KAWAMURA Tatsuro 河村達郎

Researcher Number	60528561
Affiliation (based on the past Project Information) *help	2019: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 2016: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 協力研究員 2015 – 2016: 国立研究開発法人理化学研究所, 理研-マックスプランク連携研究センター, 協力研究員 2013 – 2014: 独立行政法人理化学研究所, 長田抗生物質研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Chemical biology / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator 活性酸素種 / がん / 酸化ストレス / フェロトーシス / レドックス / 膵臓がん / MTH1 / 代謝 / すい臓がん / 細胞死 / KRAS / グルタチオン / Survivin

酸化ストレス誘導化合物“ferroxin”を用いたフェロトーシス制御機構の解明Principal Investigator
- Principal Investigator
  
  河村達郎
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
Study on small-molecule modulators of pancreatic cancer metabolismPrincipal Investigator
- Principal Investigator
  
  Kawamura Tatsuro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research
Discovery and characterization of Survivin ligandsPrincipal Investigator
- Principal Investigator
  
  KAWAMURA Tatsuro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 遺伝子医学MOOK(29)　オミックスで加速するがんバイオマーカー研究の最新動向2015
- Author(s)
  河村達郎、近藤恭光、長田裕之
- Total Pages
  278
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-15K16563
[Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.2016
- Author(s)
  Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY
- Journal Title
  
  Chem Biol Drug Des
  
  Volume: - Issue: 6 Pages: 862-869
- DOI
  10.1111/cbdd.12909
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PLANNED-17H06412
[Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.2016
- Author(s)
  Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 26521-26521
- DOI
  10.1038/srep26521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276
[Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion.2014
- Author(s)
  Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
- Journal Title
  
  Biochem J
  
  Volume: 463 Issue: 1 Pages: 53-63
- DOI
  10.1042/bj20140669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750397, KAKENHI-PROJECT-26350976
[Journal Article] Identification and Characterization of an Inhibitor of Trichothecene 3-<i>O</i>-Acetyltransferase, TRI101, by the Chemical Array Approach2013
- Author(s)
  Nakajima Y, Kawamura T, Maeda K, Ichikawa H, Motoyama T, Kondoh Y, Saito T, Kobayashi T, Yoshida M, Osada H, Kimura M
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 77 Issue: 9 Pages: 1958-1960
- DOI
  10.1271/bbb.130153
- NAID
  10031202751
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-23580125, KAKENHI-PROJECT-25750397
[Presentation] 統合表現型プロファイリングとケミカルプロテオミクスの手法による3量体Giタンパク質調節化合物の発見2020
- Author(s)
  河村達郎、二村友史、SHANG Erchang 、室井誠、JANNING Petra 、上野雅佳、WILKE Julian 、武田茂樹、近藤恭光、ZIEGLER Slava 、渡辺信元、WALDMANN Herbert、長田裕之
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K05746
[Presentation] Discovery of a small-molecule modulator of heterotrimeric G-protein through integrated phenotypic screening and chemical proteomics2019
- Author(s)
  Tatsuro Kawamura, Erchang Shang, Yushi Futamura, Petra Janning, Julian Wilke, Makoto Muroi, Masayoshi Ueno, Shigeki Takeda, Yasumitsu Kondoh, Slava Ziegler, Nobumoto Watanabe, Herbert Waldmann, Hiroyuki Osada
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology 7th Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05746
[Presentation] がん細胞に活性酸素種産生を誘導する化合物RKN9055の作用機構解析2019
- Author(s)
  河村達郎、SHANG Erchang、JANNING Petra、上野雅佳, 武田茂樹、ZIEGLER Slava、渡辺信元、WALDMANN Herbert、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K05746
[Presentation] ChemProteoBase を用いたMTH1阻害剤の作用解析2017
- Author(s)
  室井誠、川谷誠、河村達郎、近藤恭光、二村友史、田中美帆、青野晴美、本田香織、長田裕之
- Organizer
  日本農芸化学会 2017年度大会
- Place of Presentation
  京都女子大学 (京都府・京都市)
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] Identification of MTH1 inhibitors by chemical arrays2016
- Author(s)
  Tatsuro Kawamura, Makoto Kawatani, Yasumitsu Kondoh, Makoto Muroi, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda, Hiroyuki Osada
- Organizer
  5th RIKEN-MPG Joint Symposium on Chemical Biology
- Place of Presentation
  Harneck-Haus (Berlin)
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] 酸化ヌクレオチド加水分解酵素MTH1はがん細胞の生存に必須でない2016
- Author(s)
  河村達郎、川谷誠、室井誠、青野晴美、二村友史、長田裕之
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (神奈川県・横浜市)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
- Author(s)
  Tatsuro Kawamura, Makoto Kawatani, Makoto Muroi, Yasumitsu Kondoh, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda, Hiroyuki Osada
- Organizer
  28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  ICM - International Congress Center Munich (Munich)
- Year and Date
  2016-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] 酸化ヌクレオチド加水分解酵素MTH1阻害剤の作用解析2016
- Author(s)
  川谷誠、河村達郎、室井誠、青野晴美、二村友史、田中美帆、長田裕之
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター (大分県・別府市)
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] 化合物アレイによるソニックヘッジホッグ(Shh)結合化合物の探索とそれらとShhとの相互作用の解析2015
- Author(s)
  近藤恭光、河村達郎、本田香織、関根朋美、長田裕之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学津島キャンパス(岡山県)
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25750397
[Presentation] A small molecule that induces reactive oxygen species via cellular glutathione depletion2015
- Author(s)
  Kawamura T., Kondoh Y., Muroi M., Kawatani M., Osada H.
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology - The 4th Symposium
- Place of Presentation
  神戸ニチイ学館ポートアイランド（兵庫県）
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] 化合物アレイを用いた新規MTH1阻害剤の探索2015
- Author(s)
  河村達郎、川谷誠、長田裕之
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県）
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-15K16563
[Presentation] NPD926, a small molecule inducer of reactive oxygen species, kills cancer cells via glutathione depletion2014
- Author(s)
  Tatsuro Kawamura, Yasumitsu Kondoh, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada
- Organizer
  26th EORTC-NCI-AACR Symposium on Molecular Targets & Cancer Therapeutics
- Place of Presentation
  バルセロナ(スペイン)
- Year and Date
  2014-11-19
- Data Source
  KAKENHI-PROJECT-25750397
[Presentation] 活性酸素種産生を誘導するアセトアミド誘導体の発見
- Author(s)
  河村達郎、室井誠、川谷誠、長田裕之
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-25750397
[Presentation] Glutathione S-transferase P1-1阻害活性を有するアセトアミド誘導体の同定
- Author(s)
  河村達郎、室井誠、川谷誠、長田裕之
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-25750397
[Presentation] がん細胞にROS産生を介した細胞死を誘導するα-chloroacetamideの作用機序と効果
- Author(s)
  河村達郎、近藤恭光、室井誠、川谷誠、長田裕之
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス(神奈川県)
- Data Source
  KAKENHI-PROJECT-25750397

1. FUTAMURA Yushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 長田裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 室井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAMURA Tatsuro 河村 達郎

Research Projects

Research Products

Co-Researchers

酸化ストレス誘導化合物“ferroxin”を用いたフェロトーシス制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on small-molecule modulators of pancreatic cancer metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery and characterization of Survivin ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子医学MOOK(29) オミックスで加速するがんバイオマーカー研究の最新動向2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and Characterization of an Inhibitor of Trichothecene 3-<i>O</i>-Acetyltransferase, TRI101, by the Chemical Array Approach2013

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] 統合表現型プロファイリングとケミカルプロテオミクスの手法による3量体Giタンパク質調節化合物の発見2020

Author(s)

Organizer

Data Source

[Presentation] Discovery of a small-molecule modulator of heterotrimeric G-protein through integrated phenotypic screening and chemical proteomics2019

Author(s)

Organizer

Data Source

[Presentation] がん細胞に活性酸素種産生を誘導する化合物RKN9055の作用機構解析2019

Author(s)

Organizer

Data Source

[Presentation] ChemProteoBase を用いたMTH1阻害剤の作用解析2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Identification of MTH1 inhibitors by chemical arrays2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 酸化ヌクレオチド加水分解酵素MTH1はがん細胞の生存に必須でない2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

KAWAMURA Tatsuro 河村達郎

[Book] 遺伝子医学MOOK(29)　オミックスで加速するがんバイオマーカー研究の最新動向2015