HIDEO Kohno 神野英生

Researcher Number	60514536
Affiliation (based on the past Project Information) *help	2016 – 2021: 東京慈恵会医科大学, 医学部, 講師 2013 – 2015: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Ophthalmology / Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 炎症 / 加齢黄斑変性 / マイクログリア / マクロファージ / 網膜色素変性 / 網膜変性 / 網膜色素変性症 / 網膜炎症 / 黄斑変性 / ケモカイン … More / ドラッグ・リポジショニング / 視細胞死 / ドラッグリポジショニング / マウロファージ / マラビロク / 網膜 / 細胞死 / 光受容体細胞死 Less

Examination of drug repositioning in retinal degenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Kohno Hideo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Jikei University School of Medicine
CCL3-CCR5 axis is potential therapeutic target in retinal degeneration.Principal Investigator
- Principal Investigator
  
  Kohno Hideo
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Jikei University School of Medicine
New inflammation targeted strategy for retinal degenerationPrincipal Investigator
- Principal Investigator
  
  HIDEO Kohno
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Ophthalmology
- Research Institution
  Jikei University School of Medicine

All 2021 2019 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Effect of Lecithin-Bound Iodine Treatment on Inherited Retinal Degeneration in Mice.2021
- Author(s)
  Kohno H, Terauchi R, Watanabe S, Ichihara K, Watanabe T, Nishijima E, Watanabe A, Nakano T.
- Journal Title
  
  Transl Vis Sci Technol.
  
  Volume: 10 Issue: 13 Pages: 8-8
- DOI
  10.1167/tvst.10.13.8
- Data Source
  KAKENHI-PROJECT-19K09960
[Journal Article] Minocycline decreases CCR2-positive monocytes in the retina and ameliorates photoreceptor degeneration in a mouse model of retinitis pigmentosa.2021
- Author(s)
  Terauchi R, Kohno H, Watanabe S, Saito S, Watanabe A, Nakano T.
- Journal Title
  
  PLoS One.
  
  Volume: 16 Issue: 4 Pages: e0239108-e0239108
- DOI
  10.1371/journal.pone.0239108
- Data Source
  KAKENHI-PROJECT-19K09960
[Journal Article] Three-year visual outcomes of intravitreal ranibizumab with or without photodynamic therapy for polypoidal choroidal vasculopathy.2016
- Author(s)
  Sakai T, Okano K, Kohno H, Tsuneoka H.
- Journal Title
  
  Acta Ophthalmol.
  
  Volume: 94 Issue: 8
- DOI
  10.1111/aos.13130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20288
[Journal Article] Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.2015
- Author(s)
  Kohno H, Koso H, Okano K, Sundermeier TR, Saito S, Watanabe S, Tsuneoka H, Sakai T.
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 12 Issue: 1 Pages: 188-188
- DOI
  10.1186/s12974-015-0408-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430108, KAKENHI-PROJECT-15K15628, KAKENHI-PROJECT-15K20288, KAKENHI-PUBLICLY-15H01482, KAKENHI-PROJECT-26861472
[Journal Article] Association between the major histocompatibility complex and clinical response to infliximab therapy in patients with Behçet uveitis.2015
- Author(s)
  Kuroyanagi K, Sakai T, Kohno H, Okano K, Akiyama G, Aoyagi R, Inaba M, Tsuneoka H.
- Journal Title
  
  Jpn J Ophthalmol
  
  Volume: 59 Issue: 6 Pages: 401-8
- DOI
  10.1007/s10384-015-0404-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20288, KAKENHI-PROJECT-26861472
[Journal Article] Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.2014
- Author(s)
  Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 14
- DOI
  10.1073/pnas.1317986111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893253
[Journal Article] Treatment of experimental autoimmune uveoretinitis with peroxisome proliferator-activated receptor α agonist fenofibrate.2014
- Author(s)
  Osada M, Sakai T, Kuroyanagi K, Kohno H, Tsuneoka H.
- Journal Title
  
  Mol Vis.
  
  Volume: 20 Pages: 1518-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893253
[Journal Article] DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.2014
- Author(s)
  Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K.
- Journal Title
  
  FASEB J.
  
  Volume: 8 Issue: 8 Pages: 3780-91
- DOI
  10.1096/fj.14-254292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893253
[Journal Article] CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.2014
- Author(s)
  Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A.
- Journal Title
  
  J Immunol.
  
  Volume: 192 Issue: 8 Pages: 3816-27
- DOI
  10.4049/jimmunol.1301738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893253
[Journal Article] Three-year visual outcome of photodynamic therapy plus intravitreal bevacizumab with or without subtenon triamcinolone acetonide injections for polypoidal choroidal vasculopathy.2014
- Author(s)
  Sakai T, Ohkuma Y, Kohno H, Hayashi T, Watanabe A, Tsuneoka H.
- Journal Title
  
  Br J Ophthalmol.
  
  Volume: 98 Issue: 12 Pages: 1642-8
- DOI
  10.1136/bjophthalmol-2014-305189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893253
[Journal Article] All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.2014
- Author(s)
  Sawada O, Perusek L, Kohno H, Howell SJ, Maeda A, Matsuyama S, Maeda T.
- Journal Title
  
  Exp Eye Res.
  
  Volume: 123 Pages: 27-36
- DOI
  10.1016/j.exer.2014.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893253
[Presentation] ヨウ素レシチンによる網膜変性での視細胞保護効果2021
- Author(s)
  神野　英生
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K09960
[Presentation] Minocycline suppresses microglial Ccr2 expression in inherited retinal degeneration.2019
- Author(s)
  Ryo Terauchi, Tsutomu Sakai, Tadashi Nakano and Hideo Kohno.
- Organizer
  ARVO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09960
[Presentation] ミノサイクリン投与による変性網膜におけるCcr2発現の抑制効果2019
- Author(s)
  寺内稜、神野英生、酒井勉、中野匡
- Organizer
  第123回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K09960
[Presentation] 教育セミナー　網膜硝子体の感染；硝子体内注射2017
- Author(s)
  神野　英生
- Organizer
  第40回日本眼科手術学会学術総会
- Place of Presentation
  東京
- Year and Date
  2017-01-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K20288
[Presentation] 遺伝性網膜変性におけるCcr2およびCx3cr1の発現様式．2017
- Author(s)
  神野　英生
- Organizer
  第121回日本眼科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K20288
[Presentation] 網膜変性疾患における炎症の関与.2016
- Author(s)
  神野　英生
- Organizer
  第120回日本眼科学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-04-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K20288
[Presentation] Microglial activation in retinal degeneration.2015
- Author(s)
  Kohno H.
- Organizer
  OIST mini-symposim
- Place of Presentation
  Okinawa
- Year and Date
  2015-03-01
- Invited
- Data Source
  KAKENHI-PROJECT-25893253
[Presentation] 網膜変性における炎症と視細胞細胞死の関係2015
- Author(s)
  神野　英生
- Organizer
  第49回日本眼炎症学会
- Place of Presentation
  大阪
- Year and Date
  2015-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K20288
[Presentation] Minocycline administration suppresses microglia activation in vitro and rescue all-trans-retinal mediated photoreceptor cell death in vivo.2014
- Author(s)
  Kohno H, Sakai T, Maeda T, Tsuneoka H and Maeda A.
- Organizer
  WOC 2014
- Place of Presentation
  Tokyo
- Year and Date
  2014-04-04
- Data Source
  KAKENHI-PROJECT-25893253
[Presentation] The paradoxical role of CCL3 in acute and chronic retinal degeneration.2014
- Author(s)
  Kohno H, Sakai T, Maeda, Pearlman E, Palczewski K and Maeda A.
- Organizer
  ARVO 2014
- Place of Presentation
  Orland
- Year and Date
  2014-05-05
- Data Source
  KAKENHI-PROJECT-25893253

1. 高祖秀登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIDEO Kohno 神野 英生

Research Projects

Research Products

Co-Researchers

Examination of drug repositioning in retinal degenerative diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CCL3-CCR5 axis is potential therapeutic target in retinal degeneration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New inflammation targeted strategy for retinal degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of Lecithin-Bound Iodine Treatment on Inherited Retinal Degeneration in Mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Minocycline decreases CCR2-positive monocytes in the retina and ameliorates photoreceptor degeneration in a mouse model of retinitis pigmentosa.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-year visual outcomes of intravitreal ranibizumab with or without photodynamic therapy for polypoidal choroidal vasculopathy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between the major histocompatibility complex and clinical response to infliximab therapy in patients with Beh&ccedil;et uveitis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment of experimental autoimmune uveoretinitis with peroxisome proliferator-activated receptor α agonist fenofibrate.2014

Author(s)

Journal Title

Data Source

[Journal Article] DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-year visual outcome of photodynamic therapy plus intravitreal bevacizumab with or without subtenon triamcinolone acetonide injections for polypoidal choroidal vasculopathy.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] ヨウ素レシチンによる網膜変性での視細胞保護効果2021

Author(s)

Organizer

Data Source

HIDEO Kohno 神野英生

[Journal Article] Association between the major histocompatibility complex and clinical response to infliximab therapy in patients with Behçet uveitis.2015

[Presentation] 教育セミナー　網膜硝子体の感染；硝子体内注射2017