Ohta Etsuro 太田悦朗

… Alternative Names

OHTA ETSURO 太田悦朗

OHTA Etsuro 太田悦朗

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Researcher Number	60508042
Other IDs
Affiliation (Current)	2025: 北里大学, 健康科学部, 教授
Affiliation (based on the past Project Information) *help	2024: 北里大学, 健康科学部, 教授 2021 – 2023: 北里大学, 医療衛生学部, 准教授 2015 – 2020: 北里大学, 医療衛生学部, 講師 2012: 北里大学, 医療衛生学部, 講師 2009 – 2011: Kitasato University, 医療衛生学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 46030:Function of nervous system-related / Complex systems / Biological Sciences / Neurology / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator LRRK2 / パーキンソン病 / iPS細胞 / タウ / 神経変性 / 細胞内輸送 / 疾患iPS細胞 / 認知症 / 細胞死 / 神経サブタイプ … More / Rab / 細胞外小胞 / ミトコンドリア / 神経炎症 / 創薬 / モザイシズム / Tau / ミクログリア / 炎症 / microRNA / PARK8 / ゲノム編集 / TAU / ヘテロダイマー / Akt1 / ヘテロ二量体 / V5-LRRK2安定発現細胞株 / アポトーシス抑制能 / 蛋白質安定性 / 細胞内分解 … More Except Principal Investigator alpha-synuclein / 腸管神経系 / α-シヌクレイン / 水膜輸送 / 腸管神経 / パーキンソン病 Less

Pathological analysis of mitochondrial transmission among basal ganglia neural circuits in hereditary Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  太田悦朗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Kitasato University
神経サブタイプ分化誘導技術を用いた遺伝性パーキンソン病における細胞内輸送の解析Principal Investigator
- Principal Investigator
  
  太田悦朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Kitasato University
腸管神経におけるalphaシヌクレインの凝集と水膜輸送の関係
- Principal Investigator
  
  前川達則
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kitasato University
疾患特異的iPS細胞を用いた神経炎症を引き起こすシンギュラリティ現象の解析Principal Investigator
- Principal Investigator
  
  太田悦朗
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kitasato University
Drug discovery research using Omura natural compounds and disease-specific iPS cellsPrincipal Investigator
- Principal Investigator
  
  Ohta Etsuro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Kitasato University
疾患特異的iPS細胞を用いたモザイシズムによるシンギュラリティ現象の解析Principal Investigator
- Principal Investigator
  
  太田悦朗
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kitasato University
疾患特異的iPS細胞におけるタウを介した神経変性機構の解析Principal Investigator
- Principal Investigator
  
  太田悦朗
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
Pathological analysis of hereditary Parkinson's disease using induced pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  OHTA ETSURO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kitasato University
iPS細胞を用いたタウによる神経変性機構の解明Principal Investigator
- Principal Investigator
  
  太田悦朗
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
Elucidation of cell death mechanism by dominant negative ofmutant LRRK2, the causative molecule of Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  OHTA Etsuro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kitasato University
Elucidation of cell death mechanism by mutant LRRK2, the causative molecule of familial Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  OHTA Etsuro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kitasato University

[Book] 別冊　医学のあゆみ　パーキンソン病の新展開－発症の分子機構と新規治療2018
- Author(s)
  高橋良輔（企画）、太田悦朗（分担執筆）
- Total Pages
  110
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Book] 日本臨床　増刊号　パーキンソン病（第2版）－基礎・臨床研究のアップデート－2018
- Author(s)
  服部信孝（企画）、太田悦朗、川村俊彦（分担執筆）
- Total Pages
  708
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Book] 「週刊　医学のあゆみパーキンソン病の新展開－発症の分子機構と新規治療」2017
- Author(s)
  高橋良輔（企画）、太田悦朗（分担執筆）
- Total Pages
  116
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Book] 「週刊　医学のあゆみパーキンソン病の新展開－発症の分子機構と新規治療」2017
- Author(s)
  高橋良輔（企画）、太田悦朗（分担執筆）
- Total Pages
  116
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15K06777
[Book] 月刊細胞The CELL特集疾患特異的iPS細胞を用いた病態解明の最前線2016
- Author(s)
  太田悦朗、岡野栄之
- Total Pages
  52
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Book] 月刊細胞The CELL特集疾患特異的iPS細胞を用いた病態解明の最前線2015
- Author(s)
  太田悦朗、岡野栄之
- Total Pages
  52
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-15K06777
[Book] ブレインサイエンス・レビュー20152015
- Author(s)
  太田悦朗
- Total Pages
  252
- Publisher
  株式会社クバプロ
- Data Source
  KAKENHI-PROJECT-15K06777
[Book] ブレインサイエンス・レビュー20152015
- Author(s)
  太田悦朗
- Total Pages
  252
- Publisher
  株式会社クバプロ
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Journal Article] Nrf2 Expression Is Decreased in LRRK2 Transgenic Mouse Brain and LRRK2 Overexpressing SH-SY5Y Cells2023
- Author(s)
  Kawakami Fumitaka、Imai Motoki、Tamaki Shun、Ohta Etsuro、Kawashima Rei、Maekawa Tatsunori、Kurosaki Yoshifumi、Ohba Kenichi、Ichikawa Takafumi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 1 Pages: 123-127
- DOI
  10.1248/bpb.b22-00356
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08379, KAKENHI-PROJECT-20K06914, KAKENHI-PROJECT-20K07764, KAKENHI-PROJECT-20K21727, KAKENHI-PUBLICLY-21H00436, KAKENHI-PROJECT-22K07993, KAKENHI-PROJECT-23K07422, KAKENHI-PROJECT-20K08294
[Journal Article] Jietacin derivative, (Z)-2-(8-oxodec-9-yn-1-yl)-1-vinyldiazene 1-oxide, inhibits TNF-α-mediated inflammatory cytokine and chemokine expression via suppression of p65 phosphorylation and importin β1 expression in synovial cell line SW9822022
- Author(s)
  Kyoko Muneshige, Yuki Inahashi, Makoto Itakura, Masato Iwatsuki, Tomoyasu Hirose, Gen Inoue, Masashi Takaso, Toshiaki Sunazuka, Yoshihisa Ohashi, Etsuro Ohta, Kentaro Uchida
- Journal Title
  
  Pharmaceuticals
  
  Volume: 16 Issue: 1 Pages: 5-5
- DOI
  10.3390/ph16010005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06535, KAKENHI-PROJECT-20K06914, KAKENHI-PUBLICLY-21H00436
[Journal Article] A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination2022
- Author(s)
  Hattori Akito、Ohta Etsuro、Nagai Makiko、Iwabuchi Kazuya、Okano Hideyuki
- Journal Title
  
  Methods
  
  Volume: 203 Pages: 233-241
- DOI
  10.1016/j.ymeth.2021.04.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06914, KAKENHI-PUBLICLY-21H00436
[Journal Article] A new approach to analysis of intracellular proteins and subcellular localization using CellProfiler and ImageJ in combination2021
- Author(s)
  Hattori A, Ohta E, Nagai M, Iwabuchi K, Okano H
- Journal Title
  
  Methods
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06914
[Journal Article] A new approach to analysis of intracellular proteins and subcellular localization using CellProfiler and ImageJ in combination2021
- Author(s)
  Hattori A, Ohta E, Nagai M, Iwabuchi K, Okano H
- Journal Title
  
  Methods
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Journal Article] Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells2020
- Author(s)
  Kubo Makoto、Nagashima Ryuichi、Kurihara Mitsue、Kawakami Fumitaka、Maekawa Tatsunori、Eshima Koji、Ohta Etsuro、Kato Hirotomo、Obata Fumiya
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 5 Pages: 1890-1890
- DOI
  10.3390/ijms21051890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19460, KAKENHI-PUBLICLY-19H05428, KAKENHI-PROJECT-17H01685, KAKENHI-PROJECT-18K15374
[Journal Article] Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK22020
- Author(s)
  Ohta Etsuro、Sone Takefumi、Ukai Hideki、Hisamatsu Tomoko、Kitagawa Tokiko、Ishikawa Mitsuru、Nagai Makiko、Ueda Hiroki R.、Obata Fumiya、Okano Hideyuki
- Journal Title
  
  Stem Cell Research
  
  Volume: 49 Pages: 102073-102073
- DOI
  10.1016/j.scr.2020.102073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06914, KAKENHI-PUBLICLY-19H05428
[Journal Article] Vulnerability to stress in mouse offspring is ameliorated when pregnant dams are provided a chewing stick during prenatal stress.2019
- Author(s)
  Kubo KY, Suzuki A, Iinuma M, Sato Y, Nagashio R, Ohta E, Azuma K.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 97 Pages: 150-155
- DOI
  10.1016/j.archoralbio.2018.10.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11772, KAKENHI-PUBLICLY-17H05704, KAKENHI-PROJECT-16H05560, KAKENHI-PROJECT-17H07213
[Journal Article] Establishment of DYT5 patient-specific induced pluripotent stem cells with a GCH1 mutation2017
- Author(s)
  Murakami Nagahisa、Ishikawa Taizo、Kondo Takayuki、Imamura Keiko、Tsukita Kayoko、Enami Takako、Funayama Misato、Shibukawa Ran、Matsumoto Shinichi、Izumi Yuishin、Ohta Etsuro、Obata Fumiya、Kaji Ryuji、Inoue Haruhisa
- Journal Title
  
  Stem Cell Research
  
  Volume: 24 Pages: 36-39
- DOI
  10.1016/j.scr.2017.07.029
- NAID
  120006826719
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05704, KAKENHI-PROJECT-15K06777
[Journal Article] Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.2016
- Author(s)
  Kubo M, Nagashima R, Ohta E, Maekawa T, Isobe Y, Kurihara M, Eshima K, Iwabuchi K, Sasaoka T, Azuma S, Melrose HL, Farrer MJ, Obata F
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 292 Pages: 1-8
- DOI
  10.1016/j.jneuroim.2016.01.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777, KAKENHI-PUBLICLY-15H01565, KAKENHI-PUBLICLY-16H01606, KAKENHI-PROJECT-26290029
[Journal Article] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway2015
- Author(s)
  Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 24(17) Issue: 17 Pages: 4879-4900
- DOI
  10.1093/hmg/ddv212
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06777, KAKENHI-PROJECT-25640038, KAKENHI-PUBLICLY-15H01565, KAKENHI-PUBLICLY-15H01568, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04278, KAKENHI-PLANNED-26117007
[Journal Article] Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation2013
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 430 (2) Issue: 2 Pages: 560-566
- DOI
  10.1016/j.bbrc.2012.11.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791000
[Journal Article] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations2011
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Journal Title
  
  FEBS Lett
  
  Volume: 585 (14) Issue: 14 Pages: 2165-2170
- DOI
  10.1016/j.febslet.2011.05.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791000
[Journal Article] Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.2010
- Author(s)
  Ohta E, Kubo M, Obata F.
- Journal Title
  
  Biochemical and Blophysical Research Communications 391(1)
  
  Pages: 242-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790848
[Journal Article] Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis2010
- Author(s)
  Ohta E, Kubo M, Obata F
- Journal Title
  
  Biochemical and Biophysical Research Communications VOL391(1)
  
  Pages: 242-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790848
[Journal Article] I^<2020>T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule2009
- Author(s)
  Ohta E, Katayama Y, Kawakami F, Yamamoto M, Tajima K, Maekawa T, Iida N, Hattori S, Obata F
- Journal Title
  
  Biochemical and Biophysical Research Communications VOL.390(3)
  
  Pages: 710-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790848
[Journal Article] I^<2020>T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.2009
- Author(s)
  Ohta E, Katayama Y, Kawakami F, Yamamoto M, Tajima K, Maekawa T, Iida N, Hattori S, Obata F
- Journal Title
  
  Bzochemical and Biophysical Research Communications 390(3)
  
  Pages: 710-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] パーキンソン病原因分子α-synucleinがアストロサイトの細胞外小胞に及ぼす影響の解析2024
- Author(s)
  小野寺香奈、小堺亜美、永井真貴子、太田悦朗
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] 遺伝性パーキンソン病原因分子LRRK2の疾患特異的変異によるミクログリア炎症応答の解析2024
- Author(s)
  太田悦朗、樋代理子、小野寺香奈、佐藤雅、永井真貴子、岡野栄之
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] 遺伝性パーキンソン病患者iPSC由来神経細胞の細胞外小胞による炎症誘発機構の解析2024
- Author(s)
  太田悦朗、永井真貴子、岡野栄之
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] 遺伝性パーキンソン病の疾患特異的iPS細胞由来神経細胞が引き起こす炎症誘発機構に関する解析2023
- Author(s)
  太田悦朗、永井真貴子、岡野栄之
- Organizer
  第44回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] LRRK2安定発現ミクログリア細胞株の樹立および病態解析2023
- Author(s)
  太田悦朗、小野寺香奈、小堺亜美、砂川瑚幸、佐藤雅、岡野栄之
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] パーキンソン病原因分子α-synucleinがアストロサイトの細胞外小胞に及ぼす影響の解析2023
- Author(s)
  小野寺香奈、小堺亜美、永井真貴子、太田悦朗
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] ドーパミン可視化プローブを用いたアストロサイトにおけるドーパミントランスポーターの機能解析2023
- Author(s)
  小堺亜美、小野寺香奈、砂川瑚幸、飯塚佳子、吉川圭介、太田悦朗
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06002
[Presentation] オープンソース画像解析ソフトウェアCellProfilerを用いた免疫担当細胞における貪食能解析ツールの開発2022
- Author(s)
  小野寺　香奈，服部　精人，樋代　理子，椎津　愛美，清水　美穂，西海　有希，平原　瑞季，福田　沙織，岡野　栄之，太田　悦朗
- Organizer
  第16回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] Analysis of physiological function of mutant LRRK2-expressing microglia2022
- Author(s)
  Riko Hidai，Akito Hattori，Kana Onodera，Manami Shizu，Miho Shimizu，Yuki Nishigai，Mizuki Hirahara，Saori Fukuda，Masashi Sato，Kazuya Iwabuchi，Etsuro Ohta
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] 細胞内輸送関連分子の新規解析手法の開発と病態モデルへの応用2022
- Author(s)
  服部精人、太田悦朗、永井真貴子、岩渕和也、岡野栄之
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] オープンソース画像解析ソフトウェアCellProfilerを用いた免疫担当細胞における貪食能解析ツールの開発2022
- Author(s)
  小野寺　香奈，服部　精人，樋代　理子，椎津　愛美，清水　美穂，西海　有希，平原　瑞季，福田　沙織，岡野　栄之，太田　悦朗
- Organizer
  第16回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] A new approach to analysis of phagocytosis using CellProfiler2022
- Author(s)
  Akito Hattori, Kana Onodera, Riko Hidai, Manami Shizu, Miho Shimizu, Yuki Nishigai, Mizuki Hirahara, Saori Fukuda, Kazuya Iwabuchi, Hideyuki Okano, Etsuro Ohta
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] 遺伝性パーキンソン病原因分子LRRK2の疾患特異的変異がミクログリアに及ぼす影響の解析2022
- Author(s)
  樋代　理子，服部　精人，小野寺　香奈，椎津　愛美，清水　美穂，西海　有希，平原　瑞季，福田　沙織，岩渕　和也，太田　悦朗
- Organizer
  第16回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] The influence of I2020T mutant LRRK2, the causal molecule of familial Parkinson's disease, on intracellular membrane trafficking2022
- Author(s)
  服部精人、太田悦朗、永井真貴子、樋代理子、岩渕和也、岡野栄之
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] 細胞内輸送関連分子の新規解析手法の開発と病態モデルへの応用2022
- Author(s)
  服部精人、太田悦朗、永井真貴子、岩渕和也、岡野栄之
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] 遺伝性パーキンソン病原因分子LRRK2の疾患特異的変異がミクログリアに及ぼす影響の解析2022
- Author(s)
  樋代　理子，服部　精人，小野寺　香奈，椎津　愛美，清水　美穂，西海　有希，平原　瑞季，福田　沙織，岩渕　和也，太田　悦朗
- Organizer
  第16回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] A new approach to analysis of phagocytosis using CellProfiler2022
- Author(s)
  Akito Hattori, Kana Onodera, Riko Hidai, Manami Shizu, Miho Shimizu, Yuki Nishigai, Mizuki Hirahara, Saori Fukuda, Kazuya Iwabuchi, Hideyuki Okano, Etsuro Ohta
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] Analysis of physiological function of mutant LRRK2-expressing microglia2022
- Author(s)
  Riko Hidai，Akito Hattori，Kana Onodera，Manami Shizu，Miho Shimizu，Yuki Nishigai，Mizuki Hirahara，Saori Fukuda，Masashi Sato，Kazuya Iwabuchi，Etsuro Ohta
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] The influence of I2020T mutant LRRK2, the causal molecule of familial Parkinson's disease, on intracellular membrane trafficking2022
- Author(s)
  服部精人、太田悦朗、永井真貴子、樋代理子、岩渕和也、岡野栄之
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] Analysis of membrane trafficking through Rab proteins in PARK8 iPSC-derived neurons2021
- Author(s)
  Hattori A, Ohta E, Nagai M, Iwabuchi K, Okano H.
- Organizer
  The 19th International Society for Stem Cell Research (ISSCR) 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] Analysis of intracellular membrane traffic using iPSC-derived neurons from familial Parkinson's disease patient2021
- Author(s)
  Hattori A, Ohta E, Nagai M, Miyoshi H, Iwabuchi K, Okano H
- Organizer
  The 10th International Conference AD/PD
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] Analysis of membrane trafficking through Rab proteins in PARK8 iPSC-derived neurons2021
- Author(s)
  Hattori A, Ohta E, Nagai M, Iwabuchi K, Okano H
- Organizer
  INTERNATIONAL SOCIETY FOR STEM CELL RESEARCH (ISSCR2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] Analysis of intracellular membrane traffic using iPSC-derived neurons from familial Parkinson's disease patient2021
- Author(s)
  Hattori A, Ohta E, Nagai M, Miyoshi H, Iwabuchi K, Okano H
- Organizer
  The 10th International Conference AD/PD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] 遺伝性パーキンソン病患者iPS 細胞由来神経細胞のRab を介したメンブレントラフィッキングの解析2021
- Author(s)
  服部精人、太田悦朗、永井真貴子、岩渕和也、岡野栄之
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PUBLICLY-21H00436
[Presentation] 遺伝性パーキンソン病患者iPS 細胞由来神経細胞のRab を介したメンブレントラフィッキングの解析2021
- Author(s)
  服部精人、太田悦朗、永井真貴子、岩渕和也、岡野栄之
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] ヒト単球系細胞株を用いたLRRK2キナーゼ阻害剤による抗炎症効果の検証2020
- Author(s)
  太田悦朗、佐々木晶子、新田龍人、岡野栄之
- Organizer
  第19回日本再生医療学会総会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来単球系細胞の作製および機能解析2020
- Author(s)
  太田悦朗、新田龍人、服部精人、久保誠、永井真貴子、岡野栄之
- Organizer
  第19回日本再生医療学会総会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] ヒト単球系細胞株を用いたLRRK2キナーゼ阻害剤による抗炎症効果の解析2020
- Author(s)
  太田悦朗、佐々木晶子、新田龍人、服部精人、岡野栄之
- Organizer
  第41回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経細胞の細胞内輸送機構に関する解析2020
- Author(s)
  服部精人、太田悦朗、篠原徹朗、新田龍人、永井真貴子、岩渕和也、岡野栄之
- Organizer
  第19回日本再生医療学会総会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] Analysis of intracellular membrane traffic using iPSC-derived neurons from familial Parkinson's disease patient2020
- Author(s)
  Hattori A, Ohta E, Nagai M, Miyoshi H, Iwabuchi K, Okano H
- Organizer
  Neuro2020【第43回日本神経科学大会】
- Data Source
  KAKENHI-PROJECT-20K06914
[Presentation] Analysis of intracellular membrane traffic using iPSC-derived neurons from familial Parkinson's disease patient2020
- Author(s)
  Hattori A, Ohta E, Nagai M, Miyoshi H, Iwabuchi K, Okano H
- Organizer
  Neuro2020【第43回日本神経科学大会】
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] ヒト単球系細胞株を用いたLRRK2キナーゼ阻害剤による抗炎症効果の解析2020
- Author(s)
  太田悦朗、佐々木晶子、新田龍人、服部精人、岡野栄之
- Organizer
  第41回日本炎症・再生医学会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来単球系細胞の作製および機能解析2019
- Author(s)
  新田龍人、太田悦朗、服部精、久保誠、永井真貴子、佐藤俊哉、岡野栄之
- Organizer
  第14回日本臨床検査学教育学会学術大会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] Generation of iPS cells-derived monocytes from familial Parkinson's disease patient2019
- Author(s)
  Ohta E, Nitta R, Hattori A, Kubo M, Nagai M, Okano H
- Organizer
  The 48th Japanese Society for Immunology
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] Generation of iPS cells-derived mature neurons from familial Parkinson’s disease patient by microRNA2019
- Author(s)
  太田悦朗、服部精人、永井真貴子、三好浩之、曽根岳史、新田龍人、Andrew Yoo、岩渕和也、岡野栄之
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] パーキンソン病の分子病態:責任遺伝子からの新知見－遺伝性パーキンソン病のiPS細胞研究-2019
- Author(s)
  太田悦朗
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] microRNAを用いた遺伝性パーキンソン病患者iPS細胞の病態解析2019
- Author(s)
  服部精人、太田悦朗、曽根岳史、三好浩之、新田龍人、Andrew Yoo、川村俊彦、岡野栄之
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] microRNAを用いた遺伝性パーキンソン病患者iPS細胞由来成熟神経細胞の作製2019
- Author(s)
  服部精人、太田悦朗、永井真貴子、三好浩之、曽根岳史、新田龍人、Andrew Yoo，岩渕和也、岡野栄之
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-19H05428
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経幹細胞移植マウスの作製および病態解析2018
- Author(s)
  大日方友理、岩下由佳、永井真貴子、服部精人、江島耕二、小幡文弥、川村俊彦、岡野栄之、太田悦朗
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経細胞における経時的なmRNA発現解析2018
- Author(s)
  太田悦朗、曽根岳史、大日方友理、鵜飼英樹、久松知子、北川季子、石川充、駒野肇、上田泰己、小幡文弥、川村俊彦、岡野栄之
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経細胞における経時的なmRNA発現解析2018
- Author(s)
  太田悦朗、曽根岳史、大日方友理、鵜飼英樹、久松知子、北川季子、石川充、駒野肇、上田泰己、小幡文弥、川村俊彦、岡野栄之
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経幹細胞移植マウスの作製および病態解析2018
- Author(s)
  大日方友理、岩下由佳、永井真貴子、服部精人、江島耕二、小幡文弥、川村俊彦、岡野栄之、太田悦朗
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Generation of a mouse model of familial Parkinson’s disease bearing patient iPSC-derived transplanted neurospheres.2017
- Author(s)
  Ohta E, Obinata Y, Iwashita Y, Nagai M, Hattori A, Eshima K, Obata F, Okano H
- Organizer
  The 8th meeting of Asian Cellular Therapy Organization
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経幹細胞移植マウスの作製2017
- Author(s)
  大日方友理、岩下由佳、永井真貴子、服部精人、江島耕二、岡野栄之、小幡文弥、太田悦朗
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Generation of a mouse model of familial Parkinson’s disease bearing patient iPSC-derived transplanted neurospheres2017
- Author(s)
  Ohta E, Obinata Y, Iwashita Y, Nagai M, Hattori A, Eshima K, Obata F, Okano H
- Organizer
  Generation of a mouse model of familial Parkinson’s disease bearing patient iPSC-derived transplanted neurospheres
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Generation of gene-corrected iPSC from patient-derived iPSC with familial Parkinson's disease.2017
- Author(s)
  Ohta E, Sone T, Obinata Y, Ukai H, Hisamatsu T, Kitagawa T, Ishikawa M, Komano H, Ueda HR, Obata F, Okano H
- Organizer
  International Society for Stem Cell Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Generation of a mouse model of familial Parkinson’s disease bearing patient iPSC-derived transplanted neurospheres.2017
- Author(s)
  Obinata Y, Iwashita Y, Nagai M, Hattori A, Eshima K, Obata F, Okano H, Ohta E
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2017
- Author(s)
  太田悦朗、曽根岳史、大日方友理、鵜飼英樹、久松知子、北川季子、石川充、駒野肇、上田泰己、小幡文弥、岡野栄之
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] Generation of gene-corrected iPSC from patient-derived iPSC with familial Parkinson's disease.2017
- Author(s)
  Ohta E, Sone T, Obinata Y, Ukai H, Hisamatsu T, Kitagawa T, Ishikawa M, Komano H, Ueda HR, Obata F, Okano H
- Organizer
  International Society for Stem Cell Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] 遺伝性パーキンソン病患者iPS細胞由来神経幹細胞移植マウスの作製2017
- Author(s)
  大日方友理、岩下由佳、永井真貴子、服部精人、江島耕二、岡野栄之、小幡文弥、太田悦朗
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PUBLICLY-17H05704
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2017
- Author(s)
  太田悦朗、曽根岳史、大日方友理、鵜飼英樹、久松知子、北川季子、石川充、駒野肇、上田泰己、小幡文弥、岡野栄之
- Organizer
  第16回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Generation of a mouse model of familial Parkinson’s disease bearing patient iPSC-derived transplanted neurospheres2017
- Author(s)
  Obinata Y, Iwashita Y, Nagai M, Hattori A, Eshima K, Obata F, Okano H, Ohta E
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] I2020T mutant LRRK2 iPSC-derived neurons exhibit increased Tau phosphorylation2016
- Author(s)
  太田悦朗、仁平友子、内野彰子、今泉陽一、赤松和土、高橋加代子、永井真貴子、大山学、梁正淵、荻野美恵子、村山繁雄、高島明彦、西山和利、水野美邦、望月秀樹、小幡文弥、岡野栄之
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪府大阪市（大阪国際会議場）
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞のゲノム編集および病態解析2016
- Author(s)
  大日方友理、太田悦朗、曽根岳史、鵜飼英樹、久松知子、石川充、駒野肇、上田泰己、小幡文弥、岡野栄之
- Organizer
  第11回日本臨床検査学教育学会学術大会
- Place of Presentation
  神戸常盤大学（兵庫県神戸市）
- Year and Date
  2016-08-31
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞のゲノム編集および病態解析2016
- Author(s)
  大日方友理、太田悦朗、曽根岳史、鵜飼英樹、久松知子、石川充、駒野肇、上田泰己、小幡文弥、岡野栄之
- Organizer
  第11回日本臨床検査学教育学会学術大会
- Place of Presentation
  神戸常盤大学(兵庫県神戸市)
- Year and Date
  2016-08-31
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] Segawa disease with action retrocollis (cervical dystonia); A case report of 23-year-old female2016
- Author(s)
  Hoshino K, Hayashi M, Isono Y, Nagao Y, Kimura K, Hachimori K, Nozaki H, Ohta E, Obata F, Kawarai T, Kaji K
- Organizer
  International Child Neurology Congress (ICNC2016)
- Place of Presentation
  Amsterdam RAI Convention Centre(Netherland,Amsterdam)
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses2016
- Author(s)
  KUBO M, OHTA E, ESHIMA K, IWABUCHI K, OBATA F
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2016
- Author(s)
  太田悦朗、曽根岳史、大日方友理、鵜飼英樹、久松知子、北川季子、石川充、駒野肇、上田泰己、小幡文弥、岡野栄之
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Segawa disease with action retrocollis (cervical dystonia); A case report of 23-year-old female2016
- Author(s)
  Hoshino K, Hayashi M, Isono Y, Nagao Y, Kimura K, Hachimori K, Nozaki H, Ohta E, Obata F, Kawarai T, Kaji K
- Organizer
  International Child Neurology Congress (ICNC2016)
- Place of Presentation
  Amsterdam RAI Convention Centre(Netherland,Amsterdam)
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2016
- Author(s)
  太田悦朗、曽根岳史、大日方友理、鵜飼英樹、久松知子、北川季子、石川充、駒野肇、上田泰己、小幡文弥、岡野栄之
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] I2020T mutant LRRK2 iPSC-derived neurons exhibit increased Tau phosphorylation2016
- Author(s)
  太田悦朗、仁平友子、内野彰子、今泉陽一、岡田　洋平、赤松和土、高橋加代子、永井真貴子、大山学、梁正淵、荻野美恵子、村山繁雄、高島明彦、西山和利、水野美邦、望月秀樹、小幡文弥、岡野栄之
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪府大阪市（大阪国際会議場）
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses2016
- Author(s)
  KUBO M, OHTA E, ESHIMA K, IWABUCHI K, OBATA F
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway2015
- Author(s)
  Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
- Organizer
  XXI WFN World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Italy (Milan), Milano Congressi
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] ゲノム編集した患者由来疾患iPS細胞の全ゲノム解析によって明らかになったこと2015
- Author(s)
  曽根岳史、朴聖俊、田中泰圭、太田悦朗、日暮憲道、中井謙太、廣瀬伸一、岡野栄之
- Organizer
  BMB2015 (第38回日本分子生物学会年会、第88回日本生化学会大会合同大会)
- Place of Presentation
  兵庫県神戸市（神戸国際会議場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] TALEN-mediated genome editing of patient-derived iPSCs for disease model studies2015
- Author(s)
  Sone T, Tanaka Y, Ohta E, Hosoya M, Ichiyanagi N, Akiyama T, Higurashi N、Hirose S, Okano H
- Organizer
  The Conference on Transposition and Genome Engineering
- Place of Presentation
  Japan (Nara), Nara Kasugano International Forum IRAKA
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway2015
- Author(s)
  Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
- Organizer
  XXI WFN World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Italy (Milan), Milano Congressi
- Year and Date
  2015-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] I2020T LRRK2変異をもつ遺伝性パーキンソン病患者のiPS細胞由来神経細胞はTauのリン酸化亢進を示す2015
- Author(s)
  太田悦朗、仁平友子、内野彰子、今泉陽一、岡田　洋平、赤松和土、高橋加代子、永井真貴子、大山学、梁正淵、荻野美恵子、村山繁雄、高島明彦、西山和利、水野美邦、望月秀樹、小幡文弥、岡野栄之
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  兵庫県神戸市（神戸国際会議場）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] I2020T LRRK2 iPSC-derived neurons exhibit increased Tau phosphorylation2015
- Author(s)
  太田悦朗、仁平友子、内野彰子、今泉陽一、赤松和土、高橋加代子、永井真貴子、大山学、梁正淵、荻野美恵子、村山繁雄、高島明彦、西山和利、水野美邦、望月秀樹、小幡文弥、岡野栄之
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟県新潟市（朱鷺メッセ）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] I2020T LRRK2変異をもつ遺伝性パーキンソン病患者のiPS細胞由来神経細胞はTauのリン酸化亢進を示す2015
- Author(s)
  太田悦朗、仁平友子、内野彰子、今泉陽一、岡田　洋平、赤松和土、高橋加代子、永井真貴子、大山学、梁正淵、荻野美恵子、村山繁雄、高島明彦、西山和利、水野美邦、望月秀樹、小幡文弥、岡野栄之
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  兵庫県神戸市（神戸国際会議場）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] ゲノム編集した患者由来疾患iPS細胞の全ゲノム解析によって明らかになったこと2015
- Author(s)
  曽根岳史、朴聖俊、田中泰圭、太田悦朗、日暮憲道、中井謙太、廣瀬伸一、岡野栄之
- Organizer
  BMB2015 (第38回日本分子生物学会年会、第88回日本生化学会大会合同大会)
- Place of Presentation
  兵庫県神戸市（神戸国際会議場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01565
[Presentation] TALEN-mediated genome editing of patient-derived iPSCs for disease model studies2015
- Author(s)
  Sone T, Tanaka Y, Ohta E, Hosoya M, Ichiyanagi N, Akiyama T, Higurashi N、Hirose S, Okano H
- Organizer
  The Conference on Transposition and Genome Engineering
- Place of Presentation
  Japan (Nara), Nara Kasugano International Forum IRAKA
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] I2020T LRRK2 iPSC-derived neurons exhibit increased Tau phosphorylation2015
- Author(s)
  太田悦朗、仁平友子、内野彰子、今泉陽一、赤松和土、高橋加代子、永井真貴子、大山学、梁正淵、荻野美恵子、村山繁雄、高島明彦、西山和利、水野美邦、望月秀樹、小幡文弥、岡野栄之
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟県新潟市（朱鷺メッセ）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K06777
[Presentation] Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation2013
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Organizer
  The 11th International Conference AD/PD
- Place of Presentation
  Fortezza da Basso (Florence, Italy)
- Year and Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations2012
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Organizer
  22nd IUBMB & 37th FEBS Congress
- Place of Presentation
  FIBES-Seville Conference and Exhibition Centre (Sevilla, Spain)
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations2012
- Author(s)
  Ohta E
- Organizer
  11th APSN,55th JSN
- Place of Presentation
  Japan (Kobe)
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] Leucine-Rich Repeat Kinase 2 の新規基質分子 Akt1 の解析2012
- Author(s)
  太田悦朗、川上文貴、久保誠、小幡文弥
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations2012
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Organizer
  11th APSN, 55th JSN
- Place of Presentation
  Kobe Convention Center (Kobe, Japan)
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] I2020T変異LRRK2と正常型LRRK2のヘテロダイマーにおける蛋白質不安定性の解析2011
- Author(s)
  太田悦朗、川上文貴、久保誠、小幡文弥
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] I2020T 変異 LRRK2 と正常型 LRRK2 のヘテロダイマーにおける蛋白質不安定性の解析2011
- Author(s)
  太田悦朗、川上文貴、久保誠、小幡文
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson ' s disease-associated mutations2011
- Author(s)
  太田悦朗、川上文貴、久保誠、小幡文弥
- Organizer
  第84回日本生化学会大会合同大会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations2011
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Organizer
  XIX WFN World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  China (Shanghai)
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations2011
- Author(s)
  Ohta E, Kawakami F, Kubo M, Obata F
- Organizer
  XIX WFN World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Shanghai Ineternational Convention Centre (Shanghai, China)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson’s disease-associated mutations2011
- Author(s)
  太田悦朗、川上文貴、久保誠、小幡文弥
- Organizer
  第84回日本生化学会大会合同大会
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2の細胞内半減期がアポトーシス抑制能に及ぼす影響-ノックダウンによる解析-2010
- Author(s)
  太田悦朗、川上文貴、飯田直幸、山元茉莉、前川達則、服部成介、小幡文弥
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  日神戸国際展示場(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] LRRK2の細胞内半減期がアポトーシス抑制能に及ぼす影響-ノックダウンによる解析-2010
- Author(s)
  太田悦朗、川上文貴、飯田直幸、山元茉莉、前川達則、服部成介、小幡文弥
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] LRRK2の細胞内半減期およびLRRK2ノックダウン下における細胞生存率の解析2010
- Author(s)
  太田悦朗、川上文貴、飯田直幸、山元茉莉、前川達則、服部成介、小幡文弥
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] Mutant(I^<2020> LRRK2 has a higher susceptibility to ploteolysis and impaired protectivity against apoptosis2009
- Author(s)
  Ohta E, Katayama Y, Tajima K, Maekawa T, Yamamoto M, Obata F
- Organizer
  XVIII WFN World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Maiami Beach convention center(Florida, USA)
- Year and Date
  2009-12-16
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] Mutant (I^<2020>T) LRRK2 has a higher susceptibility to ploteolysis and impaired protectivity against apoptosis.2009
- Author(s)
  Ohta E, Katayama Y, Tajima K, Maekawa T, Yamamoto M, Obata F.
- Organizer
  XVIII WFN World Congress on Parkinson's Disease and Related Disorders
- Place of Presentation
  Maiami Beach convention center (Florida, USA)
- Year and Date
  2009-12-16
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] LRRK2安定発現SH-SY5Y細胞株の樹立およびアポトーシス抑制能の解析2009
- Author(s)
  太田悦朗、山元茉莉、前川達則、小幡文弥
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21790848
[Presentation] Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson’s disease caused by LRRK2 I2020T mutation
- Author(s)
  Ohta E
- Organizer
  The 11th International Conference AD/PD
- Place of Presentation
  Italy (Florence)
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] Leucine-Rich Repeat Kinase 2の新規基質分子Akt1の解析
- Author(s)
  太田悦朗
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京都 (東京国際フォーラム)
- Data Source
  KAKENHI-PROJECT-23791000
[Presentation] LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations
- Author(s)
  Ohta E
- Organizer
  22nd IUBMB & 37th FEBS Congress
- Place of Presentation
  Spain (Sevilla)
- Data Source
  KAKENHI-PROJECT-23791000

1. 前川達則 (30647673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 永井真貴子 (80420488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IINUMA Mitsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. CHEN Huayue

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KATO Hirotomo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 久保金弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 廣瀬友靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohta Etsuro 太田 悦朗

OHTA ETSURO 太田 悦朗

OHTA Etsuro 太田 悦朗

Research Projects

Research Products

Co-Researchers

Pathological analysis of mitochondrial transmission among basal ganglia neural circuits in hereditary Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

神経サブタイプ分化誘導技術を用いた遺伝性パーキンソン病における細胞内輸送の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

腸管神経におけるalphaシヌクレインの凝集と水膜輸送の関係

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患特異的iPS細胞を用いた神経炎症を引き起こすシンギュラリティ現象の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery research using Omura natural compounds and disease-specific iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患特異的iPS細胞を用いたモザイシズムによるシンギュラリティ現象の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患特異的iPS細胞におけるタウを介した神経変性機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological analysis of hereditary Parkinson's disease using induced pluripotent stem cellsPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

iPS細胞を用いたタウによる神経変性機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Elucidation of cell death mechanism by dominant negative ofmutant LRRK2, the causative molecule of Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Elucidation of cell death mechanism by mutant LRRK2, the causative molecule of familial Parkinson's diseasePrincipal Investigator

Principal Investigator

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Research Institution

[Book] 別冊 医学のあゆみ パーキンソン病の新展開－発症の分子機構と新規治療2018

Author(s)

Total Pages

Publisher

Data Source

[Book] 日本臨床 増刊号 パーキンソン病（第2版）－基礎・臨床研究のアップデート－2018

Author(s)

Total Pages

Ohta Etsuro 太田悦朗

OHTA ETSURO 太田悦朗

OHTA Etsuro 太田悦朗

[Book] 別冊　医学のあゆみ　パーキンソン病の新展開－発症の分子機構と新規治療2018

[Book] 日本臨床　増刊号　パーキンソン病（第2版）－基礎・臨床研究のアップデート－2018

[Book] 「週刊　医学のあゆみパーキンソン病の新展開－発症の分子機構と新規治療」2017

[Book] 「週刊　医学のあゆみパーキンソン病の新展開－発症の分子機構と新規治療」2017

[Book] 月刊細胞The CELL特集疾患特異的iPS細胞を用いた病態解明の最前線2016

[Book] 月刊細胞The CELL特集疾患特異的iPS細胞を用いた病態解明の最前線2015