Murai Junko 村井純子

… Alternative Names

MURAI Junko 村井純子

MURAI JUNKO 村井純子

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Researcher Number	60532603
Other IDs
Affiliation (Current)	2025: 愛媛大学, プロテオサイエンスセンター, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 愛媛大学, プロテオサイエンスセンター, 准教授 2019 – 2023: 慶應義塾大学, 政策・メディア研究科(藤沢), 特任准教授 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related / Risk sciences of radiation and chemicals / Tumor therapeutics Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator DNA損傷 / 抗がん剤 / DNA修復 / SLFN11 / 複製ストレス / DNAダメージ / 薬剤耐性 / エピジェネティクス / 抗がん剤耐性 / がん … More / PARP阻害剤 / リボゾーム生合成 / アポトーシス / 化学療法 / 耐性 / 薬剤スクリーニング / ヒストン脱アセチル化阻害剤 / 遺伝子発現 / DNA障害 / プロテオーム / ドラッグスクリーニング / HDAC阻害剤 / 薬剤感受性 / ヒストン / プラチナ感受性 / クロマチン / MYC / 細胞周期 / 白金製剤 / がん抑制因子 / トランスジェニックマウス / がん遺伝子 / バイオマーカー / 複製 / がん抑制遺伝子 / PARP / 併用療法 / 抗がん治療 / 放射線 / ヌクレアーゼ / 相同組み替え / トポイソメラーゼ … More Except Principal Investigator DNA障害 / 感受性増強 / 抗がん剤 / 感受性 / DNA障害型抗がん剤 / SLFN11 / 化学療法感受性 / 髄芽腫 / 脳腫瘍 / Schlafen11 Less

SLFN11の分子メカニズムから解き明かすDNA障害型抗がん剤の真の作用機序Principal Investigator
- Principal Investigator
  
  村井純子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ehime University
Drug discovery targeting SLFN11 the enhancer of sensitivity to DNA-damaging anti-cancer agentsPrincipal Investigator
- Principal Investigator
  
  Junko Murai
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Ehime University
  Keio University
Chemo-sensitization of brain tumors by manipulation of SLFN11
- Principal Investigator
  
  棗田学
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Niigata University
Development of SLFN11 as a tumor supressor genePrincipal Investigator
- Principal Investigator
  
  MURAI Junko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Keio University
DNA障害型抗がん剤の耐性獲得に関わる新規遺伝子SLFN11の機能解析Principal Investigator
- Principal Investigator
  
  村井純子
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto University
Identification and funtional analysis of endonucleases involved in irradiation sensitivityPrincipal Investigator
- Principal Investigator
  
  MURAI JUNKO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] SLFN11 is a <i>BRCA</i> Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma2023
- Author(s)
  Akashi Hidehiko、Yachida Nozomi、Ueda Haruka、Yamaguchi Manako、Yamawaki Kaoru、Tamura Ryo、Suda Kazuaki、Ishiguro Tatsuya、Adachi Sosuke、Nagase Yoshikazu、Ueda Yutaka、Ueda Masashi、Abiko Kaoru、Kagabu Masahiro、Baba Tsukasa、Nakaoka Hirofumi、Enomoto Takayuki、Murai Junko、Yoshihara Kosuke
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 23 Issue: 1 Pages: 106-116
- DOI
  10.1158/1535-7163.mct-23-0257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16431, KAKENHI-PROJECT-22K09635, KAKENHI-PROJECT-23K08794, KAKENHI-PROJECT-23K08859, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-21K16810, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27447, KAKENHI-PROJECT-23K27459
[Journal Article] The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 132023
- Author(s)
  Fujiwara Kohei、Maekawa Masashi、Iimori Yuki、Ogawa Akane、Urano Takeshi、Kono Nobuaki、Takeda Hiroyuki、Higashiyama Shigeki、Arita Makoto、Murai Junko
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 12 Pages: 108529-108529
- DOI
  10.1016/j.isci.2023.108529
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19415, KAKENHI-PROJECT-23K27459
[Journal Article] Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to cisplatin2022
- Author(s)
  Nakata Satoshi、Murai Junko、Okada Masayasu,,,,,Tateishi Kensuke、Yamashita Shinji、Eberhart Charles G、Natsumeda Manabu
- Journal Title
  
  Neuro-Oncology
  
  Volume: 25 Issue: 5 Pages: 899-912
- DOI
  10.1093/neuonc/noac243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09210, KAKENHI-PROJECT-22K16679, KAKENHI-PROJECT-21KK0156, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-23K24297, KAKENHI-PROJECT-22K20953, KAKENHI-PROJECT-21H03042
[Journal Article] Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing a Dramatic Response to Methotrexate-Case Report2022
- Author(s)
  Mouri Y, Natsumeda M, Okubo N, Sato T, Saito T, Shibuya K, Yamada S, On J, Tsukamoto Y, Okada M, Oishi M, Eda T, Murai J, Shimizu H, Kakita A, Fujii Y
- Journal Title
  
  J Clin Med
  
  Volume: 11 Issue: 19 Pages: 5548-5548
- DOI
  10.3390/jcm11195548
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0156, KAKENHI-PROJECT-21H03042
[Journal Article] Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway2021
- Author(s)
  Murai Yasuhisa、Jo Ukhyun、Murai Junko、Fukuda Shinsaku、Takebe Naoko、Pommier Yves
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 10 Pages: 103173-103173
- DOI
  10.1016/j.isci.2021.103173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-21K20887
[Journal Article] SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-2432021
- Author(s)
  Murai Yasuhisa、Jo Ukhyun、Murai Junko、Jenkins Lisa M.、Huang Shar-Yin N.、Chakka Sirisha、Chen Lu、Cheng Ken、Fukuda Shinsaku、Takebe Naoko、Pommier Yves
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 11 Pages: 3067-3078
- DOI
  10.1158/0008-5472.can-20-2694
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-21K20887
[Journal Article] Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development2021
- Author(s)
  Moribe F, Nishikori M, Takashima T, Taniyama D, Onishi N, Arima H, Sasanuma H, Akagawa R, Elloumi F, Takeda S, Pommier Y, Morii E, Takaori-Kondo A, Murai J.
- Journal Title
  
  PLoS One.
  
  Volume: 16 Issue: 1 Pages: 0237554-0237554
- DOI
  10.1371/journal.pone.0237554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-18K08324, KAKENHI-PROJECT-19K22561, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-16H06279
[Journal Article] Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers2021
- Author(s)
  Takashima Tsuyoshi、Taniyama Daiki、Sakamoto Naoya、Yasumoto Maika、Asai Ryuichi、Hattori Takuya、Honma Ririno、Thang Pham Quoc、Ukai Shoichi、Maruyama Ryota、Harada Kenji、Kuraoka Kazuya、Tanabe Kazuaki、Sasaki Atsuo T.、Ohdan Hideki、Morii Eiichi、Murai Junko、Yasui Wataru
- Journal Title
  
  British Journal of Cancer
  
  Volume: 125 Issue: 1 Pages: 65-77
- DOI
  10.1038/s41416-021-01364-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] Prognostic impact of Schlafen 11 in bladder cancer patients treated with platinum‐based chemotherapy2021
- Author(s)
  Taniyama Daiki、Sakamoto Naoya、Takashima Tsuyoshi、Takeda Masahiko、Pham Quoc Thang、Ukai Shoichi、Maruyama Ryota、Harada Kenji、Babasaki Takashi、Sekino Yohei、Hayashi Tetsutaro、Sentani Kazuhiro、Pommier Yves、Murai Junko、Yasui Wataru
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 784-795
- DOI
  10.1111/cas.15207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03505
[Journal Article] SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors2021
- Author(s)
  Jo Ukhyun、Murai Yasuhisa、Chakka Sirisha、Chen Lu、Cheng Ken、Murai Junko、Saha Liton Kumar、Miller Jenkins Lisa M.、Pommier Yves
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 6
- DOI
  10.1073/pnas.2015654118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer2020
- Author(s)
  Nair Jayakumar、Huang Tzu-Ting、Murai Junko、Haynes Brittany、Steeg Patricia S.、Pommier Yves、Lee Jung-Min
- Journal Title
  
  Oncogene
  
  Volume: 39 Issue: 33 Pages: 5520-5535
- DOI
  10.1038/s41388-020-1383-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] The first evidence for SLFN11 expression as an independent prognostic factor for patients with esophageal cancer after chemoradiotherapy2020
- Author(s)
  Kagami Takuma、Yamade Mihoko、Suzuki Takahiro、Uotani Takahiro、Tani Shinya、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Sugimoto Ken、Miyajima Hiroaki、Baba Satoshi、Sugimura Haruhiko、Murai Junko、Pommier Yves、Furuta Takahisa
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Issue: 1 Pages: 1123-1123
- DOI
  10.1186/s12885-020-07574-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-18K07908
[Journal Article] Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression2020
- Author(s)
  Rathkey Daniel、Khanal Manakamana、Murai Junko、Zhang Jingli、Sengupta Manjistha、Jiang Qun、Morrow Betsy、Evans Christine N.、Chari Raj、Fetsch Patricia、Chung Hye-Jung、Xi Liqiang、Roth Mark、Filie Armando、Raffeld Mark、Thomas Anish、Pommier Yves、Hassan Raffit
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 15 Issue: 5 Pages: 843-859
- DOI
  10.1016/j.jtho.2020.01.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress2020
- Author(s)
  Murai Junko、Zhang Hongliang、Pongor Lorinc、Tang Sai-Wen、Jo Ukhyun、Moribe Fumiya、Ma Yixiao、Tomita Masaru、Pommier Yves
- Journal Title
  
  Cell Reports
  
  Volume: 30 Issue: 12 Pages: 4137-4151.e6
- DOI
  10.1016/j.celrep.2020.02.117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq2020
- Author(s)
  Takashima Tsuyoshi、Sakamoto Naoya、Murai Junko、Taniyama Daiki、Honma Ririno、Ukai Shoichi、Maruyama Ryota、Kuraoka Kazuya、Rajapakse Vinodh N.、Pommier Yves、Yasui Wataru
- Journal Title
  
  Virchows Archiv
  
  Volume: 478 Issue: 3 Pages: 569-579
- DOI
  10.1007/s00428-020-02840-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-18K07017
[Journal Article] PARP Trapping Beyond Homologous Recombination and Platinum Sensitivity in Cancers2019
- Author(s)
  Murai Junko、Pommier Yves
- Journal Title
  
  Annual Review of Cancer Biology
  
  Volume: 3 Issue: 1 Pages: 131-150
- DOI
  10.1146/annurev-cancerbio-030518-055914
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies2019
- Author(s)
  Murai Junko、Thomas Anish、Miettinen Markku、Pommier Yves
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 201 Pages: 94-102
- DOI
  10.1016/j.pharmthera.2019.05.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP12019
- Author(s)
  Murai Junko、Pommier Yves
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 10 Pages: 2460-2461
- DOI
  10.1158/0008-5472.can-19-0798
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] PARP Inhibitor Sensitivity Does Not Depend on BAP1 but Is Enhanced by Temozolomide in MGMT Deficient Human Mesothelioma Cells2019
- Author(s)
  Rathkey D.、Khanal M.、Murai J.、Zhang J.、Jiang Q.、Morrow B.、Evans C.、Chari R.、Sengupta M.、Thomas A.、Pommier Y.、Hassan R.
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 14 Issue: 10 Pages: S296-S296
- DOI
  10.1016/j.jtho.2019.08.594
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505
[Journal Article] The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.2015
- Author(s)
  Hirota K, Yoshikiyo K, Guilbaud G, Tsurimoto T, Murai J, Tsuda M, Phillips L, Narita T, Nishihara K, Kobayashi K, Yamada K, Nakamura J, Pommier Y, Lehmann, A, Sale J, Takeda S
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 43 Issue: 3 Pages: 1671-1683
- DOI
  10.1093/nar/gkv023
- NAID
  120005825923
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PUBLICLY-25131714, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25350177, KAKENHI-PROJECT-25440011, KAKENHI-PROJECT-25740016, KAKENHI-PUBLICLY-26114714, KAKENHI-PUBLICLY-26116518
[Journal Article] SLFN11 is a transcriptional target of EWS-FLI1 and a determinant of drug response in Ewing's sarcoma2015
- Author(s)
  Tang, S. W. Bilke, S. Cao, L. Murai, J. Sousa, F. G. Yamade, M. Rajapakse, V. Varma, S. Helman, L. J. Khan, J. Meltzer, P. S. Pommier, Y.
- Journal Title
  
  Clin Cancer Res
  
  Volume: N/A Issue: 18 Pages: 4184-4193
- DOI
  10.1158/1078-0432.ccr-14-2112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25740016
[Journal Article] Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.2014
- Author(s)
  Murai J, Marchand C, Shahane SA, Sun H, Huang R, Zhang Y, Chergui A, Ji J, Doroshow JH, Jadhav A, Takeda S, Xia M, Pommier Y
- Journal Title
  
  DNA Repair
  
  Volume: 21 Pages: 177-182
- DOI
  10.1016/j.dnarep.2014.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.2014
- Author(s)
  Maede Y, Shimizu H, Fukushima T, Kogame T, Nakamura T, Miki T, Takeda S, Pommier Y, Murai J
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 13 Issue: 1 Pages: 214-220
- DOI
  10.1158/1535-7163.mct-13-0551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.2014
- Author(s)
  Murai J, Huang SY, Renaud A, Zhang Y, Ji J, Takeda S, Morris J, Teicher B, Doroshow JH, Pommier Y
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 13 Issue: 2 Pages: 433-443
- DOI
  10.1158/1535-7163.mct-13-0803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.2014
- Author(s)
  Das BB, Huang SY, Murai J, Rehman I, Ame JC, Sengupta S, Das SK, Majumdar P, Zhang H, Biard D, Majumder HK, Schreiber V, Pommier Y.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 42 Issue: 7 Pages: 4435-4449
- DOI
  10.1093/nar/gku088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25740016
[Journal Article] Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)2014
- Author(s)
  Pommier, Y. Huang, S. Y. Gao, R. Das, B. B. Murai, J. Marchand, C.
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 19 Pages: 114-29
- DOI
  10.1016/j.dnarep.2014.03.020
- Data Source
  KAKENHI-PROJECT-25740016
[Journal Article] Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.2014
- Author(s)
  Murai J, Zhang Y, Morris J, Ji J, Takeda S, Doroshow J, Pommier YG
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 349 Issue: 3 Pages: 408-416
- DOI
  10.1124/jpet.113.210146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.2014
- Author(s)
  Murai J, Zhang Y, Morris J, Ji J, Takeda S, Doroshow JH, Pommier YG.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: ahead of epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25740016
[Journal Article] TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs2013
- Author(s)
  Shar-yin N. Huang, Junko Murai, Ilaria Dalla Rosa, Thomas S. Dexheimer, Alena Naumova, William H. Gmeiner and Yves Pommier
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 41 Issue: 16 Pages: 7793-7803
- DOI
  10.1093/nar/gkt483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25740016
[Presentation] 髄芽腫における化学療法感受性マーカーSLFN11の同定 -Neuro-Oncology誌minor revisionの裏側-2023
- Author(s)
  棗田　学，中田聡，村井純子，立石健祐，山下真治，岡田正康，塚本佳広，高島秀雄，大石誠，藤井幸彦，Celio Pouponnot, Charles Eberhart
- Organizer
  第23回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] Epigenetic upregulation of Schlafen11 renders WNT- and SHH- activated medulloblastomas sensitive to cisplatin2023
- Author(s)
  Satoshi Nakata, Manabu Natsumeda, Junko Murai, Masayasu Okada, Akiyoshi Kakita, Charles Eberhart
- Organizer
  第12回国際放射線神経生物学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] Schlafen11 is a powerful biomarker of chemosensitivity in medulloblastomas2023
- Author(s)
  Natsumeda M, Nakata S, Murai J, Takahashi M, Okada M, Watanabe J, Tsukamoto Y, Tateishi K, Osuka S, Raabe E, Pouponnot C, Pommier Y, Oishi M, Kakita A, Eberhart C
- Organizer
  28th Annual Meeting for the Society of Neuro-oncology (SNO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] SLFN11 as a biomarker for sensitivity to radiation in medulloblastomas2023
- Author(s)
  Manabu Natsumeda, Satoshi Nakata, Junko Murai, Masayasu Okada, Akiyoshi Kakita, Charles Eberhart
- Organizer
  第12回国際放射線神経生物学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現によるDNA障害型抗がん剤への感受性増強2023
- Author(s)
  棗田　学，中田聡，村井純子，岡田正康，塚本佳広，大石誠，Eberhart C
- Organizer
  第36回日本脳神経外科同時通訳団夏期研修
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現およびDNA障害型抗がん剤への感受性および予後の検討2022
- Author(s)
  棗田　学、中田　聡、村井純子、岡田正康、塚本佳広、大石誠、藤井幸彦、Charles Eberhart
- Organizer
  第22回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現および新たな治療戦略の検討2022
- Author(s)
  中田聡、棗田学、村井純子、岡田正康、柿田明美、Charles Eberhart、他
- Organizer
  第40回日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現およびDNA障害型抗がん剤への感受性および予後の検討2022
- Author(s)
  棗田　学、中田　聡、村井純子、岡田正康、塚本佳広、大石誠、藤井幸彦、Charles Eberhart
- Organizer
  第50回日本小児神経外科学会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現およびDNA障害型抗がん剤への感受性の検討2022
- Author(s)
  棗田　学、中田　聡、村井純子、岡田正康、塚本佳広、大石誠、藤井幸彦、Charles Eberhart
- Organizer
  第1回新潟小児悪性腫瘍研究会・学術集会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現および新たな治療戦略の検討2022
- Author(s)
  中田聡、棗田学、村井純子、岡田正康、柿田明美、Charles Eberhart、他
- Organizer
  第40回日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] 髄芽腫におけるSLFN11発現およびDNA障害型抗がん剤への感受性の検討2022
- Author(s)
  棗田　学、中田　聡、村井　純子、岡田正康、塚本佳広、大石誠、藤井幸彦, Charles Eberhart
- Organizer
  第1回新潟小児悪性腫瘍研究会・学術集会
- Data Source
  KAKENHI-PROJECT-21KK0156
[Presentation] SLFN11 enhances chromatin accessibility in response to DNA-targeting anti-cance agents2021
- Author(s)
  村井純子
- Organizer
  第80回　日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] あなたの知らないSLFN11の世界（シンポジウム）2021
- Author(s)
  村井純子
- Organizer
  第44回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] PARP阻害剤の作用機序2021
- Author(s)
  村井純子
- Organizer
  第一回JOHBOC学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] がん治療に直結する最新複製制御機構(シンポジウム）2021
- Author(s)
  村井純子
- Organizer
  第94回　日本生化学学会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] あなたの知らないSLFN11の世界2020
- Author(s)
  村井純子
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] PARP Inhibitors Beyond Homologous Recombination and Platinum Sensitivity in Breast and Ovarian Cancers2020
- Author(s)
  村井純子
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] SLFN11が増強するDNA障害型抗がん剤の殺細胞効果2019
- Author(s)
  村井純子
- Organizer
  第28回日本cell death学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] Multiple functions of SLFN11, a restriction factor for replication stress induced by DNA-targeting anti-cancer agents2019
- Author(s)
  村井純子
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] Schlafen 11 (SLFN11): an emerging focus for DNA-targeted anti-cancer therapies2019
- Author(s)
  村井純子
- Organizer
  第78回日本ガン学会
- Data Source
  KAKENHI-PROJECT-19H03505
[Presentation] The combination of the PARP inhibitor talazoparib (BMN 673) with the ATR inhibitor VE-821 overcomes the drug resistance of Schlafen 11-deficient cells2015
- Author(s)
  Junko Murai
- Organizer
  Association of American Cancer Association 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-21
- Data Source
  KAKENHI-PROJECT-25740016
[Presentation] Mechanism of action of PARP inhibitors, new molecular targeted drugs2014
- Author(s)
  Junko Murai
- Organizer
  第47回日本骨軟部腫瘍学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-07-18
- Invited
- Data Source
  KAKENHI-PROJECT-25740016
[Presentation] Stereospecific trapping of PARP-DNA complexes by BMN 673 and comparison with olaparib and rucaparib2013
- Author(s)
  Junko Murai
- Organizer
  AACR-NCI-EORTC 2013
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-25740016
[Presentation] 新規分子標的がん治療薬PARP阻害剤の作用機序
- Author(s)
  Junko Murai
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  Pacifico Yokohama
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-25740016

1. 棗田学 (00515728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 岡田正康 (00626492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
3. 柿田明美 (80281012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 西尾真 (10330846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIMIZU Hiroyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TATEISHI Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. ONISHI Nobuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SENTANI Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 安彦郁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 武田俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
11. 廣田耕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 山田亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murai Junko 村井 純子

MURAI Junko 村井 純子

MURAI JUNKO 村井 純子

Research Projects

Research Products

Co-Researchers

SLFN11の分子メカニズムから解き明かすDNA障害型抗がん剤の真の作用機序Principal Investigator

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Drug discovery targeting SLFN11 the enhancer of sensitivity to DNA-damaging anti-cancer agentsPrincipal Investigator

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Chemo-sensitization of brain tumors by manipulation of SLFN11

Principal Investigator

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Development of SLFN11 as a tumor supressor genePrincipal Investigator

Principal Investigator

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DNA障害型抗がん剤の耐性獲得に関わる新規遺伝子SLFN11の機能解析Principal Investigator

Principal Investigator

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Identification and funtional analysis of endonucleases involved in irradiation sensitivityPrincipal Investigator

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[Journal Article] SLFN11 is a <i>BRCA</i> Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma2023

Author(s)

Journal Title

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[Journal Article] The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 132023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic upregulation of Schlafen11 renders WNT- and SHH-activated medulloblastomas sensitive to cisplatin2022

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[Journal Article] Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing a Dramatic Response to Methotrexate-Case Report2022

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[Journal Article] Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway2021

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[Journal Article] SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-2432021

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[Journal Article] Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development2021

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[Journal Article] Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers2021

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Murai Junko 村井純子

MURAI Junko 村井純子

MURAI JUNKO 村井純子