Principal Investigator
  
  MIZOGUCHI Yoshito
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Saga University
Elucidation of the mechanism underlying the modulation of microglial function by antidepressants and/or BDNFPrincipal Investigator
- Principal Investigator
  
  MIZOGUCHI Yoshito
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kyushu University

[Journal Article] Negative association between basal oxytocin and oxytocin changes after repetitive transcranial magnetic stimulation in patients with treatment-resistant depression2024
- Author(s)
  Kojima Ryohei、Tateishi Hiroshi、Kunitake Hiroko、Imamura Yoshiomi、Kunitake Yutaka、Murakawa Toru、Nagahama Chika、Shiraishi Takumi、Takada Ken、Hirano Masataka、Fukai Airi、Tomonari Akira、Monji Akira、Mizoguchi Yoshito
- Journal Title
  
  Peptides
  
  Volume: 177 Pages: 171217-171217
- DOI
  10.1016/j.peptides.2024.171217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07564
[Journal Article] Relationship between serum cortisol levels, stereotypies, and the presence of autism spectrum disorder in patients with severe intellectual disability2024
- Author(s)
  Ohtsubo Takeru、Mizoguchi Yoshito、Aita Chie、Imamura Yoshiomi、Kobayashi Momoko、Kunitake Yutaka、Tateishi Hiroshi、Ueno Takefumi、Monji Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1
- DOI
  10.1038/s41598-024-57459-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07564
[Journal Article] Salivary 3‐methoxy‐4‐hydroxyphenylglycol and MRI‐based volume change of the precuneus in community‐dwelling elderly people2023
- Author(s)
  Ohishi‐Fukuchi J, Imamura Y, Orihashi R, Kunitake H, Kunitake Y, Tateishi Hi, Yamada S, Monji A, Mizoguchi Y
- Journal Title
  
  Psychogeriatrics
  
  Volume: 23 Issue: 4 Pages: 675-681
- DOI
  10.1111/psyg.12976
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17251, KAKENHI-PROJECT-23K16260, KAKENHI-PROJECT-21K21192, KAKENHI-PROJECT-22K07564
[Journal Article] Serum oxytocin correlated with later logical memory in older Japanese women: A 7-year follow-up study2023
- Author(s)
  Kunitake Y, Mizoguchi Y, Imamura Y, Kunitake H, Orihashi R, Matsushima J, Tateishi H, Murakawa-Hirachi T, Yamada S, Monji A.
- Journal Title
  
  Compr Psychoneuroendocrinol
  
  Volume: 13 Pages: 100166-100166
- DOI
  10.1016/j.cpnec.2022.100166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07564, KAKENHI-PROJECT-21K21192, KAKENHI-PROJECT-18K18465, KAKENHI-PROJECT-21K17251
[Journal Article] Risk of delirium with antiepileptic drug use: a study based on the Japanese Adverse Drug Event Report database2023
- Author(s)
  Kubo Toshiki、Sogawa Rintaro、Tsuruhashi Satoko、Murakawa-Hirachi Toru、Matsuoka Ayaka、Mizoguchi Yoshito、Monji Akira、Shimanoe Chisato
- Journal Title
  
  International Journal of Clinical Pharmacy
  
  Volume: 45 Issue: 5 Pages: 1260-1266
- DOI
  10.1007/s11096-023-01564-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07564
[Journal Article] Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan2023
- Author(s)
  Ishibashi Yukiko、Sogawa Rintaro、Ogata Kenji、Matsuoka Ayaka、Yamada Haruna、Murakawa-Hirachi Toru、Mizoguchi Yoshito、Monji Akira、Shimanoe Chisato
- Journal Title
  
  Clinical Drug Investigation
  
  Volume: 44 Issue: 2 Pages: 115-120
- DOI
  10.1007/s40261-023-01337-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07564, KAKENHI-PROJECT-21K06645
[Journal Article] Evaluation of the delirium preventive effect of dual orexin receptor antagonist (DORA) in critically ill adult patients requiring ventilation with tracheal intubation at an advanced emergency center: A single-center, retrospective, observational study2023
- Author(s)
  Matsuoka Ayaka、Sogawa Rintaro、Murakawa-Hirachi Toru、Mizoguchi Yoshito、Monji Akira、Shimanoe Chisato、Shinada Kota、Koami Hiroyuki、Sakamoto Yuichiro
- Journal Title
  
  General Hospital Psychiatry
  
  Volume: 83 Pages: 123-129
- DOI
  10.1016/j.genhosppsych.2023.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07564
[Journal Article] Serum soluble triggering receptor expressed on myeloid cells‐2 was not altered by <scp>rTMS</scp> in patients with treatment‐resistant depression2023
- Author(s)
  Tateishi Hiroshi、Matsushima Jun、Kunitake Hiroko、Imamura Yoshiomi、Kunitake Yutaka、Murakawa Toru、Mawatari Seiji、Kojima Ryohei、Fujii Yuka、Kikuchi Jun、Fukuchi Junko、Sakemura Yuta、Shiraishi Takumi、Nagahama Chika、Maekawa Toshihiko、Asami Toyoko、Mizoguchi Yoshito、Monji Akira
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: - Issue: 2 Pages: 222-227
- DOI
  10.1002/npr2.12332
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07974, KAKENHI-PROJECT-22K07564
[Journal Article] Evaluation of the delirium preventive effect of dual orexin receptor antagonist (DORA) in critically ill adult patients requiring ventilation with tracheal intubation at an advanced emergency center: A single-center, retrospective, observational study2023
- Author(s)
  Ayaka Matsuoka 1, Rintaro Sogawa 2, Toru Murakawa-Hirachi 3, Yoshito Mizoguchi 4, Akira Monji 5, Chisato Shimanoe 6, Kota Shinada 7, Hiroyuki Koami 8, Yuichiro Sakamoto 9
- Journal Title
  
  General hospital psychiatry
  
  Volume: 83 Pages: 123-129
- Data Source
  KAKENHI-PROJECT-22K09142
[Journal Article] Is the Therapeutic Mechanism of Repetitive Transcranial Magnetic Stimulation in Cognitive Dysfunctions of Depression Related to the Neuroinflammatory Processes in Depression?2022
- Author(s)
  Tateishi Hiroshi、Mizoguchi Yoshito、Monji Akira
- Journal Title
  
  Frontiers in Psychiatry
  
  Volume: 13
- DOI
  10.3389/fpsyt.2022.834425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07974
[Journal Article] Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study2022
- Author(s)
  Tateishi Hiroshi、Setoyama Daiki、Kato Takahiro A、Kang Dongchon、Matsushima Jun、Nogami Kojiro、Mawatari Seiji、Kojima Ryohei、Fujii Yuka、Sakemura Yuta、Shiraishi Takumi、Imamura Yoshiomi、Maekawa Toshihiko、Asami Toyoko、Mizoguchi Yoshito、Monji Akira
- Journal Title
  
  Psychiatry Research
  
  Volume: 313 Pages: 114636-114636
- DOI
  10.1016/j.psychres.2022.114636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07369, KAKENHI-PROJECT-22K07564, KAKENHI-PROJECT-22H00494, KAKENHI-PROJECT-18K18465
[Journal Article] Association between cortisol and aging-related hippocampus volume changes in community-dwelling older adults: a 7-year follow-up study2022
- Author(s)
  Orihashi R, Imamura Y, Yamada S, Monji A, Mizoguchi Y
- Journal Title
  
  BMC Geriatr
  
  Volume: 22 Issue: 1 Pages: 765-765
- DOI
  10.1186/s12877-022-03455-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07564, KAKENHI-PROJECT-21K21192, KAKENHI-PROJECT-18K18465
[Journal Article] The changes in kynurenine metabolites induced by rTMS in treatment-resistant depression: A pilot study2021
- Author(s)
  Tateishi H, Setoyama D, Kang D, Matsushima J, Kojima R, Fujii Y, Mawatari S, Kikuchi J, Sakemura Y, Fukuchi J, Shiraishi T, Maekawa T, Kato TA, Asami T, Mizoguchi Y, Monji A.
- Journal Title
  
  J Psychiatr Res .
  
  Volume: 138 Pages: 194-199
- DOI
  10.1016/j.jpsychires.2021.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07974, KAKENHI-PROJECT-18K07417, KAKENHI-PROJECT-20H00530
[Journal Article] Association Between sTREM2, an Immune Biomarker of Microglial Activation, and Aging-Related Brain Volume Changes in Community-Dwelling Older Adults: A 7-Year Follow-Up Study2021
- Author(s)
  Orihashi Ryuzo、Mizoguchi Yoshito、Imamura Yoshiomi、Yamada Shigeto、Monji Akira
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 13
- DOI
  10.3389/fnagi.2021.665612
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18465
[Journal Article] No association of both serum pro‐brain‐derived neurotrophic factor ( proBDNF) and BDNF concentrations with depressive state in community‐dwelling elderly people2021
- Author(s)
  Ohto Asami、Mizoguchi Yoshito、Imamura Yoshiomi、Kojima Naoki、Yamada Shigeto、Monji Akira
- Journal Title
  
  Psychogeriatrics
  
  Volume: - Issue: 4 Pages: 503-513
- DOI
  10.1111/psyg.12695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18465
[Journal Article] Serum Oxytocin Levels and Logical Memory in Older People in Rural Japan2020
- Author(s)
  Yutaka Kunitake, Yoshiomi Imamura, Yoshito Mizoguchi, Jun Matsushima, Hiroshi Tateishi, Toru Murakawa-Hirachi, Hiromi Nabeta, Toshiro Kawashima, Naoki Kojima, Shigeto Yamada, Akira Monj
- Journal Title
  
  Journal of Geriatric Psychiatry and Neurology
  
  Volume: - Issue: 2 Pages: 156-161
- DOI
  10.1177/0891988720915526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18465, KAKENHI-PROJECT-17K10275, KAKENHI-PROJECT-17K10306
[Journal Article] Oxytocin and elderly MRI-based hippocampus and amygdala volume: A seven-year followup　study2020
- Author(s)
  Ryuzo Orihashi, Yoshito Mizoguchi, Yoshiomi Imamura, Shigeto Yamada, Takefumi Ueno, Akira Monji
- Journal Title
  
  Brain Communications (accepted)
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18465
[Journal Article] Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study2020
- Author(s)
  Hiroshi Tateishi, Yoshito Mizoguchi, Atsushi Kawaguchi, Yoshiomi Imamura, Jun Matsushima, Hiroko Kunitake, Toru Murakawa, Yoshinori Haraguchi, Yutaka Kunitake, Toshihiko Maekawa, Takahiro A. Kato, Toyoko Asami, Akira Monji
- Journal Title
  
  Psychiatry Research
  
  Volume: 289 Pages: 112995-112995
- DOI
  10.1016/j.psychres.2020.112995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18465, KAKENHI-PROJECT-17K10307
[Journal Article] Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study2020
- Author(s)
  Mizoguchi Yoshito、Yao Hiroshi、Imamura Yoshiomi、Hashimoto Manabu、Monji Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41598-020-73576-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18465
[Journal Article] ATP and Repetitive Electric Stimulation Increases Leukemia Inhibitory Factor Expression in Astrocytes: A Potential Role for Astrocytes in the Action Mechanism of Electroconvulsive Therapy2020
- Author(s)
  Maruyama S, Boku S, Okazaki S, Kikuyama H, Mizoguchi Y, Monji A, Otsuka I, Sora I, Kanazawa T, Hishimoto A, Yoneda H.
- Journal Title
  
  Psychiatry Clin Neurosci .
  
  Volume: . Issue: 5 Pages: 12986-12986
- DOI
  10.1111/pcn.12986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15483, KAKENHI-PROJECT-17H04249, KAKENHI-PROJECT-17K10275
[Journal Article] 来世信念と健康　－愛着のメカニズムからの考察－2019
- Author(s)
  今村義臣・溝口義人・門司　晃
- Journal Title
  
  九州精神医学
  
  Volume: 65 Pages: 10-16
- NAID
  130007922693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18465
[Journal Article] うつ病と認知症の共通病態としての神経炎症2019
- Author(s)
  溝口義人、門司晃
- Journal Title
  
  日本医事新報
  
  Volume: 4942 Pages: 28-28
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] その他の認知症2019
- Author(s)
  溝口義人、門司晃
- Journal Title
  
  精神科
  
  Volume: 35 Pages: 245-245
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] 血管内皮細胞と精神疾患2019
- Author(s)
  溝口義人、門司晃
- Journal Title
  
  精神科
  
  Volume: 35 Pages: 369-369
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] 来世信念と健康－愛着のメカニズムからの考察－2019
- Author(s)
  今村義臣、溝口義人、門司晃
- Journal Title
  
  九州精神神経学雑誌
  
  Volume: 65 Pages: 10-10
- NAID
  130007922693
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] Improvement of frontal lobe dysfunction and white matter integrity by rTMS in treatment-resistant depression2019
- Author(s)
  Tateishi H, Nishihara M, Kawaguchi A, Matsushima J, Murakawa T, Haraguchi Y, Kunitake Y, Maekawa T, Kato TA, Asami T, Mizoguchi Y, Monji A
- Journal Title
  
  Neuropsychiatric Disease and Treatment
  
  Volume: 15 Pages: 3079-3079
- DOI
  10.2147/ndt.s228501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10275, KAKENHI-PROJECT-17K10307
[Journal Article] Low-Grade Inflammation Is Associated with Apathy Indirectly via Deep White Matter Lesions in Community-Dwelling Older Adults: The Sefuri Study.2019
- Author(s)
  Yao H, Mizoguchi Y, Monji A, Yakushiji Y, Takashima Y, Uchino A, Yuzuriha T, Hashimoto M.
- Journal Title
  
  Int J Mol Sci. 2019
  
  Volume: 20 Issue: 8 Pages: 1905-1905
- DOI
  10.3390/ijms20081905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10322, KAKENHI-PROJECT-17K10275
[Journal Article] Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities.2018
- Author(s)
  Aita C , Mizoguchi Y , Yamamoto M , SeguchI Y , Yatsuga C , Nishimura T , Sugimoto Y , Takahashi D , Nishihara R , Ueno T , Nakayama M , Kuroki T , Nabeta H , Imamura Y , Monji A
- Journal Title
  
  Psychiatry Research
  
  Volume: 273 Pages: 67-74
- DOI
  10.1016/j.psychres.2018.12.139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18465
[Journal Article] Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities.2018
- Author(s)
  Aita C, Mizoguchi Y, Yamamoto M, SeguchI Y, Yatsuga C, Nishimura T, Sugimoto Y, Takahashi D, Nishihara R, Ueno T, Nakayama M, Kuroki T, Nabeta H, Imamura Y, Monji A.
- Journal Title
  
  Psychiatry Res.
  
  Volume: 273 Pages: 67-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] The effect of continuous positive airway pressure (CPAP) treatment on serum levels of proBDNF and mature BDNF in patients with obstructive sleep apnea.2018
- Author(s)
  Mizoguchi Y , Oyama JI , Imamura Y , Node K , Monji A
- Journal Title
  
  Sleep and Breathing
  
  Volume: 印刷中 Issue: 3 Pages: 889-889
- DOI
  10.1007/s11325-018-1761-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18465, KAKENHI-PROJECT-17K10275
[Journal Article] The effect of continuous positive airway pressure (CPAP) treatment on serum levels of proBDNF and mature BDNF in patients with obstructive sleep apnea.2018
- Author(s)
  Mizoguchi Y, Oyama JI, Imamura Y, Node K, Monji A.
- Journal Title
  
  Sleep Breath.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] TRPC Channels and Brain Inflammation2017
- Author(s)
  Mizoguchi Yoshito、Monji Akira
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 976 Pages: 111-121
- DOI
  10.1007/978-94-024-1088-4_10
- ISBN
  9789402410860, 9789402410884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder: A Case Report and Literature Review.2017
- Author(s)
  Kunitake Y, Mizoguchi Y, Sogawa R, Matsushima J, Kato TA, Kawashima T, Monji A
- Journal Title
  
  Clin Neuropharmacol.
  
  Volume: 40 Pages: 160-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10275
[Journal Article] Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia2017
- Author(s)
  Haraguchi Yoshinori、Mizoguchi Yoshito、Ohgidani Masahiro、Imamura Yoshiomi、Murakawa-Hirachi Toru、Nabeta Hiromi、Tateishi Hiroshi、Kato Takahiro A.、Monji Akira
- Journal Title
  
  J Neuroinflammation.
  
  Volume: 14 Issue: 1 Pages: 258-258
- DOI
  10.1186/s12974-017-1033-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10275, KAKENHI-PROJECT-26713039
[Journal Article] An association between belief in life after death and serum oxytocin in older people in rural Japan.2017
- Author(s)
  Imamura Y, Mizoguchi Y, Nabeta H, Haraguchi Y, Matsushima J, Kojima N, Kawashima T, Yamada S, Monji A.
- Journal Title
  
  International Journal od Geriatric Psychiatry
  
  Volume: 32 Pages: 102-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10306
[Journal Article] An association between belief in life after death and serum oxytocin in older people in rural Japan2017
- Author(s)
  Imamura Yoshiomi、Mizoguchi Yoshito、Nabeta Hiromi、Haraguchi Yoshinori、Matsushima Jun、Kojima Naoki、Kawashima Toshiro、Yamada Shigeto、Monji Akira
- Journal Title
  
  International Journal of Geriatric Psychiatry
  
  Volume: 32 Issue: 1 Pages: 102-109
- DOI
  10.1002/gps.4453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461749
[Journal Article] Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: a 3-year follow-up study.2015
- Author(s)
  Matsushima J, Kawashima T, Nabeta H, Imamura Y, Watanabe I, Mizoguchi Y, Kojima N, Yamada S, Monji A.
- Journal Title
  
  J Affect Disord
  
  Volume: 173 Pages: 9-14
- DOI
  10.1016/j.jad.2014.10.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461749
[Journal Article] Neuroinflammation in schizophrenia especially focused on the role of microglia2012
- Author(s)
  Monji A, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects: three-years follow-up study2012
- Author(s)
  Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Furukawa Y, Tateishi H, Kojima N, Mizoguchi Y, Yamada S
- Journal Title
  
  Psychiatry Res
  
  Volume: 195(3) Pages: 125-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591290
[Journal Article] 神経炎症の観点よりみたアルツハイマー病の病態生理とその治療2012
- Author(s)
  門司晃、溝口義人、山田茂人
- Journal Title
  
  分子精神医学
  
  Volume: 12(1) Pages: 9-13
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] The effect of oral presentation on salivary 3-methoxy-4- hydroxy-phenylglycol (MHPG) and cortisol concentrations in training doctors: a preliminary study2012
- Author(s)
  Mizoguchi Y, Sakami A, Imamura Y, Tsuruta T, Egami M, Yamada S
- Journal Title
  
  Endocrine.
  
  Volume: 42(3) Pages: 752-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591290
[Journal Article] The effect of oral presentation on salivary 3-methoxy-4-hydroxy-phenylglycol(MHPG) and cortisol concentrations in training doctors : a preliminary study.2012
- Author(s)
  Mizoguchi Y, Sakami A, Imamura Y, Tsuruta T, Egami M, Yamada S
- Journal Title
  
  Endocrine
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] The effect of oral presentation on salivary 3-methoxy-4-hydroxy-phenylglycol (MHPG) and cortisol concentrations in training doctors: a preliminary study.2012
- Author(s)
  Mizoguchi Y, Sakami A, Imamura Y, Tsuruta T, Egami M, Yamada S
- Journal Title
  
  Endocrine
  
  Volume: 42 Pages: 752-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591290
[Journal Article] Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole(MHPG) associates with a consequent cognitive decline in non-demented elderly subjects : three-years follow-up study2012
- Author(s)
  Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Furukawa Y, Tateishi H, Kojima N, Mizoguchi Y, Yamada S
- Journal Title
  
  Psychiatry Res
  
  Volume: 195(3) Pages: 125-8
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Inhibitory effects of SSRIs on IFN-γinduced microglial activation through the regulation of intracellular calcium2011
- Author(s)
  Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, Kanba S
- Journal Title
  
  Prog Neuropsychopharmacol Biol Psychiatry
  
  Volume: 34(7) Pages: 1306-16
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate(PMA)-stimulated microglia in vitro : implication for antioxidative psychotropic actions via microglia2011
- Author(s)
  Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
- Journal Title
  
  Schizophr Res
  
  Volume: 129(2-3) Pages: 172-82
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Lewis DA(2010) Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex2011
- Author(s)
  Eggan SM*, Mizoguchi Y*, Stoyak SR
- Journal Title
  
  Cereb Cortex
  
  Volume: 20(5) Pages: 1164-74
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Possible role of BDNF-induced microglial intracellular Ca(2+) elevation in the pathophysiology of neuropsychiatric disorders2011
- Author(s)
  Mizoguchi Y, et al
- Journal Title
  
  Mini Rev Med Chem
  
  Volume: 11 Pages: 575-585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Possible role of BDNF-induced microglial intracellular Ca(2+) elevation in the pathophysiology of neuropsychiatric disorders.2011
- Author(s)
  Mizoguchi Y, Monji A, Kato TA, Horikawa H, Seki Y, Kasai M, Kanba S, Yamada S
- Journal Title
  
  Mini Rev Med Chem
  
  Volume: 11 Pages: 575-81
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Anti-Inflammatory properties of antipsychotics via microglia modulations : are antipsychotics a' fire extinguisher' in the brain of schizophrenia?2011
- Author(s)
  Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S
- Journal Title
  
  Mini Rev Med Chem
  
  Volume: 11 Pages: 565-74
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex2010
- Author(s)
  Eggan SM, Mizoguchi Y, et al (Equal author contribution)
- Journal Title
  
  Cerebral Cortex
  
  Volume: 20 Pages: 1164-1174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791128
[Journal Article] Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Prog.2009
- Author(s)
  Monji A, Takita M, Samejima T, Takaishi T, Hashimoto K, Matsunaga H, Oda M, Sumida Y, Mizoguchi Y, Kato T, Horikawa H, Kanba S
- Journal Title
  
  Neuropsychopharamacol. Biol. Psychiatry 33
  
  Pages: 308-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Journal Article] Brain-derived neurotrophic factor (BDNF) induces sustained elevation of intracellular Ca^<2+> in rodent microglia2009
- Author(s)
  Mizoguchi Y, et al.
- Journal Title
  
  Journal of Immunology 183
  
  Pages: 7778-7786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Journal Article] Brain-derived neurotrophic factor (BDNF) induces sustained elevation of intracellular Ca2+ in rodent microglia.2009
- Author(s)
  Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S
- Journal Title
  
  J. Immunol. 183
  
  Pages: 7778-7786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Journal Article] The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ.2008
- Author(s)
  Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S
- Journal Title
  
  Prog. Neuropsychopharamacol. Biol. Psychiatry 32
  
  Pages: 42-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Journal Article] Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro.2008
- Author(s)
  Kato T, Mizoguchi Y, Monji A, Horikawa H, Suzuki SO, Seki Y, Iwaki T, Hashioka S, Kanba S
- Journal Title
  
  J. Neurochem. 106
  
  Pages: 815-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Journal Article] Development of Cannabinoid 1 Receptor Protein and Messenger RNA in Monkey Dorsolateral Prefrontal Cortex.
- Author(s)
  Eggan SM*, Mizoguchi Y*, Stoyak SR, Lewis DA.
- Journal Title
  
  Cereb. Cortex (in the press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Journal Article] Development of Cannabinoid 1 Receptor Protein and Messenger RNA in Monkey Dorsolateral Prefrontal Cortex
- Author(s)
  Eggan SM*, Mizoguchi Y*, et al. (* Equally contributed authors)
- Journal Title
  
  Cerebral Cortex (In the press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790847
[Presentation] 高齢者の精神的健康を維持するために－認知症予防における分子標的としてのオキシトシンの可能性－2023
- Author(s)
  溝口義人
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07564
[Presentation] 地域在住の高齢者における血清オキシトシン濃度と抑うつ状態との関連2023
- Author(s)
  折橋隆三,　今村義臣,　溝口義人
- Organizer
  第75回九州精神神経学会
- Data Source
  KAKENHI-PROJECT-22K07564
[Presentation] 仏壇を介した愛着機能と宗教性の関連について2023
- Author(s)
  今村義臣,　國武裕,　國武浩子,　溝口義人
- Organizer
  第75回九州精神神経学会
- Data Source
  KAKENHI-PROJECT-22K07564
[Presentation] うつ病の認知機能障害のrTMSによる改善効果における神経炎症仮説からの検討2023
- Author(s)
  立石　洋、溝口義人、門司　晃
- Organizer
  第119回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07974
[Presentation] 地域在住の高齢者の来世信念と縦断的線条体脳構造分析．2022
- Author(s)
  今村義臣，國武　裕，國武浩子，小島直樹，山田茂人，門司　晃，溝口義人
- Organizer
  第7回日本老年精神医学会・第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K18465
[Presentation] わが国で進行中の疫学研究からみた認知症の発症リスク低減高齢者の精神的健康を維持するために－伊万里市黒川町研究から－2022
- Author(s)
  溝口義人
- Organizer
  第118回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07564
[Presentation] ミクログリアの精神医学：脳内脇役細胞の働きから精神疾患の病態治療機序を再構築する2022
- Author(s)
  溝口義人
- Organizer
  第118回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07564
[Presentation] 佐賀大学医学部附属病院におけるrTMS療法の現状2022
- Author(s)
  立石　洋、小嶋亮平、國武　裕、溝口義人、門司　晃
- Organizer
  第118回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07974
[Presentation] コロナ禍の心理ストレスと地域在住の高齢者のうつ状態、認知機能との関連．2022
- Author(s)
  國武　裕，溝口義人，今村義臣，國武浩子，大石（福地）絢子，門司　晃
- Organizer
  第118回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-18K18465
[Presentation] オキシトシンと精神医学－自閉性障害を越えてー高齢者の精神的健康を維持するために－オキシトシンに着目して－2022
- Author(s)
  溝口義人
- Organizer
  第118回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07564
[Presentation] 高齢者の精神的健康を維持するために ―伊万里市黒川町研究から―2021
- Author(s)
  溝口義人，今村義臣，門司晃
- Organizer
  第117回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-18K18465
[Presentation] 日本の農村部在住の高齢者のオキシトシンと論理記憶との関連：7年の継続研究2021
- Author(s)
  國武裕，溝口義人，今村義臣，折橋隆三，立石洋，村川徹，松島淳，門司晃
- Organizer
  第117回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-18K18465
[Presentation] ミクログリアは精神疾患の成り立ちにどのように関与するのか？うつ病と認知症の共通病態としての神経炎症－ミクログリアの役割は？－2019
- Author(s)
  溝口義人
- Organizer
  第115回日本精神神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10275
[Presentation] The effects of anti-Alzheimer's drug donepezil on rodent microglial functions2019
- Author(s)
  Mizoguchi Y, Monji A
- Organizer
  Society for Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10275
[Presentation] 地方在住の高齢者における来世信念と7年後の認知能力の関係について2019
- Author(s)
  今村義臣・溝口義人・國武浩子・山田茂人・門司晃
- Organizer
  第72回九州精神神経学会
- Data Source
  KAKENHI-PROJECT-18K18465
[Presentation] 地域在住の高齢者を対象として血清オキシトシン濃度と頭部MRI画像解析結果の関連を検討する2018
- Author(s)
  折橋隆三、溝口義人、今村義臣、門司　晃
- Organizer
  第１１４回日本精神神経学会
- Data Source
  KAKENHI-PROJECT-17K10306
[Presentation] 地域在住の高齢者を対象として血清オキシトシン濃度と頭部MRI画像解析結果の関連を検討する2018
- Author(s)
  折橋隆三、溝口義人、今村義臣、門司　晃
- Organizer
  第114回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-18K18465
[Presentation] うつ病・双極性障害と認知症うつ病と認知症－「炎症」が繋ぐふたつの疾患2017
- Author(s)
  溝口義人
- Organizer
  第14回日本うつ病学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10275
[Presentation] Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia2017
- Author(s)
  Mizoguchi Y, Haraguchi Y, Murakawa-Hirachi T. Imamura Y, Monji A
- Organizer
  Society for Neuroscience 2017
- Data Source
  KAKENHI-PROJECT-17K10275
[Presentation] 気分障害の履歴が認知症の新規発症リスクとなる背景メカニズムは何か？神経炎症における脳神経血管機構（NVU）の関与に着目したうつ病の病態解明2017
- Author(s)
  溝口義人
- Organizer
  第113回日本精神神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K10275
[Presentation] 高齢者のうつ症状と生理学的指標との関連についての検討2016
- Author(s)
  鍋田　紘美、今村　義臣、溝口　義人、原口　祥典、松島　淳、小島　直樹、山田　茂人、門司　晃
- Organizer
  第31回日本老年精神医学会
- Place of Presentation
  石川県金沢市
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-26461749
[Presentation] 高齢者における宗教性と生化学的指標との関連2016
- Author(s)
  今村　義臣、溝口　義人、鍋田　紘美、原口　祥典、松島　淳、川島　敏郎、小島直　樹、山田　茂人、門司　晃
- Organizer
  第31回日本老年精神医学会
- Place of Presentation
  石川県金沢市
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-26461749
[Presentation] SSRI potentiates BDNF-induced microglial intracellular Ca^<2+> elevation Society for Neuroscience2011
- Author(s)
  Mizoguchi Y et al
- Organizer
  41st Annual Meeting
- Place of Presentation
  Washington Convention Center
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22791128
[Presentation] SSRI potentiates BDNF-induced microglial intracellular Ca2+ elevation2011
- Author(s)
  Mizoguchi Y, et al
- Organizer
  Society for Neuroscience, 41st Annual Meeting
- Place of Presentation
  Washington Convention Center
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22791128
[Presentation] Possible role of BDNF-induced microglial intracellular Ca^<2+> elevation in the pathophysiology of neuropsychiatric disorders2010
- Author(s)
  Mizoguchi Y et al
- Organizer
  40th annual meeting of the Society for Neuroscience 2010 in San Diego
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22791128
[Presentation] Possible role of BDNF-induced microglial intracellular Ca2+ elevation in the pathophysiology of neuropsychiatric disorders2010
- Author(s)
  Mizoguchi Y, et al
- Organizer
  40th annual meeting of the Society for Neuroscience 2010 in San Diego
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22791128
[Presentation] Possible role of BDNF-induced microglial intracellular Ca2+ elevation in the pathophysiology of neuropsychiatric disoders2009
- Author(s)
  Mizoguchi, et al.
- Organizer
  Society for Neuroscience 2009 in Chicago
- Place of Presentation
  McCormick Place
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20790847
[Presentation] Possible Roles of BDNF-induced Microglial Intracellular Ca^<2+> Elevation in the Pathophysiology of Psychiatric Disorders2008
- Author(s)
  Mizoguchi Y, et.al.
- Organizer
  XIV World Congress of Psychiatry
- Place of Presentation
  Prague Congress Centre
- Year and Date
  2008-09-21
- Data Source
  KAKENHI-PROJECT-20790847

1. monji akira (00294942)

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# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 岡崎賢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 橋本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizoguchi Yoshito 溝口 義人

MIZOGUCHI Yoshito 溝口 義人

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高齢者うつ病および認知症における脳内ミクログリアの機能の共通点と相違点Principal Investigator

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How anti-Alzheimer's drug affect microglia and neurovascular unit ?Principal Investigator

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Mechanisms underlying effects of BDNF and antidepressants on microglia ; Possible role of TRPC channels(MIZOGUCHI YOSHITO)Principal Investigator

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Elucidation of the mechanism underlying the modulation of microglial function by antidepressants and/or BDNFPrincipal Investigator

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[Journal Article] Negative association between basal oxytocin and oxytocin changes after repetitive transcranial magnetic stimulation in patients with treatment-resistant depression2024

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[Journal Article] Relationship between serum cortisol levels, stereotypies, and the presence of autism spectrum disorder in patients with severe intellectual disability2024

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[Journal Article] Salivary 3‐methoxy‐4‐hydroxyphenylglycol and MRI‐based volume change of the precuneus in community‐dwelling elderly people2023

Mizoguchi Yoshito 溝口義人

MIZOGUCHI Yoshito 溝口義人