Kashiwagi Hitoshi 柏木仁

… Alternative Names

KASHIWAGI Hitoshi 柏木仁

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Researcher Number	60510609
Other IDs
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 北海道大学, 薬学研究院, 講師 2018 – 2020: 旭川医科大学, 医学部, 助教 2010 – 2016: 旭川医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator General pharmacology / Basic Section 47040:Pharmacology-related / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 血小板 / 受容体欠損マウス / 薬物耐性 / 輸送活性増大 / 輸送活性変動 / トランスポーター / 輸送活性 / アミノ酸トランスポーターSNAT4 / 肝細胞 / 活性化血小板上清 … More / TP受容体 / EP3受容体 / プロスタグランジンF2α / EP_4受容体 / EP_2受容体 / プロスタグランジンE_2 / EP4受容体 / EP2受容体 / プロスタグランジンE2 / 血液 / 心血管 … More Except Principal Investigator プロスタノイド / 心筋梗塞 / トロンボキサン / プロスタグランジン / 唾液 / 薬物濃度モニタリング / NASH / 線維化 / 心虚血再還流傷害 / 心臓 / 糖質コルチコイド / 肝炎 / 免疫依存性肝炎 / 誘発肝炎 / Con A / 腎間質繊維化 / 血小板 / 脳血栓 / 腎線維化 / 循環器疾患 / 循環器系疾患 / 循環器 Less

プロスタグランジンＥ合成酵素のトリプルネガティブ乳がんにおける役割解明
- Principal Investigator
  
  小島史章
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kitasato University
唾液中薬物濃度モニタリングが適用可能な薬物の選択方法の確立
- Principal Investigator
  
  武隈洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
The role of platelets in cancer cell proliferation and drug resistancePrincipal Investigator
- Principal Investigator
  
  Kashiwagi Hitoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hokkaido University
Elucidation of the role of prostanoids in the development of liver fibrosis
- Principal Investigator
  
  Ushikubi Fumitaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Asahikawa Medical College
The role of prostaglandin F2 alpha in the regulation of platelet functionPrincipal Investigator
- Principal Investigator
  
  KASHIWAGI Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College
Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning
- Principal Investigator
  
  USHIKUBI Fumitaka
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College
Roles of the prostanoids in the regulation of immunological responses
- Principal Investigator
  
  USHIKUBI Fumitaka
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College
Roles of the prostanoids in the pathogenesis of cardiovascular diseases
- Principal Investigator
  
  USHIKUBI Fumitaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College
Clarification of the mechanism of a novel inhibitory effect on platelet aggregation via prostaglandin E_2 receptorPrincipal Investigator
- Principal Investigator
  
  KASHIWAGI Hitoshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College

All 2024 2021 2018 2017 2016 2015 2014 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Platelets Affect the Activity of Amino Acid Transporter SNAT4 in HuH-7 Human Hepatoma Cells2024
- Author(s)
  Kashiwagi Hitoshi, Sato Yuki, Nashimoto Shunsuke, Imai Shungo, Takekuma Yoh, Sugawara Mitsuru
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 3 Pages: 652-659
- DOI
  10.1248/bpb.b23-00904
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-03-19
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06706
[Journal Article] 非アルコール性脂肪肝炎におけるプロスタノイドの役割2018
- Author(s)
  結城幸一、粂井志麻、柏木仁、今道力敬、牛首文隆
- Journal Title
  
  炎症と免疫
  
  Volume: 26 Pages: 24-29
- Data Source
  KAKENHI-PROJECT-18H02576
[Journal Article] The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an anti-platelet effect due to its inhibitory action on thromboxane A2 synthesis in mice2015
- Author(s)
  Hitoshi Kashiwagi, Koh-ichi Yuhki, Fumiaki Kojima, Shima Kumei, Osamu Takahata, Yoshiki Sakai, Shuh Narumiya and Fumitaka Ushikubi
- Journal Title
  
  The Journal of pharmacology and experimental therapeutics
  
  Volume: 353 Issue: 2 Pages: 269-278
- DOI
  10.1124/jpet.115.222612
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860167
[Journal Article] 臓器線維化におけるプロスタノイドの役割2015
- Author(s)
  結城幸一、柏木仁、小島史章、今道力敬、牛首文隆
- Journal Title
  
  細胞
  
  Volume: 47 Pages: 16-19
- Data Source
  KAKENHI-PROJECT-26860167
[Journal Article] 虚血による神経障害の分子メカニズム　プロスタノイドの役割2014
- Author(s)
  小島史章、結城幸一、柏木仁、粂井志麻、牛首文隆
- Journal Title
  
  日本臨牀
  
  Volume: 72 Pages: 121-125
- Data Source
  KAKENHI-PROJECT-26860167
[Journal Article] The intrinsic prostaglandin E_2-EP_4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice2012
- Author(s)
  Nakagawa N, Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
- Volume
  82
- Pages
  158-171
- Data Source
  KAKENHI-PROJECT-22390045
[Journal Article] The intrinsic prostaglandin E_2-EP_4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice2012
- Author(s)
  Nakagawa N, Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
- Journal Title
  
  T. Kidney Int
  
  Volume: 82 Pages: 158-171
- Data Source
  KAKENHI-PROJECT-23659130
[Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular system: Novel insights from knockout mouse studies2011
- Author(s)
  Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
- Journal Title
  
  Pharmacol Ther
  
  Volume: 129 Pages: 195-205
- Data Source
  KAKENHI-PROJECT-23659130
[Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular system: Novel insights from knockout mouse studies2011
- Author(s)
  Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
- Journal Title
  
  Pharmacol Ther
  
  Volume: 129 Pages: 195-205
- Data Source
  KAKENHI-PROJECT-22390045
[Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases : Novel insights from knockout mouse studies2011
- Author(s)
  Koh-ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, 他4名
- Journal Title
  
  Pharmacology and Therapeutics
  
  Volume: Vol.129 Pages: 195-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790241
[Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation2010
- Author(s)
  Shuhko Kuriyama, Hitoshi Kashiwagi
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: Volume 104 Pages: 796-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790241
[Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation2010
- Author(s)
  Kuriyama S, Kashiwagi H, Yuhki K, Kojima F, Ushikubi F, et al
- Journal Title
  
  Thromb Haemost
  
  Volume: 104 Pages: 796-803
- Data Source
  KAKENHI-PROJECT-22390045
[Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation2010
- Author(s)
  Shuhko Kuriyama, Hitoshi Kashiwagi (These authors contributed equally to this work.), 他10名
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: Vol.104 Pages: 796-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790241
[Journal Article] Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation2010
- Author(s)
  Kashiwagi, H., et al.
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 104 Pages: 796-803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390045
[Presentation] マウス肝再生におけるプロスタグランジンI2とTNF-aの役割2021
- Author(s)
  結城幸一、平田朋浩、今道力敬、柏木仁、中山恒、成宮周、牛首文隆
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18H02576
[Presentation] Prostaglandin F2α potentiates platelet aggregation via prostaglandin E2 and thromboxane A2 receptors2017
- Author(s)
  Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Shuh Narumiya, Fumitaka Ushikubi
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] Promoting effect of prostaglandin F2α on platelet aggregation2016
- Author(s)
  Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Shuh Narumiya, Fumitaka Ushikubi
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（横浜市、神奈川県）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] プロスタグランジンF2αの血小板凝集促進作用2016
- Author(s)
  柏木仁、結城幸一、今道力敬、小島史章、粂井志麻、成宮周、牛首文隆
- Organizer
  第26回日本循環薬理学会
- Place of Presentation
  信州大学医学部付属病院（長野県松本市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] 血小板機能調節におけるプロスタノイドの役割2015
- Author(s)
  柏木仁
- Organizer
  第17回旭川心血管リモデリング研究会
- Place of Presentation
  旭川グランドホテル（旭川市、北海道）
- Year and Date
  2015-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] ヒト生殖腺における11-ケトテストステロンの合成とその機能2015
- Author(s)
  今道力敬、矢澤隆志、結城幸一、柏木仁、宮本薫、牛首文隆
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山市、富山県）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] Protective effects of the prostaglandin I2-IP signal in nonalcoholic steatohepatitis2015
- Author(s)
  Shima Kumei, Koh-ichi Yuhki, Hitoshi Kashiwagi, Toshikatsu Okumura, Fumitaka Ushikubi
- Organizer
  Digestive Disease Week (DDW) 2015
- Place of Presentation
  Walter E. Washington Convention Center (Washington, D.C., USA)
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] タバコ煙抽出液は血小板凝集を抑制する2015
- Author(s)
  柏木仁、結城幸一、今道力敬、小島史章、粂井志麻、成宮周、牛首文隆
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山市、富山県）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] 血小板凝集に及ぼすタバコ煙抽出液の作用2014
- Author(s)
  柏木仁、結城幸一、小島史章、粂井志麻、成宮周、牛首文隆
- Organizer
  第24回日本循環薬理学会
- Place of Presentation
  山形テルサ（山形県・山形市）
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] Inhibition of thromboxane A2 synthase prevents reduction in the anti-platelet effect of a prostaglandin I2 receptor agonist after repeated administration2012
- Author(s)
  柏木仁
- Organizer
  日本薬理学会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22390045
[Presentation] Inhibition of thromboxane A_2 synthase prevents reduction in the anti-platelet effect of a prostaglandin I_2 receptor agonist after repeated administration2012
- Author(s)
  Hitoshi Kashiwagi
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22790241
[Presentation] トロンボキサンA_2合成酵素の阻害はプロスタグランジンI_2受容体の脱感作を抑制する2011
- Author(s)
  柏木仁
- Organizer
  第62回日本薬理学会北部会
- Place of Presentation
  江陽グランドホテル(宮城県)
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-22790241
[Presentation] プロスタグランジンE_2受容体サブタイプEP_4の抗血小板療法ターゲットとしての可能性2010
- Author(s)
  柏木仁
- Organizer
  第20回日本循環薬理学会
- Place of Presentation
  札幌市教育文化会館(北海道)
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22790241
[Presentation] Prostaglandin E_2 receptor subtype EP_2 and EP_4 emerge as novel targets for anti-platelet therapy2010
- Author(s)
  Hitoshi Kashiwagi
- Organizer
  2010 Keystone Symposia (Bioactive Lipids : Biochemistry and Diseases)
- Place of Presentation
  ウェスティン都ホテル京都(京都府)
- Year and Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-22790241
[Presentation] 、プロスタグランジンE_2受容体サブタイプEP_4の抗血小板療法ターゲットとしての可能性2010
- Author(s)
  柏木仁
- Organizer
  第20回日本循環薬理学会
- Place of Presentation
  札幌市教育文化会館(北海道)
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22790241
[Presentation] タバコ煙抽出液の血小板凝集抑制作用
- Author(s)
  柏木仁、結城幸一、小島史章、粂井志麻、牛首文隆
- Organizer
  第65回日本薬理学会北部会
- Place of Presentation
  コラッセ福島（福島県・福島市）
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] Roles of the prostaglandin I2-IP system in nonalcoholic steatohepatitis
- Author(s)
  Shima Kumei, Koh-ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Toshikatsu Okumura, Shuh Narumiya, Fumitaka Ushikubi
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] 非アルコール性脂肪性肝炎におけるプロスタノイドの役割解明
- Author(s)
  結城幸一、粂井志麻、柏木仁、小島史章、成宮周、牛首文隆
- Organizer
  第65回日本薬理学会北部会
- Place of Presentation
  コラッセ福島（福島県・福島市）
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] Protective effect of the prostaglandin I2-IP signal through the suppression of cytokines expression in nonalcoholic steatohepatitis
- Author(s)
  Shima Kumei, Koh-ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Toshikatsu Okumura, Fumitaka Ushikubi
- Organizer
  Digestive Disease Week (DDW) 2014
- Place of Presentation
  Chicago（USA）
- Year and Date
  2014-05-03 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-26860167
[Presentation] Cigarette smoke extract inhibits platelet aggregation
- Author(s)
  Hitoshi Kashiwagi, Koh-ichi Yuhki, Fumiaki Kojima, Shima Kumei, Shuh Narumiya, Fumitaka Ushikubi
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860167

1. USHIKUBI Fumitaka (50243035)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. YUHKI Koh-ichi (80302420)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. KOJIMA Fumiaki (30550545)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 今道力敬 (00570194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 鍵谷豪 (30524243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 武隈洋 (00396293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐藤夕紀 (00564981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kashiwagi Hitoshi 柏木 仁

KASHIWAGI Hitoshi 柏木 仁

Research Projects

Research Products

Co-Researchers

プロスタグランジンＥ合成酵素のトリプルネガティブ乳がんにおける役割解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

唾液中薬物濃度モニタリングが適用可能な薬物の選択方法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of platelets in cancer cell proliferation and drug resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of prostanoids in the development of liver fibrosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of prostaglandin F2 alpha in the regulation of platelet functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of cardiac prostanoid synthesis by glucocorticoid and its pathophysiological meaning

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of the prostanoids in the regulation of immunological responses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of the prostanoids in the pathogenesis of cardiovascular diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the mechanism of a novel inhibitory effect on platelet aggregation via prostaglandin E_2 receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Platelets Affect the Activity of Amino Acid Transporter SNAT4 in HuH-7 Human Hepatoma Cells2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] 非アルコール性脂肪肝炎におけるプロスタノイドの役割2018

Author(s)

Journal Title

Data Source

[Journal Article] The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an anti-platelet effect due to its inhibitory action on thromboxane A2 synthesis in mice2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 臓器線維化におけるプロスタノイドの役割2015

Author(s)

Journal Title

Data Source

Kashiwagi Hitoshi 柏木仁

KASHIWAGI Hitoshi 柏木仁

[Journal Article] 虚血による神経障害の分子メカニズム　プロスタノイドの役割2014