Kitago Yu 北郷悠

Researcher Number	60507185
Other IDs
Affiliation (based on the past Project Information) *help	2018: 大阪大学, 蛋白質研究所, 助教 2013 – 2017: 大阪大学, たんぱく質研究所, 助教
Review Section/Research Field	Principal Investigator Structural biochemistry Except Principal Investigator Biological Sciences
Keywords	Principal Investigator sorLA / アルツハイマー病 / 低分子バインダー / 結晶構造解析 / 創薬 / スクリーニング / 低分子化合物 / 蛋白質分子 / ネガティブ染色 / 細胞外領域 … More / 動物細胞 / 細胞外 / Vps10p / 培養細胞 / 電子顕微鏡 / 結晶化 / 細胞外蛋白質 … More Except Principal Investigator セマフォリン / インテグリン / 電子顕微鏡イメージング / X線結晶構造解析 / 免疫-神経インターフェイス Less

Protein binder screening for SorLA, a risk factor of Alzheimer's diesease, to identify novel targets for drug dicovery(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  KITAGO Yu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Structural elucidation of a risk factor for Alzheimer's Disease, sorLA extracellular regionPrincipal Investigator
- Principal Investigator
  
  Kitago Yu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Structural basis for the cell-cell communication at the neuro-immune interface
- Principal Investigator
  
  TAKAGI JUNICHI
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2016 2015 2014 2012 Other

All Journal Article Presentation

[Journal Article] Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.2016
- Author(s)
  Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 478 Issue: 3 Pages: 1274-1279
- DOI
  10.1016/j.bbrc.2016.08.110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-16K10748
[Journal Article] Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.2016
- Author(s)
  Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kaneko M, Kato Y, Takagi J
- Journal Title
  
  J Cell Sci.
  
  Volume: 12- Issue: 7 Pages: 1512-1522
- DOI
  10.1242/jcs.176685
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide.2016
- Author(s)
  Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J, Suga H.
- Journal Title
  
  Cell Chem Biol
  
  Volume: 23 Issue: 11 Pages: 1341-1350
- DOI
  10.1016/j.chembiol.2016.09.015
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Structural basis for amyloidogenic peptide recognition by sorLA.2015
- Author(s)
  Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 22 Issue: 3 Pages: 199-206
- DOI
  10.1038/nsmb.2954
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-25121738, KAKENHI-PUBLICLY-26110724
[Journal Article] 巨大受容体sorLAによるアミロイドβ分解の促進2015
- Author(s)
  北郷　悠、高木　淳一
- Journal Title
  
  医学のあゆみ(医歯薬出版)
  
  Volume: vol.252(9) Pages: 963-964
- Data Source
  KAKENHI-PLANNED-24111006
[Journal Article] 巨大受容体sorLAのVps10pドメインによるアミロイドβ認識機構とそのAlzheimer病発症における役割2015
- Author(s)
  北郷　悠，高木　淳一
- Journal Title
  
  医学のあゆみ
  
  Volume: 254 Pages: 535-539
- Data Source
  KAKENHI-PROJECT-26840022
[Journal Article] 巨大受容体sorLAのVps10pドメインによるアミロイドペプチド認>識の分子機構2015
- Author(s)
  北郷　悠
- Journal Title
  
  日本結晶学会誌
  
  Volume: 57 Pages: 331-337
- Data Source
  KAKENHI-PROJECT-26840022
[Journal Article] Novel role for SORLA/SORL1 as lysosomal sorting receptor for amyloid-b peptide is impaired by familial Alzheimer disease mutation2014
- Author(s)
  Caglayan S, Takagi-Niidome S, Liao F, Carlo A-S, Schmidt V, Burgert T, Kitago Y, Fuchtbauer E-M, Fachtbauer A, Holtzman DM, Takagi J, and Wilnow TE
- Journal Title
  
  Science Translational Medicine
  
  Volume: 6(223) Issue: 223
- DOI
  10.1126/scitranslmed.3007747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00097, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006
[Journal Article] Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer.2014
- Author(s)
  Nagae M, Ikeda A, Kitago Y, Matsumoto N, Yamamoto K, Yamaguchi Y.
- Journal Title
  
  Proteins
  
  Volume: 82 Issue: 7 Pages: 1512-1518
- DOI
  10.1002/prot.24504
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24770111
[Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用2012
- Author(s)
  北郷　悠
- Journal Title
  
  The Lipid
  
  Volume: 23 Pages: 56-62
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] New format antibody drives the crystallization of sorLA Vps10p domain2016
- Author(s)
  Kitago Y
- Organizer
  Gordon Research Conference, Diffraction Methods in Structural Biology
- Place of Presentation
  Bates College, Lewston ME, USA
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] New format antibody drives the crystallization of sorLA Vps10p domain2016
- Author(s)
  Kitago Y, Arimori T, Takagi J.
- Organizer
  Diffraction Methods in Structural Biology, Gordon Research Conference
- Place of Presentation
  Bates College, Lewiston ME, USA
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840022
[Presentation] 特異抗体FabによるSorLA Vps10pドメインの結晶化促進2016
- Author(s)
  北郷　悠，高木　淳一
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県，福岡市)
- Data Source
  KAKENHI-PROJECT-26840022
[Presentation] 特異抗体FabによるSorLA Vps10pドメインの結晶化促進2016
- Author(s)
  北郷　悠
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際センター（福岡県、福岡市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Molecular mechanism for peptide recognition by sorLA Vps10p domain2015
- Author(s)
  Yu Kitago
- Organizer
  The 10th International Symposium of the Institute Network
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840022
[Presentation] SorLA Vps10pドメインのAβペプチド認識機構
- Author(s)
  北郷　悠
- Organizer
  第13回日本蛋白質科学会年会、ワークショップ
- Place of Presentation
  とりぎん文化会館（鳥取県）
- Data Source
  KAKENHI-PLANNED-24111006
[Presentation] Molecular basis of peptide ligand recognition by SorLA Vps10p domain
- Author(s)
  Yu Kitago
- Organizer
  International Conference on Structural Genomics 2013 - Structural Life Science
- Place of Presentation
  札幌京王プラザホテル（北海道）
- Data Source
  KAKENHI-PLANNED-24111006

1. TAKAGI JUNICHI (90212000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. IWASAKI Kenji (20342751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Petsko Gregory A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Wu Rui

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Liu Ce-Feng

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Glickman J. Fraser

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Ramos-Espiritu Lavoisier

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kitago Yu 北郷 悠

Research Projects

Research Products

Co-Researchers

Protein binder screening for SorLA, a risk factor of Alzheimer's diesease, to identify novel targets for drug dicovery(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural elucidation of a risk factor for Alzheimer's Disease, sorLA extracellular regionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural basis for the cell-cell communication at the neuro-immune interface

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for amyloidogenic peptide recognition by sorLA.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 巨大受容体sorLAによるアミロイドβ分解の促進2015

Author(s)

Journal Title

Data Source

[Journal Article] 巨大受容体sorLAのVps10pドメインによるアミロイドβ認識機構とそのAlzheimer病発症における役割2015

Author(s)

Journal Title

Data Source

[Journal Article] 巨大受容体sorLAのVps10pドメインによるアミロイドペプチド認>識の分子機構2015

Author(s)

Journal Title

Data Source

[Journal Article] Novel role for SORLA/SORL1 as lysosomal sorting receptor for amyloid-b peptide is impaired by familial Alzheimer disease mutation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LDL受容体ファミリーの構造と蛋白質間相互作用2012

Author(s)

Journal Title

Data Source

[Presentation] New format antibody drives the crystallization of sorLA Vps10p domain2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] New format antibody drives the crystallization of sorLA Vps10p domain2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Kitago Yu 北郷悠